Putative ribose-phosphate pyrophosphokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribose-phosphate pyrophosphokinase, putative

Species:

Leishmania mexicana

UniProt:

E9AMD0_LEIMU

TriTrypDb:

LmxM.08.0510

Length:

838

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0002189	ribose phosphate diphosphokinase complex	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9AMD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMD0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006753	nucleoside phosphate metabolic process	4	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	8
GO:0009117	nucleotide metabolic process	5	8
GO:0009165	nucleotide biosynthetic process	6	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0018130	heterocycle biosynthetic process	4	8
GO:0019438	aromatic compound biosynthetic process	4	8
GO:0019637	organophosphate metabolic process	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034654	nucleobase-containing compound biosynthetic process	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	8
GO:0044271	cellular nitrogen compound biosynthetic process	4	8
GO:0044281	small molecule metabolic process	2	8
GO:0046483	heterocycle metabolic process	3	8
GO:0055086	nucleobase-containing small molecule metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090407	organophosphate biosynthetic process	4	8
GO:1901293	nucleoside phosphate biosynthetic process	5	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:1901362	organic cyclic compound biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	8
GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process	6	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006164	purine nucleotide biosynthetic process	6	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0046390	ribose phosphate biosynthetic process	5	1
GO:0046391	5-phosphoribose 1-diphosphate metabolic process	5	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	8
GO:0003824	catalytic activity	1	8
GO:0004749	ribose phosphate diphosphokinase activity	5	8
GO:0005488	binding	1	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016778	diphosphotransferase activity	4	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	516	520	PF00656	0.428
CLV_NRD_NRD_1	100	102	PF00675	0.560
CLV_NRD_NRD_1	117	119	PF00675	0.597
CLV_NRD_NRD_1	157	159	PF00675	0.364
CLV_NRD_NRD_1	232	234	PF00675	0.371
CLV_NRD_NRD_1	541	543	PF00675	0.531
CLV_NRD_NRD_1	569	571	PF00675	0.601
CLV_NRD_NRD_1	712	714	PF00675	0.644
CLV_NRD_NRD_1	806	808	PF00675	0.290
CLV_PCSK_FUR_1	175	179	PF00082	0.399
CLV_PCSK_KEX2_1	100	102	PF00082	0.560
CLV_PCSK_KEX2_1	117	119	PF00082	0.597
CLV_PCSK_KEX2_1	157	159	PF00082	0.392
CLV_PCSK_KEX2_1	177	179	PF00082	0.308
CLV_PCSK_KEX2_1	541	543	PF00082	0.510
CLV_PCSK_KEX2_1	569	571	PF00082	0.540
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.408
CLV_PCSK_SKI1_1	142	146	PF00082	0.588
CLV_PCSK_SKI1_1	16	20	PF00082	0.482
CLV_PCSK_SKI1_1	233	237	PF00082	0.375
CLV_PCSK_SKI1_1	297	301	PF00082	0.590
CLV_PCSK_SKI1_1	350	354	PF00082	0.308
CLV_PCSK_SKI1_1	48	52	PF00082	0.446
CLV_PCSK_SKI1_1	762	766	PF00082	0.308
CLV_PCSK_SKI1_1	802	806	PF00082	0.189
CLV_Separin_Metazoa	205	209	PF03568	0.456
CLV_Separin_Metazoa	560	564	PF03568	0.678
DEG_Nend_Nbox_1	1	3	PF02207	0.655
DOC_CKS1_1	112	117	PF01111	0.623
DOC_CKS1_1	598	603	PF01111	0.646
DOC_CKS1_1	631	636	PF01111	0.554
DOC_CYCLIN_RxL_1	13	21	PF00134	0.475
DOC_MAPK_DCC_7	208	216	PF00069	0.403
DOC_MAPK_gen_1	175	183	PF00069	0.427
DOC_MAPK_gen_1	731	738	PF00069	0.450
DOC_MAPK_gen_1	807	814	PF00069	0.475
DOC_MAPK_MEF2A_6	208	216	PF00069	0.403
DOC_MAPK_MEF2A_6	274	282	PF00069	0.466
DOC_MAPK_MEF2A_6	731	738	PF00069	0.450
DOC_PP2B_LxvP_1	378	381	PF13499	0.487
DOC_PP4_FxxP_1	127	130	PF00568	0.579
DOC_PP4_FxxP_1	136	139	PF00568	0.571
DOC_PP4_FxxP_1	470	473	PF00568	0.384
DOC_USP7_MATH_1	244	248	PF00917	0.404
DOC_USP7_MATH_1	362	366	PF00917	0.467
DOC_USP7_MATH_1	395	399	PF00917	0.523
DOC_USP7_MATH_1	433	437	PF00917	0.487
DOC_USP7_MATH_1	473	477	PF00917	0.395
DOC_USP7_MATH_1	50	54	PF00917	0.452
DOC_USP7_MATH_1	60	64	PF00917	0.504
DOC_USP7_MATH_1	601	605	PF00917	0.647
DOC_USP7_MATH_1	639	643	PF00917	0.690
DOC_USP7_MATH_1	770	774	PF00917	0.559
DOC_USP7_MATH_2	473	479	PF00917	0.359
DOC_USP7_UBL2_3	145	149	PF12436	0.489
DOC_USP7_UBL2_3	230	234	PF12436	0.391
DOC_USP7_UBL2_3	38	42	PF12436	0.395
DOC_WW_Pin1_4	111	116	PF00397	0.646
DOC_WW_Pin1_4	129	134	PF00397	0.701
DOC_WW_Pin1_4	597	602	PF00397	0.677
DOC_WW_Pin1_4	615	620	PF00397	0.688
DOC_WW_Pin1_4	627	632	PF00397	0.735
DOC_WW_Pin1_4	65	70	PF00397	0.586
DOC_WW_Pin1_4	780	785	PF00397	0.508
DOC_WW_Pin1_4	93	98	PF00397	0.626
LIG_14-3-3_CanoR_1	118	127	PF00244	0.509
LIG_14-3-3_CanoR_1	16	26	PF00244	0.468
LIG_14-3-3_CanoR_1	289	293	PF00244	0.436
LIG_14-3-3_CanoR_1	424	432	PF00244	0.465
LIG_14-3-3_CanoR_1	594	601	PF00244	0.586
LIG_14-3-3_CanoR_1	689	695	PF00244	0.604
LIG_Actin_WH2_2	25	40	PF00022	0.420
LIG_APCC_ABBA_1	459	464	PF00400	0.376
LIG_BIR_III_2	324	328	PF00653	0.577
LIG_BIR_III_4	621	625	PF00653	0.711
LIG_BRCT_BRCA1_1	131	135	PF00533	0.566
LIG_BRCT_BRCA1_1	269	273	PF00533	0.468
LIG_BRCT_BRCA1_1	316	320	PF00533	0.490
LIG_BRCT_BRCA1_1	506	510	PF00533	0.428
LIG_CORNRBOX	734	742	PF00104	0.523
LIG_CtBP_PxDLS_1	784	788	PF00389	0.491
LIG_EH1_1	387	395	PF00400	0.508
LIG_eIF4E_1	721	727	PF01652	0.508
LIG_FHA_1	121	127	PF00498	0.711
LIG_FHA_1	317	323	PF00498	0.584
LIG_FHA_1	332	338	PF00498	0.443
LIG_FHA_1	341	347	PF00498	0.482
LIG_FHA_1	351	357	PF00498	0.439
LIG_FHA_1	424	430	PF00498	0.483
LIG_FHA_1	433	439	PF00498	0.502
LIG_FHA_1	609	615	PF00498	0.641
LIG_FHA_1	639	645	PF00498	0.600
LIG_FHA_1	68	74	PF00498	0.679
LIG_FHA_1	691	697	PF00498	0.564
LIG_FHA_1	766	772	PF00498	0.465
LIG_FHA_1	789	795	PF00498	0.465
LIG_FHA_2	145	151	PF00498	0.570
LIG_FHA_2	194	200	PF00498	0.430
LIG_FHA_2	2	8	PF00498	0.630
LIG_FHA_2	72	78	PF00498	0.556
LIG_FHA_2	738	744	PF00498	0.446
LIG_FHA_2	831	837	PF00498	0.474
LIG_Integrin_RGD_1	383	385	PF01839	0.265
LIG_LIR_Apic_2	124	130	PF02991	0.591
LIG_LIR_Apic_2	467	473	PF02991	0.395
LIG_LIR_Apic_2	558	562	PF02991	0.638
LIG_LIR_Apic_2	595	601	PF02991	0.585
LIG_LIR_Gen_1	163	174	PF02991	0.367
LIG_LIR_Gen_1	213	222	PF02991	0.423
LIG_LIR_Gen_1	478	487	PF02991	0.352
LIG_LIR_Gen_1	497	506	PF02991	0.377
LIG_LIR_LC3C_4	786	789	PF02991	0.462
LIG_LIR_Nem_3	163	169	PF02991	0.365
LIG_LIR_Nem_3	171	176	PF02991	0.360
LIG_LIR_Nem_3	213	218	PF02991	0.420
LIG_LIR_Nem_3	29	34	PF02991	0.410
LIG_LIR_Nem_3	478	484	PF02991	0.351
LIG_LIR_Nem_3	497	501	PF02991	0.409
LIG_LIR_Nem_3	720	724	PF02991	0.510
LIG_OCRL_FandH_1	165	177	PF00620	0.445
LIG_PCNA_APIM_2	176	182	PF02747	0.397
LIG_Rb_pABgroove_1	829	837	PF01858	0.491
LIG_REV1ctd_RIR_1	163	172	PF16727	0.428
LIG_SH2_CRK	141	145	PF00017	0.345
LIG_SH2_CRK	224	228	PF00017	0.422
LIG_SH2_CRK	284	288	PF00017	0.371
LIG_SH2_GRB2like	302	305	PF00017	0.572
LIG_SH2_GRB2like	663	666	PF00017	0.507
LIG_SH2_PTP2	173	176	PF00017	0.313
LIG_SH2_PTP2	724	727	PF00017	0.487
LIG_SH2_SRC	210	213	PF00017	0.418
LIG_SH2_SRC	517	520	PF00017	0.388
LIG_SH2_SRC	559	562	PF00017	0.629
LIG_SH2_STAP1	262	266	PF00017	0.456
LIG_SH2_STAP1	292	296	PF00017	0.417
LIG_SH2_STAP1	434	438	PF00017	0.465
LIG_SH2_STAP1	517	521	PF00017	0.387
LIG_SH2_STAT5	173	176	PF00017	0.362
LIG_SH2_STAT5	179	182	PF00017	0.360
LIG_SH2_STAT5	210	213	PF00017	0.369
LIG_SH2_STAT5	215	218	PF00017	0.351
LIG_SH2_STAT5	31	34	PF00017	0.389
LIG_SH2_STAT5	431	434	PF00017	0.470
LIG_SH2_STAT5	486	489	PF00017	0.419
LIG_SH2_STAT5	663	666	PF00017	0.557
LIG_SH2_STAT5	724	727	PF00017	0.487
LIG_SH3_1	810	816	PF00018	0.465
LIG_SH3_3	109	115	PF00018	0.645
LIG_SH3_3	127	133	PF00018	0.623
LIG_SH3_3	356	362	PF00018	0.508
LIG_SH3_3	500	506	PF00018	0.371
LIG_SH3_3	61	67	PF00018	0.606
LIG_SH3_3	613	619	PF00018	0.740
LIG_SH3_3	625	631	PF00018	0.650
LIG_SH3_3	810	816	PF00018	0.465
LIG_SH3_4	38	45	PF00018	0.391
LIG_SUMO_SIM_anti_2	246	252	PF11976	0.481
LIG_SUMO_SIM_anti_2	279	284	PF11976	0.450
LIG_SUMO_SIM_anti_2	409	414	PF11976	0.465
LIG_SUMO_SIM_anti_2	446	452	PF11976	0.392
LIG_SUMO_SIM_anti_2	499	505	PF11976	0.452
LIG_SUMO_SIM_anti_2	641	652	PF11976	0.668
LIG_SUMO_SIM_anti_2	761	768	PF11976	0.465
LIG_SUMO_SIM_anti_2	782	789	PF11976	0.473
LIG_SUMO_SIM_par_1	392	399	PF11976	0.523
LIG_SUMO_SIM_par_1	455	460	PF11976	0.336
LIG_SUMO_SIM_par_1	70	77	PF11976	0.635
LIG_SUMO_SIM_par_1	761	768	PF11976	0.508
LIG_SUMO_SIM_par_1	786	793	PF11976	0.465
LIG_TRFH_1	35	39	PF08558	0.414
LIG_TYR_ITIM	222	227	PF00017	0.358
LIG_TYR_ITIM	282	287	PF00017	0.460
LIG_TYR_ITIM	32	37	PF00017	0.401
MOD_CDK_SPxK_1	111	117	PF00069	0.562
MOD_CDK_SPxxK_3	111	118	PF00069	0.674
MOD_CDK_SPxxK_3	93	100	PF00069	0.557
MOD_CK1_1	107	113	PF00069	0.734
MOD_CK1_1	264	270	PF00069	0.460
MOD_CK1_1	535	541	PF00069	0.436
MOD_CK1_1	604	610	PF00069	0.667
MOD_CK1_1	630	636	PF00069	0.637
MOD_CK1_1	656	662	PF00069	0.664
MOD_CK1_1	68	74	PF00069	0.675
MOD_CK1_1	690	696	PF00069	0.573
MOD_CK2_1	144	150	PF00069	0.500
MOD_CK2_1	161	167	PF00069	0.257
MOD_CK2_1	193	199	PF00069	0.418
MOD_CK2_1	30	36	PF00069	0.445
MOD_CK2_1	573	579	PF00069	0.660
MOD_CK2_1	60	66	PF00069	0.599
MOD_CK2_1	71	77	PF00069	0.697
MOD_CK2_1	780	786	PF00069	0.487
MOD_GlcNHglycan	105	109	PF01048	0.737
MOD_GlcNHglycan	274	277	PF01048	0.513
MOD_GlcNHglycan	340	343	PF01048	0.323
MOD_GlcNHglycan	415	418	PF01048	0.312
MOD_GlcNHglycan	441	444	PF01048	0.409
MOD_GlcNHglycan	477	480	PF01048	0.336
MOD_GlcNHglycan	506	509	PF01048	0.436
MOD_GlcNHglycan	52	55	PF01048	0.361
MOD_GlcNHglycan	528	531	PF01048	0.522
MOD_GlcNHglycan	576	579	PF01048	0.618
MOD_GlcNHglycan	603	606	PF01048	0.629
MOD_GlcNHglycan	772	775	PF01048	0.333
MOD_GSK3_1	107	114	PF00069	0.548
MOD_GSK3_1	121	128	PF00069	0.614
MOD_GSK3_1	17	24	PF00069	0.467
MOD_GSK3_1	338	345	PF00069	0.383
MOD_GSK3_1	395	402	PF00069	0.502
MOD_GSK3_1	433	440	PF00069	0.542
MOD_GSK3_1	490	497	PF00069	0.490
MOD_GSK3_1	544	551	PF00069	0.551
MOD_GSK3_1	593	600	PF00069	0.590
MOD_GSK3_1	601	608	PF00069	0.697
MOD_GSK3_1	649	656	PF00069	0.795
MOD_GSK3_1	65	72	PF00069	0.624
MOD_GSK3_1	684	691	PF00069	0.641
MOD_GSK3_1	89	96	PF00069	0.625
MOD_LATS_1	329	335	PF00433	0.547
MOD_N-GLC_1	264	269	PF02516	0.454
MOD_N-GLC_1	303	308	PF02516	0.614
MOD_N-GLC_1	399	404	PF02516	0.323
MOD_N-GLC_1	499	504	PF02516	0.376
MOD_N-GLC_1	601	606	PF02516	0.674
MOD_N-GLC_1	666	671	PF02516	0.682
MOD_N-GLC_1	746	751	PF02516	0.233
MOD_N-GLC_2	364	366	PF02516	0.308
MOD_NEK2_1	1	6	PF00069	0.642
MOD_NEK2_1	106	111	PF00069	0.498
MOD_NEK2_1	161	166	PF00069	0.362
MOD_NEK2_1	169	174	PF00069	0.378
MOD_NEK2_1	340	345	PF00069	0.508
MOD_NEK2_1	413	418	PF00069	0.512
MOD_NEK2_1	432	437	PF00069	0.465
MOD_NEK2_1	655	660	PF00069	0.500
MOD_NEK2_1	765	770	PF00069	0.491
MOD_NEK2_1	88	93	PF00069	0.584
MOD_NEK2_2	342	347	PF00069	0.465
MOD_PIKK_1	264	270	PF00454	0.460
MOD_PIKK_1	314	320	PF00454	0.551
MOD_PIKK_1	6	12	PF00454	0.571
MOD_PIKK_1	649	655	PF00454	0.623
MOD_PIKK_1	684	690	PF00454	0.678
MOD_PKA_1	713	719	PF00069	0.553
MOD_PKA_2	288	294	PF00069	0.427
MOD_PKA_2	423	429	PF00069	0.465
MOD_PKA_2	593	599	PF00069	0.591
MOD_PKA_2	688	694	PF00069	0.758
MOD_Plk_1	24	30	PF00069	0.450
MOD_Plk_1	372	378	PF00069	0.465
MOD_Plk_1	499	505	PF00069	0.370
MOD_Plk_1	746	752	PF00069	0.393
MOD_Plk_1	827	833	PF00069	0.508
MOD_Plk_1	89	95	PF00069	0.598
MOD_Plk_2-3	193	199	PF00069	0.424
MOD_Plk_2-3	494	500	PF00069	0.504
MOD_Plk_4	107	113	PF00069	0.500
MOD_Plk_4	122	128	PF00069	0.639
MOD_Plk_4	161	167	PF00069	0.395
MOD_Plk_4	169	175	PF00069	0.392
MOD_Plk_4	210	216	PF00069	0.450
MOD_Plk_4	283	289	PF00069	0.383
MOD_Plk_4	30	36	PF00069	0.469
MOD_Plk_4	316	322	PF00069	0.503
MOD_Plk_4	342	348	PF00069	0.465
MOD_Plk_4	389	395	PF00069	0.465
MOD_Plk_4	737	743	PF00069	0.475
MOD_Plk_4	830	836	PF00069	0.508
MOD_ProDKin_1	111	117	PF00069	0.647
MOD_ProDKin_1	129	135	PF00069	0.697
MOD_ProDKin_1	597	603	PF00069	0.676
MOD_ProDKin_1	615	621	PF00069	0.691
MOD_ProDKin_1	627	633	PF00069	0.735
MOD_ProDKin_1	65	71	PF00069	0.588
MOD_ProDKin_1	780	786	PF00069	0.508
MOD_ProDKin_1	93	99	PF00069	0.626
MOD_SUMO_for_1	181	184	PF00179	0.425
MOD_SUMO_for_1	216	219	PF00179	0.430
MOD_SUMO_rev_2	33	40	PF00179	0.462
TRG_DiLeu_BaEn_1	150	155	PF01217	0.451
TRG_DiLeu_BaEn_1	409	414	PF01217	0.508
TRG_DiLeu_BaEn_1	446	451	PF01217	0.385
TRG_DiLeu_BaEn_1	761	766	PF01217	0.491
TRG_DiLeu_BaLyEn_6	256	261	PF01217	0.459
TRG_DiLeu_BaLyEn_6	674	679	PF01217	0.524
TRG_DiLeu_BaLyEn_6	813	818	PF01217	0.489
TRG_ENDOCYTIC_2	141	144	PF00928	0.344
TRG_ENDOCYTIC_2	173	176	PF00928	0.418
TRG_ENDOCYTIC_2	215	218	PF00928	0.363
TRG_ENDOCYTIC_2	224	227	PF00928	0.369
TRG_ENDOCYTIC_2	284	287	PF00928	0.369
TRG_ENDOCYTIC_2	34	37	PF00928	0.409
TRG_ENDOCYTIC_2	481	484	PF00928	0.355
TRG_ENDOCYTIC_2	524	527	PF00928	0.397
TRG_ENDOCYTIC_2	724	727	PF00928	0.508
TRG_ER_diArg_1	157	159	PF00400	0.364
TRG_ER_diArg_1	540	542	PF00400	0.506
TRG_NES_CRM1_1	246	258	PF08389	0.415
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	16	21	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	753	758	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDZ8	Leptomonas seymouri	62%	98%
A0A3R7LSY3	Trypanosoma rangeli	43%	100%
A0A3S5H655	Leishmania donovani	91%	100%
A4H5B8	Leishmania braziliensis	76%	95%
A4HTJ9	Leishmania infantum	91%	100%
Q4QIB8	Leishmania major	90%	100%