Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMC8_LEIMU

TriTrypDb:

LmxM.08.0490

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMC8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.560
CLV_NRD_NRD_1	217	219	PF00675	0.681
CLV_NRD_NRD_1	365	367	PF00675	0.553
CLV_PCSK_KEX2_1	219	221	PF00082	0.682
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.682
DEG_Nend_Nbox_1	1	3	PF02207	0.579
DEG_SCF_FBW7_1	208	214	PF00400	0.541
DEG_SCF_FBW7_1	22	29	PF00400	0.604
DEG_SCF_TRCP1_1	167	172	PF00400	0.575
DOC_CKS1_1	208	213	PF01111	0.539
DOC_CYCLIN_RxL_1	277	286	PF00134	0.615
DOC_PP2B_LxvP_1	228	231	PF13499	0.633
DOC_PP2B_LxvP_1	345	348	PF13499	0.660
DOC_PP4_FxxP_1	138	141	PF00568	0.588
DOC_PP4_MxPP_1	17	20	PF00568	0.650
DOC_USP7_MATH_1	141	145	PF00917	0.523
DOC_USP7_MATH_1	186	190	PF00917	0.542
DOC_USP7_MATH_1	211	215	PF00917	0.653
DOC_USP7_MATH_1	237	241	PF00917	0.544
DOC_USP7_MATH_1	49	53	PF00917	0.712
DOC_USP7_MATH_1	55	59	PF00917	0.689
DOC_USP7_MATH_1	82	86	PF00917	0.669
DOC_WW_Pin1_4	139	144	PF00397	0.743
DOC_WW_Pin1_4	15	20	PF00397	0.693
DOC_WW_Pin1_4	177	182	PF00397	0.769
DOC_WW_Pin1_4	207	212	PF00397	0.620
DOC_WW_Pin1_4	22	27	PF00397	0.627
DOC_WW_Pin1_4	231	236	PF00397	0.669
DOC_WW_Pin1_4	300	305	PF00397	0.641
DOC_WW_Pin1_4	377	382	PF00397	0.499
DOC_WW_Pin1_4	44	49	PF00397	0.551
DOC_WW_Pin1_4	77	82	PF00397	0.659
DOC_WW_Pin1_4	92	97	PF00397	0.495
LIG_14-3-3_CanoR_1	222	227	PF00244	0.560
LIG_14-3-3_CanoR_1	299	304	PF00244	0.645
LIG_14-3-3_CanoR_1	61	67	PF00244	0.572
LIG_14-3-3_CanoR_1	83	91	PF00244	0.609
LIG_BRCT_BRCA1_1	336	340	PF00533	0.655
LIG_EVH1_2	30	34	PF00568	0.573
LIG_FHA_1	156	162	PF00498	0.710
LIG_FHA_1	237	243	PF00498	0.664
LIG_FHA_1	271	277	PF00498	0.636
LIG_FHA_1	311	317	PF00498	0.567
LIG_FHA_1	328	334	PF00498	0.611
LIG_FHA_1	357	363	PF00498	0.640
LIG_FHA_2	152	158	PF00498	0.649
LIG_Integrin_isoDGR_2	364	366	PF01839	0.521
LIG_Integrin_RGD_1	269	271	PF01839	0.524
LIG_LIR_Gen_1	194	203	PF02991	0.645
LIG_LIR_Gen_1	337	348	PF02991	0.652
LIG_LIR_Nem_3	194	198	PF02991	0.641
LIG_LIR_Nem_3	337	343	PF02991	0.649
LIG_MYND_3	205	209	PF01753	0.522
LIG_NRBOX	98	104	PF00104	0.556
LIG_PDZ_Class_2	393	398	PF00595	0.620
LIG_Pex14_1	336	340	PF04695	0.655
LIG_RPA_C_Fungi	104	116	PF08784	0.496
LIG_SH2_STAT5	195	198	PF00017	0.646
LIG_SH3_3	175	181	PF00018	0.737
LIG_SH3_3	200	206	PF00018	0.663
LIG_SH3_3	24	30	PF00018	0.654
LIG_SH3_3	61	67	PF00018	0.528
LIG_SH3_3	75	81	PF00018	0.553
LIG_SUMO_SIM_anti_2	392	397	PF11976	0.616
LIG_SUMO_SIM_par_1	320	325	PF11976	0.626
LIG_ULM_U2AF65_1	218	224	PF00076	0.640
LIG_WRC_WIRS_1	91	96	PF05994	0.571
MOD_CDC14_SPxK_1	80	83	PF00782	0.573
MOD_CDK_SPxK_1	77	83	PF00069	0.567
MOD_CDK_SPxxK_3	300	307	PF00069	0.645
MOD_CK1_1	131	137	PF00069	0.659
MOD_CK1_1	144	150	PF00069	0.575
MOD_CK1_1	180	186	PF00069	0.659
MOD_CK1_1	272	278	PF00069	0.616
MOD_CK1_1	300	306	PF00069	0.683
MOD_CK1_1	327	333	PF00069	0.649
MOD_CK1_1	6	12	PF00069	0.679
MOD_CK1_1	77	83	PF00069	0.766
MOD_CK1_1	85	91	PF00069	0.699
MOD_CK2_1	151	157	PF00069	0.656
MOD_CK2_1	169	175	PF00069	0.606
MOD_CK2_1	377	383	PF00069	0.611
MOD_CMANNOS	223	226	PF00535	0.683
MOD_Cter_Amidation	364	367	PF01082	0.523
MOD_DYRK1A_RPxSP_1	92	96	PF00069	0.451
MOD_GlcNHglycan	125	128	PF01048	0.716
MOD_GlcNHglycan	167	170	PF01048	0.656
MOD_GlcNHglycan	213	216	PF01048	0.676
MOD_GlcNHglycan	336	339	PF01048	0.655
MOD_GlcNHglycan	387	390	PF01048	0.600
MOD_GlcNHglycan	51	54	PF01048	0.603
MOD_GlcNHglycan	84	87	PF01048	0.578
MOD_GSK3_1	144	151	PF00069	0.649
MOD_GSK3_1	165	172	PF00069	0.602
MOD_GSK3_1	207	214	PF00069	0.622
MOD_GSK3_1	218	225	PF00069	0.569
MOD_GSK3_1	22	29	PF00069	0.656
MOD_GSK3_1	298	305	PF00069	0.672
MOD_GSK3_1	306	313	PF00069	0.603
MOD_GSK3_1	320	327	PF00069	0.644
MOD_GSK3_1	385	392	PF00069	0.593
MOD_GSK3_1	90	97	PF00069	0.571
MOD_N-GLC_1	6	11	PF02516	0.678
MOD_NEK2_1	196	201	PF00069	0.606
MOD_NEK2_1	306	311	PF00069	0.574
MOD_NEK2_1	334	339	PF00069	0.754
MOD_NEK2_1	34	39	PF00069	0.552
MOD_NEK2_1	385	390	PF00069	0.596
MOD_NEK2_2	169	174	PF00069	0.666
MOD_PIKK_1	141	147	PF00454	0.672
MOD_PIKK_1	148	154	PF00454	0.657
MOD_PIKK_1	85	91	PF00454	0.726
MOD_PIKK_1	97	103	PF00454	0.450
MOD_PKA_1	218	224	PF00069	0.640
MOD_PKA_2	165	171	PF00069	0.762
MOD_PKA_2	298	304	PF00069	0.645
MOD_PKA_2	3	9	PF00069	0.617
MOD_PKA_2	62	68	PF00069	0.500
MOD_PKA_2	82	88	PF00069	0.567
MOD_PKB_1	220	228	PF00069	0.528
MOD_Plk_1	156	162	PF00069	0.666
MOD_Plk_4	237	243	PF00069	0.529
MOD_Plk_4	94	100	PF00069	0.639
MOD_ProDKin_1	139	145	PF00069	0.747
MOD_ProDKin_1	15	21	PF00069	0.695
MOD_ProDKin_1	177	183	PF00069	0.770
MOD_ProDKin_1	207	213	PF00069	0.620
MOD_ProDKin_1	22	28	PF00069	0.626
MOD_ProDKin_1	231	237	PF00069	0.671
MOD_ProDKin_1	300	306	PF00069	0.644
MOD_ProDKin_1	377	383	PF00069	0.499
MOD_ProDKin_1	44	50	PF00069	0.550
MOD_ProDKin_1	77	83	PF00069	0.661
MOD_ProDKin_1	92	98	PF00069	0.488
TRG_ENDOCYTIC_2	195	198	PF00928	0.646
TRG_ER_diArg_1	217	220	PF00400	0.682
TRG_ER_diArg_1	61	64	PF00400	0.502
TRG_NES_CRM1_1	194	209	PF08389	0.617
TRG_NLS_MonoExtC_3	217	222	PF00514	0.640
TRG_NLS_MonoExtN_4	217	223	PF00514	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H653	Leishmania donovani	76%	100%
A4H5B6	Leishmania braziliensis	54%	100%
A4HTJ7	Leishmania infantum	76%	96%
Q4QIC0	Leishmania major	79%	100%