Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMC7_LEIMU

TriTrypDb:

LmxM.08.0480

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMC7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	90	94	PF00656	0.783
CLV_PCSK_KEX2_1	47	49	PF00082	0.583
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.583
CLV_PCSK_SKI1_1	139	143	PF00082	0.500
DOC_CKS1_1	20	25	PF01111	0.555
DOC_MAPK_gen_1	130	140	PF00069	0.534
DOC_MAPK_MEF2A_6	139	148	PF00069	0.580
DOC_USP7_MATH_1	76	80	PF00917	0.560
DOC_USP7_MATH_1	88	92	PF00917	0.672
DOC_WW_Pin1_4	19	24	PF00397	0.554
DOC_WW_Pin1_4	191	196	PF00397	0.662
DOC_WW_Pin1_4	223	228	PF00397	0.656
DOC_WW_Pin1_4	35	40	PF00397	0.498
LIG_14-3-3_CanoR_1	139	148	PF00244	0.547
LIG_Actin_WH2_2	112	128	PF00022	0.634
LIG_APCC_ABBA_1	129	134	PF00400	0.602
LIG_BIR_II_1	1	5	PF00653	0.609
LIG_FHA_1	135	141	PF00498	0.459
LIG_FHA_2	3	9	PF00498	0.582
LIG_FHA_2	36	42	PF00498	0.650
LIG_PCNA_yPIPBox_3	240	252	PF02747	0.629
LIG_PTB_Apo_2	165	172	PF02174	0.613
LIG_PTB_Phospho_1	165	171	PF10480	0.608
LIG_SH2_GRB2like	166	169	PF00017	0.609
LIG_SH2_NCK_1	49	53	PF00017	0.531
LIG_SH2_SRC	12	15	PF00017	0.505
LIG_SH2_SRC	49	52	PF00017	0.536
LIG_SH2_STAP1	12	16	PF00017	0.576
LIG_SH2_STAP1	166	170	PF00017	0.614
LIG_SH2_STAT5	56	59	PF00017	0.547
LIG_SH2_STAT5	61	64	PF00017	0.586
LIG_SH3_3	187	193	PF00018	0.689
LIG_SH3_3	224	230	PF00018	0.653
LIG_SUMO_SIM_anti_2	117	123	PF11976	0.528
LIG_TRAF2_1	24	27	PF00917	0.609
LIG_UBA3_1	16	21	PF00899	0.575
LIG_WW_2	227	230	PF00397	0.603
MOD_CK1_1	150	156	PF00069	0.476
MOD_CK1_1	70	76	PF00069	0.756
MOD_CK1_1	78	84	PF00069	0.649
MOD_CK2_1	171	177	PF00069	0.756
MOD_CK2_1	2	8	PF00069	0.555
MOD_GlcNHglycan	257	260	PF01048	0.702
MOD_GlcNHglycan	263	266	PF01048	0.705
MOD_GlcNHglycan	72	75	PF01048	0.743
MOD_GlcNHglycan	77	81	PF01048	0.763
MOD_GSK3_1	147	154	PF00069	0.329
MOD_GSK3_1	166	173	PF00069	0.676
MOD_GSK3_1	75	82	PF00069	0.696
MOD_GSK3_1	88	95	PF00069	0.778
MOD_N-GLC_1	223	228	PF02516	0.691
MOD_NEK2_1	147	152	PF00069	0.456
MOD_NEK2_1	246	251	PF00069	0.510
MOD_NEK2_2	166	171	PF00069	0.652
MOD_PIKK_1	147	153	PF00454	0.464
MOD_PIKK_1	88	94	PF00454	0.756
MOD_PKA_2	211	217	PF00069	0.620
MOD_PKA_2	261	267	PF00069	0.612
MOD_PKA_2	68	74	PF00069	0.558
MOD_Plk_1	134	140	PF00069	0.409
MOD_Plk_2-3	8	14	PF00069	0.508
MOD_Plk_4	166	172	PF00069	0.636
MOD_ProDKin_1	19	25	PF00069	0.547
MOD_ProDKin_1	191	197	PF00069	0.657
MOD_ProDKin_1	223	229	PF00069	0.653
MOD_ProDKin_1	35	41	PF00069	0.498
TRG_DiLeu_BaEn_1	136	141	PF01217	0.505
TRG_DiLeu_BaEn_1	143	148	PF01217	0.510
TRG_DiLeu_LyEn_5	136	141	PF01217	0.577
TRG_ENDOCYTIC_2	49	52	PF00928	0.518
TRG_NES_CRM1_1	120	135	PF08389	0.534
TRG_NES_CRM1_1	96	108	PF08389	0.702
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMT4	Leptomonas seymouri	52%	97%
A0A1X0NP32	Trypanosomatidae	28%	100%
A0A3S7WQ75	Leishmania donovani	85%	98%
A0A422NB91	Trypanosoma rangeli	28%	100%
A4H5B5	Leishmania braziliensis	71%	100%
A4HTJ6	Leishmania infantum	85%	98%
C9ZPH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4QIC1	Leishmania major	87%	100%
V5BLF3	Trypanosoma cruzi	25%	100%