Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AMC5_LEIMU

TriTrypDb:

LmxM.08.0460

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 0
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AMC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	288	290	PF00675	0.584
CLV_PCSK_KEX2_1	287	289	PF00082	0.588
CLV_PCSK_SKI1_1	2	6	PF00082	0.728
CLV_PCSK_SKI1_1	230	234	PF00082	0.608
DEG_APCC_DBOX_1	229	237	PF00400	0.265
DOC_PP4_FxxP_1	251	254	PF00568	0.406
DOC_USP7_MATH_1	190	194	PF00917	0.409
DOC_USP7_MATH_1	241	245	PF00917	0.449
DOC_USP7_MATH_1	97	101	PF00917	0.417
DOC_WW_Pin1_4	4	9	PF00397	0.605
DOC_WW_Pin1_4	78	83	PF00397	0.385
LIG_14-3-3_CanoR_1	135	145	PF00244	0.292
LIG_14-3-3_CanoR_1	258	262	PF00244	0.649
LIG_FHA_1	120	126	PF00498	0.495
LIG_FHA_1	18	24	PF00498	0.600
LIG_FHA_1	219	225	PF00498	0.434
LIG_FHA_1	61	67	PF00498	0.353
LIG_FHA_2	205	211	PF00498	0.563
LIG_FHA_2	97	103	PF00498	0.306
LIG_LIR_Apic_2	210	215	PF02991	0.477
LIG_LIR_Apic_2	63	68	PF02991	0.346
LIG_LIR_Gen_1	128	137	PF02991	0.433
LIG_LIR_Nem_3	128	133	PF02991	0.474
LIG_LIR_Nem_3	139	145	PF02991	0.364
LIG_LIR_Nem_3	71	76	PF02991	0.347
LIG_Pex14_2	130	134	PF04695	0.347
LIG_SH2_CRK	73	77	PF00017	0.338
LIG_SH2_GRB2like	84	87	PF00017	0.319
LIG_SH2_PTP2	212	215	PF00017	0.476
LIG_SH2_SRC	145	148	PF00017	0.277
LIG_SH2_SRC	212	215	PF00017	0.366
LIG_SH2_SRC	65	68	PF00017	0.403
LIG_SH2_STAP1	220	224	PF00017	0.404
LIG_SH2_STAT5	109	112	PF00017	0.290
LIG_SH2_STAT5	120	123	PF00017	0.436
LIG_SH2_STAT5	145	148	PF00017	0.454
LIG_SH2_STAT5	206	209	PF00017	0.420
LIG_SH2_STAT5	212	215	PF00017	0.432
LIG_SH2_STAT5	220	223	PF00017	0.429
LIG_SH2_STAT5	65	68	PF00017	0.403
LIG_SH3_3	167	173	PF00018	0.409
LIG_SH3_3	213	219	PF00018	0.430
LIG_SUMO_SIM_par_1	28	34	PF11976	0.472
LIG_WW_2	216	219	PF00397	0.430
MOD_CK1_1	118	124	PF00069	0.403
MOD_CK1_1	277	283	PF00069	0.747
MOD_CK1_1	31	37	PF00069	0.525
MOD_GlcNHglycan	105	108	PF01048	0.648
MOD_GlcNHglycan	112	115	PF01048	0.586
MOD_GlcNHglycan	117	120	PF01048	0.603
MOD_GlcNHglycan	138	141	PF01048	0.469
MOD_GlcNHglycan	245	248	PF01048	0.312
MOD_GlcNHglycan	33	36	PF01048	0.715
MOD_GSK3_1	115	122	PF00069	0.400
MOD_GSK3_1	277	284	PF00069	0.723
MOD_GSK3_1	92	99	PF00069	0.391
MOD_N-GLC_1	110	115	PF02516	0.561
MOD_N-GLC_1	204	209	PF02516	0.618
MOD_NEK2_1	236	241	PF00069	0.341
MOD_NEK2_1	30	35	PF00069	0.470
MOD_OFUCOSY	197	202	PF10250	0.618
MOD_PIKK_1	204	210	PF00454	0.419
MOD_PIKK_1	223	229	PF00454	0.418
MOD_PIKK_1	281	287	PF00454	0.595
MOD_PKA_2	257	263	PF00069	0.680
MOD_ProDKin_1	4	10	PF00069	0.606
MOD_ProDKin_1	78	84	PF00069	0.379
MOD_SUMO_for_1	264	267	PF00179	0.605
MOD_SUMO_rev_2	100	106	PF00179	0.310
TRG_DiLeu_BaLyEn_6	259	264	PF01217	0.579
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.605
TRG_ENDOCYTIC_2	73	76	PF00928	0.341
TRG_ER_diArg_1	287	289	PF00400	0.778
TRG_Pf-PMV_PEXEL_1	222	227	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICA2	Leptomonas seymouri	65%	100%
A0A3S7WQ91	Leishmania donovani	81%	100%
E9AG80	Leishmania infantum	81%	100%
Q4QIC3	Leishmania major	78%	100%