Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMC2_LEIMU

TriTrypDb:

LmxM.08.0430

Length:

914

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AMC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMC2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.772
CLV_C14_Caspase3-7	253	257	PF00656	0.604
CLV_NRD_NRD_1	142	144	PF00675	0.552
CLV_NRD_NRD_1	153	155	PF00675	0.527
CLV_NRD_NRD_1	345	347	PF00675	0.609
CLV_NRD_NRD_1	388	390	PF00675	0.447
CLV_NRD_NRD_1	402	404	PF00675	0.412
CLV_NRD_NRD_1	425	427	PF00675	0.496
CLV_NRD_NRD_1	430	432	PF00675	0.539
CLV_NRD_NRD_1	462	464	PF00675	0.542
CLV_NRD_NRD_1	498	500	PF00675	0.420
CLV_NRD_NRD_1	604	606	PF00675	0.512
CLV_NRD_NRD_1	700	702	PF00675	0.673
CLV_NRD_NRD_1	705	707	PF00675	0.684
CLV_NRD_NRD_1	750	752	PF00675	0.650
CLV_NRD_NRD_1	793	795	PF00675	0.576
CLV_PCSK_FUR_1	423	427	PF00082	0.490
CLV_PCSK_FUR_1	698	702	PF00082	0.626
CLV_PCSK_KEX2_1	144	146	PF00082	0.573
CLV_PCSK_KEX2_1	162	164	PF00082	0.516
CLV_PCSK_KEX2_1	276	278	PF00082	0.467
CLV_PCSK_KEX2_1	345	347	PF00082	0.614
CLV_PCSK_KEX2_1	402	404	PF00082	0.422
CLV_PCSK_KEX2_1	425	427	PF00082	0.668
CLV_PCSK_KEX2_1	430	432	PF00082	0.539
CLV_PCSK_KEX2_1	498	500	PF00082	0.516
CLV_PCSK_KEX2_1	604	606	PF00082	0.507
CLV_PCSK_KEX2_1	700	702	PF00082	0.629
CLV_PCSK_KEX2_1	705	707	PF00082	0.684
CLV_PCSK_KEX2_1	749	751	PF00082	0.649
CLV_PCSK_KEX2_1	757	759	PF00082	0.650
CLV_PCSK_KEX2_1	782	784	PF00082	0.474
CLV_PCSK_KEX2_1	793	795	PF00082	0.576
CLV_PCSK_KEX2_1	848	850	PF00082	0.606
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.518
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.516
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.467
CLV_PCSK_PC1ET2_1	757	759	PF00082	0.624
CLV_PCSK_PC1ET2_1	782	784	PF00082	0.474
CLV_PCSK_PC1ET2_1	848	850	PF00082	0.547
CLV_PCSK_PC7_1	426	432	PF00082	0.519
CLV_PCSK_PC7_1	701	707	PF00082	0.801
CLV_PCSK_PC7_1	753	759	PF00082	0.606
CLV_PCSK_PC7_1	778	784	PF00082	0.482
CLV_PCSK_SKI1_1	148	152	PF00082	0.516
CLV_PCSK_SKI1_1	154	158	PF00082	0.435
CLV_PCSK_SKI1_1	480	484	PF00082	0.605
CLV_PCSK_SKI1_1	605	609	PF00082	0.511
CLV_PCSK_SKI1_1	758	762	PF00082	0.678
CLV_PCSK_SKI1_1	813	817	PF00082	0.450
CLV_PCSK_SKI1_1	848	852	PF00082	0.618
CLV_PCSK_SKI1_1	870	874	PF00082	0.573
CLV_Separin_Metazoa	335	339	PF03568	0.475
DEG_APCC_DBOX_1	350	358	PF00400	0.469
DEG_SCF_FBW7_2	906	913	PF00400	0.580
DEG_SPOP_SBC_1	561	565	PF00917	0.633
DOC_CYCLIN_RxL_1	809	817	PF00134	0.450
DOC_MAPK_gen_1	345	354	PF00069	0.476
DOC_MAPK_gen_1	496	506	PF00069	0.522
DOC_MAPK_MEF2A_6	498	507	PF00069	0.677
DOC_MAPK_MEF2A_6	65	73	PF00069	0.442
DOC_MAPK_MEF2A_6	826	833	PF00069	0.533
DOC_MAPK_NFAT4_5	826	834	PF00069	0.598
DOC_PP1_RVXF_1	4	10	PF00149	0.406
DOC_PP2B_LxvP_1	20	23	PF13499	0.492
DOC_PP2B_LxvP_1	391	394	PF13499	0.500
DOC_PP4_FxxP_1	554	557	PF00568	0.551
DOC_USP7_MATH_1	132	136	PF00917	0.632
DOC_USP7_MATH_1	215	219	PF00917	0.749
DOC_USP7_MATH_1	561	565	PF00917	0.580
DOC_USP7_MATH_1	566	570	PF00917	0.569
DOC_USP7_MATH_1	634	638	PF00917	0.774
DOC_USP7_MATH_1	64	68	PF00917	0.535
DOC_USP7_MATH_1	652	656	PF00917	0.507
DOC_USP7_MATH_1	684	688	PF00917	0.757
DOC_USP7_MATH_1	781	785	PF00917	0.471
DOC_USP7_MATH_1	832	836	PF00917	0.559
DOC_USP7_UBL2_3	140	144	PF12436	0.508
DOC_USP7_UBL2_3	147	151	PF12436	0.499
DOC_USP7_UBL2_3	158	162	PF12436	0.405
DOC_USP7_UBL2_3	222	226	PF12436	0.684
DOC_USP7_UBL2_3	492	496	PF12436	0.525
DOC_USP7_UBL2_3	844	848	PF12436	0.567
DOC_WW_Pin1_4	450	455	PF00397	0.615
DOC_WW_Pin1_4	53	58	PF00397	0.464
DOC_WW_Pin1_4	571	576	PF00397	0.574
DOC_WW_Pin1_4	906	911	PF00397	0.599
LIG_14-3-3_CanoR_1	430	436	PF00244	0.569
LIG_14-3-3_CanoR_1	517	522	PF00244	0.719
LIG_14-3-3_CanoR_1	656	661	PF00244	0.674
LIG_14-3-3_CanoR_1	705	712	PF00244	0.665
LIG_14-3-3_CanoR_1	728	733	PF00244	0.608
LIG_14-3-3_CanoR_1	826	832	PF00244	0.535
LIG_14-3-3_CanoR_1	849	855	PF00244	0.492
LIG_Actin_WH2_2	838	853	PF00022	0.574
LIG_BIR_II_1	1	5	PF00653	0.495
LIG_BIR_III_2	392	396	PF00653	0.339
LIG_BRCT_BRCA1_1	111	115	PF00533	0.531
LIG_BRCT_BRCA1_1	563	567	PF00533	0.595
LIG_Clathr_ClatBox_1	308	312	PF01394	0.454
LIG_Clathr_ClatBox_1	41	45	PF01394	0.399
LIG_eIF4E_1	303	309	PF01652	0.409
LIG_eIF4E_1	36	42	PF01652	0.448
LIG_FHA_1	112	118	PF00498	0.693
LIG_FHA_1	2	8	PF00498	0.474
LIG_FHA_1	436	442	PF00498	0.589
LIG_FHA_1	45	51	PF00498	0.418
LIG_FHA_1	517	523	PF00498	0.563
LIG_FHA_1	648	654	PF00498	0.495
LIG_FHA_1	887	893	PF00498	0.487
LIG_FHA_2	26	32	PF00498	0.478
LIG_FHA_2	328	334	PF00498	0.494
LIG_FHA_2	432	438	PF00498	0.546
LIG_FHA_2	440	446	PF00498	0.515
LIG_FHA_2	451	457	PF00498	0.540
LIG_FHA_2	526	532	PF00498	0.597
LIG_FHA_2	895	901	PF00498	0.655
LIG_GBD_Chelix_1	336	344	PF00786	0.400
LIG_LIR_Apic_2	300	306	PF02991	0.426
LIG_LIR_Apic_2	485	491	PF02991	0.541
LIG_LIR_Apic_2	553	557	PF02991	0.549
LIG_LIR_Gen_1	231	242	PF02991	0.573
LIG_LIR_Gen_1	523	533	PF02991	0.604
LIG_LIR_Gen_1	538	548	PF02991	0.387
LIG_LIR_Gen_1	83	90	PF02991	0.563
LIG_LIR_Nem_3	231	237	PF02991	0.570
LIG_LIR_Nem_3	312	318	PF02991	0.429
LIG_LIR_Nem_3	413	419	PF02991	0.665
LIG_LIR_Nem_3	485	490	PF02991	0.588
LIG_LIR_Nem_3	606	611	PF02991	0.542
LIG_LIR_Nem_3	687	692	PF02991	0.597
LIG_LIR_Nem_3	83	88	PF02991	0.552
LIG_LYPXL_yS_3	305	308	PF13949	0.474
LIG_LYPXL_yS_3	689	692	PF13949	0.603
LIG_SH2_CRK	12	16	PF00017	0.553
LIG_SH2_CRK	303	307	PF00017	0.411
LIG_SH2_CRK	315	319	PF00017	0.463
LIG_SH2_CRK	36	40	PF00017	0.482
LIG_SH2_CRK	488	492	PF00017	0.549
LIG_SH2_NCK_1	36	40	PF00017	0.456
LIG_SH2_SRC	16	19	PF00017	0.419
LIG_SH2_SRC	303	306	PF00017	0.484
LIG_SH2_SRC	58	61	PF00017	0.539
LIG_SH2_STAP1	36	40	PF00017	0.548
LIG_SH2_STAT3	465	468	PF00017	0.528
LIG_SH2_STAT3	521	524	PF00017	0.560
LIG_SH2_STAT5	307	310	PF00017	0.600
LIG_SH2_STAT5	353	356	PF00017	0.469
LIG_SH2_STAT5	40	43	PF00017	0.417
LIG_SH2_STAT5	465	468	PF00017	0.565
LIG_SH2_STAT5	521	524	PF00017	0.560
LIG_SH2_STAT5	691	694	PF00017	0.681
LIG_SH2_STAT5	857	860	PF00017	0.468
LIG_SH3_1	289	295	PF00018	0.615
LIG_SH3_3	12	18	PF00018	0.536
LIG_SH3_3	289	295	PF00018	0.615
LIG_SH3_3	487	493	PF00018	0.568
LIG_SH3_3	54	60	PF00018	0.415
LIG_SH3_4	492	499	PF00018	0.522
LIG_SUMO_SIM_anti_2	437	445	PF11976	0.518
LIG_SUMO_SIM_par_1	437	445	PF11976	0.526
LIG_SUMO_SIM_par_1	45	51	PF11976	0.480
LIG_SUMO_SIM_par_1	617	626	PF11976	0.598
LIG_TRAF2_1	23	26	PF00917	0.492
LIG_TRAF2_1	243	246	PF00917	0.640
LIG_TRAF2_1	330	333	PF00917	0.493
LIG_UBA3_1	190	199	PF00899	0.515
MOD_CDK_SPK_2	450	455	PF00069	0.615
MOD_CK1_1	130	136	PF00069	0.637
MOD_CK1_1	2	8	PF00069	0.514
MOD_CK1_1	207	213	PF00069	0.543
MOD_CK1_1	410	416	PF00069	0.657
MOD_CK1_1	439	445	PF00069	0.579
MOD_CK1_1	520	526	PF00069	0.595
MOD_CK1_1	569	575	PF00069	0.581
MOD_CK1_1	668	674	PF00069	0.612
MOD_CK1_1	678	684	PF00069	0.609
MOD_CK1_1	708	714	PF00069	0.668
MOD_CK1_1	723	729	PF00069	0.643
MOD_CK1_1	731	737	PF00069	0.727
MOD_CK1_1	871	877	PF00069	0.550
MOD_CK2_1	132	138	PF00069	0.622
MOD_CK2_1	183	189	PF00069	0.595
MOD_CK2_1	207	213	PF00069	0.637
MOD_CK2_1	222	228	PF00069	0.653
MOD_CK2_1	240	246	PF00069	0.490
MOD_CK2_1	25	31	PF00069	0.492
MOD_CK2_1	327	333	PF00069	0.496
MOD_CK2_1	353	359	PF00069	0.469
MOD_CK2_1	439	445	PF00069	0.579
MOD_CK2_1	450	456	PF00069	0.506
MOD_CK2_1	525	531	PF00069	0.601
MOD_CK2_1	643	649	PF00069	0.687
MOD_CK2_1	714	720	PF00069	0.569
MOD_CK2_1	781	787	PF00069	0.460
MOD_CK2_1	89	95	PF00069	0.468
MOD_CK2_1	894	900	PF00069	0.647
MOD_Cter_Amidation	219	222	PF01082	0.830
MOD_Cter_Amidation	274	277	PF01082	0.471
MOD_Cter_Amidation	755	758	PF01082	0.681
MOD_GlcNHglycan	1	4	PF01048	0.613
MOD_GlcNHglycan	111	114	PF01048	0.528
MOD_GlcNHglycan	130	133	PF01048	0.615
MOD_GlcNHglycan	207	210	PF01048	0.657
MOD_GlcNHglycan	218	221	PF01048	0.716
MOD_GlcNHglycan	256	259	PF01048	0.530
MOD_GlcNHglycan	263	266	PF01048	0.497
MOD_GlcNHglycan	282	285	PF01048	0.605
MOD_GlcNHglycan	36	39	PF01048	0.411
MOD_GlcNHglycan	409	412	PF01048	0.546
MOD_GlcNHglycan	682	685	PF01048	0.657
MOD_GlcNHglycan	712	715	PF01048	0.661
MOD_GlcNHglycan	733	736	PF01048	0.774
MOD_GlcNHglycan	753	756	PF01048	0.726
MOD_GlcNHglycan	870	873	PF01048	0.683
MOD_GlcNHglycan	881	884	PF01048	0.692
MOD_GSK3_1	128	135	PF00069	0.647
MOD_GSK3_1	179	186	PF00069	0.625
MOD_GSK3_1	216	223	PF00069	0.705
MOD_GSK3_1	371	378	PF00069	0.571
MOD_GSK3_1	403	410	PF00069	0.631
MOD_GSK3_1	431	438	PF00069	0.612
MOD_GSK3_1	44	51	PF00069	0.511
MOD_GSK3_1	516	523	PF00069	0.594
MOD_GSK3_1	556	563	PF00069	0.569
MOD_GSK3_1	566	573	PF00069	0.580
MOD_GSK3_1	60	67	PF00069	0.482
MOD_GSK3_1	643	650	PF00069	0.688
MOD_GSK3_1	652	659	PF00069	0.637
MOD_GSK3_1	668	675	PF00069	0.519
MOD_GSK3_1	680	687	PF00069	0.544
MOD_GSK3_1	704	711	PF00069	0.693
MOD_GSK3_1	720	727	PF00069	0.613
MOD_GSK3_1	758	765	PF00069	0.657
MOD_GSK3_1	866	873	PF00069	0.564
MOD_GSK3_1	89	96	PF00069	0.633
MOD_LATS_1	703	709	PF00433	0.617
MOD_N-GLC_1	254	259	PF02516	0.531
MOD_N-GLC_1	285	290	PF02516	0.525
MOD_N-GLC_1	724	729	PF02516	0.726
MOD_NEK2_1	1	6	PF00069	0.484
MOD_NEK2_1	285	290	PF00069	0.525
MOD_NEK2_1	297	302	PF00069	0.490
MOD_NEK2_1	327	332	PF00069	0.434
MOD_NEK2_1	435	440	PF00069	0.602
MOD_NEK2_1	44	49	PF00069	0.489
MOD_NEK2_1	482	487	PF00069	0.571
MOD_NEK2_1	560	565	PF00069	0.709
MOD_NEK2_1	567	572	PF00069	0.597
MOD_NEK2_1	643	648	PF00069	0.638
MOD_NEK2_1	677	682	PF00069	0.673
MOD_NEK2_1	868	873	PF00069	0.591
MOD_NEK2_1	879	884	PF00069	0.626
MOD_PIKK_1	520	526	PF00454	0.556
MOD_PIKK_1	93	99	PF00454	0.673
MOD_PK_1	728	734	PF00069	0.609
MOD_PKA_1	154	160	PF00069	0.399
MOD_PKA_1	705	711	PF00069	0.699
MOD_PKA_2	128	134	PF00069	0.652
MOD_PKA_2	429	435	PF00069	0.651
MOD_PKA_2	516	522	PF00069	0.720
MOD_PKA_2	704	710	PF00069	0.644
MOD_PKA_2	727	733	PF00069	0.607
MOD_PKA_2	840	846	PF00069	0.615
MOD_PKB_1	749	757	PF00069	0.535
MOD_Plk_1	166	172	PF00069	0.484
MOD_Plk_1	436	442	PF00069	0.522
MOD_Plk_1	44	50	PF00069	0.483
MOD_Plk_1	665	671	PF00069	0.677
MOD_Plk_2-3	179	185	PF00069	0.647
MOD_Plk_2-3	240	246	PF00069	0.594
MOD_Plk_2-3	25	31	PF00069	0.492
MOD_Plk_2-3	550	556	PF00069	0.534
MOD_Plk_4	111	117	PF00069	0.646
MOD_Plk_4	353	359	PF00069	0.469
MOD_Plk_4	436	442	PF00069	0.522
MOD_Plk_4	44	50	PF00069	0.449
MOD_Plk_4	517	523	PF00069	0.563
MOD_Plk_4	550	556	PF00069	0.534
MOD_Plk_4	787	793	PF00069	0.491
MOD_Plk_4	863	869	PF00069	0.606
MOD_ProDKin_1	450	456	PF00069	0.611
MOD_ProDKin_1	53	59	PF00069	0.468
MOD_ProDKin_1	571	577	PF00069	0.573
MOD_ProDKin_1	906	912	PF00069	0.597
MOD_SUMO_for_1	161	164	PF00179	0.530
MOD_SUMO_rev_2	473	477	PF00179	0.520
MOD_SUMO_rev_2	737	745	PF00179	0.637
TRG_AP2beta_CARGO_1	606	615	PF09066	0.522
TRG_DiLeu_BaEn_1	810	815	PF01217	0.513
TRG_DiLeu_BaLyEn_6	576	581	PF01217	0.453
TRG_DiLeu_LyEn_5	810	815	PF01217	0.513
TRG_ENDOCYTIC_2	12	15	PF00928	0.569
TRG_ENDOCYTIC_2	305	308	PF00928	0.474
TRG_ENDOCYTIC_2	315	318	PF00928	0.270
TRG_ENDOCYTIC_2	36	39	PF00928	0.480
TRG_ENDOCYTIC_2	526	529	PF00928	0.620
TRG_ENDOCYTIC_2	689	692	PF00928	0.603
TRG_ER_diArg_1	174	177	PF00400	0.537
TRG_ER_diArg_1	344	346	PF00400	0.457
TRG_ER_diArg_1	401	403	PF00400	0.413
TRG_ER_diArg_1	423	426	PF00400	0.495
TRG_ER_diArg_1	430	433	PF00400	0.550
TRG_ER_diArg_1	497	499	PF00400	0.422
TRG_ER_diArg_1	697	700	PF00400	0.621
TRG_ER_diArg_1	749	751	PF00400	0.544
TRG_ER_diArg_1	792	794	PF00400	0.607
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	783	787	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	813	817	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	860	864	PF00026	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP1	Leptomonas seymouri	53%	100%
A0A3S7WQ64	Leishmania donovani	89%	98%
A4HTJ2	Leishmania infantum	89%	99%
Q4QIC6	Leishmania major	90%	99%