Cytochrome c oxidase subunit ApiCOX24

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMB6_LEIMU

TriTrypDb:

LmxM.08.0370

Length:

219

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AMB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.480
CLV_PCSK_KEX2_1	192	194	PF00082	0.637
CLV_PCSK_KEX2_1	4	6	PF00082	0.481
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.637
CLV_PCSK_SKI1_1	213	217	PF00082	0.635
CLV_PCSK_SKI1_1	70	74	PF00082	0.436
DEG_MDM2_SWIB_1	123	130	PF02201	0.389
DOC_MAPK_FxFP_2	66	69	PF00069	0.642
DOC_MAPK_MEF2A_6	102	109	PF00069	0.637
DOC_MAPK_NFAT4_5	102	110	PF00069	0.635
DOC_PP4_FxxP_1	66	69	PF00568	0.642
DOC_USP7_MATH_1	207	211	PF00917	0.494
DOC_USP7_MATH_1	21	25	PF00917	0.630
DOC_USP7_UBL2_3	188	192	PF12436	0.436
DOC_WW_Pin1_4	17	22	PF00397	0.664
LIG_14-3-3_CanoR_1	106	116	PF00244	0.610
LIG_14-3-3_CanoR_1	22	28	PF00244	0.681
LIG_14-3-3_CanoR_1	86	92	PF00244	0.637
LIG_APCC_ABBA_1	59	64	PF00400	0.636
LIG_BRCT_BRCA1_1	23	27	PF00533	0.617
LIG_deltaCOP1_diTrp_1	140	146	PF00928	0.419
LIG_deltaCOP1_diTrp_1	182	187	PF00928	0.461
LIG_deltaCOP1_diTrp_1	208	219	PF00928	0.469
LIG_FHA_1	197	203	PF00498	0.512
LIG_FHA_2	78	84	PF00498	0.629
LIG_FHA_2	93	99	PF00498	0.592
LIG_KLC1_Yacidic_2	162	167	PF13176	0.411
LIG_LIR_Apic_2	167	172	PF02991	0.423
LIG_LIR_Apic_2	64	69	PF02991	0.641
LIG_LIR_Gen_1	140	151	PF02991	0.422
LIG_LIR_Gen_1	179	189	PF02991	0.492
LIG_LIR_Nem_3	126	130	PF02991	0.338
LIG_LIR_Nem_3	140	146	PF02991	0.383
LIG_LIR_Nem_3	176	181	PF02991	0.483
LIG_LIR_Nem_3	30	35	PF02991	0.734
LIG_LIR_Nem_3	64	68	PF02991	0.642
LIG_MYND_3	156	160	PF01753	0.435
LIG_PDZ_Class_1	214	219	PF00595	0.500
LIG_Pex14_1	116	120	PF04695	0.416
LIG_Pex14_2	115	119	PF04695	0.378
LIG_Pex14_2	120	124	PF04695	0.378
LIG_Pex14_2	73	77	PF04695	0.718
LIG_SH2_STAP1	181	185	PF00017	0.459
LIG_SH2_STAT3	165	168	PF00017	0.438
LIG_SH2_STAT5	128	131	PF00017	0.354
LIG_SH2_STAT5	165	168	PF00017	0.425
LIG_SH2_STAT5	79	82	PF00017	0.638
LIG_SH3_3	151	157	PF00018	0.403
LIG_SH3_3	50	56	PF00018	0.680
LIG_SH3_3	72	78	PF00018	0.642
LIG_SH3_4	188	195	PF00018	0.436
LIG_TRAF2_1	80	83	PF00917	0.626
MOD_CDK_SPK_2	17	22	PF00069	0.718
MOD_CK1_1	111	117	PF00069	0.562
MOD_CK1_1	12	18	PF00069	0.691
MOD_CK1_1	126	132	PF00069	0.241
MOD_CK1_1	91	97	PF00069	0.624
MOD_CK2_1	46	52	PF00069	0.730
MOD_CK2_1	77	83	PF00069	0.629
MOD_CK2_1	92	98	PF00069	0.589
MOD_CMANNOS	116	119	PF00535	0.335
MOD_GlcNHglycan	11	14	PF01048	0.377
MOD_GlcNHglycan	23	26	PF01048	0.538
MOD_GlcNHglycan	38	41	PF01048	0.501
MOD_GSK3_1	107	114	PF00069	0.466
MOD_GSK3_1	17	24	PF00069	0.688
MOD_GSK3_1	77	84	PF00069	0.629
MOD_GSK3_1	88	95	PF00069	0.614
MOD_GSK3_1	9	16	PF00069	0.731
MOD_N-GLC_1	107	112	PF02516	0.407
MOD_NEK2_1	107	112	PF00069	0.620
MOD_NEK2_1	123	128	PF00069	0.355
MOD_PK_1	81	87	PF00069	0.639
MOD_PKA_2	21	27	PF00069	0.746
MOD_PKA_2	85	91	PF00069	0.631
MOD_Plk_1	81	87	PF00069	0.639
MOD_Plk_1	88	94	PF00069	0.634
MOD_Plk_4	111	117	PF00069	0.482
MOD_Plk_4	123	129	PF00069	0.335
MOD_ProDKin_1	17	23	PF00069	0.664
MOD_SUMO_rev_2	30	35	PF00179	0.687
MOD_SUMO_rev_2	71	78	PF00179	0.652
TRG_ENDOCYTIC_2	134	137	PF00928	0.382
TRG_ENDOCYTIC_2	181	184	PF00928	0.454
TRG_ER_diArg_1	3	5	PF00400	0.682
TRG_ER_diArg_1	35	38	PF00400	0.713
TRG_PTS1	216	219	PF00515	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P933	Leptomonas seymouri	82%	99%
A0A0S4IVJ7	Bodo saltans	66%	100%
A0A1X0NP20	Trypanosomatidae	73%	100%
A0A3S5H645	Leishmania donovani	92%	100%
A4H5A9	Leishmania braziliensis	88%	100%
A4HTI8	Leishmania infantum	91%	100%
C9ZPJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
Q4QID2	Leishmania major	96%	100%
V5DHY0	Trypanosoma cruzi	73%	100%