Isochorismatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Isochorismatase family, putative

Species:

Leishmania mexicana

UniProt:

E9AMB0_LEIMU

TriTrypDb:

LmxM.08.0310

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 23
NetGPI	no	yes: 0, no: 25

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMB0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.410
CLV_C14_Caspase3-7	234	238	PF00656	0.454
CLV_NRD_NRD_1	168	170	PF00675	0.219
CLV_NRD_NRD_1	232	234	PF00675	0.487
CLV_PCSK_FUR_1	230	234	PF00082	0.454
CLV_PCSK_KEX2_1	232	234	PF00082	0.645
CLV_PCSK_SKI1_1	16	20	PF00082	0.582
CLV_PCSK_SKI1_1	204	208	PF00082	0.405
CLV_PCSK_SKI1_1	34	38	PF00082	0.342
CLV_PCSK_SKI1_1	74	78	PF00082	0.548
DOC_ANK_TNKS_1	232	239	PF00023	0.488
DOC_MAPK_gen_1	154	162	PF00069	0.460
DOC_MAPK_gen_1	204	212	PF00069	0.485
DOC_MAPK_MEF2A_6	154	162	PF00069	0.477
DOC_MAPK_MEF2A_6	204	212	PF00069	0.373
DOC_PP2B_PxIxI_1	207	213	PF00149	0.293
DOC_PP4_FxxP_1	205	208	PF00568	0.445
DOC_USP7_MATH_1	249	253	PF00917	0.482
DOC_USP7_MATH_1	265	269	PF00917	0.390
DOC_USP7_MATH_1	72	76	PF00917	0.477
LIG_14-3-3_CanoR_1	107	111	PF00244	0.485
LIG_14-3-3_CanoR_1	16	21	PF00244	0.613
LIG_14-3-3_CanoR_1	221	225	PF00244	0.331
LIG_Actin_WH2_2	191	209	PF00022	0.232
LIG_FHA_1	106	112	PF00498	0.384
LIG_FHA_1	151	157	PF00498	0.496
LIG_FHA_1	173	179	PF00498	0.573
LIG_FHA_1	6	12	PF00498	0.503
LIG_FHA_1	82	88	PF00498	0.567
LIG_FHA_2	145	151	PF00498	0.507
LIG_FHA_2	17	23	PF00498	0.381
LIG_FHA_2	197	203	PF00498	0.371
LIG_LIR_Apic_2	202	208	PF02991	0.551
LIG_LIR_Gen_1	258	269	PF02991	0.390
LIG_LIR_Nem_3	181	186	PF02991	0.453
LIG_LIR_Nem_3	258	264	PF02991	0.391
LIG_Pex14_2	216	220	PF04695	0.311
LIG_SH2_CRK	261	265	PF00017	0.389
LIG_SH2_CRK	41	45	PF00017	0.315
LIG_SH2_NCK_1	41	45	PF00017	0.313
LIG_SH2_SRC	41	44	PF00017	0.298
LIG_SH2_STAP1	261	265	PF00017	0.389
LIG_SH3_1	9	15	PF00018	0.467
LIG_SH3_3	245	251	PF00018	0.443
LIG_SH3_3	45	51	PF00018	0.327
LIG_SH3_3	8	14	PF00018	0.733
LIG_SH3_4	207	214	PF00018	0.372
LIG_TYR_ITIM	39	44	PF00017	0.265
LIG_UBA3_1	209	215	PF00899	0.537
LIG_WW_3	13	17	PF00397	0.445
MOD_CK1_1	21	27	PF00069	0.517
MOD_CK1_1	7	13	PF00069	0.572
MOD_CK2_1	16	22	PF00069	0.395
MOD_GlcNHglycan	192	195	PF01048	0.475
MOD_GlcNHglycan	251	254	PF01048	0.569
MOD_GlcNHglycan	267	270	PF01048	0.577
MOD_GSK3_1	1	8	PF00069	0.667
MOD_GSK3_1	186	193	PF00069	0.357
MOD_GSK3_1	77	84	PF00069	0.384
MOD_N-GLC_1	255	260	PF02516	0.403
MOD_NEK2_1	172	177	PF00069	0.502
MOD_NEK2_1	178	183	PF00069	0.503
MOD_NEK2_1	186	191	PF00069	0.371
MOD_NEK2_1	196	201	PF00069	0.321
MOD_NEK2_2	72	77	PF00069	0.424
MOD_OFUCOSY	136	141	PF10250	0.161
MOD_PIKK_1	164	170	PF00454	0.497
MOD_PIKK_1	220	226	PF00454	0.494
MOD_PKA_2	106	112	PF00069	0.493
MOD_PKA_2	220	226	PF00069	0.548
MOD_Plk_1	21	27	PF00069	0.483
MOD_Plk_1	72	78	PF00069	0.316
MOD_Plk_1	97	103	PF00069	0.488
MOD_Plk_4	106	112	PF00069	0.418
MOD_Plk_4	97	103	PF00069	0.412
TRG_DiLeu_BaEn_1	22	27	PF01217	0.391
TRG_DiLeu_LyEn_5	22	27	PF01217	0.391
TRG_ENDOCYTIC_2	261	264	PF00928	0.391
TRG_ENDOCYTIC_2	41	44	PF00928	0.300
TRG_NES_CRM1_1	150	163	PF08389	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P932	Leptomonas seymouri	37%	100%
A0A0N1HWD2	Leptomonas seymouri	31%	100%
A0A0N1I400	Leptomonas seymouri	54%	100%
A0A0N1IAK4	Leptomonas seymouri	41%	100%
A0A3S5H641	Leishmania donovani	37%	100%
A0A3S5H642	Leishmania donovani	46%	100%
A0A3S5IQS6	Trypanosoma rangeli	37%	100%
A0A3S7WQ71	Leishmania donovani	83%	89%
A4H5A0	Leishmania braziliensis	40%	100%
A4H5A1	Leishmania braziliensis	68%	100%
A4H5A2	Leishmania braziliensis	46%	100%
A4H6S1	Leishmania braziliensis	33%	98%
A4HTI1	Leishmania infantum	37%	100%
A4HTI2	Leishmania infantum	83%	89%
A4HTI3	Leishmania infantum	46%	100%
A4HV50	Leishmania infantum	30%	100%
D0VWV0	Leishmania donovani	30%	100%
E9AMA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AMB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9ANT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
P85094	Mus musculus	30%	100%
Q08C33	Danio rerio	25%	97%
Q4QGT7	Leishmania major	31%	98%
Q4QID7	Leishmania major	46%	100%
Q4QID8	Leishmania major	81%	100%
Q4QID9	Leishmania major	38%	100%