Isochorismatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Isochorismatase family, putative

Species:

Leishmania mexicana

UniProt:

E9AMA9_LEIMU

TriTrypDb:

LmxM.08.0300

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 19
NetGPI	no	yes: 0, no: 21

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMA9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.310
CLV_NRD_NRD_1	180	182	PF00675	0.222
CLV_NRD_NRD_1	232	234	PF00675	0.422
CLV_NRD_NRD_1	31	33	PF00675	0.512
CLV_NRD_NRD_1	38	40	PF00675	0.304
CLV_PCSK_KEX2_1	164	166	PF00082	0.279
CLV_PCSK_KEX2_1	180	182	PF00082	0.178
CLV_PCSK_KEX2_1	232	234	PF00082	0.592
CLV_PCSK_KEX2_1	30	32	PF00082	0.502
CLV_PCSK_SKI1_1	39	43	PF00082	0.398
CLV_PCSK_SKI1_1	45	49	PF00082	0.316
CLV_Separin_Metazoa	161	165	PF03568	0.517
DEG_SIAH_1	108	116	PF03145	0.405
DEG_SIAH_1	14	22	PF03145	0.448
DOC_CYCLIN_yClb3_PxF_3	108	114	PF00134	0.492
DOC_MAPK_gen_1	164	171	PF00069	0.492
DOC_MAPK_gen_1	180	188	PF00069	0.450
DOC_MAPK_RevD_3	17	31	PF00069	0.437
DOC_PP4_FxxP_1	231	234	PF00568	0.702
DOC_USP7_UBL2_3	56	60	PF12436	0.517
LIG_14-3-3_CanoR_1	39	48	PF00244	0.461
LIG_14-3-3_CterR_2	250	252	PF00244	0.552
LIG_Actin_WH2_2	149	166	PF00022	0.517
LIG_APCC_ABBA_1	74	79	PF00400	0.517
LIG_BIR_II_1	1	5	PF00653	0.474
LIG_FHA_1	198	204	PF00498	0.449
LIG_FHA_1	20	26	PF00498	0.492
LIG_FHA_1	205	211	PF00498	0.389
LIG_FHA_1	33	39	PF00498	0.408
LIG_FHA_1	44	50	PF00498	0.210
LIG_FHA_1	65	71	PF00498	0.496
LIG_FHA_2	156	162	PF00498	0.516
LIG_FHA_2	7	13	PF00498	0.470
LIG_LIR_Gen_1	8	18	PF02991	0.390
LIG_LIR_Gen_1	84	92	PF02991	0.464
LIG_LIR_Nem_3	192	197	PF02991	0.584
LIG_LIR_Nem_3	214	220	PF02991	0.344
LIG_LIR_Nem_3	84	88	PF02991	0.458
LIG_SH2_CRK	206	210	PF00017	0.416
LIG_SH2_CRK	85	89	PF00017	0.541
LIG_SH2_SRC	129	132	PF00017	0.512
LIG_SH2_STAP1	206	210	PF00017	0.416
LIG_SH2_STAT5	129	132	PF00017	0.521
LIG_SH2_STAT5	206	209	PF00017	0.399
LIG_SH2_STAT5	85	88	PF00017	0.446
LIG_SH3_2	241	246	PF14604	0.407
LIG_SH3_3	106	112	PF00018	0.524
LIG_SH3_3	22	28	PF00018	0.646
LIG_SH3_3	238	244	PF00018	0.728
LIG_SH3_3	89	95	PF00018	0.556
LIG_SUMO_SIM_anti_2	185	190	PF11976	0.517
LIG_UBA3_1	188	193	PF00899	0.517
LIG_WW_3	243	247	PF00397	0.406
MOD_CK2_1	155	161	PF00069	0.491
MOD_CK2_1	189	195	PF00069	0.441
MOD_CK2_1	6	12	PF00069	0.437
MOD_GSK3_1	1	8	PF00069	0.611
MOD_GSK3_1	19	26	PF00069	0.655
MOD_GSK3_1	235	242	PF00069	0.602
MOD_GSK3_1	39	46	PF00069	0.323
MOD_GSK3_1	64	71	PF00069	0.527
MOD_N-GLC_1	64	69	PF02516	0.308
MOD_NEK2_1	1	6	PF00069	0.618
MOD_NEK2_1	189	194	PF00069	0.511
MOD_NEK2_1	197	202	PF00069	0.384
MOD_NEK2_1	64	69	PF00069	0.517
MOD_PIKK_1	32	38	PF00454	0.481
MOD_PKA_1	39	45	PF00069	0.299
MOD_PKA_2	19	25	PF00069	0.474
MOD_PKA_2	68	74	PF00069	0.545
MOD_PKB_1	30	38	PF00069	0.420
MOD_Plk_1	23	29	PF00069	0.684
MOD_Plk_1	64	70	PF00069	0.405
MOD_Plk_4	117	123	PF00069	0.485
MOD_Plk_4	205	211	PF00069	0.321
MOD_SUMO_for_1	115	118	PF00179	0.405
TRG_DiLeu_BaEn_1	118	123	PF01217	0.471
TRG_ENDOCYTIC_2	102	105	PF00928	0.478
TRG_ENDOCYTIC_2	206	209	PF00928	0.420
TRG_ENDOCYTIC_2	85	88	PF00928	0.541
TRG_ER_diArg_1	163	165	PF00400	0.517
TRG_ER_diArg_1	180	182	PF00400	0.517
TRG_ER_diArg_1	231	233	PF00400	0.417
TRG_ER_diArg_1	30	32	PF00400	0.523
TRG_Pf-PMV_PEXEL_1	180	185	PF00026	0.224

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P932	Leptomonas seymouri	70%	100%
A0A0N1HWD2	Leptomonas seymouri	31%	100%
A0A0N1I400	Leptomonas seymouri	40%	100%
A0A0N1IAK4	Leptomonas seymouri	49%	100%
A0A0S4IVV9	Bodo saltans	36%	100%
A0A1X0NQH8	Trypanosomatidae	41%	100%
A0A3S5H641	Leishmania donovani	88%	100%
A0A3S5H642	Leishmania donovani	52%	100%
A0A3S5IQS6	Trypanosoma rangeli	38%	100%
A0A3S7WQ71	Leishmania donovani	39%	82%
A0JME6	Danio rerio	29%	100%
A4H5A0	Leishmania braziliensis	76%	100%
A4H5A1	Leishmania braziliensis	38%	85%
A4H5A2	Leishmania braziliensis	53%	100%
A4H6S1	Leishmania braziliensis	33%	100%
A4HTI1	Leishmania infantum	88%	100%
A4HTI2	Leishmania infantum	38%	82%
A4HTI3	Leishmania infantum	52%	100%
A4HV50	Leishmania infantum	30%	100%
A6QLY4	Bos taurus	35%	85%
B5X0W9	Salmo salar	34%	89%
D0VWV0	Leishmania donovani	30%	100%
E9AMB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	92%
E9AMB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9ANT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
G4YEI5	Phytophthora sojae (strain P6497)	30%	100%
P85094	Mus musculus	30%	100%
Q08C33	Danio rerio	32%	89%
Q0IHU5	Xenopus tropicalis	34%	82%
Q32KX0	Bos taurus	27%	100%
Q4QGT7	Leishmania major	30%	100%
Q4QID7	Leishmania major	52%	100%
Q4QID8	Leishmania major	38%	81%
Q4QID9	Leishmania major	89%	100%
Q4R826	Macaca fascicularis	28%	100%
Q54NZ8	Dictyostelium discoideum	28%	100%
Q54RC7	Dictyostelium discoideum	28%	100%
Q5PQ71	Xenopus laevis	29%	100%
Q5PQA5	Xenopus laevis	34%	82%
Q5RC03	Pongo abelii	27%	100%
Q5U3Z3	Rattus norvegicus	33%	100%
Q6DF67	Xenopus tropicalis	29%	100%
Q6I7R3	Rattus norvegicus	35%	85%
Q91V64	Mus musculus	35%	85%
Q96AB3	Homo sapiens	29%	100%
Q96CN7	Homo sapiens	35%	85%
Q9DCC7	Mus musculus	34%	100%