Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMA5_LEIMU

TriTrypDb:

LmxM.08.0260

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.754
CLV_NRD_NRD_1	124	126	PF00675	0.658
CLV_NRD_NRD_1	189	191	PF00675	0.556
CLV_NRD_NRD_1	234	236	PF00675	0.805
CLV_NRD_NRD_1	321	323	PF00675	0.713
CLV_NRD_NRD_1	330	332	PF00675	0.539
CLV_NRD_NRD_1	433	435	PF00675	0.656
CLV_PCSK_FUR_1	142	146	PF00082	0.713
CLV_PCSK_FUR_1	328	332	PF00082	0.684
CLV_PCSK_KEX2_1	144	146	PF00082	0.605
CLV_PCSK_KEX2_1	189	191	PF00082	0.556
CLV_PCSK_KEX2_1	233	235	PF00082	0.827
CLV_PCSK_KEX2_1	321	323	PF00082	0.713
CLV_PCSK_KEX2_1	328	330	PF00082	0.576
CLV_PCSK_KEX2_1	344	346	PF00082	0.481
CLV_PCSK_KEX2_1	425	427	PF00082	0.650
CLV_PCSK_KEX2_1	433	435	PF00082	0.529
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.713
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.735
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.650
CLV_PCSK_SKI1_1	103	107	PF00082	0.734
CLV_PCSK_SKI1_1	160	164	PF00082	0.692
CLV_PCSK_SKI1_1	295	299	PF00082	0.804
CLV_PCSK_SKI1_1	333	337	PF00082	0.682
DEG_APCC_DBOX_1	159	167	PF00400	0.710
DEG_APCC_DBOX_1	27	35	PF00400	0.807
DEG_Nend_UBRbox_1	1	4	PF02207	0.821
DEG_SPOP_SBC_1	184	188	PF00917	0.736
DEG_SPOP_SBC_1	200	204	PF00917	0.551
DEG_SPOP_SBC_1	210	214	PF00917	0.639
DEG_SPOP_SBC_1	22	26	PF00917	0.786
DEG_SPOP_SBC_1	305	309	PF00917	0.537
DOC_CKS1_1	248	253	PF01111	0.550
DOC_CYCLIN_RxL_1	408	419	PF00134	0.665
DOC_MAPK_gen_1	408	418	PF00069	0.666
DOC_MAPK_gen_1	425	431	PF00069	0.370
DOC_PP2B_LxvP_1	17	20	PF13499	0.606
DOC_PP2B_LxvP_1	301	304	PF13499	0.800
DOC_PP2B_LxvP_1	32	35	PF13499	0.762
DOC_USP7_MATH_1	184	188	PF00917	0.768
DOC_USP7_MATH_1	194	198	PF00917	0.677
DOC_USP7_MATH_1	20	24	PF00917	0.532
DOC_USP7_MATH_1	200	204	PF00917	0.595
DOC_USP7_MATH_1	259	263	PF00917	0.823
DOC_USP7_MATH_1	281	285	PF00917	0.630
DOC_USP7_MATH_1	305	309	PF00917	0.537
DOC_USP7_MATH_1	37	41	PF00917	0.537
DOC_USP7_MATH_1	374	378	PF00917	0.564
DOC_USP7_MATH_1	58	62	PF00917	0.792
DOC_USP7_MATH_1	65	69	PF00917	0.657
DOC_USP7_MATH_1	97	101	PF00917	0.782
DOC_WW_Pin1_4	180	185	PF00397	0.797
DOC_WW_Pin1_4	226	231	PF00397	0.668
DOC_WW_Pin1_4	247	252	PF00397	0.706
DOC_WW_Pin1_4	262	267	PF00397	0.689
DOC_WW_Pin1_4	277	282	PF00397	0.602
DOC_WW_Pin1_4	290	295	PF00397	0.714
DOC_WW_Pin1_4	346	351	PF00397	0.769
DOC_WW_Pin1_4	391	396	PF00397	0.511
DOC_WW_Pin1_4	5	10	PF00397	0.767
DOC_WW_Pin1_4	72	77	PF00397	0.824
DOC_WW_Pin1_4	86	91	PF00397	0.600
LIG_14-3-3_CanoR_1	223	230	PF00244	0.776
LIG_14-3-3_CanoR_1	267	274	PF00244	0.828
LIG_14-3-3_CanoR_1	306	314	PF00244	0.538
LIG_14-3-3_CanoR_1	333	338	PF00244	0.684
LIG_Clathr_ClatBox_1	415	419	PF01394	0.655
LIG_FHA_1	177	183	PF00498	0.796
LIG_FHA_1	368	374	PF00498	0.815
LIG_FHA_2	22	28	PF00498	0.794
LIG_FHA_2	253	259	PF00498	0.639
LIG_FHA_2	347	353	PF00498	0.783
LIG_FHA_2	422	428	PF00498	0.643
LIG_LIR_Nem_3	104	110	PF02991	0.715
LIG_LIR_Nem_3	113	118	PF02991	0.508
LIG_NRBOX	411	417	PF00104	0.663
LIG_PDZ_Class_2	433	438	PF00595	0.668
LIG_RPA_C_Fungi	334	346	PF08784	0.698
LIG_SH2_CRK	115	119	PF00017	0.529
LIG_SH2_STAP1	151	155	PF00017	0.679
LIG_SH2_STAP1	337	341	PF00017	0.688
LIG_SH3_1	345	351	PF00018	0.511
LIG_SH3_3	294	300	PF00018	0.802
LIG_SH3_3	31	37	PF00018	0.732
LIG_SH3_3	345	351	PF00018	0.511
LIG_SH3_3	398	404	PF00018	0.516
LIG_SH3_3	87	93	PF00018	0.603
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.549
LIG_SUMO_SIM_anti_2	427	433	PF11976	0.387
LIG_SUMO_SIM_par_1	414	419	PF11976	0.659
LIG_WRPW_2	107	110	PF00400	0.701
LIG_WW_3	235	239	PF00397	0.816
LIG_WW_3	303	307	PF00397	0.789
MOD_CDC14_SPxK_1	8	11	PF00782	0.807
MOD_CDK_SPK_2	262	267	PF00069	0.758
MOD_CDK_SPK_2	290	295	PF00069	0.749
MOD_CDK_SPxK_1	5	11	PF00069	0.807
MOD_CDK_SPxxK_3	226	233	PF00069	0.582
MOD_CK1_1	10	16	PF00069	0.787
MOD_CK1_1	101	107	PF00069	0.682
MOD_CK1_1	111	117	PF00069	0.413
MOD_CK1_1	183	189	PF00069	0.802
MOD_CK1_1	199	205	PF00069	0.562
MOD_CK1_1	218	224	PF00069	0.540
MOD_CK1_1	226	232	PF00069	0.596
MOD_CK1_1	23	29	PF00069	0.566
MOD_CK1_1	261	267	PF00069	0.795
MOD_CK1_1	3	9	PF00069	0.714
MOD_CK1_1	363	369	PF00069	0.665
MOD_CK1_1	89	95	PF00069	0.805
MOD_CK2_1	21	27	PF00069	0.792
MOD_CK2_1	252	258	PF00069	0.636
MOD_CK2_1	281	287	PF00069	0.821
MOD_CK2_1	346	352	PF00069	0.582
MOD_CK2_1	421	427	PF00069	0.642
MOD_GlcNHglycan	103	106	PF01048	0.701
MOD_GlcNHglycan	12	15	PF01048	0.811
MOD_GlcNHglycan	198	201	PF01048	0.706
MOD_GlcNHglycan	223	226	PF01048	0.807
MOD_GlcNHglycan	261	264	PF01048	0.827
MOD_GlcNHglycan	269	272	PF01048	0.698
MOD_GlcNHglycan	301	304	PF01048	0.628
MOD_GlcNHglycan	308	311	PF01048	0.679
MOD_GlcNHglycan	362	365	PF01048	0.738
MOD_GSK3_1	110	117	PF00069	0.500
MOD_GSK3_1	176	183	PF00069	0.794
MOD_GSK3_1	18	25	PF00069	0.541
MOD_GSK3_1	195	202	PF00069	0.508
MOD_GSK3_1	205	212	PF00069	0.663
MOD_GSK3_1	213	220	PF00069	0.552
MOD_GSK3_1	253	260	PF00069	0.792
MOD_GSK3_1	277	284	PF00069	0.632
MOD_GSK3_1	286	293	PF00069	0.712
MOD_GSK3_1	3	10	PF00069	0.721
MOD_GSK3_1	356	363	PF00069	0.559
MOD_GSK3_1	72	79	PF00069	0.660
MOD_GSK3_1	89	96	PF00069	0.554
MOD_GSK3_1	97	104	PF00069	0.664
MOD_N-GLC_1	101	106	PF02516	0.748
MOD_N-GLC_1	180	185	PF02516	0.797
MOD_N-GLC_1	356	361	PF02516	0.559
MOD_N-GLC_1	37	42	PF02516	0.564
MOD_NEK2_1	421	426	PF00069	0.640
MOD_PIKK_1	3	9	PF00454	0.549
MOD_PIKK_1	339	345	PF00454	0.704
MOD_PKA_2	194	200	PF00069	0.806
MOD_PKA_2	305	311	PF00069	0.537
MOD_PKB_1	193	201	PF00069	0.745
MOD_PKB_1	331	339	PF00069	0.685
MOD_Plk_1	37	43	PF00069	0.558
MOD_Plk_4	114	120	PF00069	0.516
MOD_Plk_4	13	19	PF00069	0.549
MOD_ProDKin_1	180	186	PF00069	0.801
MOD_ProDKin_1	226	232	PF00069	0.670
MOD_ProDKin_1	247	253	PF00069	0.709
MOD_ProDKin_1	262	268	PF00069	0.690
MOD_ProDKin_1	277	283	PF00069	0.603
MOD_ProDKin_1	290	296	PF00069	0.715
MOD_ProDKin_1	346	352	PF00069	0.773
MOD_ProDKin_1	391	397	PF00069	0.511
MOD_ProDKin_1	5	11	PF00069	0.769
MOD_ProDKin_1	72	78	PF00069	0.823
MOD_ProDKin_1	86	92	PF00069	0.600
MOD_SUMO_rev_2	363	368	PF00179	0.558
TRG_DiLeu_BaEn_1	27	32	PF01217	0.809
TRG_DiLeu_BaLyEn_6	411	416	PF01217	0.664
TRG_ENDOCYTIC_2	115	118	PF00928	0.533
TRG_ER_diArg_1	233	235	PF00400	0.573
TRG_ER_diArg_1	320	322	PF00400	0.713
TRG_ER_diArg_1	328	331	PF00400	0.561
TRG_ER_diArg_1	345	348	PF00400	0.484
TRG_ER_diArg_1	369	372	PF00400	0.562
TRG_ER_diArg_1	432	434	PF00400	0.653
TRG_NLS_Bipartite_1	328	348	PF00514	0.701
TRG_NLS_MonoExtC_3	343	348	PF00514	0.742
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.697
TRG_Pf-PMV_PEXEL_1	414	419	PF00026	0.659

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H638	Leishmania donovani	83%	100%
A4HTH7	Leishmania infantum	83%	100%
Q4QIE3	Leishmania major	82%	100%