ADG1-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

ADG1-like protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMA4_LEIMU

TriTrypDb:

LmxM.08.0250

Length:

113

Annotations

LeishMANIAdb annotations

Specific to Kinetoplastids, where evolution has duplicated this protein more than one time. However, this already happened at free-living forms.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AMA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	85	87	PF00675	0.582
CLV_PCSK_KEX2_1	85	87	PF00082	0.582
CLV_PCSK_SKI1_1	63	67	PF00082	0.578
DEG_APCC_DBOX_1	85	93	PF00400	0.382
DEG_Nend_UBRbox_3	1	3	PF02207	0.685
DOC_CDC14_PxL_1	13	21	PF14671	0.556
DOC_CYCLIN_RxL_1	80	93	PF00134	0.418
LIG_14-3-3_CanoR_1	41	45	PF00244	0.375
LIG_FHA_1	23	29	PF00498	0.378
LIG_FHA_1	93	99	PF00498	0.365
LIG_LIR_Nem_3	32	36	PF02991	0.356
LIG_LYPXL_yS_3	16	19	PF13949	0.440
LIG_Pex14_2	31	35	PF04695	0.408
LIG_SH2_STAP1	36	40	PF00017	0.495
LIG_UBA3_1	5	11	PF00899	0.674
MOD_CK1_1	39	45	PF00069	0.418
MOD_GlcNHglycan	102	105	PF01048	0.625
MOD_GSK3_1	15	22	PF00069	0.515
MOD_GSK3_1	35	42	PF00069	0.224
MOD_NEK2_1	19	24	PF00069	0.354
MOD_NEK2_1	44	49	PF00069	0.374
MOD_NEK2_2	36	41	PF00069	0.519
MOD_PIKK_1	44	50	PF00454	0.357
MOD_PKA_2	40	46	PF00069	0.346
MOD_Plk_1	69	75	PF00069	0.402
MOD_Plk_4	40	46	PF00069	0.392
TRG_ENDOCYTIC_2	16	19	PF00928	0.384
TRG_ER_diArg_1	77	80	PF00400	0.385
TRG_ER_diArg_1	84	86	PF00400	0.357
TRG_Pf-PMV_PEXEL_1	85	90	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFQ4	Leptomonas seymouri	89%	100%
A0A0S4KHT3	Bodo saltans	35%	74%
A0A1X0NPM0	Trypanosomatidae	48%	93%
A0A3R7KSK8	Trypanosoma rangeli	48%	93%
A0A3S7WQ48	Leishmania donovani	99%	100%
A4H592	Leishmania braziliensis	96%	100%
C9ZPK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	96%
Q4QIE4	Leishmania major	97%	100%