ABC1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC1 family, putative

Species:

Leishmania mexicana

UniProt:

E9AMA2_LEIMU

TriTrypDb:

LmxM.08.0230

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AMA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMA2

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	269	271	PF00675	0.296
CLV_NRD_NRD_1	354	356	PF00675	0.373
CLV_NRD_NRD_1	83	85	PF00675	0.492
CLV_PCSK_KEX2_1	131	133	PF00082	0.404
CLV_PCSK_KEX2_1	269	271	PF00082	0.318
CLV_PCSK_KEX2_1	354	356	PF00082	0.373
CLV_PCSK_KEX2_1	83	85	PF00082	0.459
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.414
CLV_PCSK_SKI1_1	147	151	PF00082	0.418
CLV_PCSK_SKI1_1	269	273	PF00082	0.341
CLV_PCSK_SKI1_1	42	46	PF00082	0.439
DEG_SPOP_SBC_1	400	404	PF00917	0.490
DOC_AGCK_PIF_2	212	217	PF00069	0.373
DOC_CYCLIN_RxL_1	39	46	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	27	30	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	392	398	PF00134	0.366
DOC_MAPK_DCC_7	31	39	PF00069	0.590
DOC_MAPK_MEF2A_6	31	39	PF00069	0.590
DOC_MAPK_MEF2A_6	335	343	PF00069	0.414
DOC_MAPK_MEF2A_6	479	487	PF00069	0.416
DOC_PP1_RVXF_1	259	265	PF00149	0.414
DOC_PP1_RVXF_1	40	46	PF00149	0.496
DOC_PP1_RVXF_1	477	483	PF00149	0.461
DOC_PP2B_LxvP_1	27	30	PF13499	0.516
DOC_USP7_MATH_1	108	112	PF00917	0.387
DOC_USP7_MATH_1	162	166	PF00917	0.282
DOC_USP7_MATH_1	206	210	PF00917	0.415
DOC_WW_Pin1_4	156	161	PF00397	0.373
DOC_WW_Pin1_4	366	371	PF00397	0.341
DOC_WW_Pin1_4	406	411	PF00397	0.485
LIG_14-3-3_CanoR_1	147	156	PF00244	0.390
LIG_14-3-3_CanoR_1	270	278	PF00244	0.315
LIG_14-3-3_CanoR_1	467	471	PF00244	0.368
LIG_14-3-3_CanoR_1	501	505	PF00244	0.512
LIG_Actin_WH2_2	427	445	PF00022	0.388
LIG_BRCT_BRCA1_1	201	205	PF00533	0.431
LIG_BRCT_BRCA1_1	208	212	PF00533	0.390
LIG_FHA_1	198	204	PF00498	0.298
LIG_FHA_1	21	27	PF00498	0.489
LIG_FHA_1	367	373	PF00498	0.371
LIG_FHA_1	446	452	PF00498	0.481
LIG_FHA_2	300	306	PF00498	0.414
LIG_FHA_2	363	369	PF00498	0.349
LIG_FHA_2	470	476	PF00498	0.516
LIG_FHA_2	68	74	PF00498	0.558
LIG_GBD_Chelix_1	137	145	PF00786	0.373
LIG_LIR_Apic_2	154	158	PF02991	0.438
LIG_LIR_Apic_2	209	213	PF02991	0.419
LIG_LIR_Apic_2	503	508	PF02991	0.436
LIG_LIR_Gen_1	150	161	PF02991	0.371
LIG_LIR_Gen_1	301	312	PF02991	0.352
LIG_LIR_Gen_1	382	392	PF02991	0.344
LIG_LIR_Gen_1	437	446	PF02991	0.341
LIG_LIR_Gen_1	492	502	PF02991	0.455
LIG_LIR_Gen_1	76	86	PF02991	0.434
LIG_LIR_Nem_3	150	156	PF02991	0.413
LIG_LIR_Nem_3	209	215	PF02991	0.407
LIG_LIR_Nem_3	216	220	PF02991	0.261
LIG_LIR_Nem_3	301	307	PF02991	0.352
LIG_LIR_Nem_3	382	387	PF02991	0.367
LIG_LIR_Nem_3	437	441	PF02991	0.343
LIG_LIR_Nem_3	492	498	PF02991	0.435
LIG_LIR_Nem_3	76	81	PF02991	0.456
LIG_LYPXL_SIV_4	133	141	PF13949	0.419
LIG_MAD2	270	278	PF02301	0.452
LIG_MLH1_MIPbox_1	208	212	PF16413	0.395
LIG_MYND_1	36	40	PF01753	0.589
LIG_Pex14_2	312	316	PF04695	0.282
LIG_Pex14_2	387	391	PF04695	0.359
LIG_SH2_CRK	118	122	PF00017	0.428
LIG_SH2_CRK	438	442	PF00017	0.343
LIG_SH2_CRK	495	499	PF00017	0.498
LIG_SH2_PTP2	155	158	PF00017	0.400
LIG_SH2_PTP2	187	190	PF00017	0.319
LIG_SH2_SRC	134	137	PF00017	0.419
LIG_SH2_SRC	155	158	PF00017	0.414
LIG_SH2_SRC	187	190	PF00017	0.298
LIG_SH2_STAP1	134	138	PF00017	0.419
LIG_SH2_STAP1	384	388	PF00017	0.349
LIG_SH2_STAP1	396	400	PF00017	0.469
LIG_SH2_STAP1	438	442	PF00017	0.337
LIG_SH2_STAP1	495	499	PF00017	0.522
LIG_SH2_STAP1	65	69	PF00017	0.450
LIG_SH2_STAT5	100	103	PF00017	0.332
LIG_SH2_STAT5	118	121	PF00017	0.344
LIG_SH2_STAT5	155	158	PF00017	0.414
LIG_SH2_STAT5	187	190	PF00017	0.298
LIG_SH2_STAT5	210	213	PF00017	0.414
LIG_SH2_STAT5	398	401	PF00017	0.583
LIG_SH2_STAT5	62	65	PF00017	0.373
LIG_SH3_3	127	133	PF00018	0.367
LIG_SH3_3	254	260	PF00018	0.347
LIG_SH3_3	34	40	PF00018	0.523
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.376
LIG_SUMO_SIM_anti_2	200	205	PF11976	0.414
LIG_SUMO_SIM_par_1	136	142	PF11976	0.376
LIG_SUMO_SIM_par_1	337	342	PF11976	0.284
LIG_SUMO_SIM_par_1	35	41	PF11976	0.555
LIG_SUMO_SIM_par_1	87	94	PF11976	0.411
LIG_TYR_ITIM	185	190	PF00017	0.282
LIG_WW_3	28	32	PF00397	0.585
MOD_CDK_SPK_2	366	371	PF00069	0.419
MOD_CK1_1	469	475	PF00069	0.486
MOD_CK2_1	469	475	PF00069	0.494
MOD_GlcNHglycan	348	352	PF01048	0.342
MOD_GlcNHglycan	403	406	PF01048	0.646
MOD_GSK3_1	147	154	PF00069	0.314
MOD_GSK3_1	355	362	PF00069	0.310
MOD_GSK3_1	366	373	PF00069	0.275
MOD_GSK3_1	441	448	PF00069	0.461
MOD_GSK3_1	466	473	PF00069	0.416
MOD_GSK3_1	514	521	PF00069	0.588
MOD_N-GLC_1	108	113	PF02516	0.398
MOD_N-GLC_1	224	229	PF02516	0.284
MOD_N-GLC_1	400	405	PF02516	0.617
MOD_NEK2_1	224	229	PF00069	0.298
MOD_NEK2_1	3	8	PF00069	0.540
MOD_NEK2_1	386	391	PF00069	0.326
MOD_NEK2_1	399	404	PF00069	0.500
MOD_NEK2_1	416	421	PF00069	0.543
MOD_NEK2_1	466	471	PF00069	0.352
MOD_NEK2_1	500	505	PF00069	0.451
MOD_NEK2_1	514	519	PF00069	0.456
MOD_PIKK_1	271	277	PF00454	0.418
MOD_PIKK_1	67	73	PF00454	0.519
MOD_PKA_2	238	244	PF00069	0.414
MOD_PKA_2	3	9	PF00069	0.505
MOD_PKA_2	30	36	PF00069	0.579
MOD_PKA_2	416	422	PF00069	0.563
MOD_PKA_2	466	472	PF00069	0.319
MOD_PKA_2	500	506	PF00069	0.469
MOD_Plk_1	108	114	PF00069	0.383
MOD_Plk_1	224	230	PF00069	0.291
MOD_Plk_1	514	520	PF00069	0.461
MOD_Plk_2-3	151	157	PF00069	0.366
MOD_Plk_4	206	212	PF00069	0.419
MOD_Plk_4	299	305	PF00069	0.374
MOD_Plk_4	494	500	PF00069	0.353
MOD_ProDKin_1	156	162	PF00069	0.373
MOD_ProDKin_1	366	372	PF00069	0.341
MOD_ProDKin_1	406	412	PF00069	0.480
TRG_ENDOCYTIC_2	118	121	PF00928	0.433
TRG_ENDOCYTIC_2	134	137	PF00928	0.335
TRG_ENDOCYTIC_2	187	190	PF00928	0.282
TRG_ENDOCYTIC_2	384	387	PF00928	0.349
TRG_ENDOCYTIC_2	396	399	PF00928	0.411
TRG_ENDOCYTIC_2	438	441	PF00928	0.329
TRG_ENDOCYTIC_2	495	498	PF00928	0.492
TRG_ER_diArg_1	171	174	PF00400	0.373
TRG_ER_diArg_1	269	271	PF00400	0.295
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	270	275	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	453	457	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML7	Leptomonas seymouri	77%	100%
A0A0N1PA82	Leptomonas seymouri	32%	83%
A0A0N1PBZ9	Leptomonas seymouri	22%	87%
A0A0S4KEI7	Bodo saltans	45%	98%
A0A0S4KLC8	Bodo saltans	30%	90%
A0A179HKZ8	Purpureocillium lilacinum	29%	88%
A0A1X0NQM8	Trypanosomatidae	56%	96%
A0A1X0P192	Trypanosomatidae	31%	82%
A0A3Q8IRU0	Leishmania donovani	23%	98%
A0A3R7KBH2	Trypanosoma rangeli	31%	81%
A0A3R7KJM1	Trypanosoma rangeli	58%	99%
A0A3S5H636	Leishmania donovani	95%	100%
A0A3S5H7U4	Leishmania donovani	29%	80%
A0A3S7WR61	Leishmania donovani	23%	88%
A4H590	Leishmania braziliensis	86%	100%
A4HLI6	Leishmania braziliensis	29%	100%
A4HTH4	Leishmania infantum	95%	100%
A4HUH2	Leishmania infantum	23%	88%
A4I8Z6	Leishmania infantum	29%	80%
C9ZPL3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	99%
D0A4Z6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	80%
E9B3W5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	83%
O04212	Arabidopsis thaliana	27%	97%
O42653	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	98%
O60111	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	94%
Q06567	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	92%
Q3MIX3	Homo sapiens	37%	90%
Q46189	Clostridium pasteurianum	24%	98%
Q4Q459	Leishmania major	30%	100%
Q4QHF5	Leishmania major	22%	88%
Q4QIE6	Leishmania major	94%	100%
Q54P00	Dictyostelium discoideum	36%	75%
Q54TR5	Dictyostelium discoideum	30%	78%
Q5M7P6	Xenopus tropicalis	30%	100%
Q5ZMT7	Gallus gallus	33%	100%
Q6INL7	Xenopus laevis	30%	100%
Q80V03	Mus musculus	38%	90%
Q86TW2	Homo sapiens	29%	98%
Q8RWG1	Arabidopsis thaliana	26%	77%
Q9D0L4	Mus musculus	29%	99%
Q9MA15	Arabidopsis thaliana	27%	73%
Q9W133	Drosophila melanogaster	28%	100%
V5AX60	Trypanosoma cruzi	55%	99%
V5BB22	Trypanosoma cruzi	23%	78%
V5BCS0	Trypanosoma cruzi	32%	82%