Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AMA0_LEIMU

TriTrypDb:

LmxM.08.0210

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.509
CLV_NRD_NRD_1	117	119	PF00675	0.534
CLV_NRD_NRD_1	194	196	PF00675	0.784
CLV_NRD_NRD_1	207	209	PF00675	0.608
CLV_NRD_NRD_1	260	262	PF00675	0.499
CLV_NRD_NRD_1	315	317	PF00675	0.710
CLV_NRD_NRD_1	6	8	PF00675	0.638
CLV_PCSK_FUR_1	4	8	PF00082	0.513
CLV_PCSK_KEX2_1	117	119	PF00082	0.715
CLV_PCSK_KEX2_1	194	196	PF00082	0.793
CLV_PCSK_KEX2_1	207	209	PF00082	0.578
CLV_PCSK_KEX2_1	229	231	PF00082	0.534
CLV_PCSK_KEX2_1	260	262	PF00082	0.499
CLV_PCSK_KEX2_1	314	316	PF00082	0.731
CLV_PCSK_KEX2_1	4	6	PF00082	0.649
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.552
CLV_PCSK_SKI1_1	200	204	PF00082	0.692
CLV_Separin_Metazoa	387	391	PF03568	0.598
DEG_SPOP_SBC_1	303	307	PF00917	0.621
DEG_SPOP_SBC_1	441	445	PF00917	0.526
DOC_MAPK_gen_1	260	267	PF00069	0.553
DOC_MAPK_MEF2A_6	260	267	PF00069	0.686
DOC_PP1_RVXF_1	416	423	PF00149	0.485
DOC_PP2B_LxvP_1	286	289	PF13499	0.653
DOC_PP2B_LxvP_1	372	375	PF13499	0.704
DOC_USP7_MATH_1	140	144	PF00917	0.477
DOC_USP7_MATH_1	15	19	PF00917	0.648
DOC_USP7_MATH_1	187	191	PF00917	0.619
DOC_USP7_MATH_1	272	276	PF00917	0.641
DOC_USP7_MATH_1	295	299	PF00917	0.565
DOC_USP7_MATH_1	303	307	PF00917	0.655
DOC_USP7_MATH_1	44	48	PF00917	0.673
DOC_WW_Pin1_4	209	214	PF00397	0.535
DOC_WW_Pin1_4	281	286	PF00397	0.737
DOC_WW_Pin1_4	288	293	PF00397	0.605
DOC_WW_Pin1_4	328	333	PF00397	0.526
DOC_WW_Pin1_4	463	468	PF00397	0.534
LIG_14-3-3_CanoR_1	162	168	PF00244	0.533
LIG_14-3-3_CanoR_1	186	192	PF00244	0.618
LIG_14-3-3_CanoR_1	200	209	PF00244	0.554
LIG_APCC_ABBA_1	120	125	PF00400	0.692
LIG_BRCT_BRCA1_1	455	459	PF00533	0.635
LIG_deltaCOP1_diTrp_1	174	178	PF00928	0.582
LIG_FHA_1	143	149	PF00498	0.546
LIG_FHA_1	27	33	PF00498	0.714
LIG_FHA_1	333	339	PF00498	0.685
LIG_FHA_1	445	451	PF00498	0.616
LIG_FHA_2	187	193	PF00498	0.699
LIG_FHA_2	254	260	PF00498	0.526
LIG_FHA_2	482	488	PF00498	0.619
LIG_GBD_Chelix_1	416	424	PF00786	0.477
LIG_Integrin_RGD_1	107	109	PF01839	0.656
LIG_LIR_Apic_2	221	226	PF02991	0.507
LIG_LIR_Apic_2	508	512	PF02991	0.445
LIG_LIR_Gen_1	31	41	PF02991	0.540
LIG_LIR_Gen_1	456	467	PF02991	0.531
LIG_LIR_Nem_3	31	36	PF02991	0.546
LIG_LIR_Nem_3	345	351	PF02991	0.502
LIG_LIR_Nem_3	456	462	PF02991	0.577
LIG_MYND_1	285	289	PF01753	0.647
LIG_Pex14_2	459	463	PF04695	0.576
LIG_SH2_CRK	223	227	PF00017	0.505
LIG_SH2_CRK	348	352	PF00017	0.503
LIG_SH2_SRC	423	426	PF00017	0.624
LIG_SH2_STAP1	172	176	PF00017	0.505
LIG_SH2_STAT5	119	122	PF00017	0.763
LIG_SH2_STAT5	172	175	PF00017	0.511
LIG_SH2_STAT5	423	426	PF00017	0.624
LIG_SH3_3	154	160	PF00018	0.688
LIG_SH3_3	286	292	PF00018	0.592
LIG_SH3_3	465	471	PF00018	0.590
LIG_SH3_3	510	516	PF00018	0.536
LIG_SH3_3	91	97	PF00018	0.789
LIG_SUMO_SIM_par_1	284	291	PF11976	0.685
LIG_SUMO_SIM_par_1	443	457	PF11976	0.461
LIG_TRAF2_1	122	125	PF00917	0.688
LIG_TRAF2_1	379	382	PF00917	0.521
LIG_TRAF2_1	83	86	PF00917	0.647
LIG_TRFH_1	422	426	PF08558	0.628
LIG_WW_3	1	5	PF00397	0.644
LIG_WW_3	159	163	PF00397	0.679
MOD_CK1_1	291	297	PF00069	0.684
MOD_CK1_1	363	369	PF00069	0.687
MOD_CK1_1	443	449	PF00069	0.611
MOD_CK1_1	452	458	PF00069	0.559
MOD_CK1_1	466	472	PF00069	0.465
MOD_CK2_1	253	259	PF00069	0.526
MOD_CK2_1	272	278	PF00069	0.638
MOD_CK2_1	315	321	PF00069	0.760
MOD_CK2_1	331	337	PF00069	0.494
MOD_CK2_1	381	387	PF00069	0.589
MOD_CK2_1	46	52	PF00069	0.657
MOD_GlcNHglycan	100	103	PF01048	0.666
MOD_GlcNHglycan	141	145	PF01048	0.482
MOD_GlcNHglycan	17	20	PF01048	0.586
MOD_GlcNHglycan	178	181	PF01048	0.709
MOD_GlcNHglycan	273	277	PF01048	0.524
MOD_GlcNHglycan	293	296	PF01048	0.654
MOD_GlcNHglycan	317	320	PF01048	0.724
MOD_GlcNHglycan	362	365	PF01048	0.688
MOD_GlcNHglycan	367	370	PF01048	0.660
MOD_GlcNHglycan	382	386	PF01048	0.513
MOD_GlcNHglycan	412	415	PF01048	0.552
MOD_GlcNHglycan	456	459	PF01048	0.558
MOD_GlcNHglycan	74	77	PF01048	0.657
MOD_GlcNHglycan	78	81	PF01048	0.668
MOD_GSK3_1	249	256	PF00069	0.547
MOD_GSK3_1	287	294	PF00069	0.776
MOD_GSK3_1	326	333	PF00069	0.740
MOD_GSK3_1	39	46	PF00069	0.658
MOD_GSK3_1	398	405	PF00069	0.820
MOD_GSK3_1	406	413	PF00069	0.648
MOD_GSK3_1	440	447	PF00069	0.724
MOD_GSK3_1	449	456	PF00069	0.647
MOD_GSK3_1	72	79	PF00069	0.549
MOD_N-GLC_1	295	300	PF02516	0.658
MOD_NEK2_1	304	309	PF00069	0.538
MOD_NEK2_1	326	331	PF00069	0.701
MOD_NEK2_1	442	447	PF00069	0.724
MOD_NEK2_1	450	455	PF00069	0.583
MOD_NEK2_2	112	117	PF00069	0.658
MOD_NEK2_2	28	33	PF00069	0.713
MOD_PKA_1	315	321	PF00069	0.702
MOD_PKA_2	15	21	PF00069	0.515
MOD_PKA_2	161	167	PF00069	0.538
MOD_PKA_2	216	222	PF00069	0.638
MOD_PKA_2	315	321	PF00069	0.622
MOD_PKA_2	410	416	PF00069	0.768
MOD_Plk_1	253	259	PF00069	0.493
MOD_Plk_1	272	278	PF00069	0.548
MOD_Plk_4	235	241	PF00069	0.492
MOD_Plk_4	347	353	PF00069	0.636
MOD_ProDKin_1	209	215	PF00069	0.537
MOD_ProDKin_1	281	287	PF00069	0.737
MOD_ProDKin_1	288	294	PF00069	0.607
MOD_ProDKin_1	328	334	PF00069	0.525
MOD_ProDKin_1	463	469	PF00069	0.541
TRG_DiLeu_BaEn_1	321	326	PF01217	0.502
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.656
TRG_DiLeu_BaLyEn_6	415	420	PF01217	0.494
TRG_ENDOCYTIC_2	172	175	PF00928	0.565
TRG_ENDOCYTIC_2	33	36	PF00928	0.521
TRG_ENDOCYTIC_2	348	351	PF00928	0.505
TRG_ER_diArg_1	116	118	PF00400	0.534
TRG_ER_diArg_1	207	209	PF00400	0.551
TRG_ER_diArg_1	220	223	PF00400	0.523
TRG_ER_diArg_1	3	6	PF00400	0.645
TRG_ER_diArg_1	314	316	PF00400	0.718
TRG_NLS_MonoExtC_3	228	234	PF00514	0.679
TRG_NLS_MonoExtN_4	226	233	PF00514	0.682
TRG_Pf-PMV_PEXEL_1	376	381	PF00026	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H635	Leishmania donovani	75%	100%
A4H588	Leishmania braziliensis	51%	100%
A4HTH2	Leishmania infantum	75%	100%
Q4QIE8	Leishmania major	73%	97%