Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AM98_LEIMU

TriTrypDb:

LmxM.08.0190

Length:

959

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AM98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.492
CLV_NRD_NRD_1	187	189	PF00675	0.414
CLV_NRD_NRD_1	377	379	PF00675	0.511
CLV_NRD_NRD_1	565	567	PF00675	0.477
CLV_NRD_NRD_1	600	602	PF00675	0.389
CLV_NRD_NRD_1	74	76	PF00675	0.391
CLV_PCSK_KEX2_1	187	189	PF00082	0.414
CLV_PCSK_KEX2_1	377	379	PF00082	0.442
CLV_PCSK_KEX2_1	596	598	PF00082	0.552
CLV_PCSK_KEX2_1	600	602	PF00082	0.539
CLV_PCSK_KEX2_1	74	76	PF00082	0.391
CLV_PCSK_KEX2_1	956	958	PF00082	0.490
CLV_PCSK_PC1ET2_1	596	598	PF00082	0.552
CLV_PCSK_PC1ET2_1	956	958	PF00082	0.490
CLV_PCSK_SKI1_1	137	141	PF00082	0.677
CLV_PCSK_SKI1_1	377	381	PF00082	0.438
CLV_PCSK_SKI1_1	520	524	PF00082	0.660
CLV_PCSK_SKI1_1	634	638	PF00082	0.524
CLV_PCSK_SKI1_1	921	925	PF00082	0.560
DEG_APCC_DBOX_1	155	163	PF00400	0.358
DEG_APCC_DBOX_1	376	384	PF00400	0.717
DEG_Nend_UBRbox_1	1	4	PF02207	0.482
DOC_CDC14_PxL_1	264	272	PF14671	0.504
DOC_CKS1_1	138	143	PF01111	0.442
DOC_CKS1_1	315	320	PF01111	0.775
DOC_CKS1_1	431	436	PF01111	0.504
DOC_CKS1_1	572	577	PF01111	0.700
DOC_CYCLIN_yCln2_LP_2	199	205	PF00134	0.574
DOC_CYCLIN_yCln2_LP_2	488	494	PF00134	0.563
DOC_MAPK_gen_1	374	383	PF00069	0.649
DOC_MAPK_gen_1	564	572	PF00069	0.698
DOC_MAPK_MEF2A_6	374	383	PF00069	0.710
DOC_MAPK_MEF2A_6	564	572	PF00069	0.676
DOC_MAPK_MEF2A_6	812	819	PF00069	0.411
DOC_MAPK_NFAT4_5	812	820	PF00069	0.412
DOC_PP1_RVXF_1	697	704	PF00149	0.766
DOC_PP1_RVXF_1	872	879	PF00149	0.340
DOC_PP2B_LxvP_1	199	202	PF13499	0.721
DOC_PP2B_LxvP_1	215	218	PF13499	0.591
DOC_PP2B_LxvP_1	351	354	PF13499	0.575
DOC_PP2B_LxvP_1	383	386	PF13499	0.538
DOC_PP4_FxxP_1	449	452	PF00568	0.500
DOC_PP4_FxxP_1	572	575	PF00568	0.668
DOC_USP7_MATH_1	160	164	PF00917	0.429
DOC_USP7_MATH_1	209	213	PF00917	0.672
DOC_USP7_MATH_1	223	227	PF00917	0.759
DOC_USP7_MATH_1	352	356	PF00917	0.395
DOC_USP7_MATH_1	455	459	PF00917	0.474
DOC_USP7_MATH_1	514	518	PF00917	0.492
DOC_USP7_MATH_1	622	626	PF00917	0.770
DOC_USP7_MATH_1	686	690	PF00917	0.412
DOC_USP7_MATH_1	729	733	PF00917	0.623
DOC_USP7_MATH_1	765	769	PF00917	0.787
DOC_USP7_MATH_1	80	84	PF00917	0.664
DOC_USP7_MATH_1	947	951	PF00917	0.570
DOC_USP7_MATH_2	64	70	PF00917	0.661
DOC_WW_Pin1_4	137	142	PF00397	0.433
DOC_WW_Pin1_4	226	231	PF00397	0.752
DOC_WW_Pin1_4	314	319	PF00397	0.710
DOC_WW_Pin1_4	430	435	PF00397	0.511
DOC_WW_Pin1_4	448	453	PF00397	0.381
DOC_WW_Pin1_4	498	503	PF00397	0.518
DOC_WW_Pin1_4	534	539	PF00397	0.463
DOC_WW_Pin1_4	571	576	PF00397	0.702
DOC_WW_Pin1_4	831	836	PF00397	0.551
LIG_14-3-3_CanoR_1	146	155	PF00244	0.492
LIG_14-3-3_CanoR_1	156	160	PF00244	0.260
LIG_14-3-3_CanoR_1	401	411	PF00244	0.656
LIG_14-3-3_CanoR_1	506	514	PF00244	0.487
LIG_14-3-3_CanoR_1	769	779	PF00244	0.690
LIG_14-3-3_CanoR_1	877	885	PF00244	0.507
LIG_Actin_WH2_2	439	456	PF00022	0.372
LIG_AP2alpha_1	445	449	PF02296	0.497
LIG_BIR_III_2	761	765	PF00653	0.606
LIG_BRCT_BRCA1_1	354	358	PF00533	0.379
LIG_Clathr_ClatBox_1	269	273	PF01394	0.407
LIG_Clathr_ClatBox_1	4	8	PF01394	0.229
LIG_Clathr_ClatBox_1	931	935	PF01394	0.697
LIG_CSL_BTD_1	832	835	PF09270	0.547
LIG_deltaCOP1_diTrp_1	409	417	PF00928	0.722
LIG_deltaCOP1_diTrp_1	509	515	PF00928	0.490
LIG_EH1_1	542	550	PF00400	0.504
LIG_EH1_1	812	820	PF00400	0.412
LIG_eIF4E_1	543	549	PF01652	0.504
LIG_EVH1_2	568	572	PF00568	0.763
LIG_FHA_1	247	253	PF00498	0.564
LIG_FHA_1	26	32	PF00498	0.565
LIG_FHA_1	315	321	PF00498	0.705
LIG_FHA_1	343	349	PF00498	0.449
LIG_FHA_1	506	512	PF00498	0.464
LIG_FHA_1	572	578	PF00498	0.768
LIG_FHA_1	770	776	PF00498	0.697
LIG_FHA_1	791	797	PF00498	0.434
LIG_FHA_1	837	843	PF00498	0.720
LIG_FHA_1	914	920	PF00498	0.675
LIG_FHA_1	96	102	PF00498	0.644
LIG_FHA_2	138	144	PF00498	0.461
LIG_FHA_2	146	152	PF00498	0.476
LIG_FHA_2	442	448	PF00498	0.483
LIG_FHA_2	459	465	PF00498	0.372
LIG_FHA_2	832	838	PF00498	0.546
LIG_GBD_Chelix_1	287	295	PF00786	0.504
LIG_LIR_Apic_2	447	452	PF02991	0.501
LIG_LIR_Apic_2	571	575	PF02991	0.700
LIG_LIR_Gen_1	158	169	PF02991	0.496
LIG_LIR_Gen_1	326	334	PF02991	0.545
LIG_LIR_Gen_1	355	365	PF02991	0.379
LIG_LIR_Gen_1	397	407	PF02991	0.654
LIG_LIR_Gen_1	444	453	PF02991	0.500
LIG_LIR_Gen_1	803	811	PF02991	0.698
LIG_LIR_Nem_3	158	164	PF02991	0.429
LIG_LIR_Nem_3	326	330	PF02991	0.627
LIG_LIR_Nem_3	355	361	PF02991	0.379
LIG_LIR_Nem_3	444	448	PF02991	0.496
LIG_LIR_Nem_3	508	513	PF02991	0.484
LIG_LIR_Nem_3	537	543	PF02991	0.480
LIG_LIR_Nem_3	561	565	PF02991	0.580
LIG_LIR_Nem_3	803	807	PF02991	0.407
LIG_LIR_Nem_3	832	836	PF02991	0.640
LIG_LIR_Nem_3	89	95	PF02991	0.608
LIG_MAD2	378	386	PF02301	0.719
LIG_MAD2	918	926	PF02301	0.557
LIG_MYND_1	610	614	PF01753	0.620
LIG_NRBOX	181	187	PF00104	0.665
LIG_NRBOX	853	859	PF00104	0.504
LIG_PAM2_1	795	807	PF00658	0.407
LIG_PCNA_yPIPBox_3	641	655	PF02747	0.542
LIG_Pex14_1	289	293	PF04695	0.504
LIG_Pex14_1	372	376	PF04695	0.644
LIG_Pex14_2	445	449	PF04695	0.497
LIG_SH2_CRK	376	380	PF00017	0.641
LIG_SH2_CRK	899	903	PF00017	0.488
LIG_SH2_CRK	92	96	PF00017	0.603
LIG_SH2_GRB2like	494	497	PF00017	0.570
LIG_SH2_GRB2like	532	535	PF00017	0.485
LIG_SH2_PTP2	543	546	PF00017	0.504
LIG_SH2_SRC	119	122	PF00017	0.429
LIG_SH2_STAP1	908	912	PF00017	0.229
LIG_SH2_STAT3	578	581	PF00017	0.758
LIG_SH2_STAT5	119	122	PF00017	0.377
LIG_SH2_STAT5	399	402	PF00017	0.679
LIG_SH2_STAT5	532	535	PF00017	0.485
LIG_SH2_STAT5	543	546	PF00017	0.407
LIG_SH2_STAT5	644	647	PF00017	0.654
LIG_SH2_STAT5	789	792	PF00017	0.504
LIG_SH2_STAT5	85	88	PF00017	0.637
LIG_SH2_STAT5	886	889	PF00017	0.437
LIG_SH3_3	167	173	PF00018	0.385
LIG_SH3_3	428	434	PF00018	0.504
LIG_SH3_3	449	455	PF00018	0.506
LIG_SH3_3	562	568	PF00018	0.728
LIG_SH3_3	603	609	PF00018	0.781
LIG_SH3_3	737	743	PF00018	0.626
LIG_SUMO_SIM_anti_2	258	264	PF11976	0.504
LIG_SUMO_SIM_anti_2	345	350	PF11976	0.504
LIG_SUMO_SIM_anti_2	556	561	PF11976	0.504
LIG_SUMO_SIM_anti_2	823	829	PF11976	0.504
LIG_SUMO_SIM_par_1	17	24	PF11976	0.419
LIG_SUMO_SIM_par_1	267	273	PF11976	0.407
LIG_SUMO_SIM_par_1	338	343	PF11976	0.436
LIG_SUMO_SIM_par_1	344	350	PF11976	0.476
LIG_SUMO_SIM_par_1	427	433	PF11976	0.504
LIG_SUMO_SIM_par_1	544	550	PF11976	0.503
LIG_SUMO_SIM_par_1	556	561	PF11976	0.255
LIG_SUMO_SIM_par_1	834	839	PF11976	0.659
LIG_TRAF2_1	640	643	PF00917	0.736
LIG_TRAF2_1	933	936	PF00917	0.766
LIG_TYR_ITIM	541	546	PF00017	0.504
LIG_TYR_ITIM	897	902	PF00017	0.488
LIG_Vh1_VBS_1	677	695	PF01044	0.229
LIG_WRC_WIRS_1	442	447	PF05994	0.491
LIG_WRC_WIRS_1	559	564	PF05994	0.626
MOD_CDC14_SPxK_1	451	454	PF00782	0.583
MOD_CDK_SPK_2	137	142	PF00069	0.433
MOD_CDK_SPxK_1	448	454	PF00069	0.575
MOD_CK1_1	226	232	PF00069	0.758
MOD_CK1_1	458	464	PF00069	0.493
MOD_CK1_1	571	577	PF00069	0.701
MOD_CK1_1	657	663	PF00069	0.407
MOD_CK1_1	795	801	PF00069	0.407
MOD_CK2_1	137	143	PF00069	0.440
MOD_CK2_1	226	232	PF00069	0.752
MOD_CK2_1	458	464	PF00069	0.493
MOD_CK2_1	637	643	PF00069	0.749
MOD_CMANNOS	126	129	PF00535	0.515
MOD_Cter_Amidation	598	601	PF01082	0.375
MOD_GlcNHglycan	211	214	PF01048	0.473
MOD_GlcNHglycan	368	371	PF01048	0.497
MOD_GlcNHglycan	386	389	PF01048	0.363
MOD_GlcNHglycan	49	52	PF01048	0.544
MOD_GlcNHglycan	617	620	PF01048	0.588
MOD_GlcNHglycan	656	659	PF01048	0.503
MOD_GlcNHglycan	661	664	PF01048	0.451
MOD_GlcNHglycan	680	683	PF01048	0.223
MOD_GlcNHglycan	750	754	PF01048	0.436
MOD_GlcNHglycan	868	871	PF01048	0.744
MOD_GlcNHglycan	92	95	PF01048	0.475
MOD_GlcNHglycan	943	946	PF01048	0.363
MOD_GSK3_1	205	212	PF00069	0.577
MOD_GSK3_1	226	233	PF00069	0.749
MOD_GSK3_1	305	312	PF00069	0.695
MOD_GSK3_1	340	347	PF00069	0.439
MOD_GSK3_1	386	393	PF00069	0.693
MOD_GSK3_1	43	50	PF00069	0.576
MOD_GSK3_1	454	461	PF00069	0.468
MOD_GSK3_1	520	527	PF00069	0.480
MOD_GSK3_1	657	664	PF00069	0.366
MOD_GSK3_1	765	772	PF00069	0.715
MOD_GSK3_1	86	93	PF00069	0.621
MOD_N-GLC_1	473	478	PF02516	0.757
MOD_N-GLC_1	528	533	PF02516	0.758
MOD_N-GLC_2	414	416	PF02516	0.453
MOD_NEK2_1	155	160	PF00069	0.518
MOD_NEK2_1	178	183	PF00069	0.416
MOD_NEK2_1	255	260	PF00069	0.504
MOD_NEK2_1	282	287	PF00069	0.407
MOD_NEK2_1	313	318	PF00069	0.710
MOD_NEK2_1	342	347	PF00069	0.495
MOD_NEK2_1	357	362	PF00069	0.467
MOD_NEK2_1	364	369	PF00069	0.469
MOD_NEK2_1	402	407	PF00069	0.719
MOD_NEK2_1	429	434	PF00069	0.449
MOD_NEK2_1	43	48	PF00069	0.639
MOD_NEK2_1	475	480	PF00069	0.538
MOD_NEK2_1	656	661	PF00069	0.407
MOD_NEK2_1	677	682	PF00069	0.229
MOD_NEK2_1	790	795	PF00069	0.415
MOD_NEK2_1	940	945	PF00069	0.561
MOD_NEK2_2	418	423	PF00069	0.504
MOD_NEK2_2	901	906	PF00069	0.504
MOD_PK_1	390	396	PF00069	0.568
MOD_PKA_2	145	151	PF00069	0.500
MOD_PKA_2	155	161	PF00069	0.260
MOD_PKA_2	246	252	PF00069	0.567
MOD_PKA_2	407	413	PF00069	0.721
MOD_PKA_2	505	511	PF00069	0.480
MOD_PKA_2	876	882	PF00069	0.506
MOD_Plk_1	230	236	PF00069	0.731
MOD_Plk_1	309	315	PF00069	0.696
MOD_Plk_1	473	479	PF00069	0.475
MOD_Plk_1	528	534	PF00069	0.558
MOD_Plk_1	55	61	PF00069	0.712
MOD_Plk_4	230	236	PF00069	0.677
MOD_Plk_4	255	261	PF00069	0.504
MOD_Plk_4	26	32	PF00069	0.558
MOD_Plk_4	282	288	PF00069	0.407
MOD_Plk_4	344	350	PF00069	0.467
MOD_Plk_4	357	363	PF00069	0.407
MOD_Plk_4	407	413	PF00069	0.704
MOD_Plk_4	418	424	PF00069	0.353
MOD_Plk_4	43	49	PF00069	0.565
MOD_Plk_4	441	447	PF00069	0.501
MOD_Plk_4	490	496	PF00069	0.569
MOD_Plk_4	528	534	PF00069	0.541
MOD_Plk_4	553	559	PF00069	0.495
MOD_Plk_4	588	594	PF00069	0.546
MOD_Plk_4	66	72	PF00069	0.545
MOD_Plk_4	661	667	PF00069	0.369
MOD_Plk_4	680	686	PF00069	0.508
MOD_Plk_4	792	798	PF00069	0.407
MOD_Plk_4	823	829	PF00069	0.503
MOD_ProDKin_1	137	143	PF00069	0.440
MOD_ProDKin_1	226	232	PF00069	0.752
MOD_ProDKin_1	314	320	PF00069	0.707
MOD_ProDKin_1	430	436	PF00069	0.511
MOD_ProDKin_1	448	454	PF00069	0.382
MOD_ProDKin_1	498	504	PF00069	0.516
MOD_ProDKin_1	534	540	PF00069	0.463
MOD_ProDKin_1	571	577	PF00069	0.701
MOD_ProDKin_1	831	837	PF00069	0.546
MOD_SUMO_for_1	330	333	PF00179	0.747
MOD_SUMO_for_1	614	617	PF00179	0.823
TRG_DiLeu_BaEn_1	8	13	PF01217	0.429
TRG_DiLeu_BaEn_1	927	932	PF01217	0.700
TRG_DiLeu_BaLyEn_6	134	139	PF01217	0.308
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.407
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.504
TRG_ENDOCYTIC_2	376	379	PF00928	0.644
TRG_ENDOCYTIC_2	399	402	PF00928	0.653
TRG_ENDOCYTIC_2	543	546	PF00928	0.504
TRG_ENDOCYTIC_2	789	792	PF00928	0.504
TRG_ENDOCYTIC_2	899	902	PF00928	0.488
TRG_ENDOCYTIC_2	92	95	PF00928	0.600
TRG_ER_diArg_1	186	188	PF00400	0.614
TRG_ER_diArg_1	376	378	PF00400	0.721
TRG_ER_diArg_1	563	566	PF00400	0.675
TRG_ER_diArg_1	73	75	PF00400	0.590
TRG_Pf-PMV_PEXEL_1	895	900	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9F4	Leptomonas seymouri	44%	100%
A0A3S5H633	Leishmania donovani	84%	100%
A4HTH0	Leishmania infantum	84%	100%
Q4QIF0	Leishmania major	83%	97%