Bacterial transferase hexapeptide repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bacterial transferase hexapeptide (six repeats), putative

Species:

Leishmania mexicana

UniProt:

E9AM97_LEIMU

TriTrypDb:

LmxM.08.0180

Length:

294

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM97

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	255	257	PF00675	0.561
CLV_NRD_NRD_1	265	267	PF00675	0.492
CLV_PCSK_FUR_1	34	38	PF00082	0.310
CLV_PCSK_KEX2_1	255	257	PF00082	0.501
CLV_PCSK_KEX2_1	265	267	PF00082	0.536
CLV_PCSK_KEX2_1	36	38	PF00082	0.513
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.506
CLV_PCSK_PC7_1	261	267	PF00082	0.533
CLV_PCSK_SKI1_1	255	259	PF00082	0.523
CLV_PCSK_SKI1_1	52	56	PF00082	0.366
CLV_PCSK_SKI1_1	94	98	PF00082	0.400
DEG_ODPH_VHL_1	64	76	PF01847	0.284
DOC_MAPK_HePTP_8	252	264	PF00069	0.505
DOC_MAPK_MEF2A_6	245	252	PF00069	0.551
DOC_MAPK_MEF2A_6	255	264	PF00069	0.482
DOC_MAPK_RevD_3	242	256	PF00069	0.509
DOC_PP4_FxxP_1	257	260	PF00568	0.514
DOC_PP4_FxxP_1	63	66	PF00568	0.289
DOC_USP7_MATH_1	142	146	PF00917	0.377
DOC_USP7_MATH_1	159	163	PF00917	0.381
DOC_USP7_MATH_1	189	193	PF00917	0.542
DOC_USP7_UBL2_3	207	211	PF12436	0.411
DOC_WW_Pin1_4	185	190	PF00397	0.429
LIG_14-3-3_CanoR_1	108	112	PF00244	0.340
LIG_14-3-3_CanoR_1	25	29	PF00244	0.382
LIG_14-3-3_CanoR_1	272	276	PF00244	0.575
LIG_Actin_WH2_2	196	213	PF00022	0.250
LIG_CSL_BTD_1	282	285	PF09270	0.568
LIG_FHA_1	218	224	PF00498	0.398
LIG_LIR_Apic_2	136	142	PF02991	0.376
LIG_LIR_Apic_2	60	66	PF02991	0.317
LIG_LYPXL_yS_3	40	43	PF13949	0.544
LIG_Pex14_2	11	15	PF04695	0.453
LIG_Rb_LxCxE_1	128	145	PF01857	0.433
LIG_SH2_CRK	84	88	PF00017	0.300
LIG_SH2_PTP2	139	142	PF00017	0.404
LIG_SH2_STAT5	122	125	PF00017	0.306
LIG_SH2_STAT5	139	142	PF00017	0.309
LIG_SH2_STAT5	14	17	PF00017	0.389
LIG_SH3_1	279	285	PF00018	0.564
LIG_SH3_3	279	285	PF00018	0.564
LIG_TYR_ITIM	82	87	PF00017	0.294
MOD_CK1_1	24	30	PF00069	0.473
MOD_CK1_1	4	10	PF00069	0.413
MOD_GlcNHglycan	153	157	PF01048	0.263
MOD_GlcNHglycan	161	164	PF01048	0.454
MOD_GlcNHglycan	286	289	PF01048	0.627
MOD_GlcNHglycan	3	6	PF01048	0.449
MOD_GlcNHglycan	66	69	PF01048	0.239
MOD_GSK3_1	185	192	PF00069	0.536
MOD_GSK3_1	284	291	PF00069	0.639
MOD_GSK3_1	90	97	PF00069	0.426
MOD_LATS_1	92	98	PF00433	0.388
MOD_N-GLC_1	277	282	PF02516	0.669
MOD_NEK2_1	271	276	PF00069	0.548
MOD_NEK2_1	83	88	PF00069	0.339
MOD_PIKK_1	55	61	PF00454	0.347
MOD_PKA_2	107	113	PF00069	0.340
MOD_PKA_2	24	30	PF00069	0.455
MOD_PKA_2	271	277	PF00069	0.547
MOD_Plk_1	94	100	PF00069	0.331
MOD_Plk_4	107	113	PF00069	0.257
MOD_Plk_4	118	124	PF00069	0.324
MOD_Plk_4	24	30	PF00069	0.476
MOD_Plk_4	77	83	PF00069	0.264
MOD_Plk_4	94	100	PF00069	0.304
MOD_ProDKin_1	185	191	PF00069	0.427
TRG_DiLeu_BaEn_2	252	258	PF01217	0.484
TRG_ENDOCYTIC_2	40	43	PF00928	0.503
TRG_ENDOCYTIC_2	51	54	PF00928	0.313
TRG_ENDOCYTIC_2	84	87	PF00928	0.308
TRG_ER_diArg_1	255	257	PF00400	0.539
TRG_ER_diArg_1	264	266	PF00400	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0A3	Leptomonas seymouri	26%	96%
A0A0N1ICC0	Leptomonas seymouri	84%	100%
A0A0S4JVD5	Bodo saltans	30%	92%
A0A0S4KEG1	Bodo saltans	60%	83%
A0A1X0NNY9	Trypanosomatidae	62%	100%
A0A1X0NVC1	Trypanosomatidae	27%	98%
A0A3S7WQ41	Leishmania donovani	92%	100%
A0A3S7WRH8	Leishmania donovani	26%	96%
A4H585	Leishmania braziliensis	90%	100%
A4HTG9	Leishmania infantum	92%	100%
A4HUR5	Leishmania infantum	26%	96%
C5CHX7	Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 19.5.1)	29%	100%
C9ZPP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
Q4QH77	Leishmania major	26%	100%
Q4QIF1	Leishmania major	94%	100%
Q54JC2	Dictyostelium discoideum	29%	100%
Q94AU7	Arabidopsis thaliana	27%	100%
Q9C6B3	Arabidopsis thaliana	31%	100%
Q9FWR5	Arabidopsis thaliana	28%	100%
V5BBY5	Trypanosoma cruzi	28%	97%
V5BCJ4	Trypanosoma cruzi	71%	100%