Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AM96_LEIMU

TriTrypDb:

LmxM.08.0170

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

E9AM96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM96

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	5
GO:0006952	defense response	3	5
GO:0050896	response to stimulus	1	5

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	520	524	PF00656	0.424
CLV_MEL_PAP_1	561	567	PF00089	0.567
CLV_NRD_NRD_1	170	172	PF00675	0.637
CLV_NRD_NRD_1	230	232	PF00675	0.593
CLV_NRD_NRD_1	29	31	PF00675	0.639
CLV_NRD_NRD_1	297	299	PF00675	0.699
CLV_NRD_NRD_1	324	326	PF00675	0.532
CLV_NRD_NRD_1	356	358	PF00675	0.491
CLV_NRD_NRD_1	621	623	PF00675	0.574
CLV_NRD_NRD_1	76	78	PF00675	0.577
CLV_PCSK_FUR_1	295	299	PF00082	0.704
CLV_PCSK_KEX2_1	170	172	PF00082	0.637
CLV_PCSK_KEX2_1	230	232	PF00082	0.594
CLV_PCSK_KEX2_1	29	31	PF00082	0.639
CLV_PCSK_KEX2_1	297	299	PF00082	0.705
CLV_PCSK_KEX2_1	300	302	PF00082	0.647
CLV_PCSK_KEX2_1	324	326	PF00082	0.527
CLV_PCSK_KEX2_1	621	623	PF00082	0.574
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.474
CLV_PCSK_SKI1_1	147	151	PF00082	0.524
CLV_PCSK_SKI1_1	204	208	PF00082	0.471
CLV_PCSK_SKI1_1	24	28	PF00082	0.540
CLV_PCSK_SKI1_1	338	342	PF00082	0.574
CLV_PCSK_SKI1_1	357	361	PF00082	0.282
CLV_PCSK_SKI1_1	383	387	PF00082	0.487
CLV_PCSK_SKI1_1	460	464	PF00082	0.394
CLV_PCSK_SKI1_1	613	617	PF00082	0.574
DEG_APCC_DBOX_1	402	410	PF00400	0.505
DEG_APCC_DBOX_1	612	620	PF00400	0.503
DEG_Nend_Nbox_1	1	3	PF02207	0.754
DEG_ODPH_VHL_1	58	70	PF01847	0.610
DOC_CDC14_PxL_1	473	481	PF14671	0.473
DOC_CDC14_PxL_1	568	576	PF14671	0.437
DOC_CYCLIN_RxL_1	295	305	PF00134	0.680
DOC_CYCLIN_RxL_1	454	466	PF00134	0.559
DOC_CYCLIN_yCln2_LP_2	196	202	PF00134	0.522
DOC_MAPK_gen_1	144	154	PF00069	0.504
DOC_MAPK_gen_1	170	178	PF00069	0.602
DOC_MAPK_gen_1	295	304	PF00069	0.764
DOC_MAPK_gen_1	333	342	PF00069	0.294
DOC_MAPK_gen_1	354	364	PF00069	0.547
DOC_MAPK_gen_1	49	58	PF00069	0.527
DOC_MAPK_gen_1	618	626	PF00069	0.587
DOC_MAPK_MEF2A_6	170	178	PF00069	0.504
DOC_PP1_RVXF_1	392	399	PF00149	0.482
DOC_PP2B_LxvP_1	440	443	PF13499	0.456
DOC_PP2B_LxvP_1	601	604	PF13499	0.414
DOC_USP7_MATH_1	206	210	PF00917	0.596
DOC_USP7_MATH_1	323	327	PF00917	0.626
DOC_USP7_MATH_1	423	427	PF00917	0.703
DOC_USP7_MATH_1	453	457	PF00917	0.511
DOC_USP7_UBL2_3	214	218	PF12436	0.597
DOC_WW_Pin1_4	129	134	PF00397	0.685
DOC_WW_Pin1_4	163	168	PF00397	0.515
DOC_WW_Pin1_4	195	200	PF00397	0.525
DOC_WW_Pin1_4	208	213	PF00397	0.529
DOC_WW_Pin1_4	256	261	PF00397	0.736
DOC_WW_Pin1_4	302	307	PF00397	0.459
DOC_WW_Pin1_4	499	504	PF00397	0.476
DOC_WW_Pin1_4	6	11	PF00397	0.695
LIG_14-3-3_CanoR_1	123	127	PF00244	0.592
LIG_14-3-3_CanoR_1	183	193	PF00244	0.620
LIG_14-3-3_CanoR_1	204	213	PF00244	0.504
LIG_14-3-3_CanoR_1	230	236	PF00244	0.696
LIG_14-3-3_CanoR_1	24	33	PF00244	0.642
LIG_14-3-3_CanoR_1	324	328	PF00244	0.598
LIG_14-3-3_CanoR_1	343	348	PF00244	0.343
LIG_14-3-3_CanoR_1	357	363	PF00244	0.567
LIG_14-3-3_CanoR_1	383	388	PF00244	0.537
LIG_14-3-3_CanoR_1	509	517	PF00244	0.469
LIG_14-3-3_CanoR_1	564	568	PF00244	0.555
LIG_14-3-3_CanoR_1	580	586	PF00244	0.311
LIG_Actin_RPEL_3	396	415	PF02755	0.295
LIG_Actin_WH2_2	145	163	PF00022	0.501
LIG_Actin_WH2_2	186	203	PF00022	0.608
LIG_Actin_WH2_2	369	385	PF00022	0.531
LIG_Actin_WH2_2	389	405	PF00022	0.572
LIG_BRCT_BRCA1_1	351	355	PF00533	0.434
LIG_deltaCOP1_diTrp_1	395	401	PF00928	0.296
LIG_eIF4E_1	573	579	PF01652	0.254
LIG_FHA_1	105	111	PF00498	0.625
LIG_FHA_1	205	211	PF00498	0.554
LIG_FHA_1	230	236	PF00498	0.570
LIG_FHA_1	297	303	PF00498	0.708
LIG_FHA_1	358	364	PF00498	0.518
LIG_FHA_1	581	587	PF00498	0.405
LIG_FHA_2	232	238	PF00498	0.698
LIG_FHA_2	456	462	PF00498	0.445
LIG_FHA_2	518	524	PF00498	0.420
LIG_FHA_2	550	556	PF00498	0.538
LIG_LIR_Gen_1	346	355	PF02991	0.318
LIG_LIR_Gen_1	405	416	PF02991	0.510
LIG_LIR_Gen_1	463	473	PF02991	0.474
LIG_LIR_Gen_1	550	561	PF02991	0.538
LIG_LIR_Nem_3	346	350	PF02991	0.317
LIG_LIR_Nem_3	405	411	PF02991	0.478
LIG_LIR_Nem_3	471	476	PF02991	0.434
LIG_LIR_Nem_3	550	556	PF02991	0.531
LIG_LIR_Nem_3	588	592	PF02991	0.448
LIG_MYND_1	260	264	PF01753	0.840
LIG_MYND_3	479	483	PF01753	0.454
LIG_PCNA_PIPBox_1	186	195	PF02747	0.542
LIG_PCNA_yPIPBox_3	179	193	PF02747	0.621
LIG_PTB_Apo_2	341	348	PF02174	0.592
LIG_PTB_Phospho_1	341	347	PF10480	0.586
LIG_SH2_CRK	412	416	PF00017	0.342
LIG_SH2_NCK_1	347	351	PF00017	0.612
LIG_SH2_SRC	553	556	PF00017	0.532
LIG_SH2_STAT5	227	230	PF00017	0.615
LIG_SH2_STAT5	31	34	PF00017	0.444
LIG_SH2_STAT5	408	411	PF00017	0.429
LIG_SH2_STAT5	553	556	PF00017	0.431
LIG_SH2_STAT5	573	576	PF00017	0.228
LIG_SH3_3	232	238	PF00018	0.698
LIG_SH3_3	474	480	PF00018	0.422
LIG_SH3_3	590	596	PF00018	0.378
LIG_SH3_3	600	606	PF00018	0.463
LIG_SH3_3	7	13	PF00018	0.663
LIG_SUMO_SIM_anti_2	563	569	PF11976	0.444
LIG_SUMO_SIM_anti_2	66	71	PF11976	0.465
LIG_SUMO_SIM_par_1	172	177	PF11976	0.581
LIG_TRFH_1	412	416	PF08558	0.342
LIG_TYR_ITIM	406	411	PF00017	0.473
LIG_TYR_ITIM	551	556	PF00017	0.432
LIG_UBA3_1	110	115	PF00899	0.437
LIG_Vh1_VBS_1	452	470	PF01044	0.493
LIG_WRC_WIRS_1	419	424	PF05994	0.457
LIG_WRC_WIRS_1	5	10	PF05994	0.745
LIG_WW_3	11	15	PF00397	0.566
MOD_CDC14_SPxK_1	198	201	PF00782	0.523
MOD_CDC14_SPxK_1	211	214	PF00782	0.504
MOD_CDK_SPK_2	499	504	PF00069	0.476
MOD_CDK_SPxK_1	195	201	PF00069	0.525
MOD_CDK_SPxK_1	208	214	PF00069	0.531
MOD_CDK_SPxxK_3	163	170	PF00069	0.619
MOD_CK1_1	129	135	PF00069	0.621
MOD_CK1_1	195	201	PF00069	0.525
MOD_CK1_1	285	291	PF00069	0.685
MOD_CK1_1	35	41	PF00069	0.676
MOD_CK1_1	397	403	PF00069	0.361
MOD_CK1_1	418	424	PF00069	0.595
MOD_CK1_1	441	447	PF00069	0.497
MOD_CK1_1	455	461	PF00069	0.340
MOD_CK1_1	471	477	PF00069	0.389
MOD_CK2_1	430	436	PF00069	0.551
MOD_CK2_1	455	461	PF00069	0.494
MOD_CK2_1	563	569	PF00069	0.568
MOD_CMANNOS	398	401	PF00535	0.291
MOD_Cter_Amidation	295	298	PF01082	0.521
MOD_Cter_Amidation	75	78	PF01082	0.644
MOD_GlcNHglycan	134	137	PF01048	0.667
MOD_GlcNHglycan	321	324	PF01048	0.410
MOD_GlcNHglycan	423	426	PF01048	0.674
MOD_GlcNHglycan	432	435	PF01048	0.394
MOD_GlcNHglycan	455	458	PF01048	0.521
MOD_GlcNHglycan	470	473	PF01048	0.385
MOD_GlcNHglycan	96	99	PF01048	0.348
MOD_GSK3_1	122	129	PF00069	0.565
MOD_GSK3_1	204	211	PF00069	0.620
MOD_GSK3_1	254	261	PF00069	0.637
MOD_GSK3_1	281	288	PF00069	0.593
MOD_GSK3_1	319	326	PF00069	0.588
MOD_GSK3_1	35	42	PF00069	0.562
MOD_GSK3_1	417	424	PF00069	0.684
MOD_GSK3_1	511	518	PF00069	0.553
MOD_N-GLC_1	286	291	PF02516	0.523
MOD_N-GLC_1	343	348	PF02516	0.311
MOD_N-GLC_1	35	40	PF02516	0.426
MOD_N-GLC_1	438	443	PF02516	0.558
MOD_N-GLC_1	580	585	PF02516	0.576
MOD_N-GLC_2	534	536	PF02516	0.553
MOD_NEK2_1	134	139	PF00069	0.551
MOD_NEK2_1	192	197	PF00069	0.560
MOD_NEK2_1	219	224	PF00069	0.498
MOD_NEK2_1	229	234	PF00069	0.608
MOD_NEK2_1	283	288	PF00069	0.517
MOD_NEK2_1	317	322	PF00069	0.402
MOD_NEK2_1	4	9	PF00069	0.745
MOD_NEK2_1	402	407	PF00069	0.532
MOD_NEK2_1	430	435	PF00069	0.518
MOD_NEK2_1	438	443	PF00069	0.390
MOD_NEK2_1	468	473	PF00069	0.505
MOD_NEK2_1	497	502	PF00069	0.394
MOD_NEK2_1	517	522	PF00069	0.443
MOD_NEK2_1	554	559	PF00069	0.534
MOD_NEK2_1	68	73	PF00069	0.497
MOD_PIKK_1	508	514	PF00454	0.466
MOD_PK_1	358	364	PF00069	0.488
MOD_PKA_1	230	236	PF00069	0.621
MOD_PKA_1	357	363	PF00069	0.464
MOD_PKA_2	122	128	PF00069	0.596
MOD_PKA_2	229	235	PF00069	0.597
MOD_PKA_2	296	302	PF00069	0.723
MOD_PKA_2	323	329	PF00069	0.605
MOD_PKA_2	402	408	PF00069	0.480
MOD_PKA_2	508	514	PF00069	0.503
MOD_PKA_2	563	569	PF00069	0.568
MOD_Plk_1	286	292	PF00069	0.523
MOD_Plk_1	343	349	PF00069	0.489
MOD_Plk_1	35	41	PF00069	0.412
MOD_Plk_1	394	400	PF00069	0.592
MOD_Plk_1	438	444	PF00069	0.541
MOD_Plk_1	460	466	PF00069	0.443
MOD_Plk_1	580	586	PF00069	0.573
MOD_Plk_4	122	128	PF00069	0.596
MOD_Plk_4	358	364	PF00069	0.566
MOD_Plk_4	394	400	PF00069	0.466
MOD_Plk_4	460	466	PF00069	0.465
MOD_Plk_4	549	555	PF00069	0.519
MOD_Plk_4	563	569	PF00069	0.364
MOD_Plk_4	581	587	PF00069	0.479
MOD_ProDKin_1	129	135	PF00069	0.696
MOD_ProDKin_1	163	169	PF00069	0.511
MOD_ProDKin_1	195	201	PF00069	0.525
MOD_ProDKin_1	208	214	PF00069	0.531
MOD_ProDKin_1	256	262	PF00069	0.738
MOD_ProDKin_1	302	308	PF00069	0.454
MOD_ProDKin_1	499	505	PF00069	0.469
MOD_ProDKin_1	6	12	PF00069	0.695
TRG_DiLeu_BaEn_2	187	193	PF01217	0.490
TRG_ENDOCYTIC_2	347	350	PF00928	0.486
TRG_ENDOCYTIC_2	408	411	PF00928	0.471
TRG_ENDOCYTIC_2	412	415	PF00928	0.486
TRG_ENDOCYTIC_2	553	556	PF00928	0.431
TRG_ER_diArg_1	142	145	PF00400	0.431
TRG_ER_diArg_1	169	171	PF00400	0.616
TRG_ER_diArg_1	229	231	PF00400	0.668
TRG_ER_diArg_1	29	31	PF00400	0.454
TRG_ER_diArg_1	295	298	PF00400	0.703
TRG_ER_diArg_1	301	304	PF00400	0.566
TRG_NES_CRM1_1	164	177	PF08389	0.509
TRG_NES_CRM1_1	523	537	PF08389	0.549
TRG_NLS_MonoExtN_4	297	304	PF00514	0.460
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P939	Leptomonas seymouri	47%	95%
A0A3S5H632	Leishmania donovani	89%	100%
A4H584	Leishmania braziliensis	73%	100%
A4HTG8	Leishmania infantum	89%	97%
Q4QIF2	Leishmania major	86%	100%