DUF1279 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM95_LEIMU

TriTrypDb:

LmxM.08.0160

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AM95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM95

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	26	28	PF00675	0.539
CLV_PCSK_KEX2_1	219	221	PF00082	0.647
CLV_PCSK_KEX2_1	25	27	PF00082	0.544
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.697
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.375
CLV_PCSK_SKI1_1	174	178	PF00082	0.554
CLV_PCSK_SKI1_1	219	223	PF00082	0.704
DEG_APCC_DBOX_1	173	181	PF00400	0.379
DEG_Nend_Nbox_1	1	3	PF02207	0.694
DEG_SPOP_SBC_1	54	58	PF00917	0.617
DOC_CDC14_PxL_1	198	206	PF14671	0.417
DOC_CYCLIN_yCln2_LP_2	204	210	PF00134	0.475
DOC_MAPK_gen_1	104	114	PF00069	0.538
DOC_MAPK_MEF2A_6	104	112	PF00069	0.668
DOC_PP2B_LxvP_1	152	155	PF13499	0.282
DOC_USP7_MATH_1	49	53	PF00917	0.632
DOC_USP7_MATH_1	54	58	PF00917	0.706
DOC_USP7_MATH_1	65	69	PF00917	0.677
DOC_USP7_MATH_1	80	84	PF00917	0.764
DOC_WW_Pin1_4	169	174	PF00397	0.376
DOC_WW_Pin1_4	227	232	PF00397	0.575
DOC_WW_Pin1_4	74	79	PF00397	0.738
LIG_14-3-3_CanoR_1	220	224	PF00244	0.499
LIG_BRCT_BRCA1_1	90	94	PF00533	0.572
LIG_FHA_1	130	136	PF00498	0.352
LIG_FHA_1	198	204	PF00498	0.443
LIG_FHA_1	54	60	PF00498	0.769
LIG_LIR_Gen_1	117	127	PF02991	0.420
LIG_LIR_Gen_1	157	167	PF02991	0.458
LIG_LIR_Nem_3	117	122	PF02991	0.408
LIG_LIR_Nem_3	157	162	PF02991	0.492
LIG_LYPXL_S_1	186	190	PF13949	0.656
LIG_LYPXL_yS_3	187	190	PF13949	0.426
LIG_NRBOX	130	136	PF00104	0.398
LIG_SH2_CRK	119	123	PF00017	0.477
LIG_SH2_STAT3	167	170	PF00017	0.456
LIG_SH2_STAT5	121	124	PF00017	0.352
LIG_SH2_STAT5	133	136	PF00017	0.336
LIG_SH2_STAT5	179	182	PF00017	0.406
LIG_SH3_3	185	191	PF00018	0.392
LIG_SH3_3	221	227	PF00018	0.446
LIG_SUMO_SIM_par_1	16	21	PF11976	0.729
LIG_SxIP_EBH_1	36	49	PF03271	0.644
LIG_TYR_ITIM	177	182	PF00017	0.440
LIG_TYR_ITSM	115	122	PF00017	0.420
MOD_CDK_SPK_2	169	174	PF00069	0.399
MOD_CK1_1	42	48	PF00069	0.738
MOD_CK1_1	52	58	PF00069	0.727
MOD_CK1_1	76	82	PF00069	0.775
MOD_CK1_1	83	89	PF00069	0.774
MOD_GlcNHglycan	10	13	PF01048	0.397
MOD_GlcNHglycan	227	230	PF01048	0.669
MOD_GlcNHglycan	67	70	PF01048	0.570
MOD_GlcNHglycan	78	81	PF01048	0.550
MOD_GlcNHglycan	82	85	PF01048	0.512
MOD_GlcNHglycan	94	97	PF01048	0.396
MOD_GSK3_1	215	222	PF00069	0.505
MOD_GSK3_1	225	232	PF00069	0.540
MOD_GSK3_1	38	45	PF00069	0.722
MOD_GSK3_1	48	55	PF00069	0.703
MOD_GSK3_1	70	77	PF00069	0.714
MOD_GSK3_1	85	92	PF00069	0.678
MOD_N-GLC_2	183	185	PF02516	0.621
MOD_NEK2_1	123	128	PF00069	0.465
MOD_NEK2_1	129	134	PF00069	0.387
MOD_NEK2_1	18	23	PF00069	0.700
MOD_NEK2_1	215	220	PF00069	0.492
MOD_PK_1	16	22	PF00069	0.706
MOD_PK_1	39	45	PF00069	0.582
MOD_PK_1	60	66	PF00069	0.593
MOD_PKA_1	219	225	PF00069	0.483
MOD_PKA_2	219	225	PF00069	0.424
MOD_PKA_2	38	44	PF00069	0.747
MOD_PKA_2	65	71	PF00069	0.714
MOD_Plk_4	114	120	PF00069	0.413
MOD_Plk_4	129	135	PF00069	0.354
MOD_Plk_4	144	150	PF00069	0.376
MOD_Plk_4	162	168	PF00069	0.433
MOD_ProDKin_1	169	175	PF00069	0.376
MOD_ProDKin_1	74	80	PF00069	0.739
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.512
TRG_ENDOCYTIC_2	119	122	PF00928	0.362
TRG_ENDOCYTIC_2	179	182	PF00928	0.424
TRG_ENDOCYTIC_2	187	190	PF00928	0.401
TRG_ER_diArg_1	4	7	PF00400	0.739

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAL2	Leptomonas seymouri	48%	100%
A0A0S4IYT0	Bodo saltans	32%	100%
A0A1X0NNX7	Trypanosomatidae	36%	88%
A0A3S7WQ61	Leishmania donovani	88%	100%
A4H583	Leishmania braziliensis	74%	100%
A4HTG7	Leishmania infantum	88%	100%
Q4QIF3	Leishmania major	89%	100%