PIG-H domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI-GlcNAc transferase complex, PIG-H component, putative

Species:

Leishmania mexicana

UniProt:

E9AM94_LEIMU

TriTrypDb:

LmxM.08.0150

Length:

436

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	3	7
GO:0016020	membrane	2	7
GO:0032991	protein-containing complex	1	7
GO:0098796	membrane protein complex	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0140534	endoplasmic reticulum protein-containing complex	2	7
GO:1902494	catalytic complex	2	7
GO:1990234	transferase complex	3	7

Expansion

Sequence features

E9AM94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM94

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	7
GO:0006505	GPI anchor metabolic process	6	7
GO:0006506	GPI anchor biosynthetic process	6	7
GO:0006629	lipid metabolic process	3	7
GO:0006643	membrane lipid metabolic process	4	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006661	phosphatidylinositol biosynthetic process	6	7
GO:0006664	glycolipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008610	lipid biosynthetic process	4	7
GO:0008654	phospholipid biosynthetic process	5	7
GO:0009058	biosynthetic process	2	7
GO:0009247	glycolipid biosynthetic process	5	7
GO:0009987	cellular process	1	7
GO:0019538	protein metabolic process	3	7
GO:0019637	organophosphate metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0045017	glycerolipid biosynthetic process	4	7
GO:0046467	membrane lipid biosynthetic process	4	7
GO:0046474	glycerophospholipid biosynthetic process	5	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046488	phosphatidylinositol metabolic process	6	7
GO:0071704	organic substance metabolic process	2	7
GO:0090407	organophosphate biosynthetic process	4	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901137	carbohydrate derivative biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901576	organic substance biosynthetic process	3	7
GO:1903509	liposaccharide metabolic process	4	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	402	406	PF00656	0.603
CLV_PCSK_KEX2_1	282	284	PF00082	0.340
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.340
CLV_PCSK_SKI1_1	146	150	PF00082	0.396
CLV_PCSK_SKI1_1	248	252	PF00082	0.633
CLV_PCSK_SKI1_1	28	32	PF00082	0.343
CLV_PCSK_SKI1_1	369	373	PF00082	0.322
CLV_PCSK_SKI1_1	376	380	PF00082	0.365
DEG_APCC_DBOX_1	368	376	PF00400	0.497
DOC_CKS1_1	419	424	PF01111	0.646
DOC_CKS1_1	92	97	PF01111	0.673
DOC_MAPK_gen_1	316	323	PF00069	0.469
DOC_MAPK_MEF2A_6	316	325	PF00069	0.469
DOC_MAPK_RevD_3	268	283	PF00069	0.303
DOC_PP1_RVXF_1	144	150	PF00149	0.629
DOC_PP1_RVXF_1	246	253	PF00149	0.432
DOC_PP1_RVXF_1	352	359	PF00149	0.469
DOC_PP2B_LxvP_1	96	99	PF13499	0.667
DOC_PP4_MxPP_1	1	4	PF00568	0.633
DOC_USP7_MATH_1	203	207	PF00917	0.456
DOC_USP7_MATH_1	232	236	PF00917	0.566
DOC_USP7_MATH_1	4	8	PF00917	0.616
DOC_USP7_MATH_2	383	389	PF00917	0.636
DOC_WW_Pin1_4	110	115	PF00397	0.634
DOC_WW_Pin1_4	119	124	PF00397	0.651
DOC_WW_Pin1_4	14	19	PF00397	0.792
DOC_WW_Pin1_4	227	232	PF00397	0.390
DOC_WW_Pin1_4	400	405	PF00397	0.530
DOC_WW_Pin1_4	418	423	PF00397	0.660
DOC_WW_Pin1_4	88	93	PF00397	0.730
DOC_WW_Pin1_4	99	104	PF00397	0.698
LIG_14-3-3_CanoR_1	174	178	PF00244	0.370
LIG_14-3-3_CanoR_1	24	32	PF00244	0.583
LIG_14-3-3_CanoR_1	37	41	PF00244	0.593
LIG_14-3-3_CanoR_1	395	404	PF00244	0.602
LIG_Actin_WH2_2	164	181	PF00022	0.354
LIG_Actin_WH2_2	355	371	PF00022	0.504
LIG_AP_GAE_1	411	417	PF02883	0.678
LIG_APCC_ABBAyCdc20_2	376	382	PF00400	0.527
LIG_EH1_1	318	326	PF00400	0.516
LIG_eIF4E_1	292	298	PF01652	0.534
LIG_FHA_1	160	166	PF00498	0.289
LIG_FHA_1	245	251	PF00498	0.418
LIG_FHA_1	257	263	PF00498	0.334
LIG_FHA_1	267	273	PF00498	0.313
LIG_FHA_1	275	281	PF00498	0.359
LIG_FHA_1	29	35	PF00498	0.628
LIG_FHA_1	36	42	PF00498	0.527
LIG_FHA_1	47	53	PF00498	0.490
LIG_FHA_2	134	140	PF00498	0.583
LIG_FHA_2	418	424	PF00498	0.677
LIG_FHA_2	429	435	PF00498	0.613
LIG_GBD_Chelix_1	280	288	PF00786	0.406
LIG_LIR_Gen_1	190	199	PF02991	0.429
LIG_LIR_Gen_1	276	284	PF02991	0.405
LIG_LIR_Nem_3	190	194	PF02991	0.439
LIG_LIR_Nem_3	195	199	PF02991	0.396
LIG_LIR_Nem_3	276	281	PF02991	0.404
LIG_LIR_Nem_3	307	312	PF02991	0.469
LIG_LIR_Nem_3	314	320	PF02991	0.469
LIG_LIR_Nem_3	333	338	PF02991	0.469
LIG_NRBOX	269	275	PF00104	0.369
LIG_Pex14_1	145	149	PF04695	0.630
LIG_Pex14_2	149	153	PF04695	0.516
LIG_REV1ctd_RIR_1	333	339	PF16727	0.469
LIG_SH2_STAP1	60	64	PF00017	0.545
LIG_SH2_STAT5	292	295	PF00017	0.500
LIG_SH2_STAT5	357	360	PF00017	0.593
LIG_SH3_3	211	217	PF00018	0.403
LIG_SH3_3	353	359	PF00018	0.469
LIG_SH3_3	364	370	PF00018	0.505
LIG_SH3_3	416	422	PF00018	0.644
LIG_SH3_3	89	95	PF00018	0.759
LIG_SUMO_SIM_anti_2	265	272	PF11976	0.349
LIG_SUMO_SIM_anti_2	294	300	PF11976	0.516
LIG_SUMO_SIM_par_1	168	173	PF11976	0.313
LIG_SUMO_SIM_par_1	269	277	PF11976	0.406
LIG_SUMO_SIM_par_1	322	328	PF11976	0.516
LIG_WRC_WIRS_1	275	280	PF05994	0.270
MOD_CDK_SPxxK_3	119	126	PF00069	0.682
MOD_CK1_1	113	119	PF00069	0.675
MOD_CK1_1	122	128	PF00069	0.631
MOD_CK1_1	173	179	PF00069	0.396
MOD_CK1_1	187	193	PF00069	0.459
MOD_CK1_1	206	212	PF00069	0.371
MOD_CK1_1	428	434	PF00069	0.688
MOD_CK2_1	192	198	PF00069	0.339
MOD_CK2_1	343	349	PF00069	0.469
MOD_CK2_1	385	391	PF00069	0.596
MOD_CK2_1	410	416	PF00069	0.654
MOD_GlcNHglycan	117	120	PF01048	0.463
MOD_GlcNHglycan	186	189	PF01048	0.610
MOD_GlcNHglycan	205	208	PF01048	0.710
MOD_GlcNHglycan	242	245	PF01048	0.588
MOD_GlcNHglycan	284	287	PF01048	0.317
MOD_GlcNHglycan	306	309	PF01048	0.316
MOD_GlcNHglycan	398	401	PF01048	0.422
MOD_GlcNHglycan	88	91	PF01048	0.493
MOD_GSK3_1	106	113	PF00069	0.679
MOD_GSK3_1	115	122	PF00069	0.690
MOD_GSK3_1	180	187	PF00069	0.429
MOD_GSK3_1	199	206	PF00069	0.396
MOD_GSK3_1	227	234	PF00069	0.515
MOD_GSK3_1	24	31	PF00069	0.690
MOD_GSK3_1	240	247	PF00069	0.414
MOD_GSK3_1	253	260	PF00069	0.411
MOD_GSK3_1	282	289	PF00069	0.676
MOD_GSK3_1	36	43	PF00069	0.512
MOD_GSK3_1	396	403	PF00069	0.529
MOD_NEK2_1	117	122	PF00069	0.668
MOD_NEK2_1	159	164	PF00069	0.340
MOD_NEK2_1	189	194	PF00069	0.391
MOD_NEK2_1	199	204	PF00069	0.376
MOD_NEK2_1	251	256	PF00069	0.446
MOD_NEK2_1	264	269	PF00069	0.272
MOD_NEK2_1	273	278	PF00069	0.314
MOD_NEK2_1	304	309	PF00069	0.469
MOD_NEK2_1	325	330	PF00069	0.469
MOD_NEK2_1	342	347	PF00069	0.469
MOD_PIKK_1	253	259	PF00454	0.396
MOD_PIKK_1	79	85	PF00454	0.587
MOD_PKA_1	282	288	PF00069	0.584
MOD_PKA_2	173	179	PF00069	0.408
MOD_PKA_2	23	29	PF00069	0.563
MOD_PKA_2	282	288	PF00069	0.584
MOD_PKA_2	36	42	PF00069	0.604
MOD_Plk_1	133	139	PF00069	0.651
MOD_Plk_1	264	270	PF00069	0.331
MOD_Plk_1	410	416	PF00069	0.675
MOD_Plk_2-3	385	391	PF00069	0.596
MOD_Plk_2-3	407	413	PF00069	0.593
MOD_Plk_4	173	179	PF00069	0.461
MOD_Plk_4	192	198	PF00069	0.362
MOD_Plk_4	237	243	PF00069	0.433
MOD_Plk_4	257	263	PF00069	0.206
MOD_Plk_4	266	272	PF00069	0.404
MOD_Plk_4	274	280	PF00069	0.369
MOD_Plk_4	36	42	PF00069	0.557
MOD_ProDKin_1	110	116	PF00069	0.633
MOD_ProDKin_1	119	125	PF00069	0.653
MOD_ProDKin_1	14	20	PF00069	0.789
MOD_ProDKin_1	227	233	PF00069	0.389
MOD_ProDKin_1	400	406	PF00069	0.533
MOD_ProDKin_1	418	424	PF00069	0.663
MOD_ProDKin_1	88	94	PF00069	0.729
MOD_ProDKin_1	99	105	PF00069	0.697
MOD_SUMO_rev_2	345	352	PF00179	0.516
TRG_DiLeu_BaEn_4	384	390	PF01217	0.592
TRG_ENDOCYTIC_2	309	312	PF00928	0.469
TRG_ENDOCYTIC_2	317	320	PF00928	0.469
TRG_ENDOCYTIC_2	338	341	PF00928	0.469
TRG_ER_diArg_1	126	129	PF00400	0.631
TRG_NES_CRM1_1	322	333	PF08389	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I406	Leptomonas seymouri	53%	88%
A0A3S5H631	Leishmania donovani	87%	84%
A4H582	Leishmania braziliensis	67%	100%
A4HTG6	Leishmania infantum	88%	87%
Q4QIF4	Leishmania major	85%	100%