Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (pseudogene)

Species:

Leishmania mexicana

UniProt:

E9AM92_LEIMU

TriTrypDb:

LmxM.08.0135

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM92

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.565
CLV_NRD_NRD_1	186	188	PF00675	0.644
CLV_NRD_NRD_1	19	21	PF00675	0.497
CLV_NRD_NRD_1	364	366	PF00675	0.435
CLV_NRD_NRD_1	536	538	PF00675	0.473
CLV_PCSK_KEX2_1	186	188	PF00082	0.644
CLV_PCSK_KEX2_1	19	21	PF00082	0.497
CLV_PCSK_KEX2_1	364	366	PF00082	0.435
CLV_PCSK_KEX2_1	536	538	PF00082	0.477
CLV_PCSK_PC7_1	360	366	PF00082	0.407
CLV_PCSK_SKI1_1	19	23	PF00082	0.397
CLV_PCSK_SKI1_1	202	206	PF00082	0.539
CLV_PCSK_SKI1_1	331	335	PF00082	0.597
CLV_PCSK_SKI1_1	398	402	PF00082	0.591
DEG_APCC_DBOX_1	330	338	PF00400	0.577
DEG_Nend_Nbox_1	1	3	PF02207	0.547
DEG_SCF_FBW7_1	292	299	PF00400	0.636
DEG_SPOP_SBC_1	21	25	PF00917	0.505
DEG_SPOP_SBC_1	222	226	PF00917	0.614
DOC_AGCK_PIF_2	571	576	PF00069	0.365
DOC_CDC14_PxL_1	264	272	PF14671	0.518
DOC_CDC14_PxL_1	483	491	PF14671	0.542
DOC_CKS1_1	93	98	PF01111	0.499
DOC_CYCLIN_yCln2_LP_2	348	354	PF00134	0.719
DOC_MAPK_gen_1	255	264	PF00069	0.634
DOC_MAPK_MEF2A_6	438	445	PF00069	0.410
DOC_PP2B_LxvP_1	340	343	PF13499	0.547
DOC_PP4_FxxP_1	494	497	PF00568	0.443
DOC_PP4_FxxP_1	529	532	PF00568	0.442
DOC_USP7_MATH_1	166	170	PF00917	0.475
DOC_USP7_MATH_1	21	25	PF00917	0.624
DOC_USP7_MATH_1	457	461	PF00917	0.365
DOC_WW_Pin1_4	239	244	PF00397	0.636
DOC_WW_Pin1_4	292	297	PF00397	0.628
DOC_WW_Pin1_4	317	322	PF00397	0.725
DOC_WW_Pin1_4	92	97	PF00397	0.461
LIG_14-3-3_CanoR_1	100	108	PF00244	0.729
LIG_14-3-3_CanoR_1	20	30	PF00244	0.546
LIG_14-3-3_CanoR_1	230	236	PF00244	0.503
LIG_14-3-3_CanoR_1	365	374	PF00244	0.367
LIG_APCC_ABBAyCdc20_2	398	404	PF00400	0.488
LIG_BIR_III_4	391	395	PF00653	0.445
LIG_BRCT_BRCA1_1	119	123	PF00533	0.529
LIG_FHA_1	100	106	PF00498	0.606
LIG_FHA_1	175	181	PF00498	0.580
LIG_FHA_1	223	229	PF00498	0.614
LIG_FHA_1	343	349	PF00498	0.609
LIG_FHA_1	357	363	PF00498	0.437
LIG_FHA_1	383	389	PF00498	0.517
LIG_FHA_1	467	473	PF00498	0.492
LIG_FHA_1	509	515	PF00498	0.448
LIG_FHA_2	334	340	PF00498	0.583
LIG_FHA_2	434	440	PF00498	0.462
LIG_FHA_2	473	479	PF00498	0.317
LIG_LIR_Apic_2	283	288	PF02991	0.530
LIG_LIR_Apic_2	295	301	PF02991	0.493
LIG_LIR_Apic_2	527	532	PF02991	0.452
LIG_LIR_Gen_1	570	579	PF02991	0.409
LIG_LIR_LC3C_4	232	236	PF02991	0.501
LIG_LIR_Nem_3	120	126	PF02991	0.493
LIG_LIR_Nem_3	141	147	PF02991	0.522
LIG_LIR_Nem_3	305	309	PF02991	0.608
LIG_LIR_Nem_3	501	506	PF02991	0.449
LIG_LIR_Nem_3	525	529	PF02991	0.472
LIG_LIR_Nem_3	534	538	PF02991	0.351
LIG_LIR_Nem_3	570	574	PF02991	0.405
LIG_LIR_Nem_3	575	579	PF02991	0.410
LIG_LIR_Nem_3	87	93	PF02991	0.524
LIG_Pex14_2	522	526	PF04695	0.410
LIG_RPA_C_Fungi	15	27	PF08784	0.502
LIG_SH2_CRK	144	148	PF00017	0.522
LIG_SH2_CRK	298	302	PF00017	0.544
LIG_SH2_GRB2like	108	111	PF00017	0.517
LIG_SH2_PTP2	576	579	PF00017	0.385
LIG_SH2_SRC	108	111	PF00017	0.517
LIG_SH2_STAP1	386	390	PF00017	0.378
LIG_SH2_STAT3	149	152	PF00017	0.556
LIG_SH2_STAT5	108	111	PF00017	0.477
LIG_SH2_STAT5	158	161	PF00017	0.584
LIG_SH2_STAT5	386	389	PF00017	0.367
LIG_SH2_STAT5	576	579	PF00017	0.345
LIG_SH2_STAT5	92	95	PF00017	0.646
LIG_SH3_1	145	151	PF00018	0.501
LIG_SH3_1	216	222	PF00018	0.514
LIG_SH3_1	285	291	PF00018	0.637
LIG_SH3_2	351	356	PF14604	0.464
LIG_SH3_3	144	150	PF00018	0.669
LIG_SH3_3	216	222	PF00018	0.593
LIG_SH3_3	244	250	PF00018	0.645
LIG_SH3_3	265	271	PF00018	0.593
LIG_SH3_3	285	291	PF00018	0.568
LIG_SH3_3	315	321	PF00018	0.530
LIG_SH3_3	348	354	PF00018	0.527
LIG_SH3_3	490	496	PF00018	0.470
LIG_SH3_3	50	56	PF00018	0.590
LIG_SH3_3	82	88	PF00018	0.522
LIG_SH3_3	90	96	PF00018	0.476
LIG_SH3_CIN85_PxpxPR_1	284	289	PF14604	0.638
LIG_SUMO_SIM_par_1	344	350	PF11976	0.563
LIG_SUMO_SIM_par_1	376	381	PF11976	0.471
LIG_TRAF2_1	291	294	PF00917	0.641
LIG_TRAF2_1	326	329	PF00917	0.474
LIG_TRAF2_1	561	564	PF00917	0.435
LIG_TRFH_1	144	148	PF08558	0.487
MOD_CK1_1	136	142	PF00069	0.518
MOD_CK1_1	4	10	PF00069	0.520
MOD_CK1_1	64	70	PF00069	0.612
MOD_CK2_1	189	195	PF00069	0.444
MOD_CK2_1	266	272	PF00069	0.735
MOD_CK2_1	333	339	PF00069	0.582
MOD_CK2_1	472	478	PF00069	0.334
MOD_GlcNHglycan	135	138	PF01048	0.606
MOD_GlcNHglycan	231	234	PF01048	0.608
MOD_GlcNHglycan	236	239	PF01048	0.634
MOD_GlcNHglycan	3	6	PF01048	0.505
MOD_GlcNHglycan	459	462	PF01048	0.392
MOD_GlcNHglycan	49	52	PF01048	0.583
MOD_GlcNHglycan	66	69	PF01048	0.612
MOD_GSK3_1	176	183	PF00069	0.704
MOD_GSK3_1	217	224	PF00069	0.584
MOD_GSK3_1	234	241	PF00069	0.608
MOD_GSK3_1	245	252	PF00069	0.652
MOD_GSK3_1	292	299	PF00069	0.783
MOD_GSK3_1	378	385	PF00069	0.494
MOD_GSK3_1	508	515	PF00069	0.476
MOD_LATS_1	18	24	PF00433	0.506
MOD_NEK2_1	1	6	PF00069	0.515
MOD_NEK2_1	22	27	PF00069	0.488
MOD_NEK2_1	234	239	PF00069	0.749
MOD_NEK2_1	245	250	PF00069	0.663
MOD_NEK2_1	251	256	PF00069	0.591
MOD_NEK2_1	382	387	PF00069	0.438
MOD_NEK2_1	506	511	PF00069	0.435
MOD_PIKK_1	99	105	PF00454	0.549
MOD_PKA_2	117	123	PF00069	0.468
MOD_PKA_2	127	133	PF00069	0.561
MOD_PKA_2	217	223	PF00069	0.588
MOD_PKA_2	229	235	PF00069	0.671
MOD_PKA_2	99	105	PF00069	0.717
MOD_PKB_1	187	195	PF00069	0.545
MOD_Plk_1	382	388	PF00069	0.390
MOD_Plk_2-3	433	439	PF00069	0.452
MOD_Plk_2-3	567	573	PF00069	0.306
MOD_Plk_4	180	186	PF00069	0.630
MOD_Plk_4	223	229	PF00069	0.601
MOD_Plk_4	373	379	PF00069	0.406
MOD_Plk_4	481	487	PF00069	0.358
MOD_Plk_4	498	504	PF00069	0.443
MOD_ProDKin_1	239	245	PF00069	0.639
MOD_ProDKin_1	292	298	PF00069	0.628
MOD_ProDKin_1	317	323	PF00069	0.727
MOD_ProDKin_1	92	98	PF00069	0.461
TRG_DiLeu_BaEn_4	564	570	PF01217	0.398
TRG_ENDOCYTIC_2	108	111	PF00928	0.517
TRG_ENDOCYTIC_2	144	147	PF00928	0.473
TRG_ENDOCYTIC_2	576	579	PF00928	0.345
TRG_ER_diArg_1	185	187	PF00400	0.660
TRG_ER_diArg_1	216	219	PF00400	0.520
TRG_ER_diArg_1	364	366	PF00400	0.435
TRG_ER_diArg_1	419	422	PF00400	0.632
TRG_ER_diArg_1	535	537	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I943	Leptomonas seymouri	46%	97%
A0A3S5H629	Leishmania donovani	86%	100%
A4HTG4	Leishmania infantum	86%	100%