Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AM89_LEIMU

TriTrypDb:

LmxM.08.0110

Length:

643

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM89

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	156	162	PF00089	0.672
CLV_NRD_NRD_1	254	256	PF00675	0.655
CLV_NRD_NRD_1	297	299	PF00675	0.386
CLV_NRD_NRD_1	316	318	PF00675	0.557
CLV_NRD_NRD_1	427	429	PF00675	0.362
CLV_NRD_NRD_1	545	547	PF00675	0.547
CLV_NRD_NRD_1	570	572	PF00675	0.457
CLV_NRD_NRD_1	582	584	PF00675	0.553
CLV_NRD_NRD_1	91	93	PF00675	0.709
CLV_PCSK_FUR_1	568	572	PF00082	0.457
CLV_PCSK_KEX2_1	254	256	PF00082	0.655
CLV_PCSK_KEX2_1	297	299	PF00082	0.413
CLV_PCSK_KEX2_1	316	318	PF00082	0.557
CLV_PCSK_KEX2_1	365	367	PF00082	0.600
CLV_PCSK_KEX2_1	557	559	PF00082	0.446
CLV_PCSK_KEX2_1	568	570	PF00082	0.463
CLV_PCSK_KEX2_1	582	584	PF00082	0.530
CLV_PCSK_KEX2_1	91	93	PF00082	0.709
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.516
CLV_PCSK_PC1ET2_1	557	559	PF00082	0.324
CLV_PCSK_PC7_1	312	318	PF00082	0.544
CLV_PCSK_PC7_1	553	559	PF00082	0.314
CLV_PCSK_SKI1_1	402	406	PF00082	0.599
CLV_PCSK_SKI1_1	446	450	PF00082	0.549
CLV_PCSK_SKI1_1	547	551	PF00082	0.465
CLV_PCSK_SKI1_1	553	557	PF00082	0.452
CLV_PCSK_SKI1_1	587	591	PF00082	0.780
CLV_Separin_Metazoa	515	519	PF03568	0.548
DEG_APCC_DBOX_1	531	539	PF00400	0.551
DEG_ODPH_VHL_1	120	133	PF01847	0.513
DEG_SCF_TRCP1_1	635	641	PF00400	0.574
DEG_SPOP_SBC_1	170	174	PF00917	0.519
DEG_SPOP_SBC_1	612	616	PF00917	0.598
DOC_MAPK_gen_1	125	135	PF00069	0.631
DOC_MAPK_gen_1	468	476	PF00069	0.485
DOC_MAPK_gen_1	546	552	PF00069	0.453
DOC_MAPK_gen_1	557	565	PF00069	0.443
DOC_MAPK_MEF2A_6	128	135	PF00069	0.704
DOC_PP2B_LxvP_1	266	269	PF13499	0.569
DOC_USP7_MATH_1	151	155	PF00917	0.682
DOC_USP7_MATH_1	169	173	PF00917	0.606
DOC_USP7_MATH_1	228	232	PF00917	0.635
DOC_USP7_MATH_1	328	332	PF00917	0.599
DOC_USP7_MATH_1	39	43	PF00917	0.705
DOC_USP7_MATH_1	485	489	PF00917	0.575
DOC_USP7_MATH_1	581	585	PF00917	0.548
DOC_USP7_MATH_1	613	617	PF00917	0.611
DOC_WW_Pin1_4	106	111	PF00397	0.586
DOC_WW_Pin1_4	142	147	PF00397	0.672
DOC_WW_Pin1_4	149	154	PF00397	0.671
DOC_WW_Pin1_4	210	215	PF00397	0.655
DOC_WW_Pin1_4	238	243	PF00397	0.727
DOC_WW_Pin1_4	261	266	PF00397	0.714
DOC_WW_Pin1_4	277	282	PF00397	0.431
DOC_WW_Pin1_4	329	334	PF00397	0.493
DOC_WW_Pin1_4	588	593	PF00397	0.626
DOC_WW_Pin1_4	616	621	PF00397	0.704
DOC_WW_Pin1_4	7	12	PF00397	0.723
LIG_14-3-3_CanoR_1	128	134	PF00244	0.513
LIG_14-3-3_CanoR_1	137	146	PF00244	0.521
LIG_14-3-3_CanoR_1	197	203	PF00244	0.789
LIG_14-3-3_CanoR_1	338	346	PF00244	0.529
LIG_14-3-3_CanoR_1	348	357	PF00244	0.512
LIG_14-3-3_CanoR_1	43	48	PF00244	0.492
LIG_14-3-3_CanoR_1	489	497	PF00244	0.518
LIG_14-3-3_CanoR_1	523	527	PF00244	0.446
LIG_Actin_WH2_2	487	504	PF00022	0.454
LIG_Actin_WH2_2	514	531	PF00022	0.452
LIG_BIR_II_1	1	5	PF00653	0.501
LIG_BIR_III_4	115	119	PF00653	0.576
LIG_BIR_III_4	631	635	PF00653	0.784
LIG_FHA_1	115	121	PF00498	0.654
LIG_FHA_1	130	136	PF00498	0.569
LIG_FHA_1	233	239	PF00498	0.677
LIG_FHA_1	277	283	PF00498	0.624
LIG_FHA_1	29	35	PF00498	0.696
LIG_FHA_1	338	344	PF00498	0.523
LIG_FHA_1	352	358	PF00498	0.467
LIG_FHA_1	432	438	PF00498	0.459
LIG_FHA_1	44	50	PF00498	0.495
LIG_FHA_1	445	451	PF00498	0.460
LIG_FHA_1	489	495	PF00498	0.452
LIG_FHA_1	523	529	PF00498	0.450
LIG_FHA_2	359	365	PF00498	0.668
LIG_FHA_2	378	384	PF00498	0.409
LIG_FHA_2	403	409	PF00498	0.669
LIG_FHA_2	434	440	PF00498	0.639
LIG_FHA_2	50	56	PF00498	0.560
LIG_Integrin_RGD_1	219	221	PF01839	0.716
LIG_LIR_Apic_2	221	225	PF02991	0.652
LIG_LIR_Gen_1	172	182	PF02991	0.560
LIG_LIR_LC3C_4	46	49	PF02991	0.476
LIG_LIR_Nem_3	172	178	PF02991	0.579
LIG_MYND_1	261	265	PF01753	0.710
LIG_NRBOX	184	190	PF00104	0.535
LIG_NRBOX	342	348	PF00104	0.411
LIG_NRBOX	79	85	PF00104	0.475
LIG_PCNA_yPIPBox_3	468	480	PF02747	0.483
LIG_RPA_C_Fungi	293	305	PF08784	0.424
LIG_RPA_C_Fungi	578	590	PF08784	0.527
LIG_SH2_CRK	175	179	PF00017	0.506
LIG_SH2_CRK	222	226	PF00017	0.656
LIG_SH2_GRB2like	19	22	PF00017	0.669
LIG_SH2_NCK_1	20	24	PF00017	0.564
LIG_SH2_STAP1	175	179	PF00017	0.506
LIG_SH2_STAT3	479	482	PF00017	0.486
LIG_SH2_STAT5	293	296	PF00017	0.507
LIG_SH2_STAT5	479	482	PF00017	0.540
LIG_SH3_1	222	228	PF00018	0.651
LIG_SH3_3	128	134	PF00018	0.684
LIG_SH3_3	147	153	PF00018	0.525
LIG_SH3_3	222	228	PF00018	0.651
LIG_SH3_3	275	281	PF00018	0.555
LIG_SH3_3	8	14	PF00018	0.637
LIG_SH3_3	90	96	PF00018	0.614
LIG_SUMO_SIM_anti_2	433	439	PF11976	0.457
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.475
LIG_SUMO_SIM_par_1	433	439	PF11976	0.455
LIG_SUMO_SIM_par_1	45	50	PF11976	0.533
LIG_SUMO_SIM_par_1	561	567	PF11976	0.536
LIG_SUMO_SIM_par_1	58	64	PF11976	0.644
LIG_TRAF2_1	145	148	PF00917	0.622
LIG_TRAF2_1	381	384	PF00917	0.459
LIG_TRAF2_1	512	515	PF00917	0.551
LIG_UBA3_1	549	557	PF00899	0.323
MOD_CDK_SPK_2	588	593	PF00069	0.638
MOD_CDK_SPxK_1	238	244	PF00069	0.639
MOD_CK1_1	141	147	PF00069	0.713
MOD_CK1_1	149	155	PF00069	0.773
MOD_CK1_1	201	207	PF00069	0.709
MOD_CK1_1	349	355	PF00069	0.550
MOD_CK1_1	409	415	PF00069	0.611
MOD_CK1_1	421	427	PF00069	0.600
MOD_CK1_1	488	494	PF00069	0.551
MOD_CK1_1	614	620	PF00069	0.587
MOD_CK1_1	633	639	PF00069	0.571
MOD_CK2_1	141	147	PF00069	0.688
MOD_CK2_1	358	364	PF00069	0.527
MOD_CK2_1	377	383	PF00069	0.406
MOD_CK2_1	402	408	PF00069	0.642
MOD_CK2_1	49	55	PF00069	0.617
MOD_CK2_1	509	515	PF00069	0.526
MOD_Cter_Amidation	314	317	PF01082	0.588
MOD_GlcNHglycan	2	5	PF01048	0.689
MOD_GlcNHglycan	334	337	PF01048	0.516
MOD_GlcNHglycan	413	416	PF01048	0.602
MOD_GlcNHglycan	420	423	PF01048	0.681
MOD_GlcNHglycan	583	586	PF01048	0.658
MOD_GlcNHglycan	606	609	PF01048	0.576
MOD_GlcNHglycan	627	630	PF01048	0.689
MOD_GlcNHglycan	631	635	PF01048	0.715
MOD_GlcNHglycan	98	101	PF01048	0.682
MOD_GSK3_1	138	145	PF00069	0.753
MOD_GSK3_1	201	208	PF00069	0.733
MOD_GSK3_1	228	235	PF00069	0.651
MOD_GSK3_1	255	262	PF00069	0.721
MOD_GSK3_1	28	35	PF00069	0.665
MOD_GSK3_1	328	335	PF00069	0.632
MOD_GSK3_1	39	46	PF00069	0.543
MOD_GSK3_1	402	409	PF00069	0.588
MOD_GSK3_1	417	424	PF00069	0.749
MOD_GSK3_1	541	548	PF00069	0.487
MOD_GSK3_1	55	62	PF00069	0.761
MOD_GSK3_1	611	618	PF00069	0.647
MOD_GSK3_1	633	640	PF00069	0.618
MOD_LATS_1	253	259	PF00433	0.622
MOD_LATS_1	41	47	PF00433	0.499
MOD_N-GLC_1	444	449	PF02516	0.490
MOD_N-GLC_1	84	89	PF02516	0.637
MOD_N-GLC_2	69	71	PF02516	0.532
MOD_NEK2_1	346	351	PF00069	0.460
MOD_NEK2_1	431	436	PF00069	0.455
MOD_NEK2_1	545	550	PF00069	0.452
MOD_NEK2_1	84	89	PF00069	0.637
MOD_PIKK_1	255	261	PF00454	0.681
MOD_PIKK_1	439	445	PF00454	0.532
MOD_PIKK_1	509	515	PF00454	0.491
MOD_PIKK_1	61	67	PF00454	0.622
MOD_PKA_2	337	343	PF00069	0.468
MOD_PKA_2	488	494	PF00069	0.495
MOD_PKA_2	522	528	PF00069	0.448
MOD_PKA_2	545	551	PF00069	0.453
MOD_PKA_2	581	587	PF00069	0.567
MOD_Plk_1	27	33	PF00069	0.590
MOD_Plk_1	402	408	PF00069	0.578
MOD_Plk_1	444	450	PF00069	0.492
MOD_Plk_1	485	491	PF00069	0.565
MOD_Plk_2-3	22	28	PF00069	0.589
MOD_Plk_2-3	433	439	PF00069	0.495
MOD_Plk_4	151	157	PF00069	0.674
MOD_Plk_4	184	190	PF00069	0.437
MOD_Plk_4	43	49	PF00069	0.488
MOD_Plk_4	433	439	PF00069	0.597
MOD_Plk_4	545	551	PF00069	0.467
MOD_Plk_4	76	82	PF00069	0.481
MOD_ProDKin_1	106	112	PF00069	0.585
MOD_ProDKin_1	142	148	PF00069	0.675
MOD_ProDKin_1	149	155	PF00069	0.672
MOD_ProDKin_1	210	216	PF00069	0.657
MOD_ProDKin_1	238	244	PF00069	0.726
MOD_ProDKin_1	261	267	PF00069	0.704
MOD_ProDKin_1	277	283	PF00069	0.418
MOD_ProDKin_1	329	335	PF00069	0.486
MOD_ProDKin_1	588	594	PF00069	0.626
MOD_ProDKin_1	616	622	PF00069	0.707
MOD_ProDKin_1	7	13	PF00069	0.721
MOD_SUMO_rev_2	493	501	PF00179	0.545
MOD_SUMO_rev_2	617	627	PF00179	0.521
TRG_DiLeu_BaEn_1	76	81	PF01217	0.480
TRG_DiLeu_BaEn_4	191	197	PF01217	0.537
TRG_DiLeu_BaLyEn_6	262	267	PF01217	0.637
TRG_ENDOCYTIC_2	175	178	PF00928	0.540
TRG_ENDOCYTIC_2	20	23	PF00928	0.568
TRG_ER_diArg_1	568	571	PF00400	0.471
TRG_ER_diArg_1	90	92	PF00400	0.696
TRG_NLS_Bipartite_1	546	561	PF00514	0.328
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P938	Leptomonas seymouri	42%	78%
A0A3S7WQ53	Leishmania donovani	87%	100%
A4H578	Leishmania braziliensis	67%	100%
A4HTG1	Leishmania infantum	87%	100%
Q4QIF8	Leishmania major	88%	100%