Putative dual-specificity protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dual-specificity protein phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AM88_LEIMU

TriTrypDb:

LmxM.08.0100

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AM88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM88

Function

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Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009966	regulation of signal transduction	4	1
GO:0009968	negative regulation of signal transduction	5	1
GO:0009987	cellular process	1	7
GO:0010646	regulation of cell communication	4	1
GO:0010648	negative regulation of cell communication	5	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004722	protein serine/threonine phosphatase activity	4	6
GO:0004725	protein tyrosine phosphatase activity	4	5
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	7
GO:0008330	protein tyrosine/threonine phosphatase activity	4	1
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	5	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.718
CLV_C14_Caspase3-7	311	315	PF00656	0.695
CLV_C14_Caspase3-7	329	333	PF00656	0.575
CLV_C14_Caspase3-7	62	66	PF00656	0.410
CLV_NRD_NRD_1	179	181	PF00675	0.363
CLV_NRD_NRD_1	193	195	PF00675	0.410
CLV_NRD_NRD_1	207	209	PF00675	0.533
CLV_NRD_NRD_1	306	308	PF00675	0.533
CLV_NRD_NRD_1	41	43	PF00675	0.591
CLV_PCSK_FUR_1	205	209	PF00082	0.527

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9F6	Leptomonas seymouri	55%	85%
A0A3S5H628	Leishmania donovani	92%	100%
A4H577	Leishmania braziliensis	77%	100%
A4HTG0	Leishmania infantum	92%	100%
Q4QIF9	Leishmania major	90%	100%

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