Putative dual-specificity protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dual-specificity protein phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AM88_LEIMU

TriTrypDb:

LmxM.08.0100

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AM88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM88

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0009966	regulation of signal transduction	4	1
GO:0009968	negative regulation of signal transduction	5	1
GO:0010646	regulation of cell communication	4	1
GO:0010648	negative regulation of cell communication	5	1
GO:0023051	regulation of signaling	3	1
GO:0023057	negative regulation of signaling	4	1
GO:0043408	regulation of MAPK cascade	6	1
GO:0043409	negative regulation of MAPK cascade	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0048583	regulation of response to stimulus	3	1
GO:0048585	negative regulation of response to stimulus	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:1902531	regulation of intracellular signal transduction	5	1
GO:1902532	negative regulation of intracellular signal transduction	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004722	protein serine/threonine phosphatase activity	4	6
GO:0004725	protein tyrosine phosphatase activity	4	5
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0017018	myosin phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:0008330	protein tyrosine/threonine phosphatase activity	4	1
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	5	1
GO:0033549	MAP kinase phosphatase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.718
CLV_C14_Caspase3-7	311	315	PF00656	0.695
CLV_C14_Caspase3-7	329	333	PF00656	0.575
CLV_C14_Caspase3-7	62	66	PF00656	0.410
CLV_NRD_NRD_1	179	181	PF00675	0.363
CLV_NRD_NRD_1	193	195	PF00675	0.410
CLV_NRD_NRD_1	207	209	PF00675	0.533
CLV_NRD_NRD_1	306	308	PF00675	0.533
CLV_NRD_NRD_1	41	43	PF00675	0.591
CLV_PCSK_FUR_1	205	209	PF00082	0.527
CLV_PCSK_KEX2_1	179	181	PF00082	0.363
CLV_PCSK_KEX2_1	207	209	PF00082	0.533
CLV_PCSK_KEX2_1	234	236	PF00082	0.516
CLV_PCSK_KEX2_1	41	43	PF00082	0.543
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.577
CLV_PCSK_SKI1_1	152	156	PF00082	0.389
CLV_PCSK_SKI1_1	229	233	PF00082	0.639
CLV_PCSK_SKI1_1	344	348	PF00082	0.648
CLV_PCSK_SKI1_1	380	384	PF00082	0.592
CLV_PCSK_SKI1_1	392	396	PF00082	0.544
DEG_APCC_DBOX_1	27	35	PF00400	0.527
DOC_CKS1_1	415	420	PF01111	0.594
DOC_CYCLIN_RxL_1	226	233	PF00134	0.644
DOC_MAPK_gen_1	150	158	PF00069	0.483
DOC_MAPK_gen_1	194	202	PF00069	0.558
DOC_MAPK_MEF2A_6	180	189	PF00069	0.410
DOC_USP7_MATH_1	221	225	PF00917	0.585
DOC_USP7_MATH_1	24	28	PF00917	0.697
DOC_USP7_MATH_1	284	288	PF00917	0.800
DOC_USP7_MATH_1	33	37	PF00917	0.711
DOC_WW_Pin1_4	20	25	PF00397	0.605
DOC_WW_Pin1_4	29	34	PF00397	0.656
DOC_WW_Pin1_4	336	341	PF00397	0.621
DOC_WW_Pin1_4	414	419	PF00397	0.682
LIG_14-3-3_CanoR_1	150	158	PF00244	0.410
LIG_14-3-3_CanoR_1	207	216	PF00244	0.649
LIG_14-3-3_CanoR_1	240	246	PF00244	0.648
LIG_14-3-3_CanoR_1	338	347	PF00244	0.621
LIG_Actin_RPEL_3	143	162	PF02755	0.410
LIG_BIR_III_2	314	318	PF00653	0.558
LIG_BIR_III_4	427	431	PF00653	0.744
LIG_BRCT_BRCA1_1	198	202	PF00533	0.560
LIG_BRCT_BRCA1_1	363	367	PF00533	0.713
LIG_BRCT_BRCA1_1	400	404	PF00533	0.633
LIG_FHA_1	105	111	PF00498	0.410
LIG_FHA_1	115	121	PF00498	0.410
LIG_FHA_1	153	159	PF00498	0.392
LIG_FHA_1	242	248	PF00498	0.658
LIG_FHA_1	432	438	PF00498	0.740
LIG_FHA_1	50	56	PF00498	0.515
LIG_FHA_1	97	103	PF00498	0.410
LIG_FHA_2	351	357	PF00498	0.529
LIG_FHA_2	417	423	PF00498	0.777
LIG_LIR_Gen_1	206	216	PF02991	0.647
LIG_LIR_Gen_1	364	374	PF02991	0.665
LIG_LIR_Gen_1	56	63	PF02991	0.508
LIG_LIR_Nem_3	206	212	PF02991	0.486
LIG_LIR_Nem_3	364	370	PF02991	0.680
LIG_LIR_Nem_3	56	60	PF02991	0.508
LIG_LIR_Nem_3	86	91	PF02991	0.410
LIG_PDZ_Class_2	446	451	PF00595	0.623
LIG_Pex14_2	278	282	PF04695	0.706
LIG_REV1ctd_RIR_1	349	359	PF16727	0.650
LIG_SH2_GRB2like	163	166	PF00017	0.410
LIG_SH2_STAT5	160	163	PF00017	0.410
LIG_SH2_STAT5	175	178	PF00017	0.410
LIG_SH2_STAT5	245	248	PF00017	0.679
LIG_SH2_STAT5	59	62	PF00017	0.508
LIG_SH2_STAT5	79	82	PF00017	0.183
LIG_SH3_3	280	286	PF00018	0.809
LIG_SH3_3	412	418	PF00018	0.571
LIG_SH3_3	434	440	PF00018	0.716
LIG_SH3_3	444	450	PF00018	0.703
LIG_SUMO_SIM_anti_2	331	339	PF11976	0.521
LIG_TRAF2_1	201	204	PF00917	0.563
LIG_TRAF2_1	84	87	PF00917	0.410
LIG_WRC_WIRS_1	97	102	PF05994	0.410
MOD_CDC14_SPxK_1	32	35	PF00782	0.802
MOD_CDK_SPxK_1	29	35	PF00069	0.804
MOD_CK1_1	220	226	PF00069	0.489
MOD_CK1_1	268	274	PF00069	0.803
MOD_CK1_1	27	33	PF00069	0.649
MOD_CK1_1	339	345	PF00069	0.548
MOD_CK1_1	399	405	PF00069	0.595
MOD_CK1_1	6	12	PF00069	0.586
MOD_CK2_1	165	171	PF00069	0.410
MOD_CK2_1	198	204	PF00069	0.644
MOD_CK2_1	350	356	PF00069	0.523
MOD_CK2_1	41	47	PF00069	0.622
MOD_CK2_1	416	422	PF00069	0.750
MOD_CK2_1	81	87	PF00069	0.410
MOD_Cter_Amidation	177	180	PF01082	0.233
MOD_GlcNHglycan	103	107	PF01048	0.351
MOD_GlcNHglycan	152	155	PF01048	0.345
MOD_GlcNHglycan	219	222	PF01048	0.458
MOD_GlcNHglycan	278	281	PF01048	0.776
MOD_GlcNHglycan	35	38	PF01048	0.745
MOD_GlcNHglycan	363	366	PF01048	0.719
MOD_GlcNHglycan	422	425	PF01048	0.730
MOD_GlcNHglycan	5	8	PF01048	0.535
MOD_GSK3_1	148	155	PF00069	0.392
MOD_GSK3_1	161	168	PF00069	0.410
MOD_GSK3_1	20	27	PF00069	0.617
MOD_GSK3_1	203	210	PF00069	0.539
MOD_GSK3_1	217	224	PF00069	0.568
MOD_GSK3_1	284	291	PF00069	0.723
MOD_GSK3_1	29	36	PF00069	0.641
MOD_GSK3_1	328	335	PF00069	0.706
MOD_GSK3_1	338	345	PF00069	0.511
MOD_GSK3_1	392	399	PF00069	0.576
MOD_GSK3_1	409	416	PF00069	0.582
MOD_N-GLC_1	217	222	PF02516	0.556
MOD_N-GLC_1	81	86	PF02516	0.410
MOD_NEK2_1	120	125	PF00069	0.397
MOD_NEK2_1	161	166	PF00069	0.351
MOD_NEK2_1	196	201	PF00069	0.455
MOD_NEK2_1	278	283	PF00069	0.755
MOD_NEK2_2	59	64	PF00069	0.508
MOD_NMyristoyl	1	7	PF02799	0.596
MOD_OFUCOSY	348	354	PF10250	0.532
MOD_PIKK_1	221	227	PF00454	0.553
MOD_PIKK_1	431	437	PF00454	0.727
MOD_PIKK_1	49	55	PF00454	0.480
MOD_PIKK_1	81	87	PF00454	0.410
MOD_PIKK_1	9	15	PF00454	0.778
MOD_PKA_1	207	213	PF00069	0.537
MOD_PKA_1	307	313	PF00069	0.543
MOD_PKA_1	41	47	PF00069	0.494
MOD_PKA_2	207	213	PF00069	0.537
MOD_PKA_2	268	274	PF00069	0.644
MOD_PKA_2	27	33	PF00069	0.682
MOD_PKA_2	41	47	PF00069	0.521
MOD_PKB_1	150	158	PF00069	0.410
MOD_PKB_1	205	213	PF00069	0.630
MOD_Plk_1	342	348	PF00069	0.625
MOD_Plk_2-3	198	204	PF00069	0.570
MOD_Plk_2-3	87	93	PF00069	0.410
MOD_Plk_4	152	158	PF00069	0.410
MOD_Plk_4	241	247	PF00069	0.652
MOD_Plk_4	332	338	PF00069	0.764
MOD_Plk_4	342	348	PF00069	0.550
MOD_Plk_4	400	406	PF00069	0.639
MOD_ProDKin_1	20	26	PF00069	0.604
MOD_ProDKin_1	29	35	PF00069	0.658
MOD_ProDKin_1	336	342	PF00069	0.613
MOD_ProDKin_1	414	420	PF00069	0.684
MOD_SUMO_rev_2	86	95	PF00179	0.508
TRG_DiLeu_BaEn_2	210	216	PF01217	0.657
TRG_DiLeu_BaEn_4	191	197	PF01217	0.410
TRG_ENDOCYTIC_2	209	212	PF00928	0.535
TRG_ENDOCYTIC_2	88	91	PF00928	0.410
TRG_ER_diArg_1	124	127	PF00400	0.508
TRG_ER_diArg_1	179	181	PF00400	0.410
TRG_ER_diArg_1	205	208	PF00400	0.628
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	217	222	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9F6	Leptomonas seymouri	55%	85%
A0A3S5H628	Leishmania donovani	92%	100%
A4H577	Leishmania braziliensis	77%	100%
A4HTG0	Leishmania infantum	92%	100%
Q4QIF9	Leishmania major	90%	100%