AP-3 complex subunit delta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adaptor complex protein (AP) 3 delta subunit 1, putative

Species:

Leishmania mexicana

UniProt:

E9AM87_LEIMU

TriTrypDb:

LmxM.08.0090

Length:

1133

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	11
GO:0010008	endosome membrane	5	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0030119	AP-type membrane coat adaptor complex	3	11
GO:0030123	AP-3 adaptor complex	4	11
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11

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Expansion

Sequence features

E9AM87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM87

Function

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Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006623	protein targeting to vacuole	5	1
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0006892	post-Golgi vesicle-mediated transport	6	1
GO:0006896	Golgi to vacuole transport	5	1
GO:0007034	vacuolar transport	4	1
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.434
CLV_C14_Caspase3-7	677	681	PF00656	0.794
CLV_C14_Caspase3-7	729	733	PF00656	0.771
CLV_C14_Caspase3-7	978	982	PF00656	0.535
CLV_NRD_NRD_1	1082	1084	PF00675	0.557
CLV_NRD_NRD_1	156	158	PF00675	0.320
CLV_NRD_NRD_1	212	214	PF00675	0.335
CLV_NRD_NRD_1	329	331	PF00675	0.428
CLV_NRD_NRD_1	364	366	PF00675	0.360
CLV_NRD_NRD_1	450	452	PF00675	0.410

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML9	Leptomonas seymouri	69%	100%
A0A0S4IR09	Bodo saltans	44%	100%
A0A1X0NNX5	Trypanosomatidae	44%	95%
A0A3R7K4J8	Trypanosoma rangeli	47%	100%
A0A3S5H627	Leishmania donovani	92%	100%
A4H576	Leishmania braziliensis	83%	99%
A4HTF9	Leishmania infantum	93%	100%
C9ZPN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4QIG0	Leishmania major	91%	99%

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