ASCH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative zinc finger motif, C2HC5-type/ASCH domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AM85_LEIMU

TriTrypDb:

LmxM.08.0070

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AM85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM85

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	1
GO:0003713	transcription coactivator activity	3	1
GO:0140110	transcription regulator activity	1	1
GO:0005488	binding	1	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	442	446	PF00656	0.647
CLV_NRD_NRD_1	222	224	PF00675	0.460
CLV_NRD_NRD_1	260	262	PF00675	0.553
CLV_NRD_NRD_1	301	303	PF00675	0.714
CLV_NRD_NRD_1	397	399	PF00675	0.606
CLV_NRD_NRD_1	404	406	PF00675	0.532
CLV_NRD_NRD_1	82	84	PF00675	0.428
CLV_PCSK_FUR_1	126	130	PF00082	0.715
CLV_PCSK_FUR_1	233	237	PF00082	0.492
CLV_PCSK_KEX2_1	118	120	PF00082	0.610
CLV_PCSK_KEX2_1	125	127	PF00082	0.583
CLV_PCSK_KEX2_1	128	130	PF00082	0.587
CLV_PCSK_KEX2_1	222	224	PF00082	0.417
CLV_PCSK_KEX2_1	235	237	PF00082	0.489
CLV_PCSK_KEX2_1	260	262	PF00082	0.560
CLV_PCSK_KEX2_1	397	399	PF00082	0.620
CLV_PCSK_KEX2_1	4	6	PF00082	0.643
CLV_PCSK_KEX2_1	404	406	PF00082	0.544
CLV_PCSK_KEX2_1	505	507	PF00082	0.411
CLV_PCSK_KEX2_1	81	83	PF00082	0.422
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.638
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.605
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.607
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.514
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.643
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.411
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.431
CLV_PCSK_PC7_1	393	399	PF00082	0.601
CLV_PCSK_SKI1_1	556	560	PF00082	0.439
CLV_PCSK_SKI1_1	596	600	PF00082	0.405
DEG_APCC_KENBOX_2	302	306	PF00400	0.715
DEG_COP1_1	327	337	PF00400	0.682
DEG_SPOP_SBC_1	137	141	PF00917	0.509
DEG_SPOP_SBC_1	98	102	PF00917	0.581
DOC_CYCLIN_yCln2_LP_2	598	604	PF00134	0.345
DOC_MAPK_DCC_7	596	604	PF00069	0.344
DOC_MAPK_gen_1	125	133	PF00069	0.687
DOC_MAPK_gen_1	270	278	PF00069	0.383
DOC_MAPK_gen_1	427	435	PF00069	0.579
DOC_MAPK_MEF2A_6	270	278	PF00069	0.464
DOC_PP1_RVXF_1	594	601	PF00149	0.437
DOC_PP2B_LxvP_1	378	381	PF13499	0.578
DOC_PP4_FxxP_1	542	545	PF00568	0.281
DOC_PP4_FxxP_1	600	603	PF00568	0.372
DOC_SPAK_OSR1_1	474	478	PF12202	0.438
DOC_USP7_MATH_1	137	141	PF00917	0.620
DOC_USP7_MATH_1	263	267	PF00917	0.596
DOC_USP7_MATH_1	328	332	PF00917	0.665
DOC_USP7_MATH_1	339	343	PF00917	0.628
DOC_USP7_MATH_1	389	393	PF00917	0.741
DOC_USP7_MATH_1	470	474	PF00917	0.578
DOC_USP7_MATH_1	476	480	PF00917	0.526
DOC_USP7_MATH_1	495	499	PF00917	0.251
DOC_USP7_MATH_1	524	528	PF00917	0.366
DOC_USP7_MATH_1	60	64	PF00917	0.411
DOC_USP7_MATH_1	99	103	PF00917	0.570
DOC_USP7_UBL2_3	427	431	PF12436	0.492
DOC_WW_Pin1_4	246	251	PF00397	0.523
DOC_WW_Pin1_4	253	258	PF00397	0.500
DOC_WW_Pin1_4	347	352	PF00397	0.708
DOC_WW_Pin1_4	455	460	PF00397	0.720
DOC_WW_Pin1_4	541	546	PF00397	0.343
DOC_WW_Pin1_4	583	588	PF00397	0.267
LIG_14-3-3_CanoR_1	236	240	PF00244	0.640
LIG_14-3-3_CanoR_1	405	411	PF00244	0.671
LIG_14-3-3_CanoR_1	482	490	PF00244	0.483
LIG_APCC_ABBA_1	415	420	PF00400	0.600
LIG_BH_BH3_1	18	34	PF00452	0.427
LIG_BRCT_BRCA1_1	71	75	PF00533	0.466
LIG_Clathr_ClatBox_1	610	614	PF01394	0.361
LIG_EH1_1	474	482	PF00400	0.439
LIG_eIF4E_1	20	26	PF01652	0.441
LIG_eIF4E_1	553	559	PF01652	0.266
LIG_FHA_1	111	117	PF00498	0.701
LIG_FHA_1	20	26	PF00498	0.533
LIG_FHA_1	215	221	PF00498	0.461
LIG_FHA_1	235	241	PF00498	0.407
LIG_FHA_1	373	379	PF00498	0.587
LIG_FHA_1	553	559	PF00498	0.266
LIG_FHA_1	563	569	PF00498	0.266
LIG_FHA_1	66	72	PF00498	0.404
LIG_FHA_2	139	145	PF00498	0.735
LIG_FHA_2	236	242	PF00498	0.612
LIG_FHA_2	333	339	PF00498	0.634
LIG_FHA_2	352	358	PF00498	0.733
LIG_FHA_2	56	62	PF00498	0.491
LIG_LIR_Apic_2	252	257	PF02991	0.505
LIG_LIR_Apic_2	540	545	PF02991	0.360
LIG_LIR_Gen_1	536	545	PF02991	0.281
LIG_LIR_Gen_1	585	595	PF02991	0.282
LIG_LIR_Nem_3	536	542	PF02991	0.266
LIG_LIR_Nem_3	585	591	PF02991	0.267
LIG_Pex14_1	471	475	PF04695	0.332
LIG_Pex14_1	512	516	PF04695	0.266
LIG_SH2_CRK	588	592	PF00017	0.411
LIG_SH2_NCK_1	20	24	PF00017	0.461
LIG_SH2_NCK_1	573	577	PF00017	0.276
LIG_SH2_PTP2	561	564	PF00017	0.266
LIG_SH2_SRC	195	198	PF00017	0.598
LIG_SH2_SRC	561	564	PF00017	0.295
LIG_SH2_STAP1	195	199	PF00017	0.455
LIG_SH2_STAP1	20	24	PF00017	0.461
LIG_SH2_STAP1	216	220	PF00017	0.414
LIG_SH2_STAP1	539	543	PF00017	0.300
LIG_SH2_STAP1	573	577	PF00017	0.387
LIG_SH2_STAT5	20	23	PF00017	0.481
LIG_SH2_STAT5	216	219	PF00017	0.462
LIG_SH2_STAT5	410	413	PF00017	0.585
LIG_SH2_STAT5	561	564	PF00017	0.266
LIG_SH3_3	456	462	PF00018	0.664
LIG_SH3_3	466	472	PF00018	0.588
LIG_SUMO_SIM_anti_2	430	436	PF11976	0.685
LIG_SUMO_SIM_par_1	67	74	PF11976	0.434
LIG_TRAF2_1	198	201	PF00917	0.578
LIG_TRAF2_1	256	259	PF00917	0.578
LIG_TRAF2_1	381	384	PF00917	0.727
LIG_TRAF2_1	42	45	PF00917	0.567
LIG_TYR_ITIM	559	564	PF00017	0.266
MOD_CDK_SPxxK_3	253	260	PF00069	0.474
MOD_CK1_1	100	106	PF00069	0.673
MOD_CK1_1	249	255	PF00069	0.619
MOD_CK1_1	358	364	PF00069	0.702
MOD_CK1_1	392	398	PF00069	0.728
MOD_CK1_1	586	592	PF00069	0.300
MOD_CK2_1	138	144	PF00069	0.759
MOD_CK2_1	195	201	PF00069	0.608
MOD_CK2_1	253	259	PF00069	0.470
MOD_CK2_1	263	269	PF00069	0.487
MOD_CK2_1	332	338	PF00069	0.642
MOD_CK2_1	351	357	PF00069	0.726
MOD_CK2_1	39	45	PF00069	0.544
MOD_CK2_1	406	412	PF00069	0.664
MOD_CK2_1	55	61	PF00069	0.329
MOD_Cter_Amidation	126	129	PF01082	0.679
MOD_Cter_Amidation	361	364	PF01082	0.647
MOD_GlcNHglycan	102	105	PF01048	0.477
MOD_GlcNHglycan	14	17	PF01048	0.613
MOD_GlcNHglycan	141	144	PF01048	0.587
MOD_GlcNHglycan	241	246	PF01048	0.575
MOD_GlcNHglycan	251	254	PF01048	0.576
MOD_GlcNHglycan	264	268	PF01048	0.581
MOD_GlcNHglycan	304	308	PF01048	0.696
MOD_GlcNHglycan	357	360	PF01048	0.640
MOD_GlcNHglycan	365	369	PF01048	0.682
MOD_GlcNHglycan	465	469	PF01048	0.643
MOD_GlcNHglycan	84	88	PF01048	0.560
MOD_GSK3_1	110	117	PF00069	0.691
MOD_GSK3_1	249	256	PF00069	0.594
MOD_GSK3_1	328	335	PF00069	0.503
MOD_GSK3_1	347	354	PF00069	0.568
MOD_GSK3_1	384	391	PF00069	0.709
MOD_GSK3_1	537	544	PF00069	0.308
MOD_GSK3_1	65	72	PF00069	0.587
MOD_GSK3_1	93	100	PF00069	0.568
MOD_N-GLC_1	114	119	PF02516	0.647
MOD_N-GLC_2	36	38	PF02516	0.575
MOD_NEK2_1	114	119	PF00069	0.625
MOD_NEK2_1	162	167	PF00069	0.461
MOD_NEK2_1	475	480	PF00069	0.494
MOD_NEK2_1	71	76	PF00069	0.361
MOD_NEK2_2	155	160	PF00069	0.496
MOD_PIKK_1	291	297	PF00454	0.592
MOD_PIKK_1	392	398	PF00454	0.777
MOD_PIKK_1	524	530	PF00454	0.335
MOD_PKA_1	235	241	PF00069	0.634
MOD_PKA_2	162	168	PF00069	0.535
MOD_PKA_2	235	241	PF00069	0.634
MOD_PKA_2	392	398	PF00069	0.745
MOD_PKA_2	481	487	PF00069	0.491
MOD_Plk_1	195	201	PF00069	0.582
MOD_Plk_1	328	334	PF00069	0.581
MOD_Plk_1	419	425	PF00069	0.525
MOD_Plk_1	512	518	PF00069	0.167
MOD_Plk_4	235	241	PF00069	0.634
MOD_Plk_4	243	249	PF00069	0.627
MOD_Plk_4	328	334	PF00069	0.641
MOD_Plk_4	339	345	PF00069	0.573
MOD_Plk_4	406	412	PF00069	0.530
MOD_Plk_4	476	482	PF00069	0.590
MOD_Plk_4	495	501	PF00069	0.171
MOD_Plk_4	586	592	PF00069	0.411
MOD_Plk_4	71	77	PF00069	0.405
MOD_ProDKin_1	246	252	PF00069	0.513
MOD_ProDKin_1	253	259	PF00069	0.499
MOD_ProDKin_1	347	353	PF00069	0.705
MOD_ProDKin_1	455	461	PF00069	0.717
MOD_ProDKin_1	541	547	PF00069	0.343
MOD_ProDKin_1	583	589	PF00069	0.267
MOD_SUMO_for_1	577	580	PF00179	0.287
MOD_SUMO_rev_2	196	205	PF00179	0.530
MOD_SUMO_rev_2	589	598	PF00179	0.461
TRG_DiLeu_BaEn_1	594	599	PF01217	0.430
TRG_DiLeu_BaLyEn_6	222	227	PF01217	0.490
TRG_ENDOCYTIC_2	539	542	PF00928	0.266
TRG_ENDOCYTIC_2	561	564	PF00928	0.266
TRG_ENDOCYTIC_2	588	591	PF00928	0.388
TRG_ER_diArg_1	397	399	PF00400	0.607
TRG_ER_diArg_1	404	406	PF00400	0.533
TRG_ER_diArg_1	516	519	PF00400	0.281
TRG_NLS_MonoExtC_3	124	129	PF00514	0.714
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	272	277	PF00026	0.366
TRG_Pf-PMV_PEXEL_1	623	627	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGL1	Leptomonas seymouri	68%	100%
A0A0S4IUQ4	Bodo saltans	38%	98%
A0A1X0NNW7	Trypanosomatidae	44%	98%
A0A3S5H626	Leishmania donovani	91%	100%
A0A3S5IQP6	Trypanosoma rangeli	48%	100%
A4H574	Leishmania braziliensis	78%	100%
A4HTF7	Leishmania infantum	92%	100%
C9ZPN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4QIG2	Leishmania major	90%	100%
V5BH64	Trypanosoma cruzi	46%	100%