LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM82_LEIMU

TriTrypDb:

LmxM.08.0040

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM82

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.452
CLV_NRD_NRD_1	38	40	PF00675	0.515
CLV_PCSK_KEX2_1	105	107	PF00082	0.471
CLV_PCSK_KEX2_1	116	118	PF00082	0.433
CLV_PCSK_KEX2_1	38	40	PF00082	0.515
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.494
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.453
CLV_PCSK_SKI1_1	39	43	PF00082	0.585
DEG_APCC_DBOX_1	131	139	PF00400	0.503
DEG_APCC_DBOX_1	209	217	PF00400	0.596
DEG_Nend_UBRbox_3	1	3	PF02207	0.486
DOC_MAPK_gen_1	105	114	PF00069	0.453
DOC_MAPK_gen_1	207	217	PF00069	0.608
DOC_MAPK_MEF2A_6	210	217	PF00069	0.594
DOC_USP7_MATH_1	70	74	PF00917	0.764
DOC_USP7_MATH_1	78	82	PF00917	0.470
DOC_WW_Pin1_4	180	185	PF00397	0.535
LIG_14-3-3_CanoR_1	172	181	PF00244	0.480
LIG_14-3-3_CanoR_1	210	214	PF00244	0.590
LIG_14-3-3_CanoR_1	38	48	PF00244	0.612
LIG_14-3-3_CanoR_1	56	62	PF00244	0.547
LIG_14-3-3_CanoR_1	89	94	PF00244	0.786
LIG_FHA_1	173	179	PF00498	0.539
LIG_FHA_1	191	197	PF00498	0.266
LIG_FHA_1	40	46	PF00498	0.592
LIG_FHA_2	8	14	PF00498	0.694
LIG_LIR_Gen_1	7	17	PF02991	0.608
LIG_LIR_Nem_3	54	58	PF02991	0.517
LIG_LIR_Nem_3	7	12	PF02991	0.604
LIG_PTB_Apo_2	215	222	PF02174	0.586
LIG_PTB_Phospho_1	215	221	PF10480	0.584
LIG_SH2_CRK	55	59	PF00017	0.516
LIG_SH2_NCK_1	118	122	PF00017	0.420
LIG_SH2_STAP1	118	122	PF00017	0.420
LIG_SH2_STAP1	174	178	PF00017	0.533
LIG_SH2_STAT5	152	155	PF00017	0.553
LIG_SH2_STAT5	174	177	PF00017	0.495
LIG_SH2_STAT5	35	38	PF00017	0.439
LIG_SH3_3	156	162	PF00018	0.524
LIG_SH3_3	178	184	PF00018	0.500
LIG_SH3_3	64	70	PF00018	0.703
LIG_UBA3_1	111	116	PF00899	0.572
LIG_WW_3	93	97	PF00397	0.598
MOD_CDC14_SPxK_1	183	186	PF00782	0.595
MOD_CDK_SPxK_1	180	186	PF00069	0.571
MOD_CK1_1	7	13	PF00069	0.690
MOD_CK2_1	7	13	PF00069	0.657
MOD_CMANNOS	219	222	PF00535	0.491
MOD_GlcNHglycan	72	75	PF01048	0.719
MOD_GlcNHglycan	82	85	PF01048	0.585
MOD_GlcNHglycan	91	94	PF01048	0.749
MOD_GlcNHglycan	97	102	PF01048	0.667
MOD_GSK3_1	172	179	PF00069	0.505
MOD_GSK3_1	186	193	PF00069	0.466
MOD_N-GLC_1	1	6	PF02516	0.423
MOD_NEK2_1	31	36	PF00069	0.549
MOD_NEK2_1	41	46	PF00069	0.468
MOD_NEK2_1	79	84	PF00069	0.689
MOD_PK_1	186	192	PF00069	0.640
MOD_PKA_2	209	215	PF00069	0.596
MOD_PKB_1	87	95	PF00069	0.490
MOD_Plk_1	186	192	PF00069	0.550
MOD_Plk_1	4	10	PF00069	0.693
MOD_Plk_4	4	10	PF00069	0.664
MOD_ProDKin_1	180	186	PF00069	0.535
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.461
TRG_ENDOCYTIC_2	55	58	PF00928	0.508
TRG_ER_diArg_1	132	135	PF00400	0.505
TRG_Pf-PMV_PEXEL_1	134	139	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAM0	Leptomonas seymouri	58%	100%
A0A1X0NQK9	Trypanosomatidae	36%	91%
A0A3S7WQ20	Leishmania donovani	92%	100%
A0A422N813	Trypanosoma rangeli	32%	83%
A4H571	Leishmania braziliensis	82%	100%
A4HTF4	Leishmania infantum	92%	100%
C9ZPN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	84%
Q4QIG5	Leishmania major	93%	100%
V5BLP0	Trypanosoma cruzi	29%	78%