Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM80_LEIMU

TriTrypDb:

LmxM.08.0020

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.400
CLV_NRD_NRD_1	23	25	PF00675	0.596
CLV_PCSK_KEX2_1	25	27	PF00082	0.555
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.556
CLV_PCSK_SKI1_1	143	147	PF00082	0.479
DOC_MAPK_DCC_7	39	47	PF00069	0.643
DOC_MAPK_MEF2A_6	160	167	PF00069	0.540
DOC_MAPK_MEF2A_6	39	47	PF00069	0.662
DOC_PP1_RVXF_1	201	207	PF00149	0.351
DOC_PP2B_LxvP_1	181	184	PF13499	0.511
DOC_PP2B_LxvP_1	20	23	PF13499	0.558
DOC_PP2B_PxIxI_1	162	168	PF00149	0.472
DOC_PP4_FxxP_1	124	127	PF00568	0.618
DOC_PP4_FxxP_1	82	85	PF00568	0.507
DOC_WW_Pin1_4	147	152	PF00397	0.570
DOC_WW_Pin1_4	195	200	PF00397	0.590
LIG_14-3-3_CanoR_1	172	177	PF00244	0.518
LIG_APCC_ABBA_1	95	100	PF00400	0.585
LIG_BIR_II_1	1	5	PF00653	0.729
LIG_BIR_III_2	35	39	PF00653	0.518
LIG_BRCT_BRCA1_1	1	5	PF00533	0.553
LIG_BRCT_BRCA1_1	72	76	PF00533	0.546
LIG_EVH1_1	181	185	PF00568	0.595
LIG_EVH1_2	184	188	PF00568	0.584
LIG_FHA_1	104	110	PF00498	0.653
LIG_FHA_1	171	177	PF00498	0.547
LIG_FHA_1	53	59	PF00498	0.647
LIG_FHA_1	92	98	PF00498	0.655
LIG_FHA_2	257	263	PF00498	0.439
LIG_LIR_Apic_2	266	272	PF02991	0.397
LIG_LIR_Gen_1	54	65	PF02991	0.563
LIG_LIR_Nem_3	187	191	PF02991	0.539
LIG_LIR_Nem_3	54	60	PF02991	0.559
LIG_LIR_Nem_3	73	79	PF02991	0.451
LIG_LYPXL_yS_3	162	165	PF13949	0.556
LIG_MLH1_MIPbox_1	1	5	PF16413	0.553
LIG_SH2_CRK	269	273	PF00017	0.431
LIG_SH2_CRK	83	87	PF00017	0.572
LIG_SH2_STAP1	32	36	PF00017	0.657
LIG_SH2_STAT3	205	208	PF00017	0.421
LIG_SH2_STAT5	209	212	PF00017	0.567
LIG_SH2_STAT5	252	255	PF00017	0.419
LIG_SH3_3	117	123	PF00018	0.552
LIG_SH3_3	176	182	PF00018	0.583
LIG_SH3_3	61	67	PF00018	0.564
LIG_SUMO_SIM_anti_2	175	180	PF11976	0.624
MOD_CK1_1	166	172	PF00069	0.353
MOD_CK1_1	198	204	PF00069	0.547
MOD_CK2_1	101	107	PF00069	0.585
MOD_CK2_1	256	262	PF00069	0.542
MOD_GlcNHglycan	100	104	PF01048	0.589
MOD_GlcNHglycan	226	229	PF01048	0.512
MOD_GlcNHglycan	72	75	PF01048	0.690
MOD_GlcNHglycan	91	94	PF01048	0.577
MOD_GSK3_1	166	173	PF00069	0.503
MOD_GSK3_1	194	201	PF00069	0.649
MOD_GSK3_1	52	59	PF00069	0.596
MOD_GSK3_1	89	96	PF00069	0.586
MOD_GSK3_1	99	106	PF00069	0.548
MOD_N-GLC_1	194	199	PF02516	0.380
MOD_N-GLC_1	262	267	PF02516	0.441
MOD_N-GLC_1	52	57	PF02516	0.663
MOD_NEK2_1	99	104	PF00069	0.665
MOD_NEK2_2	93	98	PF00069	0.713
MOD_PIKK_1	166	172	PF00454	0.595
MOD_PK_1	172	178	PF00069	0.491
MOD_Plk_1	152	158	PF00069	0.533
MOD_Plk_1	52	58	PF00069	0.650
MOD_Plk_4	174	180	PF00069	0.526
MOD_Plk_4	248	254	PF00069	0.304
MOD_Plk_4	53	59	PF00069	0.571
MOD_ProDKin_1	147	153	PF00069	0.573
MOD_ProDKin_1	195	201	PF00069	0.580
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.583
TRG_ENDOCYTIC_2	162	165	PF00928	0.583
TRG_ENDOCYTIC_2	83	86	PF00928	0.698
TRG_ER_diArg_1	23	26	PF00400	0.636
TRG_NLS_MonoExtC_3	23	28	PF00514	0.634
TRG_NLS_MonoExtN_4	23	28	PF00514	0.632
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE07	Leptomonas seymouri	58%	98%
A0A1X0NNW9	Trypanosomatidae	30%	100%
A0A3S5H624	Leishmania donovani	91%	100%
A0A422N819	Trypanosoma rangeli	35%	100%
A4H569	Leishmania braziliensis	72%	100%
A4HTF2	Leishmania infantum	92%	100%
C9ZPM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4QIG7	Leishmania major	89%	100%
V5BLP6	Trypanosoma cruzi	34%	100%