3,2-trans-enoyl-CoA isomerase, mitochondrial-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3,2-trans-enoyl-CoA isomerase, mitochondrial precursor-like protein

Species:

Leishmania mexicana

UniProt:

E9AM78_LEIMU

TriTrypDb:

LmxM.08_29.0010

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0005737	cytoplasm	2	1
GO:0020023	kinetoplast	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AM78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM78

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0006635	fatty acid beta-oxidation	6	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009062	fatty acid catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0016042	lipid catabolic process	4	2
GO:0016054	organic acid catabolic process	4	2
GO:0019395	fatty acid oxidation	5	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0030258	lipid modification	4	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0034440	lipid oxidation	5	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044242	cellular lipid catabolic process	4	2
GO:0044248	cellular catabolic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	2
GO:0046395	carboxylic acid catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0072329	monocarboxylic acid catabolic process	6	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0016853	isomerase activity	2	15
GO:0004165	delta(3)-delta(2)-enoyl-CoA isomerase activity	5	4
GO:0004300	enoyl-CoA hydratase activity	5	2
GO:0016829	lyase activity	2	2
GO:0016835	carbon-oxygen lyase activity	3	2
GO:0016836	hydro-lyase activity	4	2
GO:0016860	intramolecular oxidoreductase activity	3	4
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.371
CLV_NRD_NRD_1	191	193	PF00675	0.300
CLV_NRD_NRD_1	253	255	PF00675	0.268
CLV_PCSK_KEX2_1	155	157	PF00082	0.371
CLV_PCSK_KEX2_1	253	255	PF00082	0.294
CLV_PCSK_PC7_1	151	157	PF00082	0.371
CLV_PCSK_SKI1_1	117	121	PF00082	0.317
CLV_PCSK_SKI1_1	254	258	PF00082	0.266
CLV_PCSK_SKI1_1	292	296	PF00082	0.563
DEG_APCC_DBOX_1	253	261	PF00400	0.313
DEG_Nend_UBRbox_1	1	4	PF02207	0.574
DOC_CKS1_1	260	265	PF01111	0.293
DOC_CKS1_1	53	58	PF01111	0.336
DOC_CYCLIN_RxL_1	232	241	PF00134	0.318
DOC_CYCLIN_yCln2_LP_2	239	245	PF00134	0.282
DOC_MAPK_gen_1	74	82	PF00069	0.205
DOC_MAPK_JIP1_4	160	166	PF00069	0.231
DOC_MAPK_MEF2A_6	160	168	PF00069	0.391
DOC_PP2B_LxvP_1	125	128	PF13499	0.281
DOC_PP2B_LxvP_1	237	240	PF13499	0.342
DOC_PP4_FxxP_1	175	178	PF00568	0.371
DOC_PP4_FxxP_1	277	280	PF00568	0.172
DOC_USP7_MATH_1	128	132	PF00917	0.274
DOC_USP7_MATH_1	145	149	PF00917	0.159
DOC_USP7_MATH_1	22	26	PF00917	0.519
DOC_USP7_MATH_1	72	76	PF00917	0.386
DOC_USP7_UBL2_3	292	296	PF12436	0.627
DOC_WW_Pin1_4	238	243	PF00397	0.395
DOC_WW_Pin1_4	259	264	PF00397	0.293
DOC_WW_Pin1_4	33	38	PF00397	0.322
DOC_WW_Pin1_4	52	57	PF00397	0.238
LIG_14-3-3_CanoR_1	16	21	PF00244	0.575
LIG_14-3-3_CanoR_1	5	12	PF00244	0.500
LIG_BRCT_BRCA1_1	86	90	PF00533	0.184
LIG_DLG_GKlike_1	16	24	PF00625	0.353
LIG_FHA_1	163	169	PF00498	0.295
LIG_FHA_1	19	25	PF00498	0.501
LIG_FHA_1	260	266	PF00498	0.243
LIG_LIR_Gen_1	113	122	PF02991	0.284
LIG_LIR_Nem_3	106	111	PF02991	0.288
LIG_LIR_Nem_3	113	118	PF02991	0.266
LIG_LIR_Nem_3	270	276	PF02991	0.345
LIG_Pex14_2	108	112	PF04695	0.259
LIG_Pex14_2	115	119	PF04695	0.264
LIG_Pex14_2	273	277	PF04695	0.307
LIG_Pex14_2	58	62	PF04695	0.316
LIG_SH2_STAT3	111	114	PF00017	0.256
LIG_SH2_STAT5	180	183	PF00017	0.337
LIG_SH3_1	155	161	PF00018	0.444
LIG_SH3_3	155	161	PF00018	0.360
LIG_SH3_3	50	56	PF00018	0.341
LIG_SUMO_SIM_anti_2	25	36	PF11976	0.483
LIG_SUMO_SIM_anti_2	39	45	PF11976	0.456
LIG_SUMO_SIM_par_1	142	149	PF11976	0.200
LIG_SUMO_SIM_par_1	234	241	PF11976	0.371
LIG_SUMO_SIM_par_1	25	36	PF11976	0.366
LIG_SUMO_SIM_par_1	39	45	PF11976	0.315
MOD_CDK_SPxxK_3	259	266	PF00069	0.293
MOD_CK1_1	25	31	PF00069	0.363
MOD_CK1_1	75	81	PF00069	0.293
MOD_CK1_1	84	90	PF00069	0.216
MOD_CK2_1	202	208	PF00069	0.172
MOD_GlcNHglycan	130	133	PF01048	0.261
MOD_GlcNHglycan	204	207	PF01048	0.338
MOD_GlcNHglycan	26	30	PF01048	0.555
MOD_GlcNHglycan	49	52	PF01048	0.313
MOD_GlcNHglycan	59	62	PF01048	0.295
MOD_GlcNHglycan	77	80	PF01048	0.251
MOD_GlcNHglycan	86	89	PF01048	0.254
MOD_GlcNHglycan	90	93	PF01048	0.229
MOD_GSK3_1	16	23	PF00069	0.592
MOD_GSK3_1	80	87	PF00069	0.234
MOD_GSK3_1	97	104	PF00069	0.205
MOD_N-GLC_1	101	106	PF02516	0.231
MOD_N-GLC_1	162	167	PF02516	0.275
MOD_N-GLC_1	47	52	PF02516	0.137
MOD_NEK2_1	118	123	PF00069	0.254
MOD_NEK2_1	20	25	PF00069	0.539
MOD_NEK2_1	4	9	PF00069	0.473
MOD_NEK2_1	82	87	PF00069	0.212
MOD_OFUCOSY	3	8	PF10250	0.438
MOD_PIKK_1	101	107	PF00454	0.317
MOD_PIKK_1	110	116	PF00454	0.258
MOD_PIKK_1	264	270	PF00454	0.301
MOD_PKA_2	4	10	PF00069	0.497
MOD_Plk_1	162	168	PF00069	0.364
MOD_Plk_4	10	16	PF00069	0.486
MOD_Plk_4	176	182	PF00069	0.351
MOD_ProDKin_1	238	244	PF00069	0.395
MOD_ProDKin_1	259	265	PF00069	0.293
MOD_ProDKin_1	33	39	PF00069	0.313
MOD_ProDKin_1	52	58	PF00069	0.238
TRG_ENDOCYTIC_2	150	153	PF00928	0.320
TRG_ENDOCYTIC_2	245	248	PF00928	0.327
TRG_ENDOCYTIC_2	274	277	PF00928	0.258
TRG_NES_CRM1_1	57	71	PF08389	0.132

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z0	Leptomonas seymouri	26%	100%
A0A0N1I4C8	Leptomonas seymouri	33%	84%
A0A0N1PBS2	Leptomonas seymouri	68%	99%
A0A0S4IKH3	Bodo saltans	36%	86%
A0A0S4JA19	Bodo saltans	46%	88%
A0A1X0NJ83	Trypanosomatidae	27%	100%
A0A1X0NRI1	Trypanosomatidae	33%	80%
A0A3Q8IE71	Leishmania donovani	90%	100%
A0A3Q8IIZ5	Leishmania donovani	26%	100%
A0A3R7N7B2	Trypanosoma rangeli	22%	100%
A0A3S7X4R5	Leishmania donovani	35%	87%
A0A3S7X4T7	Leishmania donovani	34%	87%
A0A422N418	Trypanosoma rangeli	34%	86%
A0A422NUW6	Trypanosoma rangeli	49%	100%
A1KN36	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	27%	100%
A4HH09	Leishmania braziliensis	76%	100%
A4HJK3	Leishmania braziliensis	32%	100%
A4HJK8	Leishmania braziliensis	33%	100%
A4HJL5	Leishmania braziliensis	32%	100%
A4I438	Leishmania infantum	90%	100%
A4I4U5	Leishmania infantum	26%	100%
A4I708	Leishmania infantum	35%	87%
A4I738	Leishmania infantum	34%	85%
A5U753	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	27%	100%
C9ZKS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	95%
C9ZLJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZWP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	83%
E9ADK3	Leishmania major	89%	100%
E9AE93	Leishmania major	26%	100%
E9ALJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B226	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	87%
E9B233	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	87%
E9B5S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
F1LU71	Rattus norvegicus	27%	94%
F4JML5	Arabidopsis thaliana	25%	98%
F9XMX6	Zymoseptoria tritici (strain CBS 115943 / IPO323)	27%	97%
O04469	Arabidopsis thaliana	26%	100%
P23965	Rattus norvegicus	34%	100%
P34559	Caenorhabditis elegans	24%	100%
P42125	Mus musculus	35%	100%
P42126	Homo sapiens	34%	98%
P53526	Mycobacterium leprae (strain TN)	27%	100%
P9WNN2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	100%
P9WNN3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	100%
Q2HJD5	Bos taurus	26%	97%
Q2TBT3	Bos taurus	27%	100%
Q3TLP5	Mus musculus	25%	100%
Q4Q628	Leishmania major	35%	85%
Q4Q636	Leishmania major	36%	78%
Q52995	Rhizobium meliloti (strain 1021)	25%	100%
Q54HG7	Dictyostelium discoideum	28%	98%
Q58DM8	Bos taurus	23%	100%
Q6AYG5	Rattus norvegicus	28%	99%
Q7TXE1	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	27%	100%
Q86YB7	Homo sapiens	27%	100%
Q9D9V3	Mus musculus	28%	92%
Q9JLZ3	Mus musculus	27%	94%
V5B2L9	Trypanosoma cruzi	37%	76%
V5BK92	Trypanosoma cruzi	49%	100%
V5BWB9	Trypanosoma cruzi	26%	81%
V5DTT7	Trypanosoma cruzi	27%	100%