Ribosomal protein L3-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal protein L3-like protein

Species:

Leishmania mexicana

UniProt:

E9AM76_LEIMU

TriTrypDb:

LmxM.08_29.0030

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	12
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AM76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM76

PDB structure(s): 7aih_A , 7am2_A , 7ane_A

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.373
CLV_NRD_NRD_1	17	19	PF00675	0.616
CLV_NRD_NRD_1	271	273	PF00675	0.276
CLV_NRD_NRD_1	28	30	PF00675	0.417
CLV_NRD_NRD_1	424	426	PF00675	0.453
CLV_NRD_NRD_1	428	430	PF00675	0.474
CLV_NRD_NRD_1	435	437	PF00675	0.488
CLV_NRD_NRD_1	455	457	PF00675	0.302
CLV_PCSK_KEX2_1	17	19	PF00082	0.617
CLV_PCSK_KEX2_1	271	273	PF00082	0.276
CLV_PCSK_KEX2_1	28	30	PF00082	0.402
CLV_PCSK_KEX2_1	282	284	PF00082	0.276
CLV_PCSK_KEX2_1	455	457	PF00082	0.491
CLV_PCSK_KEX2_1	463	465	PF00082	0.491
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.276
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.516
CLV_PCSK_SKI1_1	137	141	PF00082	0.381
CLV_PCSK_SKI1_1	229	233	PF00082	0.276
CLV_PCSK_SKI1_1	366	370	PF00082	0.542
CLV_PCSK_SKI1_1	402	406	PF00082	0.552
CLV_PCSK_SKI1_1	455	459	PF00082	0.518
CLV_PCSK_SKI1_1	463	467	PF00082	0.514
DEG_APCC_DBOX_1	129	137	PF00400	0.314
DOC_CDC14_PxL_1	315	323	PF14671	0.364
DOC_CDC14_PxL_1	35	43	PF14671	0.491
DOC_CKS1_1	213	218	PF01111	0.517
DOC_MAPK_FxFP_2	156	159	PF00069	0.367
DOC_MAPK_gen_1	229	239	PF00069	0.476
DOC_MAPK_gen_1	434	443	PF00069	0.479
DOC_MAPK_gen_1	90	100	PF00069	0.377
DOC_MAPK_MEF2A_6	232	241	PF00069	0.476
DOC_PP4_FxxP_1	156	159	PF00568	0.367
DOC_PP4_FxxP_1	189	192	PF00568	0.328
DOC_USP7_UBL2_3	426	430	PF12436	0.594
DOC_WW_Pin1_4	212	217	PF00397	0.476
DOC_WW_Pin1_4	347	352	PF00397	0.554
DOC_WW_Pin1_4	373	378	PF00397	0.427
LIG_14-3-3_CanoR_1	28	38	PF00244	0.497
LIG_14-3-3_CanoR_1	429	433	PF00244	0.536
LIG_14-3-3_CterR_2	464	467	PF00244	0.640
LIG_ActinCP_TwfCPI_2	189	199	PF01115	0.363
LIG_AP2alpha_1	383	387	PF02296	0.440
LIG_BRCT_BRCA1_1	127	131	PF00533	0.381
LIG_BRCT_BRCA1_1	208	212	PF00533	0.562
LIG_CSL_BTD_1	156	159	PF09270	0.367
LIG_FHA_1	173	179	PF00498	0.417
LIG_FHA_2	138	144	PF00498	0.396
LIG_FHA_2	222	228	PF00498	0.471
LIG_FHA_2	318	324	PF00498	0.369
LIG_FHA_2	392	398	PF00498	0.575
LIG_FHA_2	82	88	PF00498	0.427
LIG_LIR_Apic_2	111	117	PF02991	0.419
LIG_LIR_Apic_2	154	159	PF02991	0.360
LIG_LIR_Apic_2	188	192	PF02991	0.328
LIG_LIR_Gen_1	122	131	PF02991	0.400
LIG_LIR_Gen_1	143	151	PF02991	0.389
LIG_LIR_Gen_1	258	266	PF02991	0.476
LIG_LIR_Gen_1	328	336	PF02991	0.384
LIG_LIR_Gen_1	84	94	PF02991	0.417
LIG_LIR_Gen_1	95	105	PF02991	0.292
LIG_LIR_Nem_3	102	107	PF02991	0.411
LIG_LIR_Nem_3	122	126	PF02991	0.420
LIG_LIR_Nem_3	128	134	PF02991	0.356
LIG_LIR_Nem_3	143	147	PF02991	0.340
LIG_LIR_Nem_3	217	222	PF02991	0.474
LIG_LIR_Nem_3	245	251	PF02991	0.471
LIG_LIR_Nem_3	258	264	PF02991	0.476
LIG_LIR_Nem_3	299	304	PF02991	0.476
LIG_LIR_Nem_3	32	38	PF02991	0.473
LIG_LIR_Nem_3	328	332	PF02991	0.376
LIG_LIR_Nem_3	350	356	PF02991	0.542
LIG_LIR_Nem_3	48	53	PF02991	0.406
LIG_LIR_Nem_3	65	70	PF02991	0.402
LIG_LIR_Nem_3	84	89	PF02991	0.402
LIG_LIR_Nem_3	91	97	PF02991	0.365
LIG_LYPXL_S_1	66	70	PF13949	0.406
LIG_LYPXL_SIV_4	218	226	PF13949	0.476
LIG_LYPXL_yS_3	38	41	PF13949	0.442
LIG_LYPXL_yS_3	54	57	PF13949	0.381
LIG_LYPXL_yS_3	67	70	PF13949	0.415
LIG_Pex14_1	307	311	PF04695	0.476
LIG_Pex14_1	34	38	PF04695	0.442
LIG_Pex14_2	253	257	PF04695	0.476
LIG_Pex14_2	383	387	PF04695	0.427
LIG_PTB_Apo_2	240	247	PF02174	0.473
LIG_PTB_Phospho_1	240	246	PF10480	0.476
LIG_SH2_CRK	219	223	PF00017	0.486
LIG_SH2_CRK	248	252	PF00017	0.550
LIG_SH2_CRK	301	305	PF00017	0.476
LIG_SH2_CRK	462	466	PF00017	0.535
LIG_SH2_CRK	86	90	PF00017	0.416
LIG_SH2_NCK_1	219	223	PF00017	0.487
LIG_SH2_PTP2	261	264	PF00017	0.487
LIG_SH2_SRC	219	222	PF00017	0.476
LIG_SH2_STAP1	127	131	PF00017	0.365
LIG_SH2_STAP1	94	98	PF00017	0.366
LIG_SH2_STAT3	246	249	PF00017	0.562
LIG_SH2_STAT5	179	182	PF00017	0.409
LIG_SH2_STAT5	261	264	PF00017	0.487
LIG_SH2_STAT5	317	320	PF00017	0.361
LIG_SH2_STAT5	329	332	PF00017	0.375
LIG_SH2_STAT5	341	344	PF00017	0.416
LIG_SH2_STAT5	382	385	PF00017	0.417
LIG_SH2_STAT5	421	424	PF00017	0.477
LIG_SH2_STAT5	56	59	PF00017	0.385
LIG_SH3_1	348	354	PF00018	0.425
LIG_SH3_3	210	216	PF00018	0.504
LIG_SH3_3	348	354	PF00018	0.425
LIG_SH3_3	65	71	PF00018	0.405
LIG_SxIP_EBH_1	350	360	PF03271	0.298
LIG_TRAF2_1	233	236	PF00917	0.476
LIG_TRAF2_1	359	362	PF00917	0.461
LIG_TYR_ITIM	460	465	PF00017	0.529
LIG_TYR_ITSM	82	89	PF00017	0.431
LIG_WRC_WIRS_1	353	358	PF05994	0.440
LIG_WW_1	377	380	PF00397	0.436
MOD_CK1_1	297	303	PF00069	0.491
MOD_CK2_1	356	362	PF00069	0.489
MOD_CK2_1	37	43	PF00069	0.467
MOD_GlcNHglycan	20	23	PF01048	0.511
MOD_GlcNHglycan	208	211	PF01048	0.338
MOD_GlcNHglycan	296	299	PF01048	0.305
MOD_GlcNHglycan	4	7	PF01048	0.613
MOD_GSK3_1	237	244	PF00069	0.476
MOD_GSK3_1	335	342	PF00069	0.435
MOD_GSK3_1	352	359	PF00069	0.383
MOD_GSK3_1	362	369	PF00069	0.424
MOD_NEK2_1	125	130	PF00069	0.386
MOD_NEK2_1	151	156	PF00069	0.354
MOD_NEK2_1	264	269	PF00069	0.476
MOD_NEK2_1	332	337	PF00069	0.393
MOD_PIKK_1	391	397	PF00454	0.471
MOD_PKA_1	419	425	PF00069	0.597
MOD_PKA_2	2	8	PF00069	0.458
MOD_PKA_2	332	338	PF00069	0.521
MOD_PKA_2	428	434	PF00069	0.486
MOD_Plk_1	151	157	PF00069	0.362
MOD_Plk_1	235	241	PF00069	0.477
MOD_Plk_4	311	317	PF00069	0.377
MOD_Plk_4	325	331	PF00069	0.371
MOD_Plk_4	339	345	PF00069	0.430
MOD_Plk_4	352	358	PF00069	0.437
MOD_Plk_4	37	43	PF00069	0.447
MOD_Plk_4	62	68	PF00069	0.409
MOD_ProDKin_1	212	218	PF00069	0.476
MOD_ProDKin_1	347	353	PF00069	0.552
MOD_ProDKin_1	373	379	PF00069	0.426
MOD_SUMO_rev_2	397	404	PF00179	0.509
TRG_ENDOCYTIC_2	144	147	PF00928	0.402
TRG_ENDOCYTIC_2	219	222	PF00928	0.475
TRG_ENDOCYTIC_2	248	251	PF00928	0.519
TRG_ENDOCYTIC_2	261	264	PF00928	0.432
TRG_ENDOCYTIC_2	301	304	PF00928	0.476
TRG_ENDOCYTIC_2	329	332	PF00928	0.375
TRG_ENDOCYTIC_2	38	41	PF00928	0.442
TRG_ENDOCYTIC_2	380	383	PF00928	0.415
TRG_ENDOCYTIC_2	438	441	PF00928	0.538
TRG_ENDOCYTIC_2	462	465	PF00928	0.513
TRG_ENDOCYTIC_2	54	57	PF00928	0.381
TRG_ENDOCYTIC_2	67	70	PF00928	0.415
TRG_ENDOCYTIC_2	86	89	PF00928	0.424
TRG_ENDOCYTIC_2	94	97	PF00928	0.393
TRG_ER_diArg_1	17	19	PF00400	0.616
TRG_ER_diArg_1	271	273	PF00400	0.476
TRG_ER_diArg_1	28	31	PF00400	0.434
TRG_ER_diArg_1	443	446	PF00400	0.519
TRG_ER_diArg_1	98	101	PF00400	0.389
TRG_NLS_Bipartite_1	412	430	PF00514	0.463
TRG_NLS_MonoExtC_3	411	417	PF00514	0.474
TRG_NLS_MonoExtC_3	424	429	PF00514	0.461
TRG_NLS_MonoExtN_4	411	416	PF00514	0.493
TRG_NLS_MonoExtN_4	425	430	PF00514	0.442
TRG_NLS_MonoExtN_4	434	440	PF00514	0.483
TRG_NLS_MonoExtN_4	461	467	PF00514	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAL5	Leptomonas seymouri	91%	100%
A0A0S4IMW0	Bodo saltans	78%	100%
A0A1X0NZZ6	Trypanosomatidae	90%	99%
A0A3Q8IR02	Leishmania donovani	97%	100%
A0A422NUY5	Trypanosoma rangeli	90%	99%
A4HH11	Leishmania braziliensis	94%	100%
A4I440	Leishmania infantum	97%	100%
C9ZKS2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	88%	99%
E9ADK5	Leishmania major	98%	100%
V5BPV7	Trypanosoma cruzi	90%	88%