Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM75_LEIMU

TriTrypDb:

LmxM.08_29.0040

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM75

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.539
CLV_NRD_NRD_1	120	122	PF00675	0.549
CLV_NRD_NRD_1	135	137	PF00675	0.516
CLV_NRD_NRD_1	148	150	PF00675	0.570
CLV_NRD_NRD_1	15	17	PF00675	0.722
CLV_NRD_NRD_1	204	206	PF00675	0.510
CLV_NRD_NRD_1	22	24	PF00675	0.683
CLV_NRD_NRD_1	282	284	PF00675	0.460
CLV_PCSK_FUR_1	121	125	PF00082	0.588
CLV_PCSK_FUR_1	202	206	PF00082	0.515
CLV_PCSK_KEX2_1	120	122	PF00082	0.526
CLV_PCSK_KEX2_1	123	125	PF00082	0.551
CLV_PCSK_KEX2_1	135	137	PF00082	0.566
CLV_PCSK_KEX2_1	147	149	PF00082	0.575
CLV_PCSK_KEX2_1	15	17	PF00082	0.722
CLV_PCSK_KEX2_1	204	206	PF00082	0.572
CLV_PCSK_KEX2_1	22	24	PF00082	0.683
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.489
CLV_PCSK_PC7_1	144	150	PF00082	0.602
CLV_PCSK_SKI1_1	115	119	PF00082	0.486
CLV_PCSK_SKI1_1	120	124	PF00082	0.666
CLV_PCSK_SKI1_1	135	139	PF00082	0.586
CLV_PCSK_SKI1_1	171	175	PF00082	0.352
CLV_PCSK_SKI1_1	183	187	PF00082	0.514
CLV_PCSK_SKI1_1	218	222	PF00082	0.471
CLV_PCSK_SKI1_1	252	256	PF00082	0.383
DOC_CYCLIN_RxL_1	112	119	PF00134	0.574
DOC_CYCLIN_RxL_1	246	259	PF00134	0.373
DOC_MAPK_gen_1	22	30	PF00069	0.684
DOC_PP4_FxxP_1	126	129	PF00568	0.576
DOC_USP7_UBL2_3	186	190	PF12436	0.592
LIG_14-3-3_CanoR_1	107	111	PF00244	0.405
LIG_14-3-3_CanoR_1	183	192	PF00244	0.407
LIG_14-3-3_CanoR_1	209	213	PF00244	0.484
LIG_14-3-3_CanoR_1	252	258	PF00244	0.365
LIG_14-3-3_CanoR_1	37	45	PF00244	0.565
LIG_Actin_WH2_2	268	285	PF00022	0.484
LIG_Actin_WH2_2	91	109	PF00022	0.375
LIG_BIR_II_1	1	5	PF00653	0.434
LIG_FHA_1	175	181	PF00498	0.343
LIG_FHA_1	195	201	PF00498	0.558
LIG_FHA_2	107	113	PF00498	0.455
LIG_FHA_2	152	158	PF00498	0.456
LIG_FHA_2	254	260	PF00498	0.397
LIG_FHA_2	44	50	PF00498	0.483
LIG_LIR_Gen_1	83	91	PF02991	0.410
LIG_LIR_Gen_1	97	106	PF02991	0.326
LIG_LIR_Nem_3	132	137	PF02991	0.685
LIG_LIR_Nem_3	211	215	PF02991	0.479
LIG_LIR_Nem_3	276	282	PF02991	0.437
LIG_LIR_Nem_3	83	88	PF02991	0.445
LIG_LIR_Nem_3	97	103	PF02991	0.323
LIG_NRBOX	171	177	PF00104	0.339
LIG_PCNA_yPIPBox_3	171	185	PF02747	0.474
LIG_Pex14_2	215	219	PF04695	0.458
LIG_PTB_Apo_2	238	245	PF02174	0.515
LIG_SH2_CRK	100	104	PF00017	0.439
LIG_SH2_CRK	134	138	PF00017	0.623
LIG_SH2_CRK	203	207	PF00017	0.487
LIG_SH2_CRK	279	283	PF00017	0.452
LIG_SH2_NCK_1	100	104	PF00017	0.439
LIG_SH2_STAP1	100	104	PF00017	0.489
LIG_SH2_STAT5	165	168	PF00017	0.453
LIG_SH2_STAT5	253	256	PF00017	0.470
LIG_SUMO_SIM_anti_2	170	177	PF11976	0.362
LIG_SUMO_SIM_par_1	170	177	PF11976	0.344
LIG_TRAF2_1	73	76	PF00917	0.676
LIG_TRAF2_1	91	94	PF00917	0.223
LIG_TYR_ITIM	98	103	PF00017	0.424
MOD_CK1_1	40	46	PF00069	0.613
MOD_CK2_1	106	112	PF00069	0.611
MOD_CK2_1	253	259	PF00069	0.359
MOD_CK2_1	43	49	PF00069	0.568
MOD_GlcNHglycan	1	4	PF01048	0.570
MOD_GlcNHglycan	186	189	PF01048	0.467
MOD_GlcNHglycan	236	239	PF01048	0.548
MOD_GlcNHglycan	40	43	PF01048	0.736
MOD_NEK2_1	174	179	PF00069	0.347
MOD_NEK2_1	184	189	PF00069	0.455
MOD_NEK2_1	273	278	PF00069	0.535
MOD_NEK2_2	142	147	PF00069	0.612
MOD_PIKK_1	174	180	PF00454	0.422
MOD_PIKK_1	273	279	PF00454	0.476
MOD_PIKK_1	89	95	PF00454	0.350
MOD_PKA_2	106	112	PF00069	0.405
MOD_PKA_2	208	214	PF00069	0.460
MOD_Plk_1	142	148	PF00069	0.598
MOD_Plk_2-3	76	82	PF00069	0.629
MOD_SUMO_for_1	129	132	PF00179	0.646
MOD_SUMO_rev_2	69	79	PF00179	0.508
TRG_DiLeu_BaEn_4	75	81	PF01217	0.740
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.560
TRG_ENDOCYTIC_2	100	103	PF00928	0.445
TRG_ENDOCYTIC_2	134	137	PF00928	0.623
TRG_ENDOCYTIC_2	192	195	PF00928	0.384
TRG_ENDOCYTIC_2	279	282	PF00928	0.446
TRG_ER_diArg_1	120	122	PF00400	0.554
TRG_ER_diArg_1	134	136	PF00400	0.509
TRG_ER_diArg_1	146	149	PF00400	0.598
TRG_ER_diArg_1	152	155	PF00400	0.514
TRG_ER_diArg_1	203	205	PF00400	0.589
TRG_ER_diArg_1	21	23	PF00400	0.706
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.643

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIG8	Leptomonas seymouri	66%	100%
A0A0S4ITL7	Bodo saltans	34%	100%
A0A1X0NZE1	Trypanosomatidae	67%	96%
A0A3Q8IB97	Leishmania donovani	90%	100%
A0A3R7KKG3	Trypanosoma rangeli	65%	100%
A4HH12	Leishmania braziliensis	76%	100%
A4I441	Leishmania infantum	91%	100%
C9ZKS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9ADK6	Leishmania major	91%	100%
V5BUH7	Trypanosoma cruzi	60%	81%