WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM69_LEIMU

TriTrypDb:

LmxM.08_29.0100

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0030286	dynein complex	3	1
GO:0030990	intraciliary transport particle	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AM69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM69

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0010970	transport along microtubule	4	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0042073	intraciliary transport	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045503	dynein light chain binding	3	1
GO:0045504	dynein heavy chain binding	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	521	525	PF00656	0.539
CLV_NRD_NRD_1	121	123	PF00675	0.595
CLV_NRD_NRD_1	300	302	PF00675	0.483
CLV_NRD_NRD_1	438	440	PF00675	0.448
CLV_NRD_NRD_1	65	67	PF00675	0.608
CLV_PCSK_FUR_1	298	302	PF00082	0.553
CLV_PCSK_KEX2_1	300	302	PF00082	0.480
CLV_PCSK_KEX2_1	438	440	PF00082	0.498
CLV_PCSK_KEX2_1	65	67	PF00082	0.608
CLV_PCSK_SKI1_1	106	110	PF00082	0.469

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P997	Leptomonas seymouri	23%	89%
A0A0N1HUS1	Leptomonas seymouri	67%	100%
A0A0S4INJ7	Bodo saltans	23%	83%
A0A0S4KLW0	Bodo saltans	41%	96%
A0A1X0NUK4	Trypanosomatidae	25%	89%
A0A1X0P0W1	Trypanosomatidae	47%	100%
A0A3S5IRX8	Trypanosoma rangeli	47%	100%
A0A3S7X1Z8	Leishmania donovani	95%	100%
A0A3S7X5B2	Leishmania donovani	24%	89%
A0A422P1D5	Trypanosoma rangeli	24%	89%

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