WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM69_LEIMU

TriTrypDb:

LmxM.08_29.0100

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0030286	dynein complex	3	1
GO:0030990	intraciliary transport particle	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9AM69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM69

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0010970	transport along microtubule	4	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0042073	intraciliary transport	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0099111	microtubule-based transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045503	dynein light chain binding	3	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	521	525	PF00656	0.539
CLV_NRD_NRD_1	121	123	PF00675	0.595
CLV_NRD_NRD_1	300	302	PF00675	0.483
CLV_NRD_NRD_1	438	440	PF00675	0.448
CLV_NRD_NRD_1	65	67	PF00675	0.608
CLV_PCSK_FUR_1	298	302	PF00082	0.553
CLV_PCSK_KEX2_1	300	302	PF00082	0.480
CLV_PCSK_KEX2_1	438	440	PF00082	0.498
CLV_PCSK_KEX2_1	65	67	PF00082	0.608
CLV_PCSK_SKI1_1	106	110	PF00082	0.469
CLV_PCSK_SKI1_1	287	291	PF00082	0.526
CLV_PCSK_SKI1_1	384	388	PF00082	0.437
CLV_PCSK_SKI1_1	439	443	PF00082	0.494
CLV_PCSK_SKI1_1	506	510	PF00082	0.555
DEG_APCC_DBOX_1	403	411	PF00400	0.436
DEG_APCC_DBOX_1	437	445	PF00400	0.444
DOC_CYCLIN_RxL_1	381	392	PF00134	0.432
DOC_CYCLIN_yCln2_LP_2	288	294	PF00134	0.438
DOC_MAPK_gen_1	122	129	PF00069	0.548
DOC_MAPK_gen_1	172	178	PF00069	0.498
DOC_MAPK_gen_1	298	307	PF00069	0.401
DOC_MAPK_gen_1	341	349	PF00069	0.508
DOC_MAPK_gen_1	438	444	PF00069	0.422
DOC_MAPK_MEF2A_6	298	307	PF00069	0.418
DOC_USP7_MATH_1	108	112	PF00917	0.512
DOC_USP7_MATH_1	16	20	PF00917	0.648
DOC_USP7_MATH_1	259	263	PF00917	0.552
DOC_USP7_MATH_1	273	277	PF00917	0.493
DOC_USP7_MATH_1	373	377	PF00917	0.387
DOC_USP7_MATH_1	434	438	PF00917	0.338
DOC_USP7_MATH_1	458	462	PF00917	0.450
DOC_USP7_MATH_2	348	354	PF00917	0.593
DOC_USP7_UBL2_3	36	40	PF12436	0.700
DOC_WW_Pin1_4	114	119	PF00397	0.650
DOC_WW_Pin1_4	132	137	PF00397	0.286
DOC_WW_Pin1_4	280	285	PF00397	0.429
DOC_WW_Pin1_4	377	382	PF00397	0.349
DOC_WW_Pin1_4	402	407	PF00397	0.463
DOC_WW_Pin1_4	423	428	PF00397	0.357
LIG_14-3-3_CanoR_1	106	116	PF00244	0.541
LIG_14-3-3_CanoR_1	122	131	PF00244	0.456
LIG_14-3-3_CanoR_1	190	196	PF00244	0.557
LIG_14-3-3_CanoR_1	300	306	PF00244	0.489
LIG_14-3-3_CanoR_1	341	346	PF00244	0.548
LIG_14-3-3_CanoR_1	397	406	PF00244	0.466
LIG_14-3-3_CanoR_1	438	442	PF00244	0.397
LIG_14-3-3_CanoR_1	510	514	PF00244	0.601
LIG_Actin_WH2_2	174	189	PF00022	0.455
LIG_Actin_WH2_2	494	512	PF00022	0.558
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_BIR_III_4	484	488	PF00653	0.445
LIG_BRCT_BRCA1_1	109	113	PF00533	0.462
LIG_BRCT_BRCA1_1	202	206	PF00533	0.424
LIG_BRCT_BRCA1_1	379	383	PF00533	0.333
LIG_BRCT_BRCA1_1	468	472	PF00533	0.242
LIG_Clathr_ClatBox_1	331	335	PF01394	0.442
LIG_Clathr_ClatBox_1	407	411	PF01394	0.519
LIG_FHA_1	10	16	PF00498	0.574
LIG_FHA_1	107	113	PF00498	0.600
LIG_FHA_1	245	251	PF00498	0.454
LIG_FHA_1	32	38	PF00498	0.552
LIG_FHA_1	342	348	PF00498	0.513
LIG_FHA_1	455	461	PF00498	0.517
LIG_FHA_1	517	523	PF00498	0.629
LIG_FHA_1	524	530	PF00498	0.525
LIG_FHA_2	23	29	PF00498	0.665
LIG_FHA_2	388	394	PF00498	0.481
LIG_FHA_2	473	479	PF00498	0.451
LIG_FHA_2	500	506	PF00498	0.421
LIG_FHA_2	89	95	PF00498	0.558
LIG_LIR_Apic_2	344	348	PF02991	0.589
LIG_LIR_Nem_3	110	116	PF02991	0.459
LIG_LIR_Nem_3	311	315	PF02991	0.477
LIG_LIR_Nem_3	380	386	PF02991	0.338
LIG_LIR_Nem_3	422	428	PF02991	0.428
LIG_MLH1_MIPbox_1	379	383	PF16413	0.333
LIG_PAM2_1	470	482	PF00658	0.205
LIG_PDZ_Class_1	531	536	PF00595	0.622
LIG_Pex14_2	383	387	PF04695	0.466
LIG_REV1ctd_RIR_1	380	388	PF16727	0.421
LIG_SH2_CRK	312	316	PF00017	0.496
LIG_SH2_NCK_1	79	83	PF00017	0.468
LIG_SH2_PTP2	175	178	PF00017	0.448
LIG_SH2_SRC	322	325	PF00017	0.536
LIG_SH2_STAP1	237	241	PF00017	0.575
LIG_SH2_STAP1	456	460	PF00017	0.493
LIG_SH2_STAT5	131	134	PF00017	0.484
LIG_SH2_STAT5	175	178	PF00017	0.448
LIG_SH2_STAT5	268	271	PF00017	0.404
LIG_SH2_STAT5	322	325	PF00017	0.437
LIG_SH2_STAT5	419	422	PF00017	0.482
LIG_SH2_STAT5	456	459	PF00017	0.546
LIG_SH2_STAT5	77	80	PF00017	0.497
LIG_SH3_1	424	430	PF00018	0.465
LIG_SH3_3	12	18	PF00018	0.540
LIG_SH3_3	205	211	PF00018	0.495
LIG_SH3_3	221	227	PF00018	0.349
LIG_SH3_3	253	259	PF00018	0.486
LIG_SH3_3	424	430	PF00018	0.373
LIG_SUMO_SIM_anti_2	125	132	PF11976	0.532
LIG_SUMO_SIM_anti_2	247	254	PF11976	0.516
LIG_SUMO_SIM_anti_2	327	333	PF11976	0.396
LIG_SUMO_SIM_anti_2	431	437	PF11976	0.385
LIG_SUMO_SIM_par_1	212	218	PF11976	0.422
LIG_SUMO_SIM_par_1	360	365	PF11976	0.508
LIG_SUMO_SIM_par_1	405	416	PF11976	0.533
LIG_SUMO_SIM_par_1	431	437	PF11976	0.385
LIG_TRAF2_1	412	415	PF00917	0.410
LIG_TYR_ITIM	310	315	PF00017	0.499
LIG_WRC_WIRS_1	89	94	PF05994	0.524
MOD_CDC14_SPxK_1	426	429	PF00782	0.354
MOD_CDK_SPxK_1	423	429	PF00069	0.357
MOD_CDK_SPxxK_3	132	139	PF00069	0.445
MOD_CDK_SPxxK_3	280	287	PF00069	0.466
MOD_CDK_SPxxK_3	377	384	PF00069	0.443
MOD_CK1_1	239	245	PF00069	0.480
MOD_CK1_1	296	302	PF00069	0.442
MOD_CK1_1	392	398	PF00069	0.336
MOD_CK1_1	41	47	PF00069	0.669
MOD_CK1_1	413	419	PF00069	0.424
MOD_CK1_1	437	443	PF00069	0.368
MOD_CK1_1	499	505	PF00069	0.492
MOD_CK1_1	512	518	PF00069	0.527
MOD_CK2_1	22	28	PF00069	0.701
MOD_CK2_1	237	243	PF00069	0.473
MOD_CK2_1	397	403	PF00069	0.397
MOD_CK2_1	409	415	PF00069	0.452
MOD_CK2_1	472	478	PF00069	0.463
MOD_CK2_1	499	505	PF00069	0.412
MOD_CK2_1	88	94	PF00069	0.504
MOD_GlcNHglycan	165	169	PF01048	0.524
MOD_GlcNHglycan	219	222	PF01048	0.356
MOD_GlcNHglycan	239	242	PF01048	0.546
MOD_GlcNHglycan	271	274	PF01048	0.335
MOD_GlcNHglycan	275	278	PF01048	0.358
MOD_GlcNHglycan	377	380	PF01048	0.485
MOD_GlcNHglycan	393	397	PF01048	0.396
MOD_GlcNHglycan	460	463	PF01048	0.513
MOD_GSK3_1	114	121	PF00069	0.547
MOD_GSK3_1	125	132	PF00069	0.407
MOD_GSK3_1	196	203	PF00069	0.439
MOD_GSK3_1	23	30	PF00069	0.621
MOD_GSK3_1	235	242	PF00069	0.452
MOD_GSK3_1	244	251	PF00069	0.210
MOD_GSK3_1	269	276	PF00069	0.457
MOD_GSK3_1	301	308	PF00069	0.471
MOD_GSK3_1	314	321	PF00069	0.554
MOD_GSK3_1	373	380	PF00069	0.401
MOD_GSK3_1	388	395	PF00069	0.322
MOD_GSK3_1	402	409	PF00069	0.412
MOD_GSK3_1	454	461	PF00069	0.524
MOD_GSK3_1	512	519	PF00069	0.618
MOD_N-GLC_1	106	111	PF02516	0.522
MOD_N-GLC_1	227	232	PF02516	0.441
MOD_N-GLC_1	46	51	PF02516	0.564
MOD_N-GLC_1	472	477	PF02516	0.435
MOD_NEK2_1	146	151	PF00069	0.375
MOD_NEK2_1	163	168	PF00069	0.589
MOD_NEK2_1	186	191	PF00069	0.547
MOD_NEK2_1	386	391	PF00069	0.315
MOD_NEK2_1	472	477	PF00069	0.409
MOD_NEK2_1	509	514	PF00069	0.622
MOD_NEK2_1	531	536	PF00069	0.596
MOD_NEK2_1	93	98	PF00069	0.438
MOD_NEK2_2	108	113	PF00069	0.569
MOD_NEK2_2	293	298	PF00069	0.503
MOD_PIKK_1	271	277	PF00454	0.408
MOD_PIKK_1	29	35	PF00454	0.621
MOD_PIKK_1	350	356	PF00454	0.652
MOD_PIKK_1	41	47	PF00454	0.510
MOD_PIKK_1	496	502	PF00454	0.474
MOD_PIKK_1	509	515	PF00454	0.569
MOD_PIKK_1	95	101	PF00454	0.282
MOD_PK_1	301	307	PF00069	0.483
MOD_PKA_1	122	128	PF00069	0.514
MOD_PKA_1	22	28	PF00069	0.640
MOD_PKA_2	186	192	PF00069	0.542
MOD_PKA_2	318	324	PF00069	0.540
MOD_PKA_2	428	434	PF00069	0.365
MOD_PKA_2	437	443	PF00069	0.355
MOD_PKA_2	509	515	PF00069	0.505
MOD_Plk_1	125	131	PF00069	0.396
MOD_Plk_1	46	52	PF00069	0.616
MOD_Plk_1	496	502	PF00069	0.497
MOD_Plk_1	523	529	PF00069	0.452
MOD_Plk_1	93	99	PF00069	0.564
MOD_Plk_4	108	114	PF00069	0.270
MOD_Plk_4	125	131	PF00069	0.431
MOD_Plk_4	248	254	PF00069	0.473
MOD_Plk_4	318	324	PF00069	0.562
MOD_Plk_4	355	361	PF00069	0.485
MOD_Plk_4	428	434	PF00069	0.348
MOD_Plk_4	88	94	PF00069	0.491
MOD_ProDKin_1	114	120	PF00069	0.650
MOD_ProDKin_1	132	138	PF00069	0.282
MOD_ProDKin_1	280	286	PF00069	0.433
MOD_ProDKin_1	377	383	PF00069	0.349
MOD_ProDKin_1	402	408	PF00069	0.459
MOD_ProDKin_1	423	429	PF00069	0.354
TRG_DiLeu_LyEn_5	403	408	PF01217	0.506
TRG_ENDOCYTIC_2	161	164	PF00928	0.382
TRG_ENDOCYTIC_2	175	178	PF00928	0.421
TRG_ENDOCYTIC_2	312	315	PF00928	0.512
TRG_ENDOCYTIC_2	399	402	PF00928	0.371
TRG_ENDOCYTIC_2	79	82	PF00928	0.511
TRG_ER_diArg_1	297	300	PF00400	0.507
TRG_ER_diArg_1	65	67	PF00400	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P997	Leptomonas seymouri	23%	89%
A0A0N1HUS1	Leptomonas seymouri	67%	100%
A0A0S4INJ7	Bodo saltans	23%	83%
A0A0S4KLW0	Bodo saltans	41%	96%
A0A1X0NUK4	Trypanosomatidae	25%	89%
A0A1X0P0W1	Trypanosomatidae	47%	100%
A0A3S5IRX8	Trypanosoma rangeli	47%	100%
A0A3S7X1Z8	Leishmania donovani	95%	100%
A0A3S7X5B2	Leishmania donovani	24%	89%
A0A422P1D5	Trypanosoma rangeli	24%	89%
A2AC93	Mus musculus	24%	86%
A4HH18	Leishmania braziliensis	81%	100%
A4HK88	Leishmania braziliensis	24%	100%
A4I447	Leishmania infantum	95%	100%
A4I7S3	Leishmania infantum	24%	89%
C9ZKR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ADL2	Leishmania major	94%	100%
E9PYY5	Mus musculus	24%	66%
P54703	Dictyostelium discoideum	21%	82%
Q16959	Heliocidaris crassispina	23%	76%
Q16960	Heliocidaris crassispina	25%	90%
Q24246	Drosophila melanogaster	26%	81%
Q32KS2	Bos taurus	22%	76%
Q39578	Chlamydomonas reinhardtii	24%	78%
Q4Q5H6	Leishmania major	23%	100%
Q4QR00	Xenopus laevis	23%	91%
Q4V8G4	Rattus norvegicus	23%	67%
Q5U4F6	Mus musculus	29%	100%
Q5XIL8	Rattus norvegicus	22%	76%
Q8C0M8	Mus musculus	22%	76%
Q96EX3	Homo sapiens	30%	100%
Q9UI46	Homo sapiens	20%	77%
V5B145	Trypanosoma cruzi	25%	89%
V5BUI1	Trypanosoma cruzi	48%	100%