| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000428 | DNA-directed RNA polymerase complex | 4 | 12 |
| GO:0030880 | RNA polymerase complex | 3 | 12 |
| GO:0032991 | protein-containing complex | 1 | 12 |
| GO:0061695 | transferase complex, transferring phosphorus-containing groups | 4 | 12 |
| GO:0140535 | intracellular protein-containing complex | 2 | 12 |
| GO:1902494 | catalytic complex | 2 | 12 |
| GO:1990234 | transferase complex | 3 | 12 |
| GO:0005665 | RNA polymerase II, core complex | 4 | 1 |
| GO:0055029 | nuclear DNA-directed RNA polymerase complex | 3 | 1 |
| GO:0140513 | nuclear protein-containing complex | 2 | 1 |
Related structures:
AlphaFold database: E9AM65
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006139 | nucleobase-containing compound metabolic process | 3 | 12 |
| GO:0006351 | DNA-templated transcription | 7 | 12 |
| GO:0006725 | cellular aromatic compound metabolic process | 3 | 12 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 12 |
| GO:0008152 | metabolic process | 1 | 12 |
| GO:0009058 | biosynthetic process | 2 | 12 |
| GO:0009059 | macromolecule biosynthetic process | 4 | 12 |
| GO:0009987 | cellular process | 1 | 12 |
| GO:0016070 | RNA metabolic process | 5 | 12 |
| GO:0018130 | heterocycle biosynthetic process | 4 | 12 |
| GO:0019438 | aromatic compound biosynthetic process | 4 | 12 |
| GO:0032774 | RNA biosynthetic process | 5 | 12 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 12 |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 4 | 12 |
| GO:0043170 | macromolecule metabolic process | 3 | 12 |
| GO:0044237 | cellular metabolic process | 2 | 12 |
| GO:0044238 | primary metabolic process | 2 | 12 |
| GO:0044249 | cellular biosynthetic process | 3 | 12 |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 4 | 12 |
| GO:0046483 | heterocycle metabolic process | 3 | 12 |
| GO:0071704 | organic substance metabolic process | 2 | 12 |
| GO:0090304 | nucleic acid metabolic process | 4 | 12 |
| GO:0097659 | nucleic acid-templated transcription | 6 | 12 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 12 |
| GO:1901362 | organic cyclic compound biosynthetic process | 4 | 12 |
| GO:1901576 | organic substance biosynthetic process | 3 | 12 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | 3 | 6 |
| GO:0003677 | DNA binding | 4 | 6 |
| GO:0003824 | catalytic activity | 1 | 12 |
| GO:0003899 | DNA-directed 5'-3' RNA polymerase activity | 6 | 12 |
| GO:0005488 | binding | 1 | 12 |
| GO:0005515 | protein binding | 2 | 12 |
| GO:0016740 | transferase activity | 2 | 12 |
| GO:0016772 | transferase activity, transferring phosphorus-containing groups | 3 | 12 |
| GO:0016779 | nucleotidyltransferase activity | 4 | 12 |
| GO:0034062 | 5'-3' RNA polymerase activity | 5 | 12 |
| GO:0046983 | protein dimerization activity | 3 | 12 |
| GO:0097159 | organic cyclic compound binding | 2 | 6 |
| GO:0097747 | RNA polymerase activity | 4 | 12 |
| GO:0140098 | catalytic activity, acting on RNA | 3 | 12 |
| GO:0140640 | catalytic activity, acting on a nucleic acid | 2 | 12 |
| GO:1901363 | heterocyclic compound binding | 2 | 6 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 156 | 158 | PF00675 | 0.209 |
| CLV_NRD_NRD_1 | 283 | 285 | PF00675 | 0.219 |
| CLV_NRD_NRD_1 | 323 | 325 | PF00675 | 0.678 |
| CLV_NRD_NRD_1 | 35 | 37 | PF00675 | 0.218 |
| CLV_PCSK_KEX2_1 | 35 | 37 | PF00082 | 0.218 |
| CLV_PCSK_KEX2_1 | 79 | 81 | PF00082 | 0.231 |
| CLV_PCSK_PC1ET2_1 | 79 | 81 | PF00082 | 0.311 |
| CLV_PCSK_SKI1_1 | 114 | 118 | PF00082 | 0.253 |
| CLV_PCSK_SKI1_1 | 205 | 209 | PF00082 | 0.218 |
| CLV_PCSK_SKI1_1 | 36 | 40 | PF00082 | 0.209 |
| DEG_APCC_DBOX_1 | 283 | 291 | PF00400 | 0.418 |
| DEG_APCC_DBOX_1 | 35 | 43 | PF00400 | 0.407 |
| DEG_APCC_DBOX_1 | 66 | 74 | PF00400 | 0.407 |
| DEG_Nend_UBRbox_1 | 1 | 4 | PF02207 | 0.360 |
| DOC_CDC14_PxL_1 | 39 | 47 | PF14671 | 0.407 |
| DOC_CYCLIN_RxL_1 | 76 | 86 | PF00134 | 0.511 |
| DOC_CYCLIN_yCln2_LP_2 | 241 | 247 | PF00134 | 0.431 |
| DOC_MAPK_HePTP_8 | 173 | 185 | PF00069 | 0.336 |
| DOC_MAPK_MEF2A_6 | 146 | 154 | PF00069 | 0.430 |
| DOC_MAPK_MEF2A_6 | 176 | 185 | PF00069 | 0.458 |
| DOC_MAPK_MEF2A_6 | 240 | 248 | PF00069 | 0.449 |
| DOC_MAPK_RevD_3 | 270 | 286 | PF00069 | 0.418 |
| DOC_PP1_RVXF_1 | 77 | 84 | PF00149 | 0.511 |
| DOC_USP7_UBL2_3 | 158 | 162 | PF12436 | 0.407 |
| LIG_14-3-3_CanoR_1 | 289 | 295 | PF00244 | 0.454 |
| LIG_14-3-3_CanoR_1 | 53 | 59 | PF00244 | 0.511 |
| LIG_Actin_WH2_2 | 19 | 37 | PF00022 | 0.257 |
| LIG_FHA_1 | 18 | 24 | PF00498 | 0.316 |
| LIG_FHA_1 | 212 | 218 | PF00498 | 0.435 |
| LIG_FHA_1 | 259 | 265 | PF00498 | 0.418 |
| LIG_FHA_1 | 311 | 317 | PF00498 | 0.490 |
| LIG_FHA_1 | 42 | 48 | PF00498 | 0.465 |
| LIG_FHA_1 | 54 | 60 | PF00498 | 0.418 |
| LIG_FHA_1 | 98 | 104 | PF00498 | 0.438 |
| LIG_FHA_2 | 230 | 236 | PF00498 | 0.511 |
| LIG_LIR_Gen_1 | 235 | 246 | PF02991 | 0.431 |
| LIG_LIR_Nem_3 | 235 | 241 | PF02991 | 0.431 |
| LIG_LIR_Nem_3 | 48 | 52 | PF02991 | 0.458 |
| LIG_Pex14_2 | 258 | 262 | PF04695 | 0.511 |
| LIG_SH2_CRK | 277 | 281 | PF00017 | 0.511 |
| LIG_SH2_NCK_1 | 277 | 281 | PF00017 | 0.431 |
| LIG_SH2_PTP2 | 49 | 52 | PF00017 | 0.453 |
| LIG_SH2_STAP1 | 277 | 281 | PF00017 | 0.484 |
| LIG_SH2_STAT5 | 257 | 260 | PF00017 | 0.516 |
| LIG_SH2_STAT5 | 49 | 52 | PF00017 | 0.453 |
| LIG_SH3_3 | 102 | 108 | PF00018 | 0.431 |
| LIG_SH3_3 | 312 | 318 | PF00018 | 0.534 |
| LIG_SUMO_SIM_anti_2 | 278 | 284 | PF11976 | 0.418 |
| LIG_SUMO_SIM_par_1 | 43 | 48 | PF11976 | 0.511 |
| LIG_TRAF2_1 | 133 | 136 | PF00917 | 0.420 |
| LIG_TRAF2_1 | 232 | 235 | PF00917 | 0.511 |
| LIG_TYR_ITIM | 275 | 280 | PF00017 | 0.431 |
| LIG_TYR_ITIM | 47 | 52 | PF00017 | 0.453 |
| MOD_CK2_1 | 130 | 136 | PF00069 | 0.450 |
| MOD_CK2_1 | 229 | 235 | PF00069 | 0.487 |
| MOD_GlcNHglycan | 132 | 135 | PF01048 | 0.332 |
| MOD_GlcNHglycan | 74 | 77 | PF01048 | 0.215 |
| MOD_GlcNHglycan | 91 | 94 | PF01048 | 0.220 |
| MOD_GSK3_1 | 140 | 147 | PF00069 | 0.418 |
| MOD_GSK3_1 | 260 | 267 | PF00069 | 0.430 |
| MOD_GSK3_1 | 304 | 311 | PF00069 | 0.636 |
| MOD_N-GLC_1 | 332 | 337 | PF02516 | 0.453 |
| MOD_N-GLC_1 | 54 | 59 | PF02516 | 0.207 |
| MOD_NEK2_1 | 144 | 149 | PF00069 | 0.511 |
| MOD_NEK2_1 | 258 | 263 | PF00069 | 0.521 |
| MOD_NEK2_1 | 332 | 337 | PF00069 | 0.704 |
| MOD_PIKK_1 | 144 | 150 | PF00454 | 0.418 |
| MOD_PIKK_1 | 230 | 236 | PF00454 | 0.511 |
| MOD_PKA_2 | 288 | 294 | PF00069 | 0.444 |
| MOD_Plk_1 | 258 | 264 | PF00069 | 0.418 |
| MOD_Plk_1 | 26 | 32 | PF00069 | 0.418 |
| MOD_Plk_1 | 54 | 60 | PF00069 | 0.407 |
| MOD_Plk_4 | 54 | 60 | PF00069 | 0.420 |
| MOD_SUMO_for_1 | 9 | 12 | PF00179 | 0.523 |
| TRG_DiLeu_BaEn_2 | 242 | 248 | PF01217 | 0.431 |
| TRG_ENDOCYTIC_2 | 257 | 260 | PF00928 | 0.431 |
| TRG_ENDOCYTIC_2 | 277 | 280 | PF00928 | 0.321 |
| TRG_ENDOCYTIC_2 | 49 | 52 | PF00928 | 0.484 |
| TRG_ER_diArg_1 | 34 | 36 | PF00400 | 0.409 |
| TRG_NLS_MonoExtN_4 | 249 | 255 | PF00514 | 0.453 |
| TRG_Pf-PMV_PEXEL_1 | 306 | 310 | PF00026 | 0.585 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P8L4 | Leptomonas seymouri | 26% | 76% |
| A0A0N1I3K4 | Leptomonas seymouri | 88% | 100% |
| A0A0S4IYI3 | Bodo saltans | 30% | 93% |
| A0A0S4JFX1 | Bodo saltans | 49% | 100% |
| A0A1X0NZD0 | Trypanosomatidae | 68% | 100% |
| A0A1X0P6H8 | Trypanosomatidae | 29% | 84% |
| A0A3R7MJ28 | Trypanosoma rangeli | 30% | 86% |
| A0A3S5H758 | Leishmania donovani | 26% | 76% |
| A0A3S7X218 | Leishmania donovani | 98% | 100% |
| A0A422NUV2 | Trypanosoma rangeli | 69% | 100% |
| A3MXZ5 | Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1) | 28% | 100% |
| A4HA24 | Leishmania braziliensis | 26% | 100% |
| A4HH22 | Leishmania braziliensis | 93% | 100% |
| A4HY87 | Leishmania infantum | 26% | 76% |
| A4I451 | Leishmania infantum | 98% | 100% |
| A4WNA4 | Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6) | 28% | 100% |
| A5UN55 | Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) | 28% | 100% |
| B0R4Y2 | Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) | 26% | 100% |
| B1YC30 | Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta) | 29% | 100% |
| B8YB56 | Saccharolobus shibatae | 27% | 100% |
| C3MJP7 | Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) | 27% | 100% |
| C3MZ05 | Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) | 27% | 100% |
| C3N054 | Sulfolobus islandicus (strain M.16.27) | 27% | 100% |
| C3N8R8 | Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) | 27% | 100% |
| C3NMQ0 | Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) | 27% | 100% |
| C4KJ93 | Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) | 27% | 100% |
| C9ZKR1 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 57% | 100% |
| E9ADL6 | Leishmania major | 98% | 100% |
| E9AS18 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 26% | 78% |
| O15160 | Homo sapiens | 28% | 97% |
| O26144 | Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) | 30% | 100% |
| O28002 | Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) | 34% | 100% |
| O59303 | Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) | 30% | 100% |
| O94616 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 28% | 97% |
| P07703 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 29% | 100% |
| P0CG28 | Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) | 29% | 100% |
| P16370 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 31% | 100% |
| P16925 | Tetrahymena thermophila | 34% | 100% |
| P19387 | Homo sapiens | 30% | 100% |
| P37382 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 30% | 100% |
| P39471 | Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) | 28% | 100% |
| P52432 | Mus musculus | 28% | 97% |
| P95989 | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) | 28% | 100% |
| P97760 | Mus musculus | 30% | 100% |
| Q2NFZ6 | Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) | 30% | 100% |
| Q32L22 | Bos taurus | 30% | 97% |
| Q39211 | Arabidopsis thaliana | 38% | 100% |
| Q39212 | Arabidopsis thaliana | 37% | 100% |
| Q3IQT6 | Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara) | 27% | 100% |
| Q3T0Q3 | Bos taurus | 30% | 100% |
| Q4QDF5 | Leishmania major | 27% | 100% |
| Q54DH7 | Dictyostelium discoideum | 37% | 100% |
| Q54SN4 | Dictyostelium discoideum | 31% | 98% |
| Q5JJF4 | Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) | 29% | 100% |
| Q6KZP5 | Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) | 24% | 100% |
| Q8PV16 | Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) | 28% | 100% |
| Q8TVB8 | Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) | 29% | 100% |
| Q8ZYQ3 | Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) | 28% | 100% |
| Q96YW0 | Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) | 28% | 100% |
| Q9HQJ4 | Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) | 26% | 100% |
| Q9V198 | Pyrococcus abyssi (strain GE5 / Orsay) | 30% | 100% |
| V5BBX7 | Trypanosoma cruzi | 30% | 86% |
| V5BUI6 | Trypanosoma cruzi | 68% | 100% |