Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM63_LEIMU

TriTrypDb:

LmxM.08_29.0160

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AM63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.285
CLV_NRD_NRD_1	200	202	PF00675	0.684
CLV_NRD_NRD_1	273	275	PF00675	0.416
CLV_NRD_NRD_1	438	440	PF00675	0.373
CLV_NRD_NRD_1	44	46	PF00675	0.684
CLV_NRD_NRD_1	557	559	PF00675	0.361
CLV_NRD_NRD_1	6	8	PF00675	0.428
CLV_PCSK_KEX2_1	200	202	PF00082	0.716
CLV_PCSK_KEX2_1	273	275	PF00082	0.416
CLV_PCSK_KEX2_1	342	344	PF00082	0.305
CLV_PCSK_KEX2_1	438	440	PF00082	0.373
CLV_PCSK_KEX2_1	559	561	PF00082	0.363
CLV_PCSK_KEX2_1	6	8	PF00082	0.406
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.716
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.305
CLV_PCSK_PC1ET2_1	559	561	PF00082	0.361
CLV_PCSK_SKI1_1	113	117	PF00082	0.370
CLV_PCSK_SKI1_1	159	163	PF00082	0.376
CLV_PCSK_SKI1_1	250	254	PF00082	0.443
CLV_PCSK_SKI1_1	274	278	PF00082	0.348
CLV_PCSK_SKI1_1	314	318	PF00082	0.379
CLV_PCSK_SKI1_1	343	347	PF00082	0.349
CLV_PCSK_SKI1_1	402	406	PF00082	0.314
CLV_PCSK_SKI1_1	409	413	PF00082	0.328
CLV_PCSK_SKI1_1	453	457	PF00082	0.351
CLV_PCSK_SKI1_1	548	552	PF00082	0.398
CLV_PCSK_SKI1_1	7	11	PF00082	0.315
DEG_APCC_DBOX_1	342	350	PF00400	0.549
DEG_APCC_DBOX_1	401	409	PF00400	0.473
DEG_APCC_DBOX_1	5	13	PF00400	0.562
DEG_MDM2_SWIB_1	118	125	PF02201	0.447
DOC_CDC14_PxL_1	303	311	PF14671	0.448
DOC_CYCLIN_RxL_1	399	407	PF00134	0.476
DOC_CYCLIN_RxL_1	4	14	PF00134	0.586
DOC_CYCLIN_yCln2_LP_2	125	131	PF00134	0.368
DOC_MAPK_gen_1	165	174	PF00069	0.605
DOC_MAPK_gen_1	273	282	PF00069	0.613
DOC_MAPK_gen_1	341	350	PF00069	0.500
DOC_MAPK_gen_1	558	568	PF00069	0.636
DOC_MAPK_gen_1	59	67	PF00069	0.446
DOC_MAPK_gen_1	6	12	PF00069	0.534
DOC_MAPK_MEF2A_6	341	349	PF00069	0.499
DOC_MAPK_MEF2A_6	367	374	PF00069	0.482
DOC_MAPK_MEF2A_6	548	555	PF00069	0.609
DOC_MAPK_MEF2A_6	61	69	PF00069	0.359
DOC_MAPK_NFAT4_5	341	349	PF00069	0.586
DOC_PP1_RVXF_1	546	553	PF00149	0.636
DOC_PP2B_LxvP_1	125	128	PF13499	0.389
DOC_PP2B_LxvP_1	322	325	PF13499	0.188
DOC_PP2B_LxvP_1	471	474	PF13499	0.512
DOC_PP4_FxxP_1	327	330	PF00568	0.426
DOC_USP7_MATH_1	323	327	PF00917	0.428
DOC_USP7_MATH_1	384	388	PF00917	0.310
DOC_USP7_MATH_1	432	436	PF00917	0.607
DOC_USP7_MATH_1	447	451	PF00917	0.485
DOC_USP7_MATH_1	488	492	PF00917	0.484
DOC_USP7_MATH_2	447	453	PF00917	0.565
DOC_WW_Pin1_4	195	200	PF00397	0.463
DOC_WW_Pin1_4	372	377	PF00397	0.390
DOC_WW_Pin1_4	428	433	PF00397	0.605
DOC_WW_Pin1_4	99	104	PF00397	0.674
LIG_14-3-3_CanoR_1	149	157	PF00244	0.620
LIG_14-3-3_CanoR_1	229	234	PF00244	0.622
LIG_14-3-3_CanoR_1	268	272	PF00244	0.574
LIG_14-3-3_CanoR_1	273	277	PF00244	0.511
LIG_14-3-3_CanoR_1	308	316	PF00244	0.380
LIG_14-3-3_CanoR_1	45	55	PF00244	0.425
LIG_14-3-3_CanoR_1	453	458	PF00244	0.568
LIG_14-3-3_CanoR_1	500	508	PF00244	0.419
LIG_Actin_WH2_2	48	63	PF00022	0.454
LIG_BIR_II_1	1	5	PF00653	0.719
LIG_BRCT_BRCA1_1	503	507	PF00533	0.473
LIG_CaM_IQ_9	260	276	PF13499	0.585
LIG_CaM_IQ_9	550	566	PF13499	0.645
LIG_Clathr_ClatBox_1	39	43	PF01394	0.449
LIG_EH1_1	76	84	PF00400	0.327
LIG_eIF4E_1	34	40	PF01652	0.432
LIG_FHA_1	435	441	PF00498	0.516
LIG_FHA_1	454	460	PF00498	0.458
LIG_FHA_1	511	517	PF00498	0.431
LIG_FHA_1	526	532	PF00498	0.295
LIG_FHA_2	257	263	PF00498	0.666
LIG_IRF3_LxIS_1	56	63	PF10401	0.324
LIG_LIR_Apic_2	326	330	PF02991	0.480
LIG_LIR_Gen_1	111	120	PF02991	0.456
LIG_LIR_Gen_1	49	60	PF02991	0.299
LIG_LIR_Nem_3	111	117	PF02991	0.496
LIG_LIR_Nem_3	121	125	PF02991	0.353
LIG_LIR_Nem_3	140	146	PF02991	0.274
LIG_LIR_Nem_3	262	266	PF02991	0.595
LIG_LIR_Nem_3	463	469	PF02991	0.424
LIG_LIR_Nem_3	49	55	PF02991	0.320
LIG_NRBOX	345	351	PF00104	0.402
LIG_NRBOX	396	402	PF00104	0.420
LIG_Pex14_1	539	543	PF04695	0.525
LIG_Pex14_2	114	118	PF04695	0.350
LIG_Pex14_2	26	30	PF04695	0.447
LIG_Pex14_2	458	462	PF04695	0.478
LIG_REV1ctd_RIR_1	362	371	PF16727	0.515
LIG_SH2_GRB2like	542	545	PF00017	0.607
LIG_SH2_NCK_1	288	292	PF00017	0.383
LIG_SH2_SRC	288	291	PF00017	0.480
LIG_SH2_SRC	34	37	PF00017	0.392
LIG_SH2_STAP1	288	292	PF00017	0.383
LIG_SH2_STAT5	34	37	PF00017	0.355
LIG_SH3_3	125	131	PF00018	0.447
LIG_SH3_3	441	447	PF00018	0.604
LIG_SH3_3	467	473	PF00018	0.570
LIG_SUMO_SIM_anti_2	518	525	PF11976	0.434
LIG_SUMO_SIM_par_1	38	44	PF11976	0.426
LIG_SUMO_SIM_par_1	518	525	PF11976	0.464
LIG_SUMO_SIM_par_1	8	14	PF11976	0.585
LIG_TRAF2_1	166	169	PF00917	0.684
LIG_TRAF2_1	241	244	PF00917	0.676
LIG_UBA3_1	551	559	PF00899	0.511
MOD_CDC14_SPxK_1	198	201	PF00782	0.553
MOD_CDK_SPK_2	195	200	PF00069	0.521
MOD_CDK_SPK_2	99	104	PF00069	0.603
MOD_CDK_SPxK_1	195	201	PF00069	0.530
MOD_CDK_SPxxK_3	195	202	PF00069	0.455
MOD_CDK_SPxxK_3	99	106	PF00069	0.608
MOD_CK1_1	132	138	PF00069	0.415
MOD_CK1_1	246	252	PF00069	0.671
MOD_CK1_1	335	341	PF00069	0.408
MOD_CK1_1	480	486	PF00069	0.708
MOD_CK1_1	502	508	PF00069	0.652
MOD_CK1_1	525	531	PF00069	0.463
MOD_CK2_1	229	235	PF00069	0.594
MOD_CK2_1	256	262	PF00069	0.577
MOD_Cter_Amidation	339	342	PF01082	0.381
MOD_GlcNHglycan	131	134	PF01048	0.408
MOD_GlcNHglycan	179	182	PF01048	0.405
MOD_GlcNHglycan	222	225	PF01048	0.405
MOD_GlcNHglycan	238	241	PF01048	0.487
MOD_GlcNHglycan	309	312	PF01048	0.483
MOD_GlcNHglycan	334	337	PF01048	0.544
MOD_GlcNHglycan	486	489	PF01048	0.715
MOD_GlcNHglycan	490	493	PF01048	0.680
MOD_GlcNHglycan	504	507	PF01048	0.572
MOD_GSK3_1	144	151	PF00069	0.456
MOD_GSK3_1	173	180	PF00069	0.577
MOD_GSK3_1	379	386	PF00069	0.601
MOD_GSK3_1	428	435	PF00069	0.470
MOD_GSK3_1	449	456	PF00069	0.448
MOD_GSK3_1	46	53	PF00069	0.575
MOD_GSK3_1	474	481	PF00069	0.650
MOD_GSK3_1	484	491	PF00069	0.705
MOD_N-GLC_1	478	483	PF02516	0.715
MOD_NEK2_1	11	16	PF00069	0.473
MOD_NEK2_1	118	123	PF00069	0.398
MOD_NEK2_1	299	304	PF00069	0.442
MOD_NEK2_1	404	409	PF00069	0.431
MOD_NEK2_1	460	465	PF00069	0.360
MOD_NEK2_1	60	65	PF00069	0.554
MOD_NEK2_1	78	83	PF00069	0.212
MOD_NEK2_2	522	527	PF00069	0.480
MOD_PIKK_1	480	486	PF00454	0.652
MOD_PKA_2	148	154	PF00069	0.509
MOD_PKA_2	228	234	PF00069	0.538
MOD_PKA_2	267	273	PF00069	0.414
MOD_PKA_2	307	313	PF00069	0.525
MOD_PKA_2	499	505	PF00069	0.516
MOD_PKA_2	60	66	PF00069	0.533
MOD_PKB_1	104	112	PF00069	0.547
MOD_PKB_1	227	235	PF00069	0.554
MOD_Plk_1	243	249	PF00069	0.680
MOD_Plk_1	256	262	PF00069	0.364
MOD_Plk_1	478	484	PF00069	0.718
MOD_Plk_4	118	124	PF00069	0.361
MOD_Plk_4	13	19	PF00069	0.351
MOD_Plk_4	256	262	PF00069	0.603
MOD_Plk_4	323	329	PF00069	0.342
MOD_Plk_4	356	362	PF00069	0.424
MOD_Plk_4	396	402	PF00069	0.382
MOD_Plk_4	453	459	PF00069	0.331
MOD_Plk_4	516	522	PF00069	0.377
MOD_Plk_4	78	84	PF00069	0.426
MOD_Plk_4	90	96	PF00069	0.497
MOD_ProDKin_1	195	201	PF00069	0.598
MOD_ProDKin_1	372	378	PF00069	0.490
MOD_ProDKin_1	428	434	PF00069	0.502
MOD_ProDKin_1	99	105	PF00069	0.605
MOD_SUMO_for_1	166	169	PF00179	0.632
TRG_DiLeu_BaEn_1	546	551	PF01217	0.511
TRG_DiLeu_BaEn_2	261	267	PF01217	0.530
TRG_DiLeu_BaLyEn_6	399	404	PF01217	0.514
TRG_ENDOCYTIC_2	542	545	PF00928	0.441
TRG_ER_diArg_1	103	106	PF00400	0.605
TRG_ER_diArg_1	438	440	PF00400	0.463
TRG_ER_diArg_1	58	61	PF00400	0.566
TRG_NES_CRM1_1	20	32	PF08389	0.434
TRG_NLS_MonoExtN_4	199	204	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVM9	Leptomonas seymouri	43%	100%
A0A1X0NZT8	Trypanosomatidae	24%	100%
A0A3Q8IH23	Leishmania donovani	91%	100%
A0A3R7KT94	Trypanosoma rangeli	26%	100%
A4HH24	Leishmania braziliensis	73%	100%
A4I453	Leishmania infantum	91%	100%
C9ZKQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ADL8	Leishmania major	88%	100%
V5B4T3	Trypanosoma cruzi	24%	100%