Protein phosphatase inhibitor 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase inhibitor 2 (ipp-2), putative

Species:

Leishmania mexicana

UniProt:

E9AM62_LEIMU

TriTrypDb:

LmxM.08_29.0170

Length:

137

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AM62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM62

Function

Biological processes
Term	Name	Level	Count
GO:0009966	regulation of signal transduction	4	11
GO:0010646	regulation of cell communication	4	11
GO:0010921	regulation of phosphatase activity	5	11
GO:0019220	regulation of phosphate metabolic process	6	11
GO:0019222	regulation of metabolic process	3	11
GO:0023051	regulation of signaling	3	11
GO:0031323	regulation of cellular metabolic process	4	11
GO:0031399	regulation of protein modification process	6	11
GO:0035303	regulation of dephosphorylation	7	11
GO:0035304	regulation of protein dephosphorylation	7	11
GO:0043666	regulation of phosphoprotein phosphatase activity	6	11
GO:0048583	regulation of response to stimulus	3	11
GO:0050789	regulation of biological process	2	11
GO:0050790	regulation of catalytic activity	3	11
GO:0050794	regulation of cellular process	3	11
GO:0051171	regulation of nitrogen compound metabolic process	4	11
GO:0051174	regulation of phosphorus metabolic process	5	11
GO:0051246	regulation of protein metabolic process	5	11
GO:0051336	regulation of hydrolase activity	4	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0065009	regulation of molecular function	2	11
GO:0080090	regulation of primary metabolic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0004857	enzyme inhibitor activity	3	11
GO:0004864	protein phosphatase inhibitor activity	5	11
GO:0019208	phosphatase regulator activity	3	11
GO:0019212	phosphatase inhibitor activity	4	11
GO:0019888	protein phosphatase regulator activity	4	11
GO:0030234	enzyme regulator activity	2	11
GO:0098772	molecular function regulator activity	1	11
GO:0140678	molecular function inhibitor activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.447
CLV_NRD_NRD_1	104	106	PF00675	0.357
CLV_NRD_NRD_1	108	110	PF00675	0.333
CLV_NRD_NRD_1	111	113	PF00675	0.305
CLV_PCSK_SKI1_1	124	128	PF00082	0.355
CLV_PCSK_SKI1_1	64	68	PF00082	0.355
CLV_PCSK_SKI1_1	87	91	PF00082	0.355
DOC_CKS1_1	33	38	PF01111	0.335
DOC_PP1_RVXF_1	3	10	PF00149	0.537
DOC_USP7_MATH_1	128	132	PF00917	0.188
DOC_USP7_UBL2_3	106	110	PF12436	0.372
DOC_WW_Pin1_4	32	37	PF00397	0.335
LIG_APCC_ABBAyCdc20_2	112	118	PF00400	0.335
LIG_BIR_II_1	1	5	PF00653	0.699
LIG_FHA_1	25	31	PF00498	0.322
LIG_FHA_1	94	100	PF00498	0.408
LIG_SH2_SRC	39	42	PF00017	0.411
LIG_SH2_STAT3	20	23	PF00017	0.408
LIG_SH3_3	30	36	PF00018	0.335
LIG_SH3_3	75	81	PF00018	0.384
LIG_TRAF2_1	47	50	PF00917	0.496
MOD_CK2_1	128	134	PF00069	0.188
MOD_GlcNHglycan	84	87	PF01048	0.337
MOD_GSK3_1	24	31	PF00069	0.359
MOD_NEK2_1	1	6	PF00069	0.663
MOD_ProDKin_1	32	38	PF00069	0.335
MOD_SUMO_rev_2	4	14	PF00179	0.427
TRG_DiLeu_BaEn_1	48	53	PF01217	0.480
TRG_DiLeu_BaEn_4	48	54	PF01217	0.480
TRG_NLS_MonoExtC_3	108	113	PF00514	0.447
TRG_NLS_MonoExtN_4	106	113	PF00514	0.447
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.237

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAG7	Leptomonas seymouri	73%	93%
A0A0S4JAZ9	Bodo saltans	42%	67%
A0A1X0P0X7	Trypanosomatidae	52%	78%
A0A3S7X222	Leishmania donovani	94%	100%
A0A422NUV8	Trypanosoma rangeli	51%	93%
A4HH25	Leishmania braziliensis	86%	100%
A4I470	Leishmania infantum	94%	100%
C9ZKQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	77%
E9ADL9	Leishmania major	91%	100%