Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM60_LEIMU

TriTrypDb:

LmxM.08_29.0190

Length:

1019

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AM60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.774
CLV_C14_Caspase3-7	159	163	PF00656	0.756
CLV_C14_Caspase3-7	35	39	PF00656	0.720
CLV_C14_Caspase3-7	799	803	PF00656	0.496
CLV_NRD_NRD_1	183	185	PF00675	0.752
CLV_NRD_NRD_1	682	684	PF00675	0.551
CLV_NRD_NRD_1	814	816	PF00675	0.590
CLV_NRD_NRD_1	853	855	PF00675	0.741
CLV_NRD_NRD_1	966	968	PF00675	0.500
CLV_NRD_NRD_1	988	990	PF00675	0.559
CLV_PCSK_FUR_1	142	146	PF00082	0.490
CLV_PCSK_KEX2_1	144	146	PF00082	0.743
CLV_PCSK_KEX2_1	183	185	PF00082	0.712
CLV_PCSK_KEX2_1	587	589	PF00082	0.777
CLV_PCSK_KEX2_1	682	684	PF00082	0.551
CLV_PCSK_KEX2_1	814	816	PF00082	0.542
CLV_PCSK_KEX2_1	853	855	PF00082	0.795
CLV_PCSK_KEX2_1	965	967	PF00082	0.515
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.505
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.793
CLV_PCSK_SKI1_1	184	188	PF00082	0.586
CLV_PCSK_SKI1_1	233	237	PF00082	0.790
CLV_PCSK_SKI1_1	391	395	PF00082	0.704
CLV_PCSK_SKI1_1	451	455	PF00082	0.631
CLV_PCSK_SKI1_1	673	677	PF00082	0.512
CLV_PCSK_SKI1_1	678	682	PF00082	0.537
CLV_PCSK_SKI1_1	683	687	PF00082	0.582
CLV_PCSK_SKI1_1	704	708	PF00082	0.491
CLV_PCSK_SKI1_1	814	818	PF00082	0.567
DEG_APCC_DBOX_1	182	190	PF00400	0.699
DEG_Nend_UBRbox_2	1	3	PF02207	0.788
DEG_ODPH_VHL_1	777	788	PF01847	0.570
DEG_SCF_FBW7_1	839	846	PF00400	0.648
DEG_SPOP_SBC_1	172	176	PF00917	0.506
DEG_SPOP_SBC_1	24	28	PF00917	0.765
DOC_ANK_TNKS_1	472	479	PF00023	0.797
DOC_ANK_TNKS_1	513	520	PF00023	0.720
DOC_CKS1_1	227	232	PF01111	0.487
DOC_CKS1_1	840	845	PF01111	0.611
DOC_CYCLIN_yCln2_LP_2	355	361	PF00134	0.804
DOC_CYCLIN_yCln2_LP_2	423	429	PF00134	0.729
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.747
DOC_CYCLIN_yCln2_LP_2	837	840	PF00134	0.601
DOC_CYCLIN_yCln2_LP_2	86	92	PF00134	0.709
DOC_MAPK_gen_1	183	191	PF00069	0.697
DOC_MAPK_MEF2A_6	692	700	PF00069	0.452
DOC_PP1_RVXF_1	185	192	PF00149	0.651
DOC_PP2B_LxvP_1	355	358	PF13499	0.716
DOC_PP2B_LxvP_1	360	363	PF13499	0.639
DOC_PP2B_LxvP_1	423	426	PF13499	0.667
DOC_PP2B_LxvP_1	77	80	PF13499	0.747
DOC_PP2B_LxvP_1	837	840	PF13499	0.579
DOC_PP2B_LxvP_1	86	89	PF13499	0.707
DOC_PP4_FxxP_1	227	230	PF00568	0.695
DOC_PP4_FxxP_1	899	902	PF00568	0.663
DOC_USP7_MATH_1	122	126	PF00917	0.731
DOC_USP7_MATH_1	179	183	PF00917	0.737
DOC_USP7_MATH_1	284	288	PF00917	0.684
DOC_USP7_MATH_1	315	319	PF00917	0.802
DOC_USP7_MATH_1	349	353	PF00917	0.652
DOC_USP7_MATH_1	510	514	PF00917	0.712
DOC_USP7_MATH_1	532	536	PF00917	0.737
DOC_USP7_MATH_1	537	541	PF00917	0.731
DOC_USP7_MATH_1	589	593	PF00917	0.705
DOC_USP7_MATH_1	696	700	PF00917	0.739
DOC_USP7_MATH_1	983	987	PF00917	0.640
DOC_USP7_UBL2_3	247	251	PF12436	0.538
DOC_WW_Pin1_4	226	231	PF00397	0.765
DOC_WW_Pin1_4	333	338	PF00397	0.707
DOC_WW_Pin1_4	343	348	PF00397	0.691
DOC_WW_Pin1_4	377	382	PF00397	0.745
DOC_WW_Pin1_4	407	412	PF00397	0.716
DOC_WW_Pin1_4	68	73	PF00397	0.686
DOC_WW_Pin1_4	733	738	PF00397	0.635
DOC_WW_Pin1_4	819	824	PF00397	0.679
DOC_WW_Pin1_4	839	844	PF00397	0.617
DOC_WW_Pin1_4	95	100	PF00397	0.728
LIG_14-3-3_CanoR_1	145	150	PF00244	0.739
LIG_14-3-3_CanoR_1	262	267	PF00244	0.560
LIG_14-3-3_CanoR_1	497	503	PF00244	0.717
LIG_14-3-3_CanoR_1	702	707	PF00244	0.598
LIG_14-3-3_CanoR_1	783	787	PF00244	0.453
LIG_Actin_WH2_2	669	684	PF00022	0.569
LIG_BIR_III_2	731	735	PF00653	0.692
LIG_BIR_III_4	392	396	PF00653	0.587
LIG_BRCT_BRCA1_1	285	289	PF00533	0.607
LIG_BRCT_BRCA1_1	512	516	PF00533	0.695
LIG_BRCT_BRCA1_1	641	645	PF00533	0.735
LIG_FHA_1	1013	1019	PF00498	0.484
LIG_FHA_1	19	25	PF00498	0.763
LIG_FHA_1	499	505	PF00498	0.780
LIG_FHA_1	803	809	PF00498	0.320
LIG_FHA_1	824	830	PF00498	0.517
LIG_FHA_1	840	846	PF00498	0.607
LIG_FHA_1	915	921	PF00498	0.513
LIG_FHA_2	11	17	PF00498	0.719
LIG_FHA_2	134	140	PF00498	0.740
LIG_FHA_2	157	163	PF00498	0.707
LIG_FHA_2	172	178	PF00498	0.727
LIG_FHA_2	235	241	PF00498	0.546
LIG_FHA_2	30	36	PF00498	0.712
LIG_FHA_2	410	416	PF00498	0.800
LIG_FHA_2	483	489	PF00498	0.623
LIG_FHA_2	684	690	PF00498	0.589
LIG_FHA_2	797	803	PF00498	0.421
LIG_FHA_2	805	811	PF00498	0.439
LIG_FHA_2	828	834	PF00498	0.613
LIG_FHA_2	934	940	PF00498	0.693
LIG_FHA_2	948	954	PF00498	0.418
LIG_GBD_Chelix_1	1005	1013	PF00786	0.600
LIG_GSK3_LRP6_1	839	844	PF00069	0.659
LIG_Integrin_RGD_1	748	750	PF01839	0.605
LIG_Integrin_RGD_1	854	856	PF01839	0.501
LIG_LIR_Apic_2	225	230	PF02991	0.695
LIG_LIR_Apic_2	897	902	PF02991	0.682
LIG_LIR_Gen_1	195	204	PF02991	0.586
LIG_LIR_Gen_1	213	224	PF02991	0.522
LIG_LIR_Gen_1	286	296	PF02991	0.614
LIG_LIR_Gen_1	379	390	PF02991	0.572
LIG_LIR_Gen_1	667	676	PF02991	0.433
LIG_LIR_Gen_1	707	718	PF02991	0.340
LIG_LIR_Gen_1	73	84	PF02991	0.704
LIG_LIR_Gen_1	938	947	PF02991	0.509
LIG_LIR_Nem_3	195	200	PF02991	0.627
LIG_LIR_Nem_3	213	219	PF02991	0.613
LIG_LIR_Nem_3	286	292	PF02991	0.604
LIG_LIR_Nem_3	379	385	PF02991	0.706
LIG_LIR_Nem_3	667	672	PF02991	0.442
LIG_LIR_Nem_3	707	713	PF02991	0.354
LIG_LIR_Nem_3	73	79	PF02991	0.705
LIG_LIR_Nem_3	738	744	PF02991	0.552
LIG_LIR_Nem_3	874	878	PF02991	0.726
LIG_LIR_Nem_3	938	943	PF02991	0.593
LIG_LYPXL_S_1	740	744	PF13949	0.597
LIG_LYPXL_yS_3	741	744	PF13949	0.585
LIG_MAD2	835	843	PF02301	0.606
LIG_MYND_1	358	362	PF01753	0.707
LIG_MYND_1	421	425	PF01753	0.724
LIG_PCNA_APIM_2	676	682	PF02747	0.525
LIG_Pex14_1	634	638	PF04695	0.449
LIG_SH2_CRK	134	138	PF00017	0.504
LIG_SH2_CRK	216	220	PF00017	0.505
LIG_SH2_CRK	669	673	PF00017	0.475
LIG_SH2_CRK	875	879	PF00017	0.726
LIG_SH2_CRK	940	944	PF00017	0.342
LIG_SH2_NCK_1	134	138	PF00017	0.504
LIG_SH2_NCK_1	730	734	PF00017	0.629
LIG_SH2_NCK_1	940	944	PF00017	0.342
LIG_SH2_SRC	4	7	PF00017	0.673
LIG_SH2_SRC	427	430	PF00017	0.817
LIG_SH2_STAP1	216	220	PF00017	0.505
LIG_SH2_STAP1	4	8	PF00017	0.679
LIG_SH2_STAP1	940	944	PF00017	0.342
LIG_SH2_STAT5	638	641	PF00017	0.736
LIG_SH2_STAT5	679	682	PF00017	0.414
LIG_SH2_STAT5	76	79	PF00017	0.706
LIG_SH2_STAT5	940	943	PF00017	0.347
LIG_SH3_3	152	158	PF00018	0.531
LIG_SH3_3	317	323	PF00018	0.669
LIG_SH3_3	355	361	PF00018	0.725
LIG_SH3_3	418	424	PF00018	0.684
LIG_SH3_3	536	542	PF00018	0.676
LIG_SH3_3	695	701	PF00018	0.746
LIG_SH3_3	731	737	PF00018	0.671
LIG_SH3_3	79	85	PF00018	0.634
LIG_SH3_3	833	839	PF00018	0.636
LIG_SH3_3	87	93	PF00018	0.645
LIG_SH3_4	300	307	PF00018	0.824
LIG_SUMO_SIM_par_1	15	30	PF11976	0.525
LIG_SUMO_SIM_par_1	59	66	PF11976	0.706
LIG_SUMO_SIM_par_1	712	717	PF11976	0.401
LIG_TRAF2_1	15	18	PF00917	0.522
LIG_TRAF2_1	752	755	PF00917	0.584
LIG_WW_1	424	427	PF00397	0.732
LIG_WW_2	421	424	PF00397	0.705
MOD_CDK_SPxxK_3	226	233	PF00069	0.703
MOD_CDK_SPxxK_3	407	414	PF00069	0.609
MOD_CDK_SPxxK_3	68	75	PF00069	0.692
MOD_CK1_1	114	120	PF00069	0.690
MOD_CK1_1	23	29	PF00069	0.607
MOD_CK1_1	258	264	PF00069	0.748
MOD_CK1_1	287	293	PF00069	0.601
MOD_CK1_1	328	334	PF00069	0.732
MOD_CK1_1	33	39	PF00069	0.683
MOD_CK1_1	336	342	PF00069	0.753
MOD_CK1_1	366	372	PF00069	0.758
MOD_CK1_1	482	488	PF00069	0.582
MOD_CK1_1	522	528	PF00069	0.715
MOD_CK1_1	622	628	PF00069	0.703
MOD_CK1_1	66	72	PF00069	0.706
MOD_CK1_1	7	13	PF00069	0.707
MOD_CK1_1	891	897	PF00069	0.607
MOD_CK1_1	914	920	PF00069	0.508
MOD_CK1_1	922	928	PF00069	0.580
MOD_CK1_1	933	939	PF00069	0.591
MOD_CK1_1	942	948	PF00069	0.296
MOD_CK1_1	98	104	PF00069	0.802
MOD_CK2_1	104	110	PF00069	0.503
MOD_CK2_1	12	18	PF00069	0.600
MOD_CK2_1	133	139	PF00069	0.694
MOD_CK2_1	200	206	PF00069	0.671
MOD_CK2_1	234	240	PF00069	0.691
MOD_CK2_1	409	415	PF00069	0.739
MOD_CK2_1	460	466	PF00069	0.722
MOD_CK2_1	546	552	PF00069	0.644
MOD_CK2_1	571	577	PF00069	0.816
MOD_CK2_1	683	689	PF00069	0.630
MOD_CK2_1	804	810	PF00069	0.467
MOD_CK2_1	879	885	PF00069	0.666
MOD_CK2_1	891	897	PF00069	0.629
MOD_CK2_1	947	953	PF00069	0.582
MOD_Cter_Amidation	851	854	PF01082	0.716
MOD_GlcNHglycan	100	103	PF01048	0.777
MOD_GlcNHglycan	117	120	PF01048	0.703
MOD_GlcNHglycan	151	154	PF01048	0.767
MOD_GlcNHglycan	317	320	PF01048	0.750
MOD_GlcNHglycan	327	330	PF01048	0.750
MOD_GlcNHglycan	351	354	PF01048	0.663
MOD_GlcNHglycan	491	494	PF01048	0.710
MOD_GlcNHglycan	52	55	PF01048	0.499
MOD_GlcNHglycan	521	524	PF01048	0.734
MOD_GlcNHglycan	529	532	PF01048	0.675
MOD_GlcNHglycan	539	542	PF01048	0.752
MOD_GlcNHglycan	573	576	PF01048	0.812
MOD_GlcNHglycan	613	616	PF01048	0.609
MOD_GlcNHglycan	629	632	PF01048	0.758
MOD_GlcNHglycan	642	645	PF01048	0.692
MOD_GlcNHglycan	65	68	PF01048	0.641
MOD_GlcNHglycan	651	654	PF01048	0.698
MOD_GlcNHglycan	663	666	PF01048	0.528
MOD_GlcNHglycan	737	740	PF01048	0.673
MOD_GlcNHglycan	771	774	PF01048	0.661
MOD_GlcNHglycan	890	893	PF01048	0.755
MOD_GlcNHglycan	9	12	PF01048	0.694
MOD_GlcNHglycan	931	935	PF01048	0.664
MOD_GSK3_1	111	118	PF00069	0.696
MOD_GSK3_1	145	152	PF00069	0.725
MOD_GSK3_1	157	164	PF00069	0.555
MOD_GSK3_1	20	27	PF00069	0.776
MOD_GSK3_1	200	207	PF00069	0.649
MOD_GSK3_1	210	217	PF00069	0.659
MOD_GSK3_1	258	265	PF00069	0.788
MOD_GSK3_1	275	282	PF00069	0.572
MOD_GSK3_1	283	290	PF00069	0.606
MOD_GSK3_1	29	36	PF00069	0.719
MOD_GSK3_1	321	328	PF00069	0.706
MOD_GSK3_1	336	343	PF00069	0.723
MOD_GSK3_1	349	356	PF00069	0.615
MOD_GSK3_1	430	437	PF00069	0.675
MOD_GSK3_1	522	529	PF00069	0.690
MOD_GSK3_1	56	63	PF00069	0.775
MOD_GSK3_1	567	574	PF00069	0.772
MOD_GSK3_1	583	590	PF00069	0.676
MOD_GSK3_1	66	73	PF00069	0.701
MOD_GSK3_1	769	776	PF00069	0.620
MOD_GSK3_1	819	826	PF00069	0.563
MOD_GSK3_1	839	846	PF00069	0.653
MOD_GSK3_1	860	867	PF00069	0.753
MOD_GSK3_1	91	98	PF00069	0.789
MOD_GSK3_1	911	918	PF00069	0.478
MOD_GSK3_1	919	926	PF00069	0.532
MOD_GSK3_1	938	945	PF00069	0.490
MOD_N-GLC_1	145	150	PF02516	0.512
MOD_N-GLC_1	769	774	PF02516	0.617
MOD_N-GLC_2	720	722	PF02516	0.460
MOD_NEK2_1	111	116	PF00069	0.734
MOD_NEK2_1	149	154	PF00069	0.778
MOD_NEK2_1	171	176	PF00069	0.780
MOD_NEK2_1	234	239	PF00069	0.791
MOD_NEK2_1	327	332	PF00069	0.651
MOD_NEK2_1	526	531	PF00069	0.703
MOD_NEK2_1	62	67	PF00069	0.706
MOD_NEK2_1	639	644	PF00069	0.692
MOD_NEK2_1	649	654	PF00069	0.711
MOD_NEK2_1	769	774	PF00069	0.616
MOD_NEK2_1	804	809	PF00069	0.422
MOD_NEK2_2	284	289	PF00069	0.695
MOD_NEK2_2	782	787	PF00069	0.523
MOD_NEK2_2	843	848	PF00069	0.559
MOD_PIKK_1	1012	1018	PF00454	0.468
MOD_PIKK_1	290	296	PF00454	0.620
MOD_PIKK_1	393	399	PF00454	0.590
MOD_PIKK_1	632	638	PF00454	0.697
MOD_PIKK_1	790	796	PF00454	0.541
MOD_PIKK_1	972	978	PF00454	0.532
MOD_PK_1	262	268	PF00069	0.676
MOD_PK_1	279	285	PF00069	0.729
MOD_PK_1	702	708	PF00069	0.502
MOD_PKA_1	587	593	PF00069	0.725
MOD_PKA_2	24	30	PF00069	0.764
MOD_PKA_2	252	258	PF00069	0.636
MOD_PKA_2	261	267	PF00069	0.576
MOD_PKA_2	430	436	PF00069	0.692
MOD_PKA_2	437	443	PF00069	0.598
MOD_PKA_2	504	510	PF00069	0.691
MOD_PKA_2	567	573	PF00069	0.700
MOD_PKA_2	583	589	PF00069	0.530
MOD_PKA_2	619	625	PF00069	0.660
MOD_PKA_2	782	788	PF00069	0.457
MOD_PKB_1	702	710	PF00069	0.492
MOD_Plk_1	145	151	PF00069	0.687
MOD_Plk_1	161	167	PF00069	0.717
MOD_Plk_1	18	24	PF00069	0.700
MOD_Plk_1	33	39	PF00069	0.593
MOD_Plk_1	4	10	PF00069	0.685
MOD_Plk_1	930	936	PF00069	0.741
MOD_Plk_1	938	944	PF00069	0.655
MOD_Plk_1	956	962	PF00069	0.605
MOD_Plk_2-3	41	47	PF00069	0.614
MOD_Plk_2-3	546	552	PF00069	0.687
MOD_Plk_4	214	220	PF00069	0.722
MOD_Plk_4	255	261	PF00069	0.515
MOD_Plk_4	284	290	PF00069	0.615
MOD_Plk_4	911	917	PF00069	0.566
MOD_ProDKin_1	226	232	PF00069	0.767
MOD_ProDKin_1	333	339	PF00069	0.710
MOD_ProDKin_1	343	349	PF00069	0.689
MOD_ProDKin_1	377	383	PF00069	0.746
MOD_ProDKin_1	407	413	PF00069	0.718
MOD_ProDKin_1	68	74	PF00069	0.684
MOD_ProDKin_1	733	739	PF00069	0.635
MOD_ProDKin_1	819	825	PF00069	0.681
MOD_ProDKin_1	839	845	PF00069	0.609
MOD_ProDKin_1	95	101	PF00069	0.729
TRG_ENDOCYTIC_2	134	137	PF00928	0.509
TRG_ENDOCYTIC_2	216	219	PF00928	0.723
TRG_ENDOCYTIC_2	462	465	PF00928	0.677
TRG_ENDOCYTIC_2	669	672	PF00928	0.480
TRG_ENDOCYTIC_2	741	744	PF00928	0.585
TRG_ENDOCYTIC_2	76	79	PF00928	0.706
TRG_ENDOCYTIC_2	821	824	PF00928	0.564
TRG_ENDOCYTIC_2	875	878	PF00928	0.726
TRG_ENDOCYTIC_2	940	943	PF00928	0.578
TRG_ER_diArg_1	508	511	PF00400	0.714
TRG_ER_diArg_1	681	683	PF00400	0.543
TRG_ER_diArg_1	701	704	PF00400	0.650
TRG_ER_diArg_1	813	815	PF00400	0.540
TRG_ER_diArg_1	964	967	PF00400	0.563
TRG_Pf-PMV_PEXEL_1	473	477	PF00026	0.792

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C6	Leptomonas seymouri	45%	100%
A0A1X0NZF9	Trypanosomatidae	26%	100%
A0A3S7X251	Leishmania donovani	85%	100%
A0A422NUW5	Trypanosoma rangeli	29%	100%
A4HH27	Leishmania braziliensis	63%	99%
A4I472	Leishmania infantum	85%	100%
E9ADM1	Leishmania major	84%	100%
V5BPW9	Trypanosoma cruzi	27%	100%