LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AM58_LEIMU
TriTrypDb:
LmxM.08_29.0210
Length:
267

Annotations

LeishMANIAdb annotations

A protein of unknown function. Rare homologs are found outside Kinetoplastida, but also uncharacterized (e.g. E1ZIK9_CHLVA)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 9, no: 2
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

E9AM58
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM58

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 24 28 PF00656 0.534
CLV_NRD_NRD_1 104 106 PF00675 0.607
CLV_NRD_NRD_1 263 265 PF00675 0.646
CLV_NRD_NRD_1 40 42 PF00675 0.634
CLV_PCSK_KEX2_1 104 106 PF00082 0.559
CLV_PCSK_KEX2_1 263 265 PF00082 0.612
CLV_PCSK_KEX2_1 40 42 PF00082 0.611
CLV_PCSK_SKI1_1 111 115 PF00082 0.601
DEG_APCC_DBOX_1 103 111 PF00400 0.356
DEG_APCC_DBOX_1 3 11 PF00400 0.397
DOC_MAPK_gen_1 104 110 PF00069 0.354
DOC_MAPK_gen_1 4 13 PF00069 0.310
DOC_MAPK_gen_1 40 49 PF00069 0.342
DOC_MAPK_MEF2A_6 6 15 PF00069 0.337
DOC_USP7_MATH_1 28 32 PF00917 0.508
DOC_USP7_MATH_1 75 79 PF00917 0.329
LIG_14-3-3_CanoR_1 104 108 PF00244 0.413
LIG_14-3-3_CanoR_1 4 14 PF00244 0.550
LIG_BIR_III_4 27 31 PF00653 0.348
LIG_BRCT_BRCA1_1 131 135 PF00533 0.296
LIG_BRCT_BRCA1_1 160 164 PF00533 0.337
LIG_deltaCOP1_diTrp_1 156 164 PF00928 0.314
LIG_FHA_1 209 215 PF00498 0.584
LIG_FHA_1 224 230 PF00498 0.220
LIG_FHA_1 239 245 PF00498 0.396
LIG_FHA_1 6 12 PF00498 0.565
LIG_FHA_1 93 99 PF00498 0.423
LIG_FHA_2 104 110 PF00498 0.414
LIG_FHA_2 140 146 PF00498 0.370
LIG_GBD_Chelix_1 11 19 PF00786 0.558
LIG_GBD_Chelix_1 236 244 PF00786 0.287
LIG_LIR_Gen_1 170 180 PF02991 0.298
LIG_LIR_Gen_1 241 251 PF02991 0.559
LIG_LIR_Gen_1 63 74 PF02991 0.270
LIG_LIR_Nem_3 170 175 PF02991 0.373
LIG_LIR_Nem_3 241 246 PF02991 0.399
LIG_LIR_Nem_3 63 69 PF02991 0.355
LIG_NRBOX 12 18 PF00104 0.537
LIG_Pex14_1 183 187 PF04695 0.266
LIG_Pex14_2 179 183 PF04695 0.266
LIG_PTB_Apo_2 154 161 PF02174 0.386
LIG_PTB_Phospho_1 154 160 PF10480 0.385
LIG_REV1ctd_RIR_1 83 89 PF16727 0.447
LIG_SH2_CRK 128 132 PF00017 0.292
LIG_SH2_CRK 160 164 PF00017 0.295
LIG_SH2_CRK 66 70 PF00017 0.337
LIG_SH2_CRK 87 91 PF00017 0.380
LIG_SH2_GRB2like 155 158 PF00017 0.384
LIG_SH2_NCK_1 87 91 PF00017 0.438
LIG_SH2_SRC 155 158 PF00017 0.384
LIG_SH2_STAP1 155 159 PF00017 0.308
LIG_SH2_STAP1 160 164 PF00017 0.319
LIG_SH2_STAP1 198 202 PF00017 0.337
LIG_SH2_STAP1 224 228 PF00017 0.385
LIG_SH2_STAT3 249 252 PF00017 0.405
LIG_SH2_STAT3 70 73 PF00017 0.278
LIG_SH2_STAT5 210 213 PF00017 0.610
LIG_SH2_STAT5 243 246 PF00017 0.402
LIG_SH2_STAT5 87 90 PF00017 0.452
LIG_SUMO_SIM_anti_2 226 232 PF11976 0.177
LIG_SUMO_SIM_anti_2 8 15 PF11976 0.356
LIG_SUMO_SIM_par_1 236 241 PF11976 0.420
LIG_TYR_ITIM 195 200 PF00017 0.325
LIG_TYR_ITSM 239 246 PF00017 0.331
LIG_UBA3_1 120 125 PF00899 0.299
MOD_CK1_1 146 152 PF00069 0.312
MOD_CK1_1 162 168 PF00069 0.274
MOD_CK2_1 103 109 PF00069 0.369
MOD_CK2_1 139 145 PF00069 0.335
MOD_CK2_1 162 168 PF00069 0.355
MOD_CK2_1 203 209 PF00069 0.587
MOD_GlcNHglycan 21 24 PF01048 0.664
MOD_GlcNHglycan 211 214 PF01048 0.291
MOD_GlcNHglycan 77 80 PF01048 0.594
MOD_GSK3_1 139 146 PF00069 0.384
MOD_GSK3_1 158 165 PF00069 0.402
MOD_NEK2_1 19 24 PF00069 0.470
MOD_NEK2_1 238 243 PF00069 0.435
MOD_NEK2_1 85 90 PF00069 0.454
MOD_NEK2_2 129 134 PF00069 0.339
MOD_NEK2_2 159 164 PF00069 0.319
MOD_PKA_2 103 109 PF00069 0.394
MOD_PKA_2 5 11 PF00069 0.546
MOD_PKB_1 4 12 PF00069 0.476
MOD_Plk_2-3 168 174 PF00069 0.337
MOD_Plk_4 159 165 PF00069 0.310
MOD_Plk_4 238 244 PF00069 0.364
MOD_Plk_4 6 12 PF00069 0.409
MOD_SUMO_rev_2 132 142 PF00179 0.392
MOD_SUMO_rev_2 31 38 PF00179 0.361
TRG_DiLeu_BaEn_1 115 120 PF01217 0.387
TRG_DiLeu_BaLyEn_6 231 236 PF01217 0.411
TRG_DiLeu_BaLyEn_6 94 99 PF01217 0.403
TRG_DiLeu_LyEn_5 115 120 PF01217 0.329
TRG_ENDOCYTIC_2 128 131 PF00928 0.294
TRG_ENDOCYTIC_2 160 163 PF00928 0.288
TRG_ENDOCYTIC_2 197 200 PF00928 0.266
TRG_ENDOCYTIC_2 243 246 PF00928 0.469
TRG_ENDOCYTIC_2 66 69 PF00928 0.333
TRG_ER_diArg_1 103 105 PF00400 0.414
TRG_ER_diArg_1 4 7 PF00400 0.505
TRG_Pf-PMV_PEXEL_1 105 109 PF00026 0.510
TRG_Pf-PMV_PEXEL_1 111 115 PF00026 0.492
TRG_Pf-PMV_PEXEL_1 97 101 PF00026 0.530

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3Y7 Leptomonas seymouri 71% 98%
A0A0S4JLZ3 Bodo saltans 40% 82%
A0A1X0NZF4 Trypanosomatidae 48% 100%
A0A3Q8IBA6 Leishmania donovani 92% 100%
A0A422NUT6 Trypanosoma rangeli 44% 100%
A4HH29 Leishmania braziliensis 89% 100%
A4I474 Leishmania infantum 92% 100%
C9ZKQ4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 99%
E9ADM3 Leishmania major 92% 100%
V5B4T7 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS