Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM56_LEIMU

TriTrypDb:

LmxM.08_29.0230

Length:

215

Annotations

LeishMANIAdb annotations

Possibly part of a larger transporter.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AM56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.700
CLV_NRD_NRD_1	155	157	PF00675	0.431
CLV_NRD_NRD_1	180	182	PF00675	0.464
CLV_NRD_NRD_1	197	199	PF00675	0.479
CLV_NRD_NRD_1	35	37	PF00675	0.524
CLV_NRD_NRD_1	48	50	PF00675	0.384
CLV_PCSK_KEX2_1	180	182	PF00082	0.469
CLV_PCSK_KEX2_1	47	49	PF00082	0.464
CLV_PCSK_PC7_1	43	49	PF00082	0.462
CLV_PCSK_SKI1_1	198	202	PF00082	0.423
CLV_PCSK_SKI1_1	71	75	PF00082	0.454
CLV_PCSK_SKI1_1	8	12	PF00082	0.504
DEG_APCC_DBOX_1	7	15	PF00400	0.571
DEG_Nend_Nbox_1	1	3	PF02207	0.667
DEG_SCF_FBW7_1	163	168	PF00400	0.531
DOC_MAPK_gen_1	36	44	PF00069	0.697
DOC_MAPK_gen_1	47	56	PF00069	0.589
DOC_MAPK_MEF2A_6	49	58	PF00069	0.639
DOC_PP1_RVXF_1	154	161	PF00149	0.673
DOC_PP2B_LxvP_1	100	103	PF13499	0.518
DOC_USP7_MATH_1	165	169	PF00917	0.745
DOC_WW_Pin1_4	161	166	PF00397	0.745
LIG_14-3-3_CanoR_1	114	119	PF00244	0.524
LIG_14-3-3_CanoR_1	13	19	PF00244	0.665
LIG_14-3-3_CanoR_1	3	11	PF00244	0.635
LIG_14-3-3_CterR_2	211	215	PF00244	0.748
LIG_AP2alpha_2	207	209	PF02296	0.672
LIG_FHA_1	102	108	PF00498	0.465
LIG_FHA_1	61	67	PF00498	0.679
LIG_FHA_1	76	82	PF00498	0.362
LIG_FHA_1	95	101	PF00498	0.366
LIG_FHA_2	25	31	PF00498	0.674
LIG_GBD_Chelix_1	125	133	PF00786	0.413
LIG_LIR_Gen_1	110	118	PF02991	0.463
LIG_LIR_Gen_1	119	129	PF02991	0.268
LIG_LIR_Gen_1	52	61	PF02991	0.693
LIG_LIR_Gen_1	78	88	PF02991	0.462
LIG_LIR_Gen_1	97	107	PF02991	0.380
LIG_LIR_Nem_3	119	124	PF02991	0.320
LIG_LIR_Nem_3	139	144	PF02991	0.498
LIG_LIR_Nem_3	52	56	PF02991	0.683
LIG_LIR_Nem_3	68	73	PF02991	0.654
LIG_LIR_Nem_3	78	83	PF02991	0.343
LIG_LIR_Nem_3	97	102	PF02991	0.384
LIG_SH2_CRK	155	159	PF00017	0.655
LIG_SH2_STAP1	109	113	PF00017	0.486
LIG_SH2_STAP1	136	140	PF00017	0.328
LIG_SH2_STAT5	112	115	PF00017	0.427
LIG_SH2_STAT5	149	152	PF00017	0.636
LIG_SH2_STAT5	53	56	PF00017	0.663
LIG_SH2_STAT5	93	96	PF00017	0.576
LIG_SH2_STAT5	99	102	PF00017	0.437
LIG_SH3_3	147	153	PF00018	0.641
LIG_SH3_3	55	61	PF00018	0.670
LIG_SH3_3	78	84	PF00018	0.455
LIG_TRFH_1	149	153	PF08558	0.670
LIG_TRFH_1	99	103	PF08558	0.491
LIG_TYR_ITIM	51	56	PF00017	0.668
LIG_TYR_ITSM	95	102	PF00017	0.469
LIG_WRC_WIRS_1	115	120	PF05994	0.519
MOD_CK2_1	24	30	PF00069	0.688
MOD_GSK3_1	14	21	PF00069	0.728
MOD_GSK3_1	161	168	PF00069	0.640
MOD_GSK3_1	198	205	PF00069	0.694
MOD_NEK2_1	14	19	PF00069	0.622
MOD_NEK2_1	2	7	PF00069	0.642
MOD_NEK2_1	24	29	PF00069	0.662
MOD_NEK2_1	66	71	PF00069	0.616
MOD_NEK2_2	136	141	PF00069	0.538
MOD_PIKK_1	12	18	PF00454	0.699
MOD_PIKK_1	3	9	PF00454	0.705
MOD_PKA_1	198	204	PF00069	0.583
MOD_PKA_2	12	18	PF00069	0.599
MOD_PKA_2	2	8	PF00069	0.641
MOD_PKB_1	196	204	PF00069	0.555
MOD_Plk_1	136	142	PF00069	0.622
MOD_Plk_4	136	142	PF00069	0.533
MOD_Plk_4	94	100	PF00069	0.490
MOD_ProDKin_1	161	167	PF00069	0.747
TRG_ENDOCYTIC_2	112	115	PF00928	0.427
TRG_ENDOCYTIC_2	144	147	PF00928	0.632
TRG_ENDOCYTIC_2	155	158	PF00928	0.630
TRG_ENDOCYTIC_2	53	56	PF00928	0.669
TRG_ENDOCYTIC_2	98	101	PF00928	0.446
TRG_ER_diArg_1	180	182	PF00400	0.674
TRG_ER_diArg_1	47	49	PF00400	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTZ2	Leptomonas seymouri	75%	100%
A0A0S4ISU9	Bodo saltans	36%	100%
A0A1X0NZD9	Trypanosomatidae	52%	96%
A0A3S7X227	Leishmania donovani	94%	100%
A0A422NUT7	Trypanosoma rangeli	54%	87%
A4HH31	Leishmania braziliensis	82%	100%
A4I476	Leishmania infantum	94%	100%
C9ZKQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ADM5	Leishmania major	93%	100%
V5BPX2	Trypanosoma cruzi	60%	86%