Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein kinase RIO1, putative

Species:

Leishmania mexicana

UniProt:

E9AM55_LEIMU

TriTrypDb:

LmxM.08_29.0240

Length:

537

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AM55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM55

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	5
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	5
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0036211	protein modification process	4	5

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0004674	protein serine/threonine kinase activity	4	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	397	401	PF00656	0.473
CLV_C14_Caspase3-7	464	468	PF00656	0.778
CLV_C14_Caspase3-7	482	486	PF00656	0.710
CLV_MEL_PAP_1	434	440	PF00089	0.362
CLV_NRD_NRD_1	222	224	PF00675	0.222
CLV_NRD_NRD_1	295	297	PF00675	0.209
CLV_NRD_NRD_1	342	344	PF00675	0.198
CLV_NRD_NRD_1	505	507	PF00675	0.456
CLV_NRD_NRD_1	509	511	PF00675	0.468
CLV_NRD_NRD_1	530	532	PF00675	0.536

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIE8	Leptomonas seymouri	82%	97%
A0A0S4JDG4	Bodo saltans	55%	97%
A0A1X0NZG1	Trypanosomatidae	64%	97%
A0A3S7X229	Leishmania donovani	95%	100%
A0A422NUW2	Trypanosoma rangeli	62%	96%
A4HH32	Leishmania braziliensis	88%	100%
A4I477	Leishmania infantum	94%	100%
C9ZKQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	94%
E9ADM6	Leishmania major	93%	100%
G0S3J5	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	38%	100%

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