Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thymine-7-hydroxylase, putative

Species:

Leishmania mexicana

UniProt:

E9AM53_LEIMU

TriTrypDb:

LmxM.08_29.0251

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM53

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	13
GO:0016491	oxidoreductase activity	2	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0005506	iron ion binding	6	1
GO:0008198	ferrous iron binding	7	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	4
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	4
GO:0046914	transition metal ion binding	5	1
GO:0050341	thymine dioxygenase activity	5	4
GO:0051213	dioxygenase activity	3	4
GO:0003960	NADPH:quinone reductase activity	5	1
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	1
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	1
GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor	4	2
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3	2
GO:0050162	oxalate oxidase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.370
CLV_PCSK_KEX2_1	303	305	PF00082	0.377
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.384
CLV_PCSK_SKI1_1	145	149	PF00082	0.424
CLV_PCSK_SKI1_1	56	60	PF00082	0.222
DEG_APCC_DBOX_1	144	152	PF00400	0.368
DOC_CDC14_PxL_1	178	186	PF14671	0.404
DOC_CYCLIN_RxL_1	149	159	PF00134	0.420
DOC_MAPK_MEF2A_6	152	160	PF00069	0.368
DOC_PP2B_PxIxI_1	3	9	PF00149	0.483
DOC_PP4_FxxP_1	104	107	PF00568	0.530
DOC_PP4_FxxP_1	169	172	PF00568	0.364
DOC_PP4_FxxP_1	268	271	PF00568	0.310
DOC_PP4_FxxP_1	59	62	PF00568	0.472
DOC_WW_Pin1_4	248	253	PF00397	0.378
LIG_14-3-3_CanoR_1	247	252	PF00244	0.311
LIG_14-3-3_CanoR_1	262	266	PF00244	0.305
LIG_14-3-3_CanoR_1	304	310	PF00244	0.465
LIG_BIR_II_1	1	5	PF00653	0.319
LIG_BRCT_BRCA1_1	263	267	PF00533	0.325
LIG_deltaCOP1_diTrp_1	299	305	PF00928	0.372
LIG_deltaCOP1_diTrp_1	95	100	PF00928	0.530
LIG_EH1_1	198	206	PF00400	0.325
LIG_eIF4E_1	199	205	PF01652	0.325
LIG_FHA_2	125	131	PF00498	0.588
LIG_GBD_Chelix_1	146	154	PF00786	0.459
LIG_Integrin_isoDGR_2	245	247	PF01839	0.370
LIG_LIR_Apic_2	101	107	PF02991	0.530
LIG_LIR_Apic_2	167	172	PF02991	0.375
LIG_LIR_Gen_1	130	140	PF02991	0.474
LIG_LIR_Nem_3	130	135	PF02991	0.491
LIG_LIR_Nem_3	174	179	PF02991	0.325
LIG_LIR_Nem_3	197	202	PF02991	0.336
LIG_LIR_Nem_3	32	38	PF02991	0.483
LIG_LYPXL_yS_3	181	184	PF13949	0.370
LIG_NRBOX	145	151	PF00104	0.482
LIG_Pex14_1	33	37	PF04695	0.482
LIG_Pex14_1	96	100	PF04695	0.530
LIG_Pex14_2	100	104	PF04695	0.530
LIG_Pex14_2	165	169	PF04695	0.354
LIG_REV1ctd_RIR_1	162	171	PF16727	0.426
LIG_SH2_CRK	199	203	PF00017	0.325
LIG_SH2_SRC	206	209	PF00017	0.234
LIG_SH2_STAP1	309	313	PF00017	0.510
LIG_SH2_STAT5	232	235	PF00017	0.391
LIG_SH2_STAT5	37	40	PF00017	0.497
LIG_SH3_3	179	185	PF00018	0.374
LIG_SH3_3	87	93	PF00018	0.476
LIG_TRAF2_1	62	65	PF00917	0.485
LIG_TYR_ITIM	179	184	PF00017	0.404
LIG_TYR_ITSM	195	202	PF00017	0.370
MOD_CDK_SPxK_1	248	254	PF00069	0.378
MOD_CK1_1	91	97	PF00069	0.409
MOD_CK2_1	124	130	PF00069	0.521
MOD_GSK3_1	224	231	PF00069	0.346
MOD_NEK2_1	164	169	PF00069	0.415
MOD_NEK2_1	228	233	PF00069	0.445
MOD_NEK2_1	305	310	PF00069	0.438
MOD_NEK2_1	36	41	PF00069	0.614
MOD_PKA_2	261	267	PF00069	0.350
MOD_Plk_2-3	224	230	PF00069	0.346
MOD_Plk_4	109	115	PF00069	0.530
MOD_Plk_4	124	130	PF00069	0.444
MOD_Plk_4	171	177	PF00069	0.351
MOD_Plk_4	200	206	PF00069	0.417
MOD_Plk_4	228	234	PF00069	0.310
MOD_Plk_4	272	278	PF00069	0.301
MOD_ProDKin_1	248	254	PF00069	0.378
MOD_SUMO_rev_2	293	298	PF00179	0.493
MOD_SUMO_rev_2	314	318	PF00179	0.555
MOD_SUMO_rev_2	89	99	PF00179	0.473
TRG_ENDOCYTIC_2	140	143	PF00928	0.345
TRG_ENDOCYTIC_2	181	184	PF00928	0.396
TRG_ENDOCYTIC_2	199	202	PF00928	0.334
TRG_NES_CRM1_1	144	159	PF08389	0.423
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A023GS28	Ruta graveolens	28%	86%
A0A023GS29	Ruta graveolens	27%	86%
A0A0F9ZXE3	Trichoderma harzianum	33%	100%
A0A0S4IPR8	Bodo saltans	37%	81%
A0A0S6XAW4	Fungal sp. (strain No.11243)	26%	95%
A0A0S6XGJ8	Fungal sp. (strain No.11243)	24%	99%
A0A0S6XHQ0	Fungal sp. (strain No.11243)	30%	87%
A0A159BP93	Monascus ruber	36%	97%
A0A166YZY4	Metarhizium rileyi (strain RCEF 4871)	32%	90%
A0A166YZY9	Metarhizium rileyi (strain RCEF 4871)	32%	85%
A0A1X0P0P9	Trypanosomatidae	67%	100%
A0A2R6PI27	Actinidia chinensis var. chinensis	29%	90%
A0A2U8U2L3	Sarocladium schorii	28%	94%
A0A3Q8IEZ1	Leishmania donovani	94%	100%
A0A411KUQ7	Acremonium sp.	24%	96%
A0A411L030	Aspergillus burnettii	31%	100%
A0A422MUD1	Trypanosoma rangeli	66%	100%
A0A481WNL2	Penicillium crustosum	34%	94%
A0A481WQ18	Penicillium crustosum	29%	98%
A0A4D6Q440	Crocosmia x crocosmiiflora	29%	96%
A0A4D6Q4T7	Crocosmia x crocosmiiflora	29%	86%
A0A4D6Q9B0	Crocosmia x crocosmiiflora	28%	86%
A0A4P8GG75	Phoma sp.	29%	100%
A0A5C1RDG7	Didymella fabae	34%	96%
A2A1A0	Coptis japonica	29%	91%
A2WQ39	Oryza sativa subsp. indica	30%	85%
A2Z1W9	Oryza sativa subsp. indica	30%	99%
A4HH58	Leishmania braziliensis	85%	100%
A4I478	Leishmania infantum	94%	100%
A6BM06	Dictyostelium mucoroides	31%	87%
B2GVM7	Arabidopsis thaliana	25%	100%
B6HLU0	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	31%	96%
B8M9K5	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	32%	98%
B8NI22	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	26%	88%
C8VK14	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	38%	91%
C9ZJU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
C9ZNA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
C9ZUF7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
D4N500	Papaver somniferum	28%	88%
D4N501	Papaver somniferum	28%	88%
D4N502	Papaver somniferum	27%	89%
E9ADM7	Leishmania major	92%	100%
E9AM54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
F4IY03	Arabidopsis thaliana	34%	96%
F4K7D5	Arabidopsis thaliana	24%	100%
F4KAS1	Arabidopsis thaliana	25%	100%
F4KBY0	Arabidopsis thaliana	27%	98%
G9M9M0	Ipomoea batatas	29%	89%
G9M9M1	Ipomoea batatas	29%	89%
G9M9M2	Ipomoea batatas	29%	89%
G9M9M3	Ipomoea batatas	29%	89%
G9M9M4	Ipomoea batatas	30%	89%
G9M9M5	Ipomoea batatas	29%	89%
I1R9B5	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	28%	84%
I1RV21	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	23%	96%
K0DZA0	Aspergillus rugulosus	27%	97%
K0E3U5	Aspergillus rugulosus	28%	96%
L0E2Q1	Penicillium fellutanum	24%	90%
O04274	Perilla frutescens	27%	88%
O04395	Matthiola incana	26%	100%
O04705	Triticum aestivum	30%	88%
O04706	Triticum aestivum	30%	87%
O04707	Triticum aestivum	29%	87%
O04847	Catharanthus roseus	25%	80%
O24648	Pisum sativum	28%	85%
O48882	Malus domestica	29%	97%
O49561	Arabidopsis thaliana	30%	94%
O64692	Arabidopsis thaliana	28%	95%
O65378	Arabidopsis thaliana	27%	100%
O80449	Arabidopsis thaliana	28%	90%
P05116	Solanum lycopersicum	29%	100%
P05189	Acremonium chrysogenum	31%	94%
P05326	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	31%	96%
P07920	Solanum lycopersicum	28%	100%
P08703	Penicillium chrysogenum	31%	96%
P0C5H5	Oryza sativa subsp. indica	33%	82%
P10621	Streptomyces clavuligerus	34%	97%
P10967	Solanum lycopersicum	29%	88%
P11935	Acremonium chrysogenum	24%	96%
P12438	Streptomyces microflavus	30%	96%
P16020	Flavobacterium sp. (strain SC 12,154)	30%	98%
P18286	Streptomyces jumonjinensis	30%	97%
P19464	Persea americana	27%	100%
P24157	Solanum lycopersicum	29%	100%
P24397	Hyoscyamus niger	24%	93%
P27744	Amycolatopsis lactamdurans	30%	97%
P28038	Hordeum vulgare	28%	85%
P31237	Actinidia deliciosa	27%	100%
P31238	Doritaenopsis sp.	27%	98%
P31239	Pisum sativum	26%	100%
P31528	Dianthus caryophyllus	29%	99%
P32021	Pseudomonas savastanoi pv. phaseolicola	25%	91%
P40902	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	80%
P41090	Vitis vinifera	30%	88%
P41213	Zea mays	29%	81%
P42219	Amycolatopsis lactamdurans	23%	100%
P42220	Streptomyces clavuligerus	22%	100%
P51091	Malus domestica	28%	89%
P51092	Petunia hybrida	28%	74%
P51093	Vitis vinifera	28%	88%
P54847	Cucumis melo	27%	100%
P93771	Oryza sativa subsp. japonica	30%	86%
P93821	Arabidopsis thaliana	26%	92%
P93824	Arabidopsis thaliana	24%	89%
Q00985	Malus domestica	28%	100%
Q01IX6	Oryza sativa subsp. indica	27%	100%
Q03047	Amycolatopsis lactamdurans	24%	100%
Q04644	Cucumis melo	30%	100%
Q05963	Callistephus chinensis	30%	90%
Q05964	Dianthus caryophyllus	30%	87%
Q05965	Matthiola incana	30%	89%
Q06588	Arabidopsis thaliana	30%	99%
Q06942	Malus domestica	30%	88%
Q07353	Petunia hybrida	30%	86%
Q07512	Petunia hybrida	30%	92%
Q08506	Petunia hybrida	29%	100%
Q08507	Petunia hybrida	28%	100%
Q08508	Petunia hybrida	28%	100%
Q09052	Brassica juncea	29%	100%
Q0J1C1	Oryza sativa subsp. japonica	29%	99%
Q0JH50	Oryza sativa subsp. japonica	33%	82%
Q0WPW4	Arabidopsis thaliana	27%	100%
Q15JG7	Streptomyces hygroscopicus subsp. limoneus	28%	87%
Q1ERI0	Monascus purpureus	36%	97%
Q39103	Arabidopsis thaliana	28%	89%
Q39110	Arabidopsis thaliana	29%	85%
Q39111	Arabidopsis thaliana	27%	84%
Q39112	Arabidopsis thaliana	28%	84%
Q39224	Arabidopsis thaliana	29%	89%
Q39705	Doritaenopsis sp.	28%	98%
Q3I409	Triticum aestivum	26%	86%
Q3I410	Triticum aestivum	26%	86%
Q3I411	Triticum aestivum	26%	86%
Q40061	Hordeum vulgare	23%	94%
Q40062	Hordeum vulgare	24%	94%
Q41452	Solanum tuberosum	29%	91%
Q41931	Arabidopsis thaliana	29%	100%
Q43383	Arabidopsis thaliana	27%	80%
Q43792	Nicotiana tabacum	28%	100%
Q48739	Lysobacter lactamgenus	30%	98%
Q4PT02	Arabidopsis thaliana	29%	83%
Q4W946	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	34%	95%
Q53932	Streptomyces cattleya	24%	99%
Q54243	Streptomyces griseus	31%	97%
Q54RA4	Dictyostelium discoideum	38%	88%
Q5MNH6	Epichloe uncinata	25%	88%
Q5MNI4	Epichloe uncinata	23%	88%
Q651B6	Oryza sativa subsp. japonica	28%	84%
Q67VR7	Oryza sativa subsp. japonica	29%	86%
Q69LD8	Oryza sativa subsp. japonica	29%	87%
Q6AT12	Oryza sativa subsp. japonica	29%	83%
Q6K332	Oryza sativa subsp. japonica	36%	97%
Q6YYX9	Oryza sativa subsp. japonica	30%	83%
Q6Z244	Oryza sativa subsp. japonica	29%	95%
Q76NT9	Dictyostelium discoideum	31%	87%
Q7BS31	Pseudomonas cannabina	25%	91%
Q7BS32	Pseudomonas savastanoi pv. glycinea	25%	91%
Q7LL04	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	99%
Q7XKU5	Oryza sativa subsp. japonica	27%	100%
Q7XM21	Oryza sativa subsp. japonica	30%	85%
Q7XP65	Oryza sativa subsp. japonica	26%	89%
Q7XR83	Oryza sativa subsp. japonica	24%	96%
Q7XR84	Oryza sativa subsp. japonica	27%	98%
Q7XZQ6	Petroselinum crispum	29%	95%
Q7XZQ7	Petroselinum crispum	31%	87%
Q7XZQ8	Petroselinum crispum	29%	87%
Q84MB3	Arabidopsis thaliana	26%	87%
Q84MB6	Arabidopsis thaliana	37%	96%
Q84TC2	Zea mays	25%	85%
Q8H113	Arabidopsis thaliana	37%	89%
Q8H1S4	Arabidopsis thaliana	25%	86%
Q8LEA2	Arabidopsis thaliana	27%	97%
Q8LGZ9	Oryza sativa subsp. japonica	30%	94%
Q8S0S6	Oryza sativa subsp. japonica	27%	98%
Q8S932	Diospyros kaki	28%	100%
Q8W2X5	Oryza sativa subsp. japonica	28%	93%
Q8XPV7	Ralstonia solanacearum (strain GMI1000)	26%	92%
Q93VC3	Oryza sativa subsp. japonica	30%	85%
Q94A78	Arabidopsis thaliana	27%	91%
Q94LP4	Oryza sativa subsp. japonica	27%	89%
Q96323	Arabidopsis thaliana	28%	90%
Q96330	Arabidopsis thaliana	29%	95%
Q9C5K7	Arabidopsis thaliana	24%	86%
Q9C6I4	Arabidopsis thaliana	32%	95%
Q9C7Z1	Arabidopsis thaliana	26%	99%
Q9C899	Arabidopsis thaliana	31%	88%
Q9C955	Arabidopsis thaliana	27%	85%
Q9C971	Arabidopsis thaliana	26%	90%
Q9FFF6	Arabidopsis thaliana	28%	86%
Q9FFQ4	Arabidopsis thaliana	27%	98%
Q9FFQ5	Arabidopsis thaliana	29%	100%
Q9FLV0	Arabidopsis thaliana	23%	94%
Q9FR99	Musa acuminata	29%	100%
Q9FU53	Oryza sativa subsp. japonica	27%	86%
Q9FZ21	Arabidopsis thaliana	26%	97%
Q9LE86	Arabidopsis thaliana	28%	89%
Q9LHN8	Arabidopsis thaliana	30%	88%
Q9LSW6	Arabidopsis thaliana	26%	88%
Q9LSW7	Arabidopsis thaliana	26%	87%
Q9LTH7	Arabidopsis thaliana	26%	87%
Q9LTH8	Arabidopsis thaliana	27%	88%
Q9LY48	Arabidopsis thaliana	28%	88%
Q9M2C4	Arabidopsis thaliana	27%	86%
Q9M547	Eustoma exaltatum subsp. russellianum	30%	96%
Q9MB94	Prunus mume	26%	100%
Q9S818	Arabidopsis thaliana	30%	89%
Q9SKK4	Arabidopsis thaliana	26%	89%
Q9SQ80	Pisum sativum	29%	98%
Q9SRM3	Arabidopsis thaliana	27%	80%
Q9SVS8	Arabidopsis thaliana	28%	91%
Q9XFR9	Arabidopsis thaliana	28%	94%
Q9XG83	Phaseolus coccineus	28%	96%
Q9XHG2	Malus domestica	27%	95%
Q9XHM5	Pisum sativum	24%	92%
Q9Z377	Pseudomonas amygdali pv. sesami	25%	91%
Q9Z3T0	Pseudomonas syringae pv. pisi	24%	95%
Q9ZQZ1	Dendrobium crumenatum	30%	100%
Q9ZSA7	Arabidopsis thaliana	26%	92%
Q9ZSA8	Arabidopsis thaliana	27%	91%
Q9ZT84	Arabidopsis thaliana	29%	92%
Q9ZUN4	Arabidopsis thaliana	27%	100%
Q9ZWQ9	Citrus unshiu	29%	95%
S3D784	Glarea lozoyensis (strain ATCC 20868 / MF5171)	29%	97%
S3D9F9	Glarea lozoyensis (strain ATCC 20868 / MF5171)	27%	96%
S3DB70	Glarea lozoyensis (strain ATCC 20868 / MF5171)	25%	99%
S3E7Q2	Glarea lozoyensis (strain ATCC 20868 / MF5171)	23%	97%
V5BKB3	Trypanosoma cruzi	67%	100%
W5QJZ5	Ruta graveolens	28%	87%