SAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AM51_LEIMU

TriTrypDb:

LmxM.08_29.0270

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005643	nuclear pore	3	1
GO:0020023	kinetoplast	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AM51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	89	93	PF00656	0.542
CLV_NRD_NRD_1	131	133	PF00675	0.658
CLV_NRD_NRD_1	185	187	PF00675	0.628
CLV_NRD_NRD_1	194	196	PF00675	0.604
CLV_NRD_NRD_1	47	49	PF00675	0.652
CLV_PCSK_FUR_1	183	187	PF00082	0.614
CLV_PCSK_KEX2_1	183	185	PF00082	0.592
CLV_PCSK_KEX2_1	194	196	PF00082	0.567
CLV_PCSK_KEX2_1	47	49	PF00082	0.628
CLV_PCSK_PC7_1	190	196	PF00082	0.588
CLV_PCSK_SKI1_1	175	179	PF00082	0.556
CLV_PCSK_SKI1_1	196	200	PF00082	0.770
CLV_PCSK_SKI1_1	226	230	PF00082	0.458
DEG_SCF_FBW7_2	81	87	PF00400	0.715
DOC_CKS1_1	81	86	PF01111	0.648
DOC_USP7_MATH_1	105	109	PF00917	0.600
DOC_USP7_MATH_1	123	127	PF00917	0.593
DOC_USP7_MATH_1	146	150	PF00917	0.656
DOC_USP7_UBL2_3	133	137	PF12436	0.621
DOC_USP7_UBL2_3	138	142	PF12436	0.574
DOC_USP7_UBL2_3	143	147	PF12436	0.567
DOC_USP7_UBL2_3	175	179	PF12436	0.617
DOC_USP7_UBL2_3	215	219	PF12436	0.470
DOC_WW_Pin1_4	101	106	PF00397	0.605
DOC_WW_Pin1_4	111	116	PF00397	0.594
DOC_WW_Pin1_4	127	132	PF00397	0.544
DOC_WW_Pin1_4	142	147	PF00397	0.555
DOC_WW_Pin1_4	151	156	PF00397	0.644
DOC_WW_Pin1_4	159	164	PF00397	0.578
DOC_WW_Pin1_4	165	170	PF00397	0.569
DOC_WW_Pin1_4	201	206	PF00397	0.482
DOC_WW_Pin1_4	59	64	PF00397	0.590
DOC_WW_Pin1_4	80	85	PF00397	0.630
DOC_WW_Pin1_4	90	95	PF00397	0.620
LIG_14-3-3_CanoR_1	109	115	PF00244	0.587
LIG_14-3-3_CanoR_1	195	201	PF00244	0.603
LIG_Actin_WH2_2	70	88	PF00022	0.500
LIG_FHA_1	80	86	PF00498	0.630
LIG_FHA_2	228	234	PF00498	0.456
LIG_FHA_2	8	14	PF00498	0.506
LIG_LIR_Nem_3	23	27	PF02991	0.464
LIG_SH2_NCK_1	9	13	PF00017	0.539
LIG_SH2_STAT5	7	10	PF00017	0.531
LIG_SH3_1	91	97	PF00018	0.492
LIG_SH3_2	94	99	PF14604	0.575
LIG_SH3_3	168	174	PF00018	0.627
LIG_SH3_3	91	97	PF00018	0.576
LIG_SH3_4	175	182	PF00018	0.580
MOD_CDC14_SPxK_1	114	117	PF00782	0.662
MOD_CDC14_SPxK_1	135	138	PF00782	0.637
MOD_CDC14_SPxK_1	145	148	PF00782	0.580
MOD_CDC14_SPxK_1	154	157	PF00782	0.634
MOD_CDC14_SPxK_1	162	165	PF00782	0.593
MOD_CDC14_SPxK_1	170	173	PF00782	0.512
MOD_CDC14_SPxK_1	96	99	PF00782	0.653
MOD_CDK_SPK_2	127	132	PF00069	0.607
MOD_CDK_SPK_2	142	147	PF00069	0.555
MOD_CDK_SPK_2	151	156	PF00069	0.720
MOD_CDK_SPK_2	203	208	PF00069	0.485
MOD_CDK_SPxK_1	111	117	PF00069	0.655
MOD_CDK_SPxK_1	127	133	PF00069	0.579
MOD_CDK_SPxK_1	142	148	PF00069	0.514
MOD_CDK_SPxK_1	151	157	PF00069	0.648
MOD_CDK_SPxK_1	159	165	PF00069	0.581
MOD_CDK_SPxK_1	167	173	PF00069	0.534
MOD_CDK_SPxK_1	80	86	PF00069	0.626
MOD_CDK_SPxK_1	93	99	PF00069	0.657
MOD_CDK_SPxxK_3	201	208	PF00069	0.568
MOD_CK1_1	126	132	PF00069	0.647
MOD_CK1_1	150	156	PF00069	0.674
MOD_CK1_1	49	55	PF00069	0.665
MOD_CK1_1	93	99	PF00069	0.674
MOD_CK2_1	7	13	PF00069	0.508
MOD_DYRK1A_RPxSP_1	165	169	PF00069	0.700
MOD_GlcNHglycan	125	128	PF01048	0.633
MOD_GlcNHglycan	180	183	PF01048	0.628
MOD_GlcNHglycan	55	58	PF01048	0.632
MOD_GSK3_1	111	118	PF00069	0.657
MOD_GSK3_1	122	129	PF00069	0.638
MOD_GSK3_1	142	149	PF00069	0.656
MOD_GSK3_1	165	172	PF00069	0.677
MOD_GSK3_1	184	191	PF00069	0.589
MOD_GSK3_1	199	206	PF00069	0.463
MOD_GSK3_1	234	241	PF00069	0.456
MOD_GSK3_1	46	53	PF00069	0.563
MOD_GSK3_1	59	66	PF00069	0.588
MOD_GSK3_1	69	76	PF00069	0.563
MOD_GSK3_1	95	102	PF00069	0.628
MOD_NEK2_1	110	115	PF00069	0.568
MOD_NEK2_1	41	46	PF00069	0.495
MOD_NEK2_1	73	78	PF00069	0.635
MOD_PIKK_1	63	69	PF00454	0.625
MOD_PK_1	219	225	PF00069	0.527
MOD_PKA_1	147	153	PF00069	0.736
MOD_PKA_1	184	190	PF00069	0.696
MOD_PKA_1	47	53	PF00069	0.589
MOD_PKA_2	184	190	PF00069	0.648
MOD_PKA_2	46	52	PF00069	0.602
MOD_PKB_1	184	192	PF00069	0.591
MOD_Plk_1	219	225	PF00069	0.553
MOD_Plk_4	69	75	PF00069	0.616
MOD_ProDKin_1	101	107	PF00069	0.602
MOD_ProDKin_1	111	117	PF00069	0.596
MOD_ProDKin_1	127	133	PF00069	0.546
MOD_ProDKin_1	142	148	PF00069	0.538
MOD_ProDKin_1	151	157	PF00069	0.648
MOD_ProDKin_1	159	165	PF00069	0.581
MOD_ProDKin_1	167	173	PF00069	0.534
MOD_ProDKin_1	201	207	PF00069	0.480
MOD_ProDKin_1	59	65	PF00069	0.590
MOD_ProDKin_1	80	86	PF00069	0.633
MOD_ProDKin_1	90	96	PF00069	0.620
MOD_SUMO_rev_2	87	93	PF00179	0.608
TRG_ENDOCYTIC_2	24	27	PF00928	0.510
TRG_ER_diArg_1	183	186	PF00400	0.708
TRG_ER_diArg_1	46	48	PF00400	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAS3	Leptomonas seymouri	49%	94%
A0A1X0NZQ5	Trypanosomatidae	32%	74%
A0A3S5H7K5	Leishmania donovani	88%	97%
A4HH60	Leishmania braziliensis	71%	100%
C9ZKP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	77%
E9ADM9	Leishmania major	88%	100%
V5DLD7	Trypanosoma cruzi	34%	92%