FHA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AM48_LEIMU

TriTrypDb:

LmxM.08_29.0300

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AM48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.173
CLV_C14_Caspase3-7	315	319	PF00656	0.306
CLV_C14_Caspase3-7	62	66	PF00656	0.580
CLV_NRD_NRD_1	173	175	PF00675	0.463
CLV_NRD_NRD_1	328	330	PF00675	0.414
CLV_NRD_NRD_1	56	58	PF00675	0.573
CLV_NRD_NRD_1	99	101	PF00675	0.390
CLV_PCSK_KEX2_1	56	58	PF00082	0.573
CLV_PCSK_KEX2_1	99	101	PF00082	0.413
CLV_PCSK_SKI1_1	216	220	PF00082	0.410
CLV_PCSK_SKI1_1	25	29	PF00082	0.518
CLV_PCSK_SKI1_1	257	261	PF00082	0.288
CLV_PCSK_SKI1_1	36	40	PF00082	0.414
CLV_PCSK_SKI1_1	86	90	PF00082	0.433
DEG_Nend_UBRbox_2	1	3	PF02207	0.596
DEG_SIAH_1	245	253	PF03145	0.246
DOC_CDC14_PxL_1	38	46	PF14671	0.333
DOC_CYCLIN_RxL_1	22	32	PF00134	0.518
DOC_PP1_RVXF_1	34	41	PF00149	0.528
DOC_PP2B_LxvP_1	243	246	PF13499	0.173
DOC_PP2B_LxvP_1	26	29	PF13499	0.567
DOC_PP2B_LxvP_1	45	48	PF13499	0.353
DOC_PP4_FxxP_1	160	163	PF00568	0.481
DOC_PP4_FxxP_1	76	79	PF00568	0.297
DOC_PP4_MxPP_1	242	245	PF00568	0.173
DOC_USP7_MATH_1	151	155	PF00917	0.690
DOC_USP7_MATH_1	204	208	PF00917	0.297
DOC_USP7_MATH_1	259	263	PF00917	0.355
DOC_USP7_MATH_1	274	278	PF00917	0.201
DOC_USP7_MATH_1	29	33	PF00917	0.696
DOC_USP7_MATH_2	200	206	PF00917	0.391
DOC_USP7_UBL2_3	171	175	PF12436	0.461
DOC_WW_Pin1_4	103	108	PF00397	0.387
LIG_14-3-3_CanoR_1	109	116	PF00244	0.685
LIG_14-3-3_CanoR_1	216	225	PF00244	0.255
LIG_14-3-3_CanoR_1	261	271	PF00244	0.222
LIG_14-3-3_CanoR_1	72	76	PF00244	0.362
LIG_14-3-3_CanoR_1	86	91	PF00244	0.209
LIG_BRCT_BRCA1_1	156	160	PF00533	0.496
LIG_eIF4E_1	6	12	PF01652	0.628
LIG_FHA_1	109	115	PF00498	0.636
LIG_FHA_1	127	133	PF00498	0.243
LIG_FHA_1	157	163	PF00498	0.452
LIG_FHA_1	228	234	PF00498	0.391
LIG_FHA_1	285	291	PF00498	0.410
LIG_FHA_1	312	318	PF00498	0.297
LIG_FHA_1	7	13	PF00498	0.503
LIG_FHA_2	234	240	PF00498	0.259
LIG_FHA_2	313	319	PF00498	0.279
LIG_FHA_2	87	93	PF00498	0.432
LIG_LIR_Apic_2	157	163	PF02991	0.521
LIG_LIR_Apic_2	73	79	PF02991	0.329
LIG_LIR_Gen_1	125	132	PF02991	0.409
LIG_LIR_Gen_1	178	187	PF02991	0.429
LIG_LIR_Gen_1	265	275	PF02991	0.347
LIG_LIR_Gen_1	328	337	PF02991	0.360
LIG_LIR_Gen_1	83	91	PF02991	0.443
LIG_LIR_Nem_3	125	131	PF02991	0.534
LIG_LIR_Nem_3	178	182	PF02991	0.420
LIG_LIR_Nem_3	183	187	PF02991	0.403
LIG_LIR_Nem_3	222	228	PF02991	0.332
LIG_LIR_Nem_3	265	271	PF02991	0.347
LIG_LIR_Nem_3	83	87	PF02991	0.409
LIG_LYPXL_yS_3	41	44	PF13949	0.516
LIG_MLH1_MIPbox_1	157	161	PF16413	0.479
LIG_SH2_CRK	165	169	PF00017	0.427
LIG_SH2_CRK	179	183	PF00017	0.358
LIG_SH2_GRB2like	179	182	PF00017	0.485
LIG_SH2_STAP1	128	132	PF00017	0.404
LIG_SH2_STAT5	128	131	PF00017	0.424
LIG_SH2_STAT5	228	231	PF00017	0.355
LIG_SH2_STAT5	331	334	PF00017	0.359
LIG_SH2_STAT5	84	87	PF00017	0.450
LIG_SH3_3	113	119	PF00018	0.505
LIG_SH3_3	18	24	PF00018	0.601
LIG_SUMO_SIM_par_1	291	298	PF11976	0.279
LIG_TRAF2_2	48	53	PF00917	0.510
LIG_TYR_ITIM	82	87	PF00017	0.455
LIG_UBA3_1	167	175	PF00899	0.484
MOD_CDC14_SPxK_1	106	109	PF00782	0.412
MOD_CDK_SPxK_1	103	109	PF00069	0.371
MOD_CK1_1	141	147	PF00069	0.619
MOD_CK1_1	154	160	PF00069	0.575
MOD_CK1_1	262	268	PF00069	0.355
MOD_CK1_1	32	38	PF00069	0.522
MOD_CK1_1	43	49	PF00069	0.361
MOD_CK1_1	74	80	PF00069	0.483
MOD_CK2_1	86	92	PF00069	0.433
MOD_CMANNOS	98	101	PF00535	0.419
MOD_GlcNHglycan	124	127	PF01048	0.585
MOD_GlcNHglycan	140	143	PF01048	0.546
MOD_GlcNHglycan	147	150	PF01048	0.602
MOD_GlcNHglycan	206	209	PF01048	0.258
MOD_GlcNHglycan	31	34	PF01048	0.545
MOD_GSK3_1	103	110	PF00069	0.653
MOD_GSK3_1	122	129	PF00069	0.512
MOD_GSK3_1	141	148	PF00069	0.517
MOD_GSK3_1	151	158	PF00069	0.649
MOD_GSK3_1	28	35	PF00069	0.457
MOD_GSK3_1	280	287	PF00069	0.346
MOD_GSK3_1	294	301	PF00069	0.234
MOD_GSK3_1	312	319	PF00069	0.150
MOD_GSK3_1	6	13	PF00069	0.611
MOD_GSK3_1	70	77	PF00069	0.615
MOD_N-GLC_1	180	185	PF02516	0.488
MOD_N-GLC_1	233	238	PF02516	0.455
MOD_N-GLC_1	298	303	PF02516	0.279
MOD_NEK2_1	11	16	PF00069	0.606
MOD_NEK2_1	253	258	PF00069	0.355
MOD_NEK2_1	295	300	PF00069	0.279
MOD_NEK2_1	311	316	PF00069	0.292
MOD_NEK2_1	324	329	PF00069	0.285
MOD_PKA_2	108	114	PF00069	0.642
MOD_PKA_2	71	77	PF00069	0.370
MOD_Plk_1	180	186	PF00069	0.429
MOD_Plk_1	280	286	PF00069	0.373
MOD_Plk_1	311	317	PF00069	0.433
MOD_Plk_2-3	312	318	PF00069	0.357
MOD_Plk_4	156	162	PF00069	0.537
MOD_Plk_4	280	286	PF00069	0.241
MOD_Plk_4	312	318	PF00069	0.279
MOD_Plk_4	40	46	PF00069	0.378
MOD_Plk_4	71	77	PF00069	0.484
MOD_ProDKin_1	103	109	PF00069	0.400
MOD_SUMO_rev_2	172	177	PF00179	0.324
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.696
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.545
TRG_ENDOCYTIC_2	128	131	PF00928	0.442
TRG_ENDOCYTIC_2	165	168	PF00928	0.432
TRG_ENDOCYTIC_2	179	182	PF00928	0.365
TRG_ENDOCYTIC_2	331	334	PF00928	0.320
TRG_ENDOCYTIC_2	41	44	PF00928	0.516
TRG_ENDOCYTIC_2	84	87	PF00928	0.364
TRG_ER_diArg_1	23	26	PF00400	0.548
TRG_ER_diArg_1	55	57	PF00400	0.554
TRG_ER_diArg_1	98	100	PF00400	0.407
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.239

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9L3	Leptomonas seymouri	56%	99%
A0A1X0NZG4	Trypanosomatidae	36%	100%
A0A3S7X221	Leishmania donovani	88%	100%
A0A422N067	Trypanosoma rangeli	36%	100%
A4HH57	Leishmania braziliensis	81%	100%
A4I483	Leishmania infantum	89%	100%
C9ZKP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ADN2	Leishmania major	90%	100%
V5BPX7	Trypanosoma cruzi	34%	100%