STI1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AM47_LEIMU

TriTrypDb:

LmxM.08_29.0320

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM47

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0006458	'de novo' protein folding	3	1
GO:0009987	cellular process	1	1
GO:0051084	'de novo' post-translational protein folding	4	1
GO:0051085	chaperone cofactor-dependent protein refolding	4	1
GO:0061077	chaperone-mediated protein folding	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030544	Hsp70 protein binding	4	1
GO:0031072	heat shock protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.505
CLV_NRD_NRD_1	194	196	PF00675	0.609
CLV_NRD_NRD_1	200	202	PF00675	0.536
CLV_PCSK_FUR_1	177	181	PF00082	0.544
CLV_PCSK_KEX2_1	179	181	PF00082	0.509
CLV_PCSK_KEX2_1	194	196	PF00082	0.558
CLV_PCSK_KEX2_1	200	202	PF00082	0.477
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.500
CLV_PCSK_SKI1_1	111	115	PF00082	0.470
DEG_Nend_UBRbox_2	1	3	PF02207	0.590
DOC_PP1_RVXF_1	117	124	PF00149	0.331
DOC_PP4_FxxP_1	107	110	PF00568	0.473
DOC_USP7_MATH_1	219	223	PF00917	0.554
DOC_USP7_MATH_1	278	282	PF00917	0.520
DOC_USP7_MATH_1	335	339	PF00917	0.816
DOC_USP7_UBL2_3	294	298	PF12436	0.475
LIG_FHA_2	34	40	PF00498	0.550
LIG_Integrin_RGD_1	344	346	PF01839	0.519
LIG_LIR_Apic_2	106	110	PF02991	0.477
LIG_PCNA_yPIPBox_3	287	300	PF02747	0.517
LIG_Pex14_2	227	231	PF04695	0.550
LIG_SH2_STAP1	159	163	PF00017	0.492
LIG_SH2_STAT5	169	172	PF00017	0.505
LIG_TRAF2_1	187	190	PF00917	0.551
MOD_CK1_1	172	178	PF00069	0.515
MOD_GlcNHglycan	15	18	PF01048	0.669
MOD_GlcNHglycan	150	154	PF01048	0.457
MOD_GlcNHglycan	337	340	PF01048	0.796
MOD_GlcNHglycan	341	344	PF01048	0.676
MOD_GSK3_1	335	342	PF00069	0.630
MOD_GSK3_1	85	92	PF00069	0.537
MOD_N-GLC_1	163	168	PF02516	0.496
MOD_NEK2_1	163	168	PF00069	0.342
MOD_NEK2_2	144	149	PF00069	0.484
MOD_PIKK_1	172	178	PF00454	0.431
MOD_PIKK_1	267	273	PF00454	0.410
MOD_PKA_2	133	139	PF00069	0.422
MOD_PKA_2	172	178	PF00069	0.511
MOD_Plk_1	144	150	PF00069	0.477
MOD_Plk_1	163	169	PF00069	0.497
MOD_Plk_2-3	25	31	PF00069	0.620
MOD_Plk_2-3	33	39	PF00069	0.592
MOD_Plk_4	246	252	PF00069	0.531
MOD_Plk_4	278	284	PF00069	0.599
MOD_SUMO_for_1	63	66	PF00179	0.494
MOD_SUMO_rev_2	281	288	PF00179	0.520
MOD_SUMO_rev_2	38	45	PF00179	0.523
TRG_ENDOCYTIC_2	96	99	PF00928	0.463
TRG_ER_diArg_1	131	134	PF00400	0.395
TRG_ER_diArg_1	180	182	PF00400	0.505
TRG_ER_diArg_1	199	201	PF00400	0.478
TRG_NES_CRM1_1	271	285	PF08389	0.520
TRG_NLS_MonoExtN_4	177	183	PF00514	0.391
TRG_Pf-PMV_PEXEL_1	180	185	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4ITV7	Bodo saltans	27%	87%
A0A1X0NZI2	Trypanosomatidae	48%	94%
A0A3Q8III7	Leishmania donovani	86%	99%
A4I484	Leishmania infantum	86%	99%
C4NYP8	Drosophila melanogaster	27%	93%
E9ADN3	Leishmania major	82%	99%
P50502	Homo sapiens	32%	95%
P50503	Rattus norvegicus	31%	95%
Q5RF31	Pongo abelii	31%	95%
Q5ZLF0	Gallus gallus	36%	97%
Q86DS1	Drosophila melanogaster	27%	93%
Q8NFI4	Homo sapiens	32%	95%
Q99L47	Mus musculus	30%	94%
V5BUJ8	Trypanosoma cruzi	47%	91%