Arf-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative GTPase activating protein for Arf, putative

Species:

Leishmania mexicana

UniProt:

E9AM46_LEIMU

TriTrypDb:

LmxM.08_29.0330

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM46

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	9
GO:0008047	enzyme activator activity	3	9
GO:0030234	enzyme regulator activity	2	9
GO:0030695	GTPase regulator activity	4	9
GO:0060589	nucleoside-triphosphatase regulator activity	3	9
GO:0098772	molecular function regulator activity	1	9
GO:0140677	molecular function activator activity	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.317
CLV_NRD_NRD_1	25	27	PF00675	0.678
CLV_NRD_NRD_1	283	285	PF00675	0.664
CLV_NRD_NRD_1	51	53	PF00675	0.702
CLV_PCSK_FUR_1	316	320	PF00082	0.354
CLV_PCSK_KEX2_1	25	27	PF00082	0.612
CLV_PCSK_KEX2_1	261	263	PF00082	0.603
CLV_PCSK_KEX2_1	283	285	PF00082	0.606
CLV_PCSK_KEX2_1	318	320	PF00082	0.353
CLV_PCSK_KEX2_1	51	53	PF00082	0.621
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.603
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.393
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.541
CLV_PCSK_PC7_1	279	285	PF00082	0.652
CLV_PCSK_SKI1_1	210	214	PF00082	0.438
DEG_APCC_DBOX_1	147	155	PF00400	0.377
DOC_CYCLIN_yClb5_NLxxxL_5	204	213	PF00134	0.430
DOC_MAPK_gen_1	164	173	PF00069	0.184
DOC_MAPK_gen_1	316	323	PF00069	0.350
DOC_PP2B_LxvP_1	68	71	PF13499	0.511
DOC_USP7_MATH_1	177	181	PF00917	0.437
DOC_USP7_MATH_1	19	23	PF00917	0.613
DOC_USP7_MATH_1	190	194	PF00917	0.337
DOC_USP7_MATH_1	228	232	PF00917	0.573
DOC_USP7_MATH_1	370	374	PF00917	0.548
DOC_USP7_MATH_1	383	387	PF00917	0.464
DOC_USP7_MATH_1	58	62	PF00917	0.760
DOC_USP7_UBL2_3	226	230	PF12436	0.628
DOC_USP7_UBL2_3	49	53	PF12436	0.663
DOC_WW_Pin1_4	238	243	PF00397	0.585
DOC_WW_Pin1_4	354	359	PF00397	0.680
DOC_WW_Pin1_4	375	380	PF00397	0.640
LIG_14-3-3_CanoR_1	113	118	PF00244	0.317
LIG_14-3-3_CanoR_1	148	152	PF00244	0.377
LIG_14-3-3_CanoR_1	244	253	PF00244	0.603
LIG_14-3-3_CanoR_1	289	296	PF00244	0.571
LIG_14-3-3_CanoR_1	316	322	PF00244	0.495
LIG_14-3-3_CanoR_1	66	71	PF00244	0.538
LIG_14-3-3_CanoR_1	94	103	PF00244	0.370
LIG_BIR_II_1	1	5	PF00653	0.671
LIG_deltaCOP1_diTrp_1	314	324	PF00928	0.515
LIG_FHA_1	318	324	PF00498	0.655
LIG_FHA_1	376	382	PF00498	0.484
LIG_FHA_2	142	148	PF00498	0.317
LIG_FHA_2	165	171	PF00498	0.319
LIG_FHA_2	19	25	PF00498	0.549
LIG_FHA_2	33	39	PF00498	0.572
LIG_FHA_2	363	369	PF00498	0.791
LIG_FHA_2	76	82	PF00498	0.583
LIG_Integrin_RGD_1	262	264	PF01839	0.590
LIG_LIR_Apic_2	219	225	PF02991	0.483
LIG_LIR_Gen_1	112	122	PF02991	0.283
LIG_LIR_Nem_3	112	117	PF02991	0.283
LIG_LIR_Nem_3	299	303	PF02991	0.572
LIG_PDZ_Class_2	384	389	PF00595	0.683
LIG_SH2_CRK	222	226	PF00017	0.512
LIG_SH2_STAP1	169	173	PF00017	0.283
LIG_SH2_STAP1	313	317	PF00017	0.516
LIG_SH3_3	168	174	PF00018	0.184
LIG_SH3_3	236	242	PF00018	0.680
LIG_SH3_3	303	309	PF00018	0.550
LIG_SH3_3	331	337	PF00018	0.558
LIG_SUMO_SIM_par_1	319	326	PF11976	0.525
LIG_TRAF2_1	309	312	PF00917	0.524
LIG_TRAF2_1	78	81	PF00917	0.466
LIG_UBA3_1	156	164	PF00899	0.294
LIG_WRC_WIRS_1	191	196	PF05994	0.263
LIG_WRC_WIRS_1	300	305	PF05994	0.629
MOD_CDC14_SPxK_1	241	244	PF00782	0.553
MOD_CDK_SPxK_1	238	244	PF00069	0.553
MOD_CK1_1	246	252	PF00069	0.607
MOD_CK1_1	291	297	PF00069	0.587
MOD_CK1_1	6	12	PF00069	0.478
MOD_CK2_1	147	153	PF00069	0.317
MOD_CK2_1	164	170	PF00069	0.268
MOD_CK2_1	18	24	PF00069	0.590
MOD_CK2_1	322	328	PF00069	0.535
MOD_CK2_1	340	346	PF00069	0.768
MOD_CK2_1	362	368	PF00069	0.786
MOD_CK2_1	370	376	PF00069	0.715
MOD_CK2_1	75	81	PF00069	0.643
MOD_Cter_Amidation	259	262	PF01082	0.630
MOD_GlcNHglycan	127	130	PF01048	0.312
MOD_GlcNHglycan	179	182	PF01048	0.428
MOD_GlcNHglycan	230	233	PF01048	0.550
MOD_GlcNHglycan	290	293	PF01048	0.590
MOD_GlcNHglycan	342	345	PF01048	0.706
MOD_GlcNHglycan	372	375	PF01048	0.638
MOD_GlcNHglycan	53	56	PF01048	0.772
MOD_GlcNHglycan	68	71	PF01048	0.487
MOD_GSK3_1	109	116	PF00069	0.283
MOD_GSK3_1	136	143	PF00069	0.283
MOD_GSK3_1	240	247	PF00069	0.674
MOD_GSK3_1	27	34	PF00069	0.735
MOD_GSK3_1	6	13	PF00069	0.478
MOD_GSK3_1	60	67	PF00069	0.572
MOD_NEK2_1	64	69	PF00069	0.694
MOD_PIKK_1	6	12	PF00454	0.524
MOD_PIKK_1	94	100	PF00454	0.304
MOD_PK_1	113	119	PF00069	0.283
MOD_PKA_1	51	57	PF00069	0.631
MOD_PKA_2	109	115	PF00069	0.316
MOD_PKA_2	125	131	PF00069	0.281
MOD_PKA_2	147	153	PF00069	0.377
MOD_PKA_2	177	183	PF00069	0.377
MOD_PKA_2	243	249	PF00069	0.763
MOD_PKA_2	27	33	PF00069	0.707
MOD_PKA_2	278	284	PF00069	0.604
MOD_PKA_2	288	294	PF00069	0.738
MOD_PKA_2	51	57	PF00069	0.539
MOD_Plk_1	6	12	PF00069	0.478
MOD_Plk_2-3	147	153	PF00069	0.377
MOD_Plk_2-3	32	38	PF00069	0.508
MOD_Plk_4	164	170	PF00069	0.354
MOD_ProDKin_1	238	244	PF00069	0.588
MOD_ProDKin_1	354	360	PF00069	0.680
MOD_ProDKin_1	375	381	PF00069	0.638
TRG_ENDOCYTIC_2	300	303	PF00928	0.627
TRG_ER_diArg_1	25	28	PF00400	0.531
TRG_NLS_MonoCore_2	48	53	PF00514	0.504
TRG_NLS_MonoExtC_3	48	53	PF00514	0.548
TRG_NLS_MonoExtN_4	48	55	PF00514	0.667
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.283
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F7	Leptomonas seymouri	61%	100%
A0A1X0NZE9	Trypanosomatidae	45%	100%
A0A3Q8IE49	Leishmania donovani	88%	100%
A4HH34	Leishmania braziliensis	68%	100%
A4I485	Leishmania infantum	88%	100%
C9ZKP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ADN4	Leishmania major	85%	99%