UBX_domain-containing_protein_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UBX domain-containing protein

Species:

Leishmania mexicana

UniProt:

E9AM45_LEIMU

TriTrypDb:

LmxM.08_29.0340

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005783	endoplasmic reticulum	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AM45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM45

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.388
CLV_C14_Caspase3-7	281	285	PF00656	0.688
CLV_C14_Caspase3-7	335	339	PF00656	0.560
CLV_PCSK_SKI1_1	163	167	PF00082	0.516
CLV_PCSK_SKI1_1	297	301	PF00082	0.570
CLV_PCSK_SKI1_1	398	402	PF00082	0.499
DEG_SPOP_SBC_1	303	307	PF00917	0.594
DEG_SPOP_SBC_1	350	354	PF00917	0.486
DOC_CKS1_1	360	365	PF01111	0.382
DOC_CKS1_1	89	94	PF01111	0.630
DOC_MAPK_DCC_7	382	391	PF00069	0.549
DOC_MAPK_FxFP_2	80	83	PF00069	0.601
DOC_MAPK_MEF2A_6	134	142	PF00069	0.352
DOC_MAPK_MEF2A_6	273	280	PF00069	0.508
DOC_MAPK_MEF2A_6	382	391	PF00069	0.511
DOC_MAPK_MEF2A_6	417	426	PF00069	0.355
DOC_PP1_RVXF_1	119	125	PF00149	0.308
DOC_PP2B_PxIxI_1	386	392	PF00149	0.502
DOC_PP4_FxxP_1	110	113	PF00568	0.361
DOC_PP4_FxxP_1	80	83	PF00568	0.693
DOC_USP7_MATH_1	161	165	PF00917	0.515
DOC_USP7_MATH_1	245	249	PF00917	0.591
DOC_USP7_MATH_1	266	270	PF00917	0.587
DOC_USP7_MATH_1	302	306	PF00917	0.685
DOC_USP7_MATH_1	350	354	PF00917	0.547
DOC_USP7_MATH_1	97	101	PF00917	0.682
DOC_WW_Pin1_4	288	293	PF00397	0.707
DOC_WW_Pin1_4	319	324	PF00397	0.540
DOC_WW_Pin1_4	359	364	PF00397	0.392
DOC_WW_Pin1_4	44	49	PF00397	0.724
DOC_WW_Pin1_4	52	57	PF00397	0.735
DOC_WW_Pin1_4	62	67	PF00397	0.634
DOC_WW_Pin1_4	68	73	PF00397	0.621
DOC_WW_Pin1_4	88	93	PF00397	0.709
LIG_14-3-3_CanoR_1	163	171	PF00244	0.519
LIG_14-3-3_CanoR_1	348	358	PF00244	0.527
LIG_14-3-3_CanoR_1	382	386	PF00244	0.527
LIG_14-3-3_CanoR_1	96	106	PF00244	0.629
LIG_AP2alpha_2	244	246	PF02296	0.665
LIG_BIR_II_1	1	5	PF00653	0.509
LIG_deltaCOP1_diTrp_1	219	223	PF00928	0.541
LIG_FHA_1	151	157	PF00498	0.457
LIG_FHA_1	285	291	PF00498	0.601
LIG_FHA_1	298	304	PF00498	0.612
LIG_FHA_1	305	311	PF00498	0.728
LIG_FHA_1	353	359	PF00498	0.400
LIG_FHA_2	235	241	PF00498	0.490
LIG_FHA_2	323	329	PF00498	0.502
LIG_FHA_2	333	339	PF00498	0.562
LIG_FHA_2	399	405	PF00498	0.545
LIG_FHA_2	49	55	PF00498	0.626
LIG_GBD_Chelix_1	367	375	PF00786	0.221
LIG_LIR_Apic_2	327	332	PF02991	0.566
LIG_LIR_Apic_2	380	386	PF02991	0.533
LIG_LIR_Apic_2	78	83	PF02991	0.690
LIG_LIR_Gen_1	55	66	PF02991	0.613
LIG_LIR_Nem_3	369	373	PF02991	0.437
LIG_LIR_Nem_3	390	395	PF02991	0.539
LIG_LIR_Nem_3	411	416	PF02991	0.409
LIG_LIR_Nem_3	55	61	PF02991	0.620
LIG_PDZ_Class_2	423	428	PF00595	0.393
LIG_Rb_LxCxE_1	166	187	PF01857	0.448
LIG_SH2_CRK	383	387	PF00017	0.449
LIG_SH2_NCK_1	329	333	PF00017	0.566
LIG_SH2_NCK_1	383	387	PF00017	0.449
LIG_SH2_NCK_1	58	62	PF00017	0.714
LIG_SH2_STAP1	173	177	PF00017	0.398
LIG_SH2_STAP1	28	32	PF00017	0.412
LIG_SH2_STAT5	115	118	PF00017	0.416
LIG_SH2_STAT5	24	27	PF00017	0.289
LIG_SH2_STAT5	329	332	PF00017	0.554
LIG_SH2_STAT5	370	373	PF00017	0.379
LIG_SH2_STAT5	376	379	PF00017	0.420
LIG_SH3_2	89	94	PF14604	0.616
LIG_SH3_3	239	245	PF00018	0.588
LIG_SH3_3	269	275	PF00018	0.673
LIG_SH3_3	287	293	PF00018	0.518
LIG_SH3_3	357	363	PF00018	0.380
LIG_SH3_3	38	44	PF00018	0.481
LIG_SH3_3	86	92	PF00018	0.633
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.450
LIG_SUMO_SIM_par_1	138	144	PF11976	0.463
LIG_SUMO_SIM_par_1	274	279	PF11976	0.599
LIG_SUMO_SIM_par_1	305	314	PF11976	0.646
LIG_SUMO_SIM_par_1	321	328	PF11976	0.331
LIG_WW_3	91	95	PF00397	0.594
MOD_CDK_SPxK_1	88	94	PF00069	0.582
MOD_CDK_SPxxK_3	359	366	PF00069	0.500
MOD_CK1_1	164	170	PF00069	0.531
MOD_CK1_1	262	268	PF00069	0.625
MOD_CK1_1	291	297	PF00069	0.703
MOD_CK1_1	305	311	PF00069	0.567
MOD_CK1_1	322	328	PF00069	0.551
MOD_CK1_1	352	358	PF00069	0.557
MOD_CK1_1	390	396	PF00069	0.486
MOD_CK1_1	60	66	PF00069	0.630
MOD_CK1_1	68	74	PF00069	0.622
MOD_CK2_1	282	288	PF00069	0.703
MOD_CK2_1	305	311	PF00069	0.587
MOD_CK2_1	322	328	PF00069	0.364
MOD_CK2_1	398	404	PF00069	0.585
MOD_CK2_1	98	104	PF00069	0.687
MOD_DYRK1A_RPxSP_1	359	363	PF00069	0.510
MOD_DYRK1A_RPxSP_1	88	92	PF00069	0.689
MOD_GlcNHglycan	166	169	PF01048	0.516
MOD_GlcNHglycan	224	227	PF01048	0.494
MOD_GlcNHglycan	261	264	PF01048	0.755
MOD_GlcNHglycan	266	269	PF01048	0.692
MOD_GlcNHglycan	297	300	PF01048	0.768
MOD_GlcNHglycan	392	395	PF01048	0.563
MOD_GlcNHglycan	417	420	PF01048	0.407
MOD_GlcNHglycan	67	70	PF01048	0.671
MOD_GSK3_1	116	123	PF00069	0.424
MOD_GSK3_1	262	269	PF00069	0.658
MOD_GSK3_1	284	291	PF00069	0.610
MOD_GSK3_1	293	300	PF00069	0.563
MOD_GSK3_1	302	309	PF00069	0.737
MOD_GSK3_1	318	325	PF00069	0.573
MOD_GSK3_1	374	381	PF00069	0.468
MOD_GSK3_1	44	51	PF00069	0.701
MOD_GSK3_1	52	59	PF00069	0.687
MOD_N-GLC_1	175	180	PF02516	0.398
MOD_N-GLC_1	398	403	PF02516	0.498
MOD_NEK2_1	234	239	PF00069	0.519
MOD_NEK2_1	98	103	PF00069	0.666
MOD_NEK2_2	268	273	PF00069	0.586
MOD_NEK2_2	387	392	PF00069	0.372
MOD_PIKK_1	203	209	PF00454	0.560
MOD_PKA_2	381	387	PF00069	0.433
MOD_Plk_1	143	149	PF00069	0.468
MOD_Plk_1	327	333	PF00069	0.530
MOD_Plk_1	378	384	PF00069	0.499
MOD_Plk_2-3	120	126	PF00069	0.399
MOD_Plk_2-3	282	288	PF00069	0.596
MOD_Plk_2-3	327	333	PF00069	0.485
MOD_Plk_4	138	144	PF00069	0.355
MOD_Plk_4	166	172	PF00069	0.423
MOD_Plk_4	338	344	PF00069	0.565
MOD_ProDKin_1	288	294	PF00069	0.708
MOD_ProDKin_1	319	325	PF00069	0.536
MOD_ProDKin_1	359	365	PF00069	0.389
MOD_ProDKin_1	44	50	PF00069	0.728
MOD_ProDKin_1	52	58	PF00069	0.736
MOD_ProDKin_1	62	68	PF00069	0.633
MOD_ProDKin_1	88	94	PF00069	0.713
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.437
TRG_ENDOCYTIC_2	58	61	PF00928	0.618
TRG_ER_diArg_1	343	346	PF00400	0.439
TRG_ER_diArg_1	93	96	PF00400	0.724

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T7	Leptomonas seymouri	57%	100%
A0A0S4JDU8	Bodo saltans	26%	83%
A0A1X0NZG7	Trypanosomatidae	27%	97%
A0A3Q8IH33	Leishmania donovani	94%	100%
A0A3R7M3Q4	Trypanosoma rangeli	30%	100%
A4HH35	Leishmania braziliensis	85%	100%
A4I486	Leishmania infantum	94%	100%
C9ZKP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ADN5	Leishmania major	94%	100%
V5B4U5	Trypanosoma cruzi	28%	100%