C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF3451), putative

Species:

Leishmania mexicana

UniProt:

E9AM41_LEIMU

TriTrypDb:

LmxM.08_29.0380

Length:

964

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005638	lamin filament	7	1
GO:0005815	microtubule organizing center	2	1
GO:0005882	intermediate filament	6	1
GO:0035869	ciliary transition zone	2	1
GO:0036064	ciliary basal body	3	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AM41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM41

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	1
GO:0030527	structural constituent of chromatin	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	643	647	PF00656	0.557
CLV_NRD_NRD_1	100	102	PF00675	0.531
CLV_NRD_NRD_1	296	298	PF00675	0.578
CLV_NRD_NRD_1	369	371	PF00675	0.441
CLV_NRD_NRD_1	422	424	PF00675	0.411
CLV_NRD_NRD_1	426	428	PF00675	0.417
CLV_NRD_NRD_1	441	443	PF00675	0.422
CLV_NRD_NRD_1	49	51	PF00675	0.557
CLV_NRD_NRD_1	56	58	PF00675	0.581
CLV_NRD_NRD_1	600	602	PF00675	0.656
CLV_PCSK_FUR_1	420	424	PF00082	0.564
CLV_PCSK_KEX2_1	100	102	PF00082	0.512
CLV_PCSK_KEX2_1	341	343	PF00082	0.483
CLV_PCSK_KEX2_1	422	424	PF00082	0.413
CLV_PCSK_KEX2_1	440	442	PF00082	0.447
CLV_PCSK_KEX2_1	49	51	PF00082	0.519
CLV_PCSK_KEX2_1	504	506	PF00082	0.568
CLV_PCSK_KEX2_1	511	513	PF00082	0.606
CLV_PCSK_KEX2_1	56	58	PF00082	0.470
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.483
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.662
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.705
CLV_PCSK_SKI1_1	100	104	PF00082	0.666
CLV_PCSK_SKI1_1	124	128	PF00082	0.612
CLV_PCSK_SKI1_1	151	155	PF00082	0.454
CLV_PCSK_SKI1_1	272	276	PF00082	0.619
CLV_PCSK_SKI1_1	341	345	PF00082	0.435
CLV_PCSK_SKI1_1	427	431	PF00082	0.507
CLV_PCSK_SKI1_1	548	552	PF00082	0.607
CLV_PCSK_SKI1_1	569	573	PF00082	0.444
CLV_PCSK_SKI1_1	597	601	PF00082	0.548
CLV_PCSK_SKI1_1	607	611	PF00082	0.402
CLV_PCSK_SKI1_1	787	791	PF00082	0.572
CLV_PCSK_SKI1_1	876	880	PF00082	0.396
CLV_PCSK_SKI1_1	932	936	PF00082	0.364
CLV_Separin_Metazoa	598	602	PF03568	0.515
DEG_APCC_DBOX_1	207	215	PF00400	0.552
DEG_APCC_DBOX_1	596	604	PF00400	0.506
DEG_APCC_DBOX_1	786	794	PF00400	0.476
DEG_APCC_DBOX_1	99	107	PF00400	0.716
DEG_Nend_UBRbox_3	1	3	PF02207	0.689
DEG_SCF_FBW7_2	8	15	PF00400	0.422
DEG_SPOP_SBC_1	116	120	PF00917	0.537
DOC_CYCLIN_RxL_1	337	348	PF00134	0.420
DOC_CYCLIN_RxL_1	929	937	PF00134	0.354
DOC_CYCLIN_yCln2_LP_2	102	105	PF00134	0.652
DOC_CYCLIN_yCln2_LP_2	674	680	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	788	794	PF00134	0.417
DOC_MAPK_gen_1	256	265	PF00069	0.442
DOC_MAPK_gen_1	545	553	PF00069	0.532
DOC_MAPK_HePTP_8	820	832	PF00069	0.348
DOC_MAPK_MEF2A_6	256	265	PF00069	0.430
DOC_MAPK_MEF2A_6	775	783	PF00069	0.333
DOC_MAPK_MEF2A_6	787	794	PF00069	0.423
DOC_MAPK_MEF2A_6	823	832	PF00069	0.329
DOC_PP1_RVXF_1	899	906	PF00149	0.462
DOC_PP1_SILK_1	27	32	PF00149	0.465
DOC_PP2B_LxvP_1	102	105	PF13499	0.781
DOC_PP2B_LxvP_1	674	677	PF13499	0.518
DOC_PP2B_LxvP_1	788	791	PF13499	0.391
DOC_PP2B_LxvP_1	794	797	PF13499	0.465
DOC_USP7_MATH_1	112	116	PF00917	0.769
DOC_USP7_MATH_1	140	144	PF00917	0.584
DOC_USP7_MATH_1	180	184	PF00917	0.610
DOC_USP7_MATH_1	190	194	PF00917	0.570
DOC_USP7_MATH_1	399	403	PF00917	0.311
DOC_USP7_MATH_1	58	62	PF00917	0.710
DOC_USP7_MATH_1	640	644	PF00917	0.526
DOC_USP7_MATH_1	750	754	PF00917	0.510
DOC_USP7_MATH_1	95	99	PF00917	0.646
DOC_USP7_UBL2_3	124	128	PF12436	0.612
DOC_WW_Pin1_4	129	134	PF00397	0.777
DOC_WW_Pin1_4	539	544	PF00397	0.422
DOC_WW_Pin1_4	69	74	PF00397	0.657
DOC_WW_Pin1_4	8	13	PF00397	0.616
DOC_WW_Pin1_4	855	860	PF00397	0.513
DOC_WW_Pin1_4	90	95	PF00397	0.654
DOC_WW_Pin1_4	934	939	PF00397	0.374
LIG_14-3-3_CanoR_1	297	305	PF00244	0.535
LIG_14-3-3_CanoR_1	3	9	PF00244	0.661
LIG_14-3-3_CanoR_1	342	348	PF00244	0.575
LIG_14-3-3_CanoR_1	370	378	PF00244	0.425
LIG_14-3-3_CanoR_1	407	414	PF00244	0.482
LIG_14-3-3_CanoR_1	601	610	PF00244	0.596
LIG_14-3-3_CanoR_1	637	645	PF00244	0.648
LIG_14-3-3_CanoR_1	656	665	PF00244	0.533
LIG_14-3-3_CanoR_1	802	810	PF00244	0.664
LIG_14-3-3_CanoR_1	81	90	PF00244	0.559
LIG_14-3-3_CanoR_1	876	882	PF00244	0.545
LIG_14-3-3_CanoR_1	943	950	PF00244	0.430
LIG_Actin_WH2_2	586	603	PF00022	0.513
LIG_APCC_ABBA_1	289	294	PF00400	0.369
LIG_APCC_ABBA_1	910	915	PF00400	0.348
LIG_BIR_III_2	885	889	PF00653	0.466
LIG_BIR_III_4	537	541	PF00653	0.521
LIG_BIR_III_4	646	650	PF00653	0.398
LIG_BRCT_BRCA1_1	131	135	PF00533	0.530
LIG_BRCT_BRCA1_1	678	682	PF00533	0.417
LIG_BRCT_BRCA1_1	874	878	PF00533	0.507
LIG_Clathr_ClatBox_1	344	348	PF01394	0.477
LIG_CtBP_PxDLS_1	285	289	PF00389	0.562
LIG_DLG_GKlike_1	357	364	PF00625	0.429
LIG_FHA_1	174	180	PF00498	0.613
LIG_FHA_1	273	279	PF00498	0.695
LIG_FHA_1	3	9	PF00498	0.636
LIG_FHA_1	650	656	PF00498	0.390
LIG_FHA_1	738	744	PF00498	0.483
LIG_FHA_1	763	769	PF00498	0.438
LIG_FHA_1	878	884	PF00498	0.405
LIG_FHA_1	939	945	PF00498	0.417
LIG_FHA_1	951	957	PF00498	0.325
LIG_FHA_2	116	122	PF00498	0.747
LIG_FHA_2	374	380	PF00498	0.502
LIG_FHA_2	444	450	PF00498	0.473
LIG_FHA_2	487	493	PF00498	0.593
LIG_LIR_Gen_1	552	560	PF02991	0.481
LIG_LIR_Gen_1	689	698	PF02991	0.417
LIG_LIR_Gen_1	824	835	PF02991	0.385
LIG_LIR_Gen_1	881	889	PF02991	0.443
LIG_LIR_Gen_1	909	917	PF02991	0.405
LIG_LIR_Nem_3	46	51	PF02991	0.553
LIG_LIR_Nem_3	552	557	PF02991	0.483
LIG_LIR_Nem_3	679	684	PF02991	0.364
LIG_LIR_Nem_3	824	830	PF02991	0.464
LIG_LIR_Nem_3	909	913	PF02991	0.378
LIG_MLH1_MIPbox_1	678	682	PF16413	0.458
LIG_MYND_1	104	108	PF01753	0.721
LIG_PCNA_PIPBox_1	240	249	PF02747	0.340
LIG_PDZ_Class_1	959	964	PF00595	0.430
LIG_SH2_STAP1	690	694	PF00017	0.376
LIG_SH2_STAT3	453	456	PF00017	0.430
LIG_SH2_STAT5	827	830	PF00017	0.258
LIG_SH2_STAT5	851	854	PF00017	0.330
LIG_SH3_1	91	97	PF00018	0.511
LIG_SH3_3	102	108	PF00018	0.722
LIG_SH3_3	61	67	PF00018	0.726
LIG_SH3_3	76	82	PF00018	0.734
LIG_SH3_3	867	873	PF00018	0.416
LIG_SH3_3	91	97	PF00018	0.665
LIG_SUMO_SIM_par_1	5	11	PF11976	0.450
LIG_SUMO_SIM_par_1	818	824	PF11976	0.452
LIG_SxIP_EBH_1	502	512	PF03271	0.546
LIG_TRAF2_1	200	203	PF00917	0.599
LIG_TRAF2_1	445	448	PF00917	0.464
LIG_TRAF2_1	811	814	PF00917	0.377
LIG_TYR_ITIM	825	830	PF00017	0.262
LIG_UBA3_1	29	34	PF00899	0.468
LIG_UBA3_1	326	331	PF00899	0.552
LIG_WRC_WIRS_1	650	655	PF05994	0.390
LIG_WRC_WIRS_1	907	912	PF05994	0.471
MOD_CDK_SPxK_1	539	545	PF00069	0.417
MOD_CDK_SPxK_1	8	14	PF00069	0.547
MOD_CK1_1	115	121	PF00069	0.735
MOD_CK1_1	183	189	PF00069	0.586
MOD_CK1_1	193	199	PF00069	0.476
MOD_CK1_1	250	256	PF00069	0.483
MOD_CK1_1	300	306	PF00069	0.540
MOD_CK1_1	353	359	PF00069	0.565
MOD_CK1_1	388	394	PF00069	0.493
MOD_CK1_1	406	412	PF00069	0.545
MOD_CK1_1	465	471	PF00069	0.492
MOD_CK1_1	69	75	PF00069	0.698
MOD_CK2_1	115	121	PF00069	0.596
MOD_CK2_1	140	146	PF00069	0.570
MOD_CK2_1	357	363	PF00069	0.499
MOD_CK2_1	373	379	PF00069	0.383
MOD_CK2_1	442	448	PF00069	0.447
MOD_CK2_1	808	814	PF00069	0.593
MOD_CK2_1	81	87	PF00069	0.741
MOD_GlcNHglycan	114	117	PF01048	0.585
MOD_GlcNHglycan	188	191	PF01048	0.594
MOD_GlcNHglycan	192	195	PF01048	0.549
MOD_GlcNHglycan	467	470	PF01048	0.511
MOD_GlcNHglycan	60	63	PF01048	0.665
MOD_GlcNHglycan	642	645	PF01048	0.613
MOD_GlcNHglycan	68	71	PF01048	0.601
MOD_GlcNHglycan	74	77	PF01048	0.691
MOD_GlcNHglycan	810	813	PF01048	0.566
MOD_GlcNHglycan	83	86	PF01048	0.577
MOD_GlcNHglycan	840	843	PF01048	0.615
MOD_GlcNHglycan	961	964	PF01048	0.455
MOD_GSK3_1	112	119	PF00069	0.717
MOD_GSK3_1	129	136	PF00069	0.645
MOD_GSK3_1	179	186	PF00069	0.532
MOD_GSK3_1	2	9	PF00069	0.703
MOD_GSK3_1	300	307	PF00069	0.434
MOD_GSK3_1	353	360	PF00069	0.558
MOD_GSK3_1	369	376	PF00069	0.462
MOD_GSK3_1	395	402	PF00069	0.442
MOD_GSK3_1	676	683	PF00069	0.360
MOD_GSK3_1	68	75	PF00069	0.589
MOD_GSK3_1	804	811	PF00069	0.622
MOD_GSK3_1	872	879	PF00069	0.423
MOD_GSK3_1	915	922	PF00069	0.479
MOD_GSK3_1	934	941	PF00069	0.418
MOD_GSK3_1	952	959	PF00069	0.265
MOD_N-GLC_1	133	138	PF02516	0.572
MOD_N-GLC_1	183	188	PF02516	0.658
MOD_NEK2_1	179	184	PF00069	0.553
MOD_NEK2_1	304	309	PF00069	0.514
MOD_NEK2_1	385	390	PF00069	0.412
MOD_NEK2_1	581	586	PF00069	0.436
MOD_NEK2_1	611	616	PF00069	0.456
MOD_NEK2_1	665	670	PF00069	0.426
MOD_NEK2_1	808	813	PF00069	0.657
MOD_NEK2_2	938	943	PF00069	0.483
MOD_PIKK_1	206	212	PF00454	0.538
MOD_PIKK_1	230	236	PF00454	0.588
MOD_PIKK_1	43	49	PF00454	0.647
MOD_PIKK_1	443	449	PF00454	0.586
MOD_PIKK_1	529	535	PF00454	0.468
MOD_PIKK_1	657	663	PF00454	0.577
MOD_PK_1	462	468	PF00069	0.404
MOD_PK_1	775	781	PF00069	0.275
MOD_PKA_1	297	303	PF00069	0.563
MOD_PKA_1	504	510	PF00069	0.620
MOD_PKA_1	601	607	PF00069	0.611
MOD_PKA_2	174	180	PF00069	0.631
MOD_PKA_2	2	8	PF00069	0.496
MOD_PKA_2	247	253	PF00069	0.533
MOD_PKA_2	369	375	PF00069	0.479
MOD_PKA_2	393	399	PF00069	0.405
MOD_PKA_2	406	412	PF00069	0.425
MOD_PKA_2	414	420	PF00069	0.401
MOD_PKA_2	504	510	PF00069	0.590
MOD_PKA_2	866	872	PF00069	0.371
MOD_PKA_2	915	921	PF00069	0.471
MOD_PKA_2	942	948	PF00069	0.420
MOD_PKB_1	355	363	PF00069	0.431
MOD_PKB_1	440	448	PF00069	0.369
MOD_Plk_1	183	189	PF00069	0.466
MOD_Plk_1	25	31	PF00069	0.466
MOD_Plk_1	259	265	PF00069	0.619
MOD_Plk_1	300	306	PF00069	0.604
MOD_Plk_1	462	468	PF00069	0.603
MOD_Plk_1	611	617	PF00069	0.542
MOD_Plk_1	724	730	PF00069	0.383
MOD_Plk_1	738	744	PF00069	0.392
MOD_Plk_1	762	768	PF00069	0.403
MOD_Plk_2-3	555	561	PF00069	0.486
MOD_Plk_4	25	31	PF00069	0.466
MOD_Plk_4	300	306	PF00069	0.509
MOD_Plk_4	462	468	PF00069	0.390
MOD_Plk_4	623	629	PF00069	0.461
MOD_Plk_4	676	682	PF00069	0.351
MOD_Plk_4	750	756	PF00069	0.522
MOD_Plk_4	775	781	PF00069	0.507
MOD_Plk_4	866	872	PF00069	0.369
MOD_Plk_4	906	912	PF00069	0.390
MOD_Plk_4	956	962	PF00069	0.374
MOD_ProDKin_1	129	135	PF00069	0.777
MOD_ProDKin_1	539	545	PF00069	0.417
MOD_ProDKin_1	69	75	PF00069	0.660
MOD_ProDKin_1	8	14	PF00069	0.613
MOD_ProDKin_1	855	861	PF00069	0.526
MOD_ProDKin_1	90	96	PF00069	0.652
MOD_ProDKin_1	934	940	PF00069	0.372
MOD_SUMO_for_1	126	129	PF00179	0.598
MOD_SUMO_for_1	200	203	PF00179	0.475
MOD_SUMO_for_1	319	322	PF00179	0.395
MOD_SUMO_for_1	458	461	PF00179	0.563
MOD_SUMO_for_1	510	513	PF00179	0.574
MOD_SUMO_rev_2	328	333	PF00179	0.485
MOD_SUMO_rev_2	36	41	PF00179	0.507
MOD_SUMO_rev_2	421	430	PF00179	0.543
MOD_SUMO_rev_2	811	818	PF00179	0.624
TRG_DiLeu_BaEn_1	322	327	PF01217	0.401
TRG_DiLeu_BaEn_1	381	386	PF01217	0.535
TRG_DiLeu_BaEn_1	606	611	PF01217	0.404
TRG_DiLeu_BaEn_1	739	744	PF01217	0.447
TRG_DiLeu_BaEn_4	612	618	PF01217	0.458
TRG_DiLeu_BaLyEn_6	930	935	PF01217	0.382
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.566
TRG_DiLeu_LyEn_5	322	327	PF01217	0.546
TRG_ENDOCYTIC_2	690	693	PF00928	0.405
TRG_ENDOCYTIC_2	711	714	PF00928	0.412
TRG_ENDOCYTIC_2	827	830	PF00928	0.379
TRG_ER_diArg_1	354	357	PF00400	0.610
TRG_ER_diArg_1	439	442	PF00400	0.460
TRG_ER_diArg_1	48	50	PF00400	0.607
TRG_ER_diArg_1	55	57	PF00400	0.631
TRG_ER_diArg_1	617	620	PF00400	0.397
TRG_ER_diArg_1	99	101	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	49	54	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	656	661	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	699	703	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	892	896	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDE6	Leptomonas seymouri	62%	98%
A0A0S4IU72	Bodo saltans	29%	92%
A0A1X0NZR4	Trypanosomatidae	44%	100%
A0A3Q8IF75	Leishmania donovani	94%	99%
A0A3R7KK73	Trypanosoma rangeli	45%	100%
A4HH39	Leishmania braziliensis	81%	99%
A4I490	Leishmania infantum	94%	99%
C9ZKP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ADN9	Leishmania major	93%	100%
V5BPY2	Trypanosoma cruzi	43%	96%