RNA polymerase Rpb4 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA polymerase Rpb4, putative

Species:

Leishmania mexicana

UniProt:

E9AM39_LEIMU

TriTrypDb:

LmxM.08_29.0400

Length:

166

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	3
GO:0000932	P-body	5	1
GO:0005634	nucleus	5	10
GO:0005654	nucleoplasm	2	1
GO:0005665	RNA polymerase II, core complex	4	1
GO:0030880	RNA polymerase complex	3	3
GO:0032991	protein-containing complex	1	3
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	11

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Expansion

Sequence features

E9AM39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM39

Function

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Biological processes
Term	Name	Level	Count
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	6	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006352	DNA-templated transcription initiation	6	2
GO:0006367	transcription initiation at RNA polymerase II promoter	7	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006405	RNA export from nucleus	5	1
GO:0006406	mRNA export from nucleus	6	1
GO:0006417	regulation of translation	6	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	1
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	1
GO:0005488	binding	1	11
GO:0005515	protein binding	2	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0031369	translation initiation factor binding	3	1
GO:0034062	5'-3' RNA polymerase activity	5	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	32	34	PF00082	0.551
CLV_PCSK_KEX2_1	73	75	PF00082	0.595
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.664
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.678
CLV_PCSK_SKI1_1	43	47	PF00082	0.635
DEG_Nend_UBRbox_2	1	3	PF02207	0.587
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.510
DOC_MAPK_gen_1	122	131	PF00069	0.577
DOC_MAPK_RevD_3	20	33	PF00069	0.524
DOC_PP2B_LxvP_1	20	23	PF13499	0.507

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILS1	Leptomonas seymouri	76%	100%
A0A0S4KR23	Bodo saltans	38%	100%
A0A1X0NZH4	Trypanosomatidae	39%	99%
A0A3S5H7K6	Leishmania donovani	96%	100%
A0A422NUI9	Trypanosoma rangeli	40%	98%
A4HH41	Leishmania braziliensis	90%	100%
A4I494	Leishmania infantum	96%	100%
C9ZKN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ADP1	Leishmania major	93%	100%

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