Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM38_LEIMU

TriTrypDb:

LmxM.08_29.0410

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM38

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.625
CLV_C14_Caspase3-7	82	86	PF00656	0.643
CLV_NRD_NRD_1	272	274	PF00675	0.593
CLV_NRD_NRD_1	439	441	PF00675	0.688
CLV_NRD_NRD_1	478	480	PF00675	0.523
CLV_NRD_NRD_1	532	534	PF00675	0.654
CLV_PCSK_KEX2_1	390	392	PF00082	0.580
CLV_PCSK_KEX2_1	439	441	PF00082	0.688
CLV_PCSK_KEX2_1	532	534	PF00082	0.657
CLV_PCSK_KEX2_1	571	573	PF00082	0.591
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.695
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.591
CLV_PCSK_SKI1_1	445	449	PF00082	0.807
CLV_PCSK_SKI1_1	480	484	PF00082	0.696
CLV_Separin_Metazoa	505	509	PF03568	0.752
DEG_APCC_DBOX_1	448	456	PF00400	0.683
DEG_APCC_DBOX_1	561	569	PF00400	0.711
DEG_Nend_Nbox_1	1	3	PF02207	0.535
DOC_CKS1_1	44	49	PF01111	0.535
DOC_CYCLIN_yCln2_LP_2	198	204	PF00134	0.742
DOC_MAPK_RevD_3	556	572	PF00069	0.661
DOC_PP2B_LxvP_1	198	201	PF13499	0.747
DOC_PP2B_LxvP_1	448	451	PF13499	0.688
DOC_PP2B_LxvP_1	487	490	PF13499	0.528
DOC_PP2B_LxvP_1	77	80	PF13499	0.495
DOC_PP4_FxxP_1	567	570	PF00568	0.482
DOC_USP7_MATH_1	11	15	PF00917	0.674
DOC_USP7_MATH_1	124	128	PF00917	0.761
DOC_USP7_MATH_1	328	332	PF00917	0.610
DOC_USP7_MATH_1	357	361	PF00917	0.746
DOC_USP7_MATH_1	428	432	PF00917	0.633
DOC_USP7_MATH_1	541	545	PF00917	0.718
DOC_USP7_MATH_1	549	553	PF00917	0.627
DOC_USP7_MATH_1	71	75	PF00917	0.702
DOC_USP7_UBL2_3	157	161	PF12436	0.712
DOC_WW_Pin1_4	130	135	PF00397	0.799
DOC_WW_Pin1_4	183	188	PF00397	0.653
DOC_WW_Pin1_4	298	303	PF00397	0.569
DOC_WW_Pin1_4	334	339	PF00397	0.683
DOC_WW_Pin1_4	375	380	PF00397	0.768
DOC_WW_Pin1_4	39	44	PF00397	0.780
DOC_WW_Pin1_4	399	404	PF00397	0.620
DOC_WW_Pin1_4	407	412	PF00397	0.641
DOC_WW_Pin1_4	48	53	PF00397	0.698
DOC_WW_Pin1_4	488	493	PF00397	0.656
DOC_WW_Pin1_4	518	523	PF00397	0.688
LIG_14-3-3_CanoR_1	234	243	PF00244	0.518
LIG_14-3-3_CanoR_1	358	366	PF00244	0.662
LIG_14-3-3_CanoR_1	373	380	PF00244	0.575
LIG_14-3-3_CanoR_1	383	392	PF00244	0.539
LIG_14-3-3_CanoR_1	439	448	PF00244	0.727
LIG_14-3-3_CanoR_1	457	463	PF00244	0.559
LIG_14-3-3_CanoR_1	532	538	PF00244	0.627
LIG_DCNL_PONY_1	1	4	PF03556	0.654
LIG_deltaCOP1_diTrp_1	210	217	PF00928	0.683
LIG_FHA_1	179	185	PF00498	0.721
LIG_FHA_1	327	333	PF00498	0.696
LIG_FHA_1	360	366	PF00498	0.621
LIG_FHA_1	400	406	PF00498	0.713
LIG_FHA_1	422	428	PF00498	0.583
LIG_FHA_1	545	551	PF00498	0.679
LIG_FHA_1	74	80	PF00498	0.742
LIG_FHA_2	117	123	PF00498	0.488
LIG_FHA_2	164	170	PF00498	0.538
LIG_FHA_2	500	506	PF00498	0.765
LIG_MYND_1	266	270	PF01753	0.532
LIG_MYND_1	566	570	PF01753	0.632
LIG_MYND_1	57	61	PF01753	0.537
LIG_NRBOX	110	116	PF00104	0.649
LIG_NRBOX	88	94	PF00104	0.520
LIG_Pex14_2	388	392	PF04695	0.560
LIG_RPA_C_Fungi	353	365	PF08784	0.716
LIG_SH2_STAP1	146	150	PF00017	0.527
LIG_SH2_STAT5	216	219	PF00017	0.696
LIG_SH3_1	335	341	PF00018	0.628
LIG_SH3_1	511	517	PF00018	0.622
LIG_SH3_2	506	511	PF14604	0.625
LIG_SH3_3	181	187	PF00018	0.643
LIG_SH3_3	191	197	PF00018	0.685
LIG_SH3_3	200	206	PF00018	0.572
LIG_SH3_3	261	267	PF00018	0.733
LIG_SH3_3	291	297	PF00018	0.830
LIG_SH3_3	335	341	PF00018	0.721
LIG_SH3_3	41	47	PF00018	0.642
LIG_SH3_3	503	509	PF00018	0.679
LIG_SH3_3	511	517	PF00018	0.603
LIG_SH3_3	567	573	PF00018	0.704
LIG_SH3_4	157	164	PF00018	0.716
LIG_SUMO_SIM_anti_2	554	560	PF11976	0.702
LIG_SUMO_SIM_par_1	74	82	PF11976	0.552
LIG_TRAF2_1	119	122	PF00917	0.495
LIG_TRAF2_1	28	31	PF00917	0.645
LIG_TRAF2_1	302	305	PF00917	0.509
LIG_TRAF2_1	469	472	PF00917	0.680
MOD_CDC14_SPxK_1	133	136	PF00782	0.769
MOD_CDK_SPxK_1	130	136	PF00069	0.810
MOD_CK1_1	168	174	PF00069	0.670
MOD_CK1_1	238	244	PF00069	0.659
MOD_CK1_1	298	304	PF00069	0.614
MOD_CK1_1	443	449	PF00069	0.734
MOD_CK1_1	458	464	PF00069	0.461
MOD_CK1_1	535	541	PF00069	0.706
MOD_CK1_1	544	550	PF00069	0.711
MOD_CK1_1	78	84	PF00069	0.622
MOD_CK2_1	116	122	PF00069	0.472
MOD_CK2_1	298	304	PF00069	0.678
MOD_CK2_1	499	505	PF00069	0.660
MOD_Cter_Amidation	437	440	PF01082	0.689
MOD_DYRK1A_RPxSP_1	488	492	PF00069	0.526
MOD_GlcNHglycan	125	129	PF01048	0.665
MOD_GlcNHglycan	169	173	PF01048	0.747
MOD_GlcNHglycan	237	240	PF01048	0.620
MOD_GlcNHglycan	270	273	PF01048	0.830
MOD_GlcNHglycan	359	362	PF01048	0.598
MOD_GlcNHglycan	430	433	PF01048	0.614
MOD_GlcNHglycan	539	542	PF01048	0.578
MOD_GlcNHglycan	81	84	PF01048	0.527
MOD_GSK3_1	179	186	PF00069	0.677
MOD_GSK3_1	221	228	PF00069	0.732
MOD_GSK3_1	30	37	PF00069	0.710
MOD_GSK3_1	375	382	PF00069	0.716
MOD_GSK3_1	39	46	PF00069	0.668
MOD_GSK3_1	417	424	PF00069	0.562
MOD_GSK3_1	439	446	PF00069	0.657
MOD_GSK3_1	533	540	PF00069	0.720
MOD_GSK3_1	71	78	PF00069	0.659
MOD_N-GLC_1	130	135	PF02516	0.687
MOD_NEK2_1	178	183	PF00069	0.606
MOD_NEK2_1	326	331	PF00069	0.662
MOD_NEK2_1	455	460	PF00069	0.711
MOD_NEK2_2	244	249	PF00069	0.516
MOD_NEK2_2	328	333	PF00069	0.548
MOD_PIKK_1	226	232	PF00454	0.531
MOD_PIKK_1	417	423	PF00454	0.637
MOD_PKA_1	439	445	PF00069	0.682
MOD_PKA_1	532	538	PF00069	0.656
MOD_PKA_2	357	363	PF00069	0.773
MOD_PKA_2	439	445	PF00069	0.682
MOD_PKA_2	458	464	PF00069	0.576
MOD_PKA_2	499	505	PF00069	0.630
MOD_PKA_2	532	538	PF00069	0.624
MOD_Plk_1	168	174	PF00069	0.533
MOD_Plk_1	443	449	PF00069	0.734
MOD_Plk_1	84	90	PF00069	0.549
MOD_Plk_2-3	163	169	PF00069	0.540
MOD_Plk_4	212	218	PF00069	0.685
MOD_Plk_4	290	296	PF00069	0.716
MOD_Plk_4	520	526	PF00069	0.542
MOD_Plk_4	84	90	PF00069	0.425
MOD_ProDKin_1	130	136	PF00069	0.800
MOD_ProDKin_1	183	189	PF00069	0.656
MOD_ProDKin_1	298	304	PF00069	0.569
MOD_ProDKin_1	334	340	PF00069	0.682
MOD_ProDKin_1	375	381	PF00069	0.765
MOD_ProDKin_1	39	45	PF00069	0.779
MOD_ProDKin_1	399	405	PF00069	0.622
MOD_ProDKin_1	407	413	PF00069	0.641
MOD_ProDKin_1	48	54	PF00069	0.701
MOD_ProDKin_1	488	494	PF00069	0.657
MOD_ProDKin_1	518	524	PF00069	0.689
MOD_SUMO_rev_2	279	285	PF00179	0.689
MOD_SUMO_rev_2	320	329	PF00179	0.747
TRG_DiLeu_BaEn_1	15	20	PF01217	0.430
TRG_DiLeu_BaLyEn_6	361	366	PF01217	0.605
TRG_DiLeu_LyEn_5	472	477	PF01217	0.509
TRG_ER_diArg_1	332	335	PF00400	0.725
TRG_ER_diArg_1	456	459	PF00400	0.494
TRG_ER_diArg_1	531	533	PF00400	0.661
TRG_NLS_MonoCore_2	570	575	PF00514	0.676
TRG_NLS_MonoExtN_4	570	575	PF00514	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFI2	Leptomonas seymouri	29%	100%
A0A3Q8IDI0	Leishmania donovani	81%	100%
A4HH42	Leishmania braziliensis	57%	99%
A4I495	Leishmania infantum	82%	100%
E9ADP2	Leishmania major	78%	100%