C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM37_LEIMU

TriTrypDb:

LmxM.08_29.0420

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM37

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	364	368	PF00656	0.546
CLV_NRD_NRD_1	333	335	PF00675	0.569
CLV_NRD_NRD_1	57	59	PF00675	0.520
CLV_PCSK_KEX2_1	333	335	PF00082	0.695
CLV_PCSK_KEX2_1	57	59	PF00082	0.520
CLV_PCSK_SKI1_1	15	19	PF00082	0.617
CLV_PCSK_SKI1_1	219	223	PF00082	0.535
CLV_PCSK_SKI1_1	232	236	PF00082	0.437
CLV_PCSK_SKI1_1	300	304	PF00082	0.562
DEG_APCC_DBOX_1	218	226	PF00400	0.521
DEG_APCC_DBOX_1	272	280	PF00400	0.478
DEG_SPOP_SBC_1	137	141	PF00917	0.634
DOC_CKS1_1	102	107	PF01111	0.682
DOC_CKS1_1	198	203	PF01111	0.526
DOC_CYCLIN_RxL_1	297	305	PF00134	0.522
DOC_CYCLIN_RxL_1	9	22	PF00134	0.616
DOC_MAPK_gen_1	5	13	PF00069	0.621
DOC_MAPK_gen_1	57	68	PF00069	0.613
DOC_MAPK_MEF2A_6	61	70	PF00069	0.504
DOC_PP2B_LxvP_1	142	145	PF13499	0.502
DOC_PP4_FxxP_1	253	256	PF00568	0.578
DOC_USP7_MATH_1	125	129	PF00917	0.606
DOC_USP7_MATH_1	137	141	PF00917	0.732
DOC_USP7_MATH_1	145	149	PF00917	0.673
DOC_USP7_MATH_1	169	173	PF00917	0.681
DOC_USP7_MATH_1	179	183	PF00917	0.581
DOC_USP7_MATH_1	298	302	PF00917	0.512
DOC_USP7_MATH_1	328	332	PF00917	0.524
DOC_USP7_MATH_1	338	342	PF00917	0.483
DOC_USP7_MATH_1	81	85	PF00917	0.476
DOC_USP7_MATH_1	93	97	PF00917	0.474
DOC_USP7_UBL2_3	5	9	PF12436	0.625
DOC_WW_Pin1_4	146	151	PF00397	0.709
DOC_WW_Pin1_4	197	202	PF00397	0.541
DOC_WW_Pin1_4	42	47	PF00397	0.505
DOC_WW_Pin1_4	98	103	PF00397	0.652
LIG_14-3-3_CanoR_1	146	150	PF00244	0.597
LIG_14-3-3_CanoR_1	273	283	PF00244	0.646
LIG_14-3-3_CanoR_1	357	363	PF00244	0.593
LIG_Actin_WH2_2	206	221	PF00022	0.443
LIG_Actin_WH2_2	272	290	PF00022	0.467
LIG_BRCT_BRCA1_1	171	175	PF00533	0.506
LIG_CSL_BTD_1	142	145	PF09270	0.502
LIG_FHA_1	12	18	PF00498	0.615
LIG_FHA_1	191	197	PF00498	0.651
LIG_FHA_1	22	28	PF00498	0.437
LIG_FHA_1	224	230	PF00498	0.612
LIG_FHA_1	373	379	PF00498	0.467
LIG_FHA_2	243	249	PF00498	0.629
LIG_FHA_2	273	279	PF00498	0.647
LIG_FHA_2	362	368	PF00498	0.682
LIG_FHA_2	377	383	PF00498	0.587
LIG_LIR_Apic_2	250	256	PF02991	0.593
LIG_LIR_Apic_2	282	286	PF02991	0.631
LIG_LIR_Gen_1	293	302	PF02991	0.476
LIG_LIR_Gen_1	315	324	PF02991	0.611
LIG_LIR_Gen_1	84	93	PF02991	0.472
LIG_LIR_Nem_3	293	297	PF02991	0.670
LIG_LIR_Nem_3	315	320	PF02991	0.651
LIG_LIR_Nem_3	84	88	PF02991	0.557
LIG_NRBOX	379	385	PF00104	0.628
LIG_SH2_CRK	317	321	PF00017	0.655
LIG_SH2_NCK_1	121	125	PF00017	0.625
LIG_SH2_STAP1	121	125	PF00017	0.690
LIG_SH2_STAT3	281	284	PF00017	0.651
LIG_SH2_STAT5	91	94	PF00017	0.515
LIG_SH3_2	102	107	PF14604	0.682
LIG_SH3_3	144	150	PF00018	0.565
LIG_SH3_3	238	244	PF00018	0.539
LIG_SH3_3	396	402	PF00018	0.588
LIG_SH3_3	99	105	PF00018	0.665
LIG_SH3_4	5	12	PF00018	0.735
LIG_SUMO_SIM_anti_2	379	387	PF11976	0.626
LIG_SUMO_SIM_par_1	208	214	PF11976	0.549
LIG_SUMO_SIM_par_1	220	226	PF11976	0.506
LIG_SUMO_SIM_par_1	375	382	PF11976	0.574
LIG_TRAF2_1	343	346	PF00917	0.528
LIG_TYR_ITIM	89	94	PF00017	0.509
LIG_WW_3	143	147	PF00397	0.501
MOD_CDK_SPxK_1	101	107	PF00069	0.680
MOD_CK1_1	190	196	PF00069	0.643
MOD_CK1_1	203	209	PF00069	0.672
MOD_CK1_1	236	242	PF00069	0.503
MOD_CK1_1	96	102	PF00069	0.476
MOD_CK2_1	287	293	PF00069	0.577
MOD_DYRK1A_RPxSP_1	146	150	PF00069	0.504
MOD_GlcNHglycan	122	125	PF01048	0.762
MOD_GlcNHglycan	171	174	PF01048	0.642
MOD_GlcNHglycan	175	178	PF01048	0.603
MOD_GlcNHglycan	205	208	PF01048	0.653
MOD_GlcNHglycan	213	216	PF01048	0.537
MOD_GlcNHglycan	235	238	PF01048	0.466
MOD_GlcNHglycan	311	314	PF01048	0.523
MOD_GlcNHglycan	389	392	PF01048	0.566
MOD_GlcNHglycan	394	399	PF01048	0.550
MOD_GlcNHglycan	97	101	PF01048	0.495
MOD_GSK3_1	169	176	PF00069	0.676
MOD_GSK3_1	187	194	PF00069	0.657
MOD_GSK3_1	199	206	PF00069	0.523
MOD_GSK3_1	217	224	PF00069	0.484
MOD_GSK3_1	357	364	PF00069	0.617
MOD_GSK3_1	372	379	PF00069	0.528
MOD_GSK3_1	92	99	PF00069	0.436
MOD_N-GLC_1	203	208	PF02516	0.629
MOD_NEK2_1	119	124	PF00069	0.722
MOD_NEK2_1	287	292	PF00069	0.582
MOD_NEK2_1	316	321	PF00069	0.509
MOD_NEK2_1	62	67	PF00069	0.646
MOD_NEK2_2	179	184	PF00069	0.511
MOD_NEK2_2	328	333	PF00069	0.503
MOD_PIKK_1	251	257	PF00454	0.700
MOD_PIKK_1	338	344	PF00454	0.513
MOD_PIKK_1	44	50	PF00454	0.494
MOD_PKA_2	145	151	PF00069	0.502
MOD_PKA_2	272	278	PF00069	0.644
MOD_PKA_2	322	328	PF00069	0.596
MOD_Plk_1	163	169	PF00069	0.681
MOD_Plk_1	62	68	PF00069	0.509
MOD_Plk_2-3	272	278	PF00069	0.644
MOD_Plk_4	13	19	PF00069	0.623
MOD_Plk_4	138	144	PF00069	0.515
MOD_Plk_4	208	214	PF00069	0.484
MOD_Plk_4	298	304	PF00069	0.514
MOD_Plk_4	376	382	PF00069	0.622
MOD_ProDKin_1	146	152	PF00069	0.712
MOD_ProDKin_1	197	203	PF00069	0.539
MOD_ProDKin_1	42	48	PF00069	0.507
MOD_ProDKin_1	98	104	PF00069	0.657
MOD_SUMO_for_1	183	186	PF00179	0.682
MOD_SUMO_rev_2	162	167	PF00179	0.686
TRG_DiLeu_BaEn_4	162	168	PF01217	0.518
TRG_ENDOCYTIC_2	317	320	PF00928	0.659
TRG_ENDOCYTIC_2	91	94	PF00928	0.516
TRG_ER_diArg_1	332	334	PF00400	0.698
TRG_ER_diArg_1	56	58	PF00400	0.517
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X275	Leishmania donovani	88%	100%
A4HH43	Leishmania braziliensis	68%	100%
A4I496	Leishmania infantum	88%	100%
E9ADP3	Leishmania major	88%	100%