Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM36_LEIMU

TriTrypDb:

LmxM.08_29.0430

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM36

PDB structure(s): 7ane_ag

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.378
CLV_C14_Caspase3-7	420	424	PF00656	0.512
CLV_NRD_NRD_1	24	26	PF00675	0.399
CLV_NRD_NRD_1	368	370	PF00675	0.340
CLV_NRD_NRD_1	395	397	PF00675	0.356
CLV_NRD_NRD_1	51	53	PF00675	0.383
CLV_NRD_NRD_1	520	522	PF00675	0.437
CLV_NRD_NRD_1	532	534	PF00675	0.409
CLV_NRD_NRD_1	537	539	PF00675	0.405
CLV_NRD_NRD_1	540	542	PF00675	0.341
CLV_NRD_NRD_1	71	73	PF00675	0.539
CLV_PCSK_FUR_1	538	542	PF00082	0.511
CLV_PCSK_KEX2_1	394	396	PF00082	0.340
CLV_PCSK_KEX2_1	42	44	PF00082	0.377
CLV_PCSK_KEX2_1	53	55	PF00082	0.383
CLV_PCSK_KEX2_1	537	539	PF00082	0.480
CLV_PCSK_KEX2_1	540	542	PF00082	0.466
CLV_PCSK_KEX2_1	71	73	PF00082	0.413
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.377
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.383
CLV_PCSK_PC7_1	533	539	PF00082	0.521
CLV_PCSK_SKI1_1	278	282	PF00082	0.252
CLV_PCSK_SKI1_1	383	387	PF00082	0.342
CLV_PCSK_SKI1_1	446	450	PF00082	0.531
DEG_APCC_DBOX_1	445	453	PF00400	0.536
DEG_Nend_UBRbox_3	1	3	PF02207	0.586
DEG_SCF_FBW7_1	186	193	PF00400	0.442
DOC_MAPK_gen_1	115	125	PF00069	0.431
DOC_MAPK_gen_1	258	267	PF00069	0.511
DOC_MAPK_gen_1	336	343	PF00069	0.329
DOC_MAPK_gen_1	383	393	PF00069	0.347
DOC_MAPK_gen_1	42	50	PF00069	0.377
DOC_MAPK_gen_1	52	60	PF00069	0.370
DOC_MAPK_gen_1	537	548	PF00069	0.552
DOC_MAPK_MEF2A_6	336	343	PF00069	0.329
DOC_PP1_RVXF_1	63	70	PF00149	0.250
DOC_PP2B_LxvP_1	349	352	PF13499	0.361
DOC_PP4_MxPP_1	412	415	PF00568	0.575
DOC_USP7_MATH_1	190	194	PF00917	0.502
DOC_USP7_MATH_1	229	233	PF00917	0.475
DOC_USP7_MATH_1	448	452	PF00917	0.535
DOC_USP7_MATH_1	503	507	PF00917	0.513
DOC_USP7_MATH_1	81	85	PF00917	0.476
DOC_USP7_UBL2_3	407	411	PF12436	0.374
DOC_WW_Pin1_4	186	191	PF00397	0.527
DOC_WW_Pin1_4	225	230	PF00397	0.383
DOC_WW_Pin1_4	316	321	PF00397	0.343
LIG_14-3-3_CanoR_1	130	138	PF00244	0.503
LIG_14-3-3_CanoR_1	162	170	PF00244	0.344
LIG_14-3-3_CanoR_1	201	211	PF00244	0.335
LIG_14-3-3_CanoR_1	481	486	PF00244	0.522
LIG_14-3-3_CanoR_1	88	92	PF00244	0.292
LIG_14-3-3_CanoR_1	9	13	PF00244	0.531
LIG_Actin_WH2_2	116	132	PF00022	0.512
LIG_APCC_ABBA_1	98	103	PF00400	0.234
LIG_deltaCOP1_diTrp_1	380	388	PF00928	0.343
LIG_FHA_1	134	140	PF00498	0.418
LIG_FHA_1	148	154	PF00498	0.318
LIG_FHA_1	194	200	PF00498	0.331
LIG_FHA_1	242	248	PF00498	0.290
LIG_FHA_1	303	309	PF00498	0.307
LIG_FHA_1	408	414	PF00498	0.442
LIG_FHA_1	473	479	PF00498	0.386
LIG_FHA_2	104	110	PF00498	0.459
LIG_FHA_2	342	348	PF00498	0.364
LIG_FHA_2	490	496	PF00498	0.407
LIG_FHA_2	557	563	PF00498	0.648
LIG_HCF-1_HBM_1	315	318	PF13415	0.355
LIG_LIR_Gen_1	121	129	PF02991	0.522
LIG_LIR_Gen_1	205	215	PF02991	0.321
LIG_LIR_Gen_1	216	227	PF02991	0.363
LIG_LIR_Gen_1	232	242	PF02991	0.364
LIG_LIR_Gen_1	287	294	PF02991	0.491
LIG_LIR_Gen_1	491	500	PF02991	0.405
LIG_LIR_Nem_3	121	125	PF02991	0.405
LIG_LIR_Nem_3	14	18	PF02991	0.402
LIG_LIR_Nem_3	150	154	PF02991	0.356
LIG_LIR_Nem_3	164	170	PF02991	0.306
LIG_LIR_Nem_3	205	211	PF02991	0.322
LIG_LIR_Nem_3	232	237	PF02991	0.315
LIG_LIR_Nem_3	251	257	PF02991	0.348
LIG_LIR_Nem_3	287	293	PF02991	0.510
LIG_LIR_Nem_3	389	393	PF02991	0.367
LIG_LIR_Nem_3	491	497	PF02991	0.401
LIG_OCRL_FandH_1	392	404	PF00620	0.472
LIG_Pex14_1	31	35	PF04695	0.372
LIG_PTB_Apo_2	373	380	PF02174	0.428
LIG_PTB_Phospho_1	373	379	PF10480	0.430
LIG_REV1ctd_RIR_1	435	442	PF16727	0.380
LIG_SH2_CRK	270	274	PF00017	0.436
LIG_SH2_CRK	37	41	PF00017	0.439
LIG_SH2_CRK	494	498	PF00017	0.419
LIG_SH2_GRB2like	518	521	PF00017	0.398
LIG_SH2_PTP2	122	125	PF00017	0.457
LIG_SH2_SRC	234	237	PF00017	0.320
LIG_SH2_STAP1	170	174	PF00017	0.442
LIG_SH2_STAP1	234	238	PF00017	0.307
LIG_SH2_STAP1	401	405	PF00017	0.349
LIG_SH2_STAP1	494	498	PF00017	0.400
LIG_SH2_STAT3	59	62	PF00017	0.432
LIG_SH2_STAT5	122	125	PF00017	0.402
LIG_SH2_STAT5	208	211	PF00017	0.285
LIG_SH2_STAT5	309	312	PF00017	0.303
LIG_SH2_STAT5	318	321	PF00017	0.363
LIG_SH2_STAT5	518	521	PF00017	0.398
LIG_SH2_STAT5	59	62	PF00017	0.432
LIG_SH3_3	416	422	PF00018	0.502
LIG_SH3_3	429	435	PF00018	0.368
LIG_SH3_4	26	33	PF00018	0.388
LIG_SUMO_SIM_par_1	339	344	PF11976	0.446
LIG_SUMO_SIM_par_1	450	456	PF11976	0.528
LIG_WRC_WIRS_1	95	100	PF05994	0.220
MOD_CK1_1	193	199	PF00069	0.376
MOD_CK1_1	38	44	PF00069	0.384
MOD_CK1_1	451	457	PF00069	0.461
MOD_CK2_1	474	480	PF00069	0.453
MOD_CK2_1	556	562	PF00069	0.548
MOD_CK2_1	81	87	PF00069	0.552
MOD_Cter_Amidation	538	541	PF01082	0.457
MOD_GlcNHglycan	174	177	PF01048	0.500
MOD_GlcNHglycan	356	359	PF01048	0.416
MOD_GlcNHglycan	37	40	PF01048	0.381
MOD_GlcNHglycan	427	430	PF01048	0.526
MOD_GSK3_1	125	132	PF00069	0.370
MOD_GSK3_1	157	164	PF00069	0.246
MOD_GSK3_1	186	193	PF00069	0.381
MOD_GSK3_1	202	209	PF00069	0.294
MOD_GSK3_1	225	232	PF00069	0.368
MOD_GSK3_1	314	321	PF00069	0.303
MOD_GSK3_1	417	424	PF00069	0.565
MOD_GSK3_1	90	97	PF00069	0.507
MOD_LATS_1	479	485	PF00433	0.408
MOD_N-GLC_1	407	412	PF02516	0.402
MOD_NEK2_1	1	6	PF00069	0.505
MOD_NEK2_1	125	130	PF00069	0.396
MOD_NEK2_1	172	177	PF00069	0.382
MOD_NEK2_1	199	204	PF00069	0.308
MOD_NEK2_1	241	246	PF00069	0.326
MOD_NEK2_1	406	411	PF00069	0.407
MOD_NEK2_2	147	152	PF00069	0.398
MOD_NEK2_2	180	185	PF00069	0.351
MOD_PIKK_1	1	7	PF00454	0.546
MOD_PIKK_1	190	196	PF00454	0.478
MOD_PIKK_1	341	347	PF00454	0.454
MOD_PIKK_1	417	423	PF00454	0.497
MOD_PK_1	327	333	PF00069	0.445
MOD_PK_1	369	375	PF00069	0.483
MOD_PKA_1	369	375	PF00069	0.483
MOD_PKA_2	129	135	PF00069	0.511
MOD_PKA_2	161	167	PF00069	0.352
MOD_PKA_2	480	486	PF00069	0.540
MOD_PKA_2	532	538	PF00069	0.516
MOD_PKA_2	8	14	PF00069	0.528
MOD_PKA_2	87	93	PF00069	0.292
MOD_Plk_1	314	320	PF00069	0.304
MOD_Plk_1	422	428	PF00069	0.513
MOD_Plk_2-3	103	109	PF00069	0.360
MOD_Plk_2-3	474	480	PF00069	0.466
MOD_Plk_4	103	109	PF00069	0.456
MOD_Plk_4	11	17	PF00069	0.400
MOD_Plk_4	448	454	PF00069	0.448
MOD_Plk_4	481	487	PF00069	0.430
MOD_ProDKin_1	186	192	PF00069	0.519
MOD_ProDKin_1	225	231	PF00069	0.381
MOD_ProDKin_1	316	322	PF00069	0.350
MOD_SUMO_rev_2	330	339	PF00179	0.527
MOD_SUMO_rev_2	469	478	PF00179	0.516
TRG_DiLeu_BaEn_2	102	108	PF01217	0.362
TRG_ENDOCYTIC_2	122	125	PF00928	0.324
TRG_ENDOCYTIC_2	15	18	PF00928	0.406
TRG_ENDOCYTIC_2	208	211	PF00928	0.336
TRG_ENDOCYTIC_2	219	222	PF00928	0.356
TRG_ENDOCYTIC_2	234	237	PF00928	0.310
TRG_ENDOCYTIC_2	270	273	PF00928	0.446
TRG_ENDOCYTIC_2	37	40	PF00928	0.441
TRG_ENDOCYTIC_2	494	497	PF00928	0.395
TRG_ER_diArg_1	257	260	PF00400	0.459
TRG_ER_diArg_1	374	377	PF00400	0.465
TRG_ER_diArg_1	393	396	PF00400	0.260
TRG_ER_diArg_1	536	538	PF00400	0.464
TRG_ER_diArg_1	540	543	PF00400	0.450
TRG_ER_diArg_1	70	72	PF00400	0.378
TRG_NES_CRM1_1	323	335	PF08389	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G0	Leptomonas seymouri	81%	100%
A0A1X0NZI0	Trypanosomatidae	64%	98%
A0A3R7NNT1	Trypanosoma rangeli	64%	97%
A0A3S7X247	Leishmania donovani	97%	100%
A4HH44	Leishmania braziliensis	92%	100%
A4I497	Leishmania infantum	97%	100%
C9ZKN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	97%
E9ADP4	Leishmania major	96%	100%
V5DLE3	Trypanosoma cruzi	63%	97%