LeishMANIAdb
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Metallophos domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Metallophos domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AM35_LEIMU
TriTrypDb:
LmxM.08_29.0440
Length:
380

Annotations

LeishMANIAdb annotations

A metalloenzyme with the catalytic domain facing outwards. Related to plant Shewanella-like protein phosphatases. Kinetoplastids have multiple copies of these genes but probably from a very ancient gene duplication.. The cluster might merge two separate, very distantly related groups.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 15, no: 13
NetGPI no yes: 0, no: 28
Cellular components
Term Name Level Count
GO:0016020 membrane 2 17
GO:0110165 cellular anatomical entity 1 17

Expansion

Sequence features

E9AM35
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM35

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 29
GO:0016787 hydrolase activity 2 29

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 304 308 PF00656 0.217
CLV_NRD_NRD_1 117 119 PF00675 0.326
CLV_NRD_NRD_1 16 18 PF00675 0.447
CLV_NRD_NRD_1 232 234 PF00675 0.551
CLV_NRD_NRD_1 348 350 PF00675 0.637
CLV_NRD_NRD_1 4 6 PF00675 0.516
CLV_PCSK_KEX2_1 232 234 PF00082 0.524
CLV_PCSK_KEX2_1 348 350 PF00082 0.637
CLV_PCSK_PC1ET2_1 348 350 PF00082 0.519
CLV_PCSK_SKI1_1 158 162 PF00082 0.287
CLV_PCSK_SKI1_1 317 321 PF00082 0.421
CLV_PCSK_SKI1_1 345 349 PF00082 0.640
CLV_PCSK_SKI1_1 350 354 PF00082 0.602
DEG_APCC_KENBOX_2 289 293 PF00400 0.177
DOC_ANK_TNKS_1 85 92 PF00023 0.520
DOC_CKS1_1 374 379 PF01111 0.443
DOC_CKS1_1 47 52 PF01111 0.362
DOC_CKS1_1 71 76 PF01111 0.206
DOC_CYCLIN_RxL_1 178 186 PF00134 0.392
DOC_MAPK_gen_1 118 126 PF00069 0.377
DOC_MAPK_gen_1 288 297 PF00069 0.300
DOC_MAPK_gen_1 5 11 PF00069 0.526
DOC_MAPK_HePTP_8 287 299 PF00069 0.192
DOC_MAPK_MEF2A_6 119 128 PF00069 0.377
DOC_MAPK_MEF2A_6 290 299 PF00069 0.341
DOC_MAPK_MEF2A_6 317 325 PF00069 0.357
DOC_MAPK_RevD_3 336 351 PF00069 0.241
DOC_USP7_MATH_1 152 156 PF00917 0.489
DOC_USP7_MATH_1 336 340 PF00917 0.336
DOC_USP7_MATH_1 365 369 PF00917 0.345
DOC_USP7_MATH_1 69 73 PF00917 0.196
DOC_USP7_UBL2_3 346 350 PF12436 0.313
DOC_WW_Pin1_4 258 263 PF00397 0.260
DOC_WW_Pin1_4 373 378 PF00397 0.414
DOC_WW_Pin1_4 46 51 PF00397 0.448
DOC_WW_Pin1_4 70 75 PF00397 0.216
LIG_14-3-3_CanoR_1 118 128 PF00244 0.536
LIG_14-3-3_CanoR_1 158 163 PF00244 0.528
LIG_14-3-3_CanoR_1 354 360 PF00244 0.421
LIG_14-3-3_CanoR_1 81 90 PF00244 0.382
LIG_14-3-3_CanoR_1 99 105 PF00244 0.520
LIG_Actin_WH2_2 90 107 PF00022 0.435
LIG_BIR_II_1 1 5 PF00653 0.547
LIG_BIR_III_1 1 5 PF00653 0.532
LIG_BIR_III_3 1 5 PF00653 0.532
LIG_BRCT_BRCA1_1 21 25 PF00533 0.377
LIG_Clathr_ClatBox_1 318 322 PF01394 0.251
LIG_deltaCOP1_diTrp_1 241 248 PF00928 0.135
LIG_eIF4E_1 177 183 PF01652 0.358
LIG_FHA_1 120 126 PF00498 0.440
LIG_FHA_1 318 324 PF00498 0.376
LIG_FHA_1 35 41 PF00498 0.401
LIG_FHA_1 47 53 PF00498 0.363
LIG_FHA_2 374 380 PF00498 0.434
LIG_LIR_Apic_2 176 180 PF02991 0.513
LIG_LIR_Gen_1 247 256 PF02991 0.135
LIG_LIR_Gen_1 335 344 PF02991 0.350
LIG_LIR_Nem_3 247 251 PF02991 0.201
LIG_LIR_Nem_3 335 340 PF02991 0.341
LIG_PDZ_Class_1 375 380 PF00595 0.331
LIG_SH2_PTP2 177 180 PF00017 0.425
LIG_SH2_SRC 177 180 PF00017 0.406
LIG_SH2_SRC 194 197 PF00017 0.476
LIG_SH2_STAP1 334 338 PF00017 0.355
LIG_SH2_STAT5 177 180 PF00017 0.445
LIG_SH2_STAT5 194 197 PF00017 0.446
LIG_SH2_STAT5 328 331 PF00017 0.370
LIG_SH2_STAT5 48 51 PF00017 0.509
LIG_SH3_1 371 377 PF00018 0.330
LIG_SH3_3 133 139 PF00018 0.425
LIG_SH3_3 371 377 PF00018 0.331
LIG_SH3_3 65 71 PF00018 0.204
LIG_SUMO_SIM_anti_2 208 215 PF11976 0.573
LIG_SUMO_SIM_anti_2 28 34 PF11976 0.213
LIG_SUMO_SIM_par_1 158 163 PF11976 0.392
LIG_SUMO_SIM_par_1 167 172 PF11976 0.363
LIG_SUMO_SIM_par_1 212 218 PF11976 0.430
LIG_SUMO_SIM_par_1 86 92 PF11976 0.459
LIG_UBA3_1 141 149 PF00899 0.438
LIG_WRC_WIRS_1 337 342 PF05994 0.214
MOD_CDC14_SPxK_1 3 6 PF00782 0.505
MOD_CDK_SPxxK_3 70 77 PF00069 0.197
MOD_CK2_1 352 358 PF00069 0.318
MOD_CK2_1 373 379 PF00069 0.388
MOD_GlcNHglycan 145 148 PF01048 0.323
MOD_GlcNHglycan 154 157 PF01048 0.318
MOD_GlcNHglycan 162 165 PF01048 0.269
MOD_GlcNHglycan 171 174 PF01048 0.204
MOD_GlcNHglycan 185 188 PF01048 0.259
MOD_GlcNHglycan 21 24 PF01048 0.208
MOD_GlcNHglycan 280 283 PF01048 0.527
MOD_GlcNHglycan 367 370 PF01048 0.614
MOD_GSK3_1 34 41 PF00069 0.402
MOD_N-GLC_1 183 188 PF02516 0.306
MOD_N-GLC_1 249 254 PF02516 0.449
MOD_NEK2_1 100 105 PF00069 0.443
MOD_NEK2_1 169 174 PF00069 0.514
MOD_NEK2_1 183 188 PF00069 0.454
MOD_NEK2_1 249 254 PF00069 0.306
MOD_NEK2_1 25 30 PF00069 0.429
MOD_NEK2_1 34 39 PF00069 0.354
MOD_NEK2_1 54 59 PF00069 0.442
MOD_PIKK_1 81 87 PF00454 0.389
MOD_PKA_2 100 106 PF00069 0.507
MOD_PKA_2 152 158 PF00069 0.392
MOD_PKA_2 353 359 PF00069 0.402
MOD_Plk_1 264 270 PF00069 0.357
MOD_Plk_4 244 250 PF00069 0.349
MOD_Plk_4 336 342 PF00069 0.357
MOD_Plk_4 34 40 PF00069 0.408
MOD_ProDKin_1 258 264 PF00069 0.260
MOD_ProDKin_1 373 379 PF00069 0.414
MOD_ProDKin_1 46 52 PF00069 0.451
MOD_ProDKin_1 70 76 PF00069 0.216
MOD_SUMO_rev_2 304 310 PF00179 0.195
TRG_DiLeu_BaEn_1 140 145 PF01217 0.377
TRG_DiLeu_BaEn_2 243 249 PF01217 0.135
TRG_DiLeu_BaLyEn_6 155 160 PF01217 0.551
TRG_DiLeu_BaLyEn_6 178 183 PF01217 0.521
TRG_ENDOCYTIC_2 202 205 PF00928 0.553
TRG_ENDOCYTIC_2 334 337 PF00928 0.285
TRG_NES_CRM1_1 140 151 PF08389 0.361
TRG_NLS_MonoCore_2 347 352 PF00514 0.293
TRG_NLS_MonoExtC_3 344 349 PF00514 0.278
TRG_NLS_MonoExtN_4 342 349 PF00514 0.276

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3V2 Leptomonas seymouri 31% 100%
A0A0N1P9R1 Leptomonas seymouri 25% 100%
A0A0S4JMN0 Bodo saltans 33% 94%
A0A0S4KJG1 Bodo saltans 27% 100%
A0A1X0NU01 Trypanosomatidae 28% 100%
A0A1X0NZX7 Trypanosomatidae 36% 85%
A0A1X0P2G6 Trypanosomatidae 29% 100%
A0A3Q8IBB4 Leishmania donovani 30% 100%
A0A3Q8IIK0 Leishmania donovani 90% 100%
A0A3R7NTC0 Trypanosoma rangeli 27% 100%
A0A3S5IRW3 Trypanosoma rangeli 34% 92%
A0A3S7X3U9 Leishmania donovani 28% 100%
A4HCJ2 Leishmania braziliensis 30% 100%
A4HH45 Leishmania braziliensis 72% 100%
A4HIR7 Leishmania braziliensis 28% 100%
A4I008 Leishmania infantum 30% 100%
A4I498 Leishmania infantum 90% 100%
A4I612 Leishmania infantum 28% 100%
C9ZQ86 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
C9ZRD7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 86%
E9ADP5 Leishmania major 89% 100%
E9AVY1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B1A3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
Q4Q6W1 Leishmania major 30% 100%
Q4QBJ8 Leishmania major 29% 100%
Q944L7 Arabidopsis thaliana 26% 97%
V5ARZ9 Trypanosoma cruzi 26% 100%
V5BPY7 Trypanosoma cruzi 34% 87%
V5BX32 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS