Rad51 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

recA bacterial DNA recombination protein, putative

Species:

Leishmania mexicana

UniProt:

E9AM34_LEIMU

TriTrypDb:

LmxM.08_29.0450

Length:

649

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM34

Function

Biological processes
Term	Name	Level	Count
GO:0000730	DNA recombinase assembly	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006310	DNA recombination	5	1
GO:0006312	mitotic recombination	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0042148	strand invasion	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0071704	organic substance metabolic process	2	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090735	DNA repair complex assembly	6	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000150	DNA strand exchange activity	4	1
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0003697	single-stranded DNA binding	5	1
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	1
GO:0008094	ATP-dependent activity, acting on DNA	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:0140657	ATP-dependent activity	1	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.500
CLV_NRD_NRD_1	165	167	PF00675	0.653
CLV_NRD_NRD_1	225	227	PF00675	0.628
CLV_NRD_NRD_1	613	615	PF00675	0.277
CLV_PCSK_KEX2_1	105	107	PF00082	0.500
CLV_PCSK_KEX2_1	164	166	PF00082	0.662
CLV_PCSK_KEX2_1	575	577	PF00082	0.287
CLV_PCSK_PC1ET2_1	575	577	PF00082	0.277
CLV_PCSK_PC7_1	160	166	PF00082	0.593
CLV_PCSK_SKI1_1	160	164	PF00082	0.741
CLV_PCSK_SKI1_1	610	614	PF00082	0.335
CLV_PCSK_SKI1_1	65	69	PF00082	0.657
CLV_Separin_Metazoa	453	457	PF03568	0.465
CLV_Separin_Metazoa	53	57	PF03568	0.461
DEG_MDM2_SWIB_1	296	304	PF02201	0.477
DEG_SPOP_SBC_1	580	584	PF00917	0.480
DOC_CDC14_PxL_1	458	466	PF14671	0.413
DOC_CKS1_1	229	234	PF01111	0.535
DOC_CYCLIN_yCln2_LP_2	457	463	PF00134	0.554
DOC_MAPK_DCC_7	456	466	PF00069	0.391
DOC_MAPK_DCC_7	593	601	PF00069	0.480
DOC_MAPK_gen_1	105	112	PF00069	0.450
DOC_MAPK_gen_1	138	145	PF00069	0.452
DOC_MAPK_MEF2A_6	432	440	PF00069	0.276
DOC_MAPK_MEF2A_6	593	601	PF00069	0.480
DOC_PP2B_LxvP_1	171	174	PF13499	0.714
DOC_PP4_FxxP_1	252	255	PF00568	0.607
DOC_USP7_MATH_1	108	112	PF00917	0.474
DOC_USP7_MATH_1	265	269	PF00917	0.653
DOC_USP7_MATH_1	273	277	PF00917	0.480
DOC_USP7_MATH_1	41	45	PF00917	0.557
DOC_USP7_MATH_1	486	490	PF00917	0.449
DOC_USP7_MATH_1	580	584	PF00917	0.493
DOC_USP7_MATH_1	635	639	PF00917	0.535
DOC_WW_Pin1_4	228	233	PF00397	0.598
DOC_WW_Pin1_4	39	44	PF00397	0.585
DOC_WW_Pin1_4	471	476	PF00397	0.557
DOC_WW_Pin1_4	576	581	PF00397	0.518
DOC_WW_Pin1_4	84	89	PF00397	0.735
LIG_14-3-3_CanoR_1	140	146	PF00244	0.632
LIG_14-3-3_CanoR_1	206	212	PF00244	0.565
LIG_14-3-3_CanoR_1	235	245	PF00244	0.539
LIG_14-3-3_CanoR_1	247	252	PF00244	0.543
LIG_14-3-3_CanoR_1	432	437	PF00244	0.369
LIG_14-3-3_CanoR_1	446	452	PF00244	0.529
LIG_14-3-3_CanoR_1	485	492	PF00244	0.570
LIG_14-3-3_CanoR_1	56	64	PF00244	0.597
LIG_14-3-3_CanoR_1	614	624	PF00244	0.477
LIG_Actin_WH2_2	145	162	PF00022	0.532
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_BRCT_BRCA1_1	247	251	PF00533	0.514
LIG_EH1_1	618	626	PF00400	0.535
LIG_EVH1_1	171	175	PF00568	0.717
LIG_FAT_LD_1	145	153	PF03623	0.617
LIG_FHA_1	389	395	PF00498	0.444
LIG_FHA_1	431	437	PF00498	0.408
LIG_FHA_1	474	480	PF00498	0.600
LIG_FHA_1	552	558	PF00498	0.499
LIG_FHA_2	179	185	PF00498	0.710
LIG_LIR_Apic_2	250	255	PF02991	0.591
LIG_LIR_Gen_1	198	209	PF02991	0.398
LIG_LIR_Gen_1	59	69	PF02991	0.545
LIG_LIR_Nem_3	198	204	PF02991	0.407
LIG_LIR_Nem_3	425	430	PF02991	0.419
LIG_LIR_Nem_3	50	55	PF02991	0.533
LIG_LIR_Nem_3	59	64	PF02991	0.531
LIG_MYND_1	88	92	PF01753	0.645
LIG_NRBOX	316	322	PF00104	0.477
LIG_PCNA_yPIPBox_3	312	321	PF02747	0.477
LIG_PDZ_Class_3	644	649	PF00595	0.477
LIG_Pex14_2	296	300	PF04695	0.477
LIG_RPA_C_Fungi	373	385	PF08784	0.442
LIG_SH2_STAT5	383	386	PF00017	0.350
LIG_SH2_STAT5	639	642	PF00017	0.315
LIG_SH3_1	627	633	PF00018	0.282
LIG_SH3_2	51	56	PF14604	0.606
LIG_SH3_3	169	175	PF00018	0.733
LIG_SH3_3	226	232	PF00018	0.558
LIG_SH3_3	48	54	PF00018	0.617
LIG_SH3_3	627	633	PF00018	0.315
LIG_Sin3_3	334	341	PF02671	0.272
LIG_SUMO_SIM_anti_2	111	119	PF11976	0.623
LIG_SUMO_SIM_anti_2	241	248	PF11976	0.529
LIG_SUMO_SIM_anti_2	435	441	PF11976	0.284
LIG_SUMO_SIM_par_1	107	114	PF11976	0.559
LIG_SUMO_SIM_par_1	505	511	PF11976	0.315
LIG_TRAF2_1	194	197	PF00917	0.570
LIG_WW_3	173	177	PF00397	0.672
MOD_CDK_SPxxK_3	228	235	PF00069	0.587
MOD_CK1_1	141	147	PF00069	0.606
MOD_CK1_1	42	48	PF00069	0.581
MOD_CK1_1	579	585	PF00069	0.337
MOD_CK1_1	587	593	PF00069	0.292
MOD_CK1_1	602	608	PF00069	0.251
MOD_CK2_1	178	184	PF00069	0.803
MOD_CK2_1	447	453	PF00069	0.518
MOD_CK2_1	580	586	PF00069	0.208
MOD_DYRK1A_RPxSP_1	576	580	PF00069	0.395
MOD_GlcNHglycan	1	4	PF01048	0.639
MOD_GlcNHglycan	123	126	PF01048	0.651
MOD_GlcNHglycan	22	25	PF01048	0.517
MOD_GlcNHglycan	267	270	PF01048	0.693
MOD_GlcNHglycan	274	278	PF01048	0.480
MOD_GlcNHglycan	297	300	PF01048	0.315
MOD_GlcNHglycan	510	513	PF01048	0.309
MOD_GlcNHglycan	58	61	PF01048	0.565
MOD_GlcNHglycan	586	589	PF01048	0.322
MOD_GlcNHglycan	604	607	PF01048	0.418
MOD_GlcNHglycan	79	82	PF01048	0.537
MOD_GlcNHglycan	97	100	PF01048	0.717
MOD_GSK3_1	176	183	PF00069	0.682
MOD_GSK3_1	241	248	PF00069	0.722
MOD_GSK3_1	295	302	PF00069	0.325
MOD_GSK3_1	430	437	PF00069	0.315
MOD_GSK3_1	576	583	PF00069	0.348
MOD_GSK3_1	587	594	PF00069	0.430
MOD_GSK3_1	635	642	PF00069	0.315
MOD_GSK3_1	95	102	PF00069	0.655
MOD_N-GLC_1	39	44	PF02516	0.611
MOD_N-GLC_2	548	550	PF02516	0.315
MOD_NEK2_1	218	223	PF00069	0.518
MOD_NEK2_1	245	250	PF00069	0.709
MOD_NEK2_1	355	360	PF00069	0.532
MOD_NEK2_1	464	469	PF00069	0.501
MOD_NEK2_1	498	503	PF00069	0.337
MOD_NEK2_1	599	604	PF00069	0.328
MOD_NEK2_1	613	618	PF00069	0.292
MOD_NEK2_2	534	539	PF00069	0.208
MOD_OFUCOSY	429	434	PF10250	0.448
MOD_PIKK_1	310	316	PF00454	0.315
MOD_PIKK_1	464	470	PF00454	0.494
MOD_PKA_2	141	147	PF00069	0.625
MOD_PKA_2	486	492	PF00069	0.556
MOD_PKA_2	613	619	PF00069	0.315
MOD_PKB_1	576	584	PF00069	0.315
MOD_Plk_1	273	279	PF00069	0.441
MOD_Plk_1	341	347	PF00069	0.441
MOD_Plk_1	529	535	PF00069	0.315
MOD_Plk_4	108	114	PF00069	0.520
MOD_Plk_4	241	247	PF00069	0.526
MOD_Plk_4	422	428	PF00069	0.567
MOD_Plk_4	434	440	PF00069	0.257
MOD_Plk_4	635	641	PF00069	0.315
MOD_Plk_4	86	92	PF00069	0.673
MOD_ProDKin_1	228	234	PF00069	0.589
MOD_ProDKin_1	39	45	PF00069	0.580
MOD_ProDKin_1	471	477	PF00069	0.559
MOD_ProDKin_1	576	582	PF00069	0.372
MOD_ProDKin_1	84	90	PF00069	0.738
MOD_SUMO_rev_2	178	187	PF00179	0.524
MOD_SUMO_rev_2	220	229	PF00179	0.561
TRG_DiLeu_BaEn_1	453	458	PF01217	0.463
TRG_DiLeu_BaEn_1	493	498	PF01217	0.350
TRG_DiLeu_LyEn_5	453	458	PF01217	0.463
TRG_DiLeu_LyEn_5	493	498	PF01217	0.350
TRG_ER_diArg_1	140	143	PF00400	0.606
TRG_ER_diArg_1	157	160	PF00400	0.437
TRG_ER_diArg_1	163	166	PF00400	0.602
TRG_ER_diArg_1	538	541	PF00400	0.340
TRG_NLS_MonoExtN_4	573	579	PF00514	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U1	Leptomonas seymouri	45%	100%
A0A3Q8IE59	Leishmania donovani	86%	100%
A4HH46	Leishmania braziliensis	69%	98%
A4I499	Leishmania infantum	86%	100%
E9ADP6	Leishmania major	83%	100%