Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM33_LEIMU

TriTrypDb:

LmxM.08_29.0460

Length:

687

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AM33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	384	388	PF00656	0.534
CLV_C14_Caspase3-7	655	659	PF00656	0.644
CLV_NRD_NRD_1	128	130	PF00675	0.612
CLV_NRD_NRD_1	250	252	PF00675	0.433
CLV_NRD_NRD_1	302	304	PF00675	0.618
CLV_NRD_NRD_1	350	352	PF00675	0.484
CLV_NRD_NRD_1	374	376	PF00675	0.417
CLV_NRD_NRD_1	420	422	PF00675	0.525
CLV_NRD_NRD_1	493	495	PF00675	0.560
CLV_NRD_NRD_1	541	543	PF00675	0.474
CLV_NRD_NRD_1	559	561	PF00675	0.653
CLV_NRD_NRD_1	598	600	PF00675	0.521
CLV_NRD_NRD_1	611	613	PF00675	0.515
CLV_NRD_NRD_1	622	624	PF00675	0.515
CLV_NRD_NRD_1	629	631	PF00675	0.426
CLV_NRD_NRD_1	638	640	PF00675	0.510
CLV_NRD_NRD_1	84	86	PF00675	0.617
CLV_PCSK_FUR_1	609	613	PF00082	0.572
CLV_PCSK_KEX2_1	128	130	PF00082	0.606
CLV_PCSK_KEX2_1	172	174	PF00082	0.400
CLV_PCSK_KEX2_1	246	248	PF00082	0.333
CLV_PCSK_KEX2_1	302	304	PF00082	0.618
CLV_PCSK_KEX2_1	374	376	PF00082	0.417
CLV_PCSK_KEX2_1	419	421	PF00082	0.537
CLV_PCSK_KEX2_1	42	44	PF00082	0.490
CLV_PCSK_KEX2_1	493	495	PF00082	0.560
CLV_PCSK_KEX2_1	541	543	PF00082	0.497
CLV_PCSK_KEX2_1	559	561	PF00082	0.653
CLV_PCSK_KEX2_1	611	613	PF00082	0.579
CLV_PCSK_KEX2_1	629	631	PF00082	0.421
CLV_PCSK_KEX2_1	638	640	PF00082	0.518
CLV_PCSK_KEX2_1	84	86	PF00082	0.617
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.339
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.333
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.490
CLV_PCSK_PC7_1	416	422	PF00082	0.529
CLV_PCSK_SKI1_1	131	135	PF00082	0.479
CLV_PCSK_SKI1_1	172	176	PF00082	0.404
CLV_PCSK_SKI1_1	188	192	PF00082	0.460
CLV_PCSK_SKI1_1	247	251	PF00082	0.436
CLV_PCSK_SKI1_1	266	270	PF00082	0.438
CLV_PCSK_SKI1_1	42	46	PF00082	0.508
CLV_PCSK_SKI1_1	514	518	PF00082	0.460
CLV_PCSK_SKI1_1	530	534	PF00082	0.458
CLV_PCSK_SKI1_1	88	92	PF00082	0.514
CLV_Separin_Metazoa	178	182	PF03568	0.347
DEG_APCC_DBOX_1	130	138	PF00400	0.445
DEG_APCC_DBOX_1	187	195	PF00400	0.491
DEG_APCC_DBOX_1	246	254	PF00400	0.329
DEG_APCC_DBOX_1	366	374	PF00400	0.454
DEG_SCF_FBW7_2	16	23	PF00400	0.513
DEG_SPOP_SBC_1	651	655	PF00917	0.700
DOC_CKS1_1	28	33	PF01111	0.505
DOC_CKS1_1	332	337	PF01111	0.607
DOC_CYCLIN_RxL_1	276	284	PF00134	0.482
DOC_CYCLIN_RxL_1	348	359	PF00134	0.475
DOC_CYCLIN_RxL_1	508	518	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	332	338	PF00134	0.469
DOC_MAPK_gen_1	277	285	PF00069	0.495
DOC_MAPK_gen_1	374	381	PF00069	0.368
DOC_MAPK_MEF2A_6	277	285	PF00069	0.525
DOC_MAPK_MEF2A_6	374	381	PF00069	0.368
DOC_USP7_MATH_1	268	272	PF00917	0.327
DOC_USP7_MATH_1	289	293	PF00917	0.503
DOC_USP7_MATH_1	390	394	PF00917	0.627
DOC_USP7_MATH_1	447	451	PF00917	0.600
DOC_USP7_MATH_1	454	458	PF00917	0.707
DOC_USP7_MATH_1	47	51	PF00917	0.581
DOC_USP7_MATH_1	473	477	PF00917	0.502
DOC_USP7_MATH_1	552	556	PF00917	0.479
DOC_USP7_MATH_1	651	655	PF00917	0.698
DOC_WW_Pin1_4	12	17	PF00397	0.663
DOC_WW_Pin1_4	144	149	PF00397	0.578
DOC_WW_Pin1_4	27	32	PF00397	0.532
DOC_WW_Pin1_4	293	298	PF00397	0.623
DOC_WW_Pin1_4	331	336	PF00397	0.653
DOC_WW_Pin1_4	457	462	PF00397	0.614
DOC_WW_Pin1_4	548	553	PF00397	0.478
DOC_WW_Pin1_4	676	681	PF00397	0.660
DOC_WW_Pin1_4	88	93	PF00397	0.633
LIG_14-3-3_CanoR_1	173	177	PF00244	0.454
LIG_14-3-3_CanoR_1	216	225	PF00244	0.347
LIG_14-3-3_CanoR_1	251	260	PF00244	0.430
LIG_14-3-3_CanoR_1	266	271	PF00244	0.436
LIG_14-3-3_CanoR_1	508	516	PF00244	0.477
LIG_14-3-3_CanoR_1	541	546	PF00244	0.420
LIG_14-3-3_CanoR_1	638	647	PF00244	0.593
LIG_APCC_ABBA_1	18	23	PF00400	0.515
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_BIR_III_1	1	5	PF00653	0.635
LIG_BIR_III_2	658	662	PF00653	0.512
LIG_BIR_III_3	1	5	PF00653	0.635
LIG_BIR_III_4	155	159	PF00653	0.554
LIG_BIR_III_4	587	591	PF00653	0.641
LIG_BRCT_BRCA1_1	332	336	PF00533	0.480
LIG_CaM_IQ_9	269	284	PF13499	0.339
LIG_FAT_LD_1	346	354	PF03623	0.467
LIG_FHA_1	222	228	PF00498	0.396
LIG_FHA_1	308	314	PF00498	0.607
LIG_FHA_1	427	433	PF00498	0.455
LIG_FHA_1	522	528	PF00498	0.425
LIG_FHA_1	677	683	PF00498	0.660
LIG_FHA_1	96	102	PF00498	0.553
LIG_FHA_2	173	179	PF00498	0.422
LIG_FHA_2	307	313	PF00498	0.570
LIG_FHA_2	35	41	PF00498	0.553
LIG_FHA_2	457	463	PF00498	0.630
LIG_FHA_2	59	65	PF00498	0.440
LIG_GBD_Chelix_1	126	134	PF00786	0.514
LIG_IRF3_LxIS_1	28	35	PF10401	0.503
LIG_LIR_Gen_1	613	622	PF02991	0.562
LIG_LIR_Gen_1	645	652	PF02991	0.585
LIG_LIR_Nem_3	613	619	PF02991	0.560
LIG_LIR_Nem_3	645	650	PF02991	0.646
LIG_PTB_Apo_2	516	523	PF02174	0.429
LIG_PTB_Phospho_1	516	522	PF10480	0.429
LIG_Rb_pABgroove_1	189	197	PF01858	0.347
LIG_RPA_C_Fungi	489	501	PF08784	0.553
LIG_RPA_C_Fungi	607	619	PF08784	0.521
LIG_SH2_STAP1	428	432	PF00017	0.377
LIG_SH2_STAT3	522	525	PF00017	0.410
LIG_SH2_STAT5	112	115	PF00017	0.651
LIG_SH2_STAT5	428	431	PF00017	0.387
LIG_SH2_STAT5	522	525	PF00017	0.422
LIG_SH3_1	294	300	PF00018	0.498
LIG_SH3_1	407	413	PF00018	0.469
LIG_SH3_2	297	302	PF14604	0.581
LIG_SH3_3	25	31	PF00018	0.515
LIG_SH3_3	292	298	PF00018	0.549
LIG_SH3_3	332	338	PF00018	0.602
LIG_SH3_3	395	401	PF00018	0.475
LIG_SH3_3	407	413	PF00018	0.454
LIG_SUMO_SIM_anti_2	222	229	PF11976	0.407
LIG_SUMO_SIM_anti_2	258	264	PF11976	0.411
LIG_SUMO_SIM_par_1	189	196	PF11976	0.416
LIG_SUMO_SIM_par_1	30	35	PF11976	0.502
LIG_SxIP_EBH_1	643	657	PF03271	0.583
LIG_TRAF2_1	50	53	PF00917	0.426
MOD_CDK_SPK_2	548	553	PF00069	0.478
MOD_CDK_SPxK_1	16	22	PF00069	0.513
MOD_CK1_1	331	337	PF00069	0.579
MOD_CK1_1	393	399	PF00069	0.710
MOD_CK1_1	431	437	PF00069	0.377
MOD_CK1_1	457	463	PF00069	0.685
MOD_CK1_1	577	583	PF00069	0.518
MOD_CK1_1	646	652	PF00069	0.616
MOD_CK1_1	667	673	PF00069	0.522
MOD_CK1_1	9	15	PF00069	0.795
MOD_CK2_1	113	119	PF00069	0.426
MOD_CK2_1	133	139	PF00069	0.352
MOD_CK2_1	172	178	PF00069	0.460
MOD_CK2_1	216	222	PF00069	0.417
MOD_CK2_1	306	312	PF00069	0.573
MOD_CK2_1	456	462	PF00069	0.635
MOD_CK2_1	46	52	PF00069	0.581
MOD_CK2_1	507	513	PF00069	0.586
MOD_CK2_1	58	64	PF00069	0.424
MOD_CK2_1	629	635	PF00069	0.558
MOD_CK2_1	74	80	PF00069	0.688
MOD_CK2_1	96	102	PF00069	0.714
MOD_Cter_Amidation	82	85	PF01082	0.633
MOD_GlcNHglycan	243	246	PF01048	0.368
MOD_GlcNHglycan	287	290	PF01048	0.503
MOD_GlcNHglycan	291	294	PF01048	0.555
MOD_GlcNHglycan	322	325	PF01048	0.536
MOD_GlcNHglycan	392	395	PF01048	0.706
MOD_GlcNHglycan	449	453	PF01048	0.603
MOD_GlcNHglycan	454	457	PF01048	0.656
MOD_GlcNHglycan	509	512	PF01048	0.510
MOD_GlcNHglycan	554	557	PF01048	0.723
MOD_GlcNHglycan	568	572	PF01048	0.515
MOD_GlcNHglycan	666	669	PF01048	0.653
MOD_GlcNHglycan	92	95	PF01048	0.669
MOD_GlcNHglycan	97	101	PF01048	0.642
MOD_GSK3_1	140	147	PF00069	0.542
MOD_GSK3_1	251	258	PF00069	0.428
MOD_GSK3_1	281	288	PF00069	0.476
MOD_GSK3_1	289	296	PF00069	0.495
MOD_GSK3_1	30	37	PF00069	0.697
MOD_GSK3_1	304	311	PF00069	0.573
MOD_GSK3_1	356	363	PF00069	0.434
MOD_GSK3_1	43	50	PF00069	0.535
MOD_GSK3_1	448	455	PF00069	0.776
MOD_GSK3_1	503	510	PF00069	0.568
MOD_GSK3_1	548	555	PF00069	0.574
MOD_GSK3_1	598	605	PF00069	0.519
MOD_GSK3_1	6	13	PF00069	0.684
MOD_GSK3_1	634	641	PF00069	0.537
MOD_GSK3_1	642	649	PF00069	0.546
MOD_GSK3_1	672	679	PF00069	0.654
MOD_GSK3_1	84	91	PF00069	0.695
MOD_N-GLC_1	266	271	PF02516	0.464
MOD_N-GLC_1	289	294	PF02516	0.481
MOD_N-GLC_1	328	333	PF02516	0.616
MOD_NEK2_1	11	16	PF00069	0.684
MOD_NEK2_1	121	126	PF00069	0.427
MOD_NEK2_1	133	138	PF00069	0.510
MOD_NEK2_1	230	235	PF00069	0.439
MOD_NEK2_1	281	286	PF00069	0.529
MOD_NEK2_1	32	37	PF00069	0.749
MOD_NEK2_1	438	443	PF00069	0.411
MOD_NEK2_1	45	50	PF00069	0.518
MOD_NEK2_1	652	657	PF00069	0.569
MOD_NEK2_1	664	669	PF00069	0.641
MOD_NEK2_1	682	687	PF00069	0.517
MOD_NEK2_1	74	79	PF00069	0.640
MOD_PIKK_1	261	267	PF00454	0.513
MOD_PIKK_1	269	275	PF00454	0.432
MOD_PIKK_1	503	509	PF00454	0.548
MOD_PIKK_1	521	527	PF00454	0.358
MOD_PIKK_1	580	586	PF00454	0.513
MOD_PIKK_1	602	608	PF00454	0.580
MOD_PK_1	375	381	PF00069	0.364
MOD_PK_1	611	617	PF00069	0.560
MOD_PKA_1	172	178	PF00069	0.338
MOD_PKA_1	251	257	PF00069	0.428
MOD_PKA_1	541	547	PF00069	0.413
MOD_PKA_1	611	617	PF00069	0.560
MOD_PKA_1	623	629	PF00069	0.452
MOD_PKA_1	638	644	PF00069	0.509
MOD_PKA_1	84	90	PF00069	0.696
MOD_PKA_2	172	178	PF00069	0.457
MOD_PKA_2	381	387	PF00069	0.391
MOD_PKA_2	507	513	PF00069	0.562
MOD_PKA_2	534	540	PF00069	0.467
MOD_PKA_2	541	547	PF00069	0.472
MOD_PKA_2	552	558	PF00069	0.534
MOD_PKA_2	580	586	PF00069	0.554
MOD_PKA_2	598	604	PF00069	0.581
MOD_PKA_2	6	12	PF00069	0.622
MOD_PKA_2	611	617	PF00069	0.462
MOD_PKA_2	628	634	PF00069	0.535
MOD_PKA_2	638	644	PF00069	0.497
MOD_PKA_2	675	681	PF00069	0.661
MOD_PKA_2	84	90	PF00069	0.679
MOD_PKB_1	609	617	PF00069	0.548
MOD_Plk_1	221	227	PF00069	0.438
MOD_Plk_1	266	272	PF00069	0.464
MOD_Plk_2-3	196	202	PF00069	0.424
MOD_Plk_4	312	318	PF00069	0.470
MOD_Plk_4	541	547	PF00069	0.413
MOD_Plk_4	574	580	PF00069	0.581
MOD_Plk_4	611	617	PF00069	0.560
MOD_ProDKin_1	12	18	PF00069	0.662
MOD_ProDKin_1	144	150	PF00069	0.579
MOD_ProDKin_1	27	33	PF00069	0.534
MOD_ProDKin_1	293	299	PF00069	0.625
MOD_ProDKin_1	331	337	PF00069	0.648
MOD_ProDKin_1	457	463	PF00069	0.612
MOD_ProDKin_1	548	554	PF00069	0.478
MOD_ProDKin_1	676	682	PF00069	0.662
MOD_ProDKin_1	88	94	PF00069	0.632
MOD_SUMO_for_1	137	140	PF00179	0.511
MOD_SUMO_for_1	245	248	PF00179	0.438
MOD_SUMO_for_1	256	259	PF00179	0.429
MOD_SUMO_rev_2	254	258	PF00179	0.391
MOD_SUMO_rev_2	35	44	PF00179	0.492
MOD_SUMO_rev_2	510	517	PF00179	0.479
TRG_AP2beta_CARGO_1	613	623	PF09066	0.455
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.533
TRG_ER_diArg_1	128	131	PF00400	0.605
TRG_ER_diArg_1	373	375	PF00400	0.418
TRG_ER_diArg_1	418	421	PF00400	0.576
TRG_ER_diArg_1	493	495	PF00400	0.560
TRG_ER_diArg_1	527	530	PF00400	0.458
TRG_ER_diArg_1	558	560	PF00400	0.636
TRG_ER_diArg_1	608	611	PF00400	0.574
TRG_ER_diArg_1	84	86	PF00400	0.592
TRG_NES_CRM1_1	345	358	PF08389	0.479
TRG_NES_CRM1_1	369	383	PF08389	0.453
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	493	498	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	514	518	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9M3	Leptomonas seymouri	34%	90%
A0A3Q8IH40	Leishmania donovani	76%	94%
A4HH47	Leishmania braziliensis	56%	100%
A4I491	Leishmania infantum	76%	94%
E9ADP7	Leishmania major	73%	100%