Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AM32_LEIMU

TriTrypDb:

LmxM.08_29.0470

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AM32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AM32

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.615
CLV_C14_Caspase3-7	279	283	PF00656	0.711
CLV_C14_Caspase3-7	289	293	PF00656	0.714
CLV_C14_Caspase3-7	294	298	PF00656	0.668
CLV_C14_Caspase3-7	401	405	PF00656	0.700
CLV_C14_Caspase3-7	91	95	PF00656	0.654
CLV_NRD_NRD_1	217	219	PF00675	0.405
CLV_NRD_NRD_1	225	227	PF00675	0.412
CLV_PCSK_KEX2_1	101	103	PF00082	0.418
CLV_PCSK_KEX2_1	216	218	PF00082	0.409
CLV_PCSK_KEX2_1	225	227	PF00082	0.412
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.418
CLV_PCSK_SKI1_1	102	106	PF00082	0.411
CLV_PCSK_SKI1_1	225	229	PF00082	0.429
CLV_PCSK_SKI1_1	23	27	PF00082	0.407
CLV_PCSK_SKI1_1	420	424	PF00082	0.515
DEG_Nend_UBRbox_3	1	3	PF02207	0.694
DOC_CYCLIN_RxL_1	99	109	PF00134	0.603
DOC_MAPK_gen_1	216	224	PF00069	0.641
DOC_MAPK_gen_1	23	32	PF00069	0.521
DOC_MAPK_gen_1	7	15	PF00069	0.554
DOC_MAPK_MEF2A_6	347	354	PF00069	0.723
DOC_MAPK_MEF2A_6	58	65	PF00069	0.605
DOC_USP7_MATH_1	100	104	PF00917	0.616
DOC_USP7_MATH_1	178	182	PF00917	0.447
DOC_USP7_MATH_1	190	194	PF00917	0.315
DOC_USP7_MATH_1	260	264	PF00917	0.670
DOC_USP7_MATH_1	45	49	PF00917	0.615
DOC_USP7_MATH_1	95	99	PF00917	0.593
DOC_WW_Pin1_4	225	230	PF00397	0.589
DOC_WW_Pin1_4	247	252	PF00397	0.665
DOC_WW_Pin1_4	311	316	PF00397	0.674
DOC_WW_Pin1_4	346	351	PF00397	0.666
DOC_WW_Pin1_4	35	40	PF00397	0.624
LIG_14-3-3_CanoR_1	149	153	PF00244	0.657
LIG_14-3-3_CanoR_1	67	71	PF00244	0.602
LIG_deltaCOP1_diTrp_1	302	309	PF00928	0.678
LIG_FHA_1	121	127	PF00498	0.575
LIG_FHA_1	130	136	PF00498	0.572
LIG_FHA_1	248	254	PF00498	0.734
LIG_FHA_1	315	321	PF00498	0.695
LIG_FHA_1	36	42	PF00498	0.621
LIG_FHA_1	91	97	PF00498	0.595
LIG_FHA_2	287	293	PF00498	0.746
LIG_FHA_2	408	414	PF00498	0.720
LIG_FHA_2	424	430	PF00498	0.527
LIG_LIR_Gen_1	161	171	PF02991	0.395
LIG_LIR_Gen_1	303	310	PF02991	0.678
LIG_LIR_Nem_3	103	108	PF02991	0.655
LIG_LIR_Nem_3	161	167	PF02991	0.315
LIG_LIR_Nem_3	189	194	PF02991	0.395
LIG_LIR_Nem_3	303	309	PF02991	0.678
LIG_NRBOX	75	81	PF00104	0.581
LIG_PDZ_Class_2	443	448	PF00595	0.672
LIG_SH2_CRK	164	168	PF00017	0.315
LIG_SH2_NCK_1	164	168	PF00017	0.395
LIG_SH2_SRC	202	205	PF00017	0.315
LIG_SH2_STAT5	164	167	PF00017	0.315
LIG_SH2_STAT5	202	205	PF00017	0.315
LIG_SH2_STAT5	206	209	PF00017	0.489
LIG_SH2_STAT5	421	424	PF00017	0.630
LIG_SH3_3	249	255	PF00018	0.709
LIG_SUMO_SIM_anti_2	11	18	PF11976	0.673
LIG_SUMO_SIM_anti_2	351	356	PF11976	0.727
LIG_SUMO_SIM_par_1	316	323	PF11976	0.705
LIG_TRAF2_1	243	246	PF00917	0.625
LIG_TRAF2_1	426	429	PF00917	0.620
LIG_TYR_ITSM	160	167	PF00017	0.208
LIG_WRC_WIRS_1	108	113	PF05994	0.655
MOD_CDK_SPxK_1	225	231	PF00069	0.587
MOD_CK1_1	11	17	PF00069	0.679
MOD_CK1_1	116	122	PF00069	0.721
MOD_CK1_1	148	154	PF00069	0.656
MOD_CK1_1	166	172	PF00069	0.249
MOD_CK1_1	366	372	PF00069	0.711
MOD_CK1_1	391	397	PF00069	0.667
MOD_CK1_1	48	54	PF00069	0.609
MOD_CK2_1	240	246	PF00069	0.619
MOD_CK2_1	316	322	PF00069	0.705
MOD_CK2_1	407	413	PF00069	0.718
MOD_CK2_1	422	428	PF00069	0.541
MOD_DYRK1A_RPxSP_1	311	315	PF00069	0.687
MOD_GlcNHglycan	115	118	PF01048	0.401
MOD_GlcNHglycan	256	259	PF01048	0.507
MOD_GlcNHglycan	277	281	PF01048	0.520
MOD_GlcNHglycan	366	369	PF01048	0.510
MOD_GlcNHglycan	371	374	PF01048	0.495
MOD_GlcNHglycan	382	385	PF01048	0.573
MOD_GlcNHglycan	90	93	PF01048	0.459
MOD_GSK3_1	11	18	PF00069	0.627
MOD_GSK3_1	116	123	PF00069	0.582
MOD_GSK3_1	131	138	PF00069	0.575
MOD_GSK3_1	158	165	PF00069	0.477
MOD_GSK3_1	186	193	PF00069	0.395
MOD_GSK3_1	272	279	PF00069	0.750
MOD_GSK3_1	286	293	PF00069	0.670
MOD_GSK3_1	314	321	PF00069	0.705
MOD_GSK3_1	353	360	PF00069	0.687
MOD_GSK3_1	364	371	PF00069	0.716
MOD_GSK3_1	380	387	PF00069	0.763
MOD_GSK3_1	390	397	PF00069	0.686
MOD_GSK3_1	86	93	PF00069	0.622
MOD_NEK2_1	113	118	PF00069	0.658
MOD_NEK2_1	135	140	PF00069	0.588
MOD_NEK2_1	15	20	PF00069	0.615
MOD_NEK2_1	159	164	PF00069	0.315
MOD_NEK2_1	320	325	PF00069	0.784
MOD_NEK2_1	341	346	PF00069	0.735
MOD_NEK2_1	388	393	PF00069	0.678
MOD_NEK2_1	46	51	PF00069	0.632
MOD_NEK2_2	100	105	PF00069	0.674
MOD_PIKK_1	232	238	PF00454	0.567
MOD_PIKK_1	366	372	PF00454	0.617
MOD_PK_1	357	363	PF00069	0.653
MOD_PKA_2	148	154	PF00069	0.649
MOD_PKA_2	66	72	PF00069	0.598
MOD_PKA_2	8	14	PF00069	0.552
MOD_Plk_1	384	390	PF00069	0.711
MOD_Plk_4	11	17	PF00069	0.695
MOD_Plk_4	131	137	PF00069	0.574
MOD_Plk_4	159	165	PF00069	0.315
MOD_Plk_4	178	184	PF00069	0.447
MOD_Plk_4	190	196	PF00069	0.251
MOD_Plk_4	371	377	PF00069	0.609
MOD_Plk_4	384	390	PF00069	0.633
MOD_Plk_4	78	84	PF00069	0.505
MOD_ProDKin_1	225	231	PF00069	0.587
MOD_ProDKin_1	247	253	PF00069	0.667
MOD_ProDKin_1	311	317	PF00069	0.675
MOD_ProDKin_1	346	352	PF00069	0.668
MOD_ProDKin_1	35	41	PF00069	0.625
MOD_SUMO_rev_2	322	330	PF00179	0.709
TRG_DiLeu_BaEn_1	59	64	PF01217	0.663
TRG_DiLeu_LyEn_5	59	64	PF01217	0.663
TRG_ENDOCYTIC_2	157	160	PF00928	0.559
TRG_ENDOCYTIC_2	164	167	PF00928	0.315
TRG_ER_diArg_1	216	218	PF00400	0.617
TRG_ER_diArg_1	224	226	PF00400	0.616
TRG_ER_diArg_1	7	10	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G2	Leptomonas seymouri	61%	100%
A0A3S7X253	Leishmania donovani	92%	100%
A4HH48	Leishmania braziliensis	73%	98%
A4I492	Leishmania infantum	92%	100%
E9ADP8	Leishmania major	89%	100%